Genetics of ankylosing spondylitis.

abstract：:Complement defects are associated with an enhanced risk of a broad spectrum of infectious as well as systemic or local inflammatory and thrombotic disorders. Inherited complement deficiencies have been described for virtually all complement components but can be mimicked by autoantibodies, interfering with the activit...

journal_title：Molecular immunology

authors： Schröder-Braunstein J,Kirschfink M

更新日期：2019-10-01 00:00:00

abstract：:A turbidimetric method for measuring the diameters of insoluble immune complexes, based on the wavelength dependence of their ability to scatter light, was developed. The method was validated by demonstrating that it gave experimental values for the diameters of polystyrene microspheres which were in good agreement wi...

journal_title：Molecular immunology

authors： Easterbrook-Smith SB

更新日期：1993-05-01 00:00:00

abstract：:Evidence for the central role that intestinal beta-defensins play in maintaining gut health continues to accumulate within the literature. Two epithelially-derived enteric beta-defensins, hBD1 and hBD2, have been identified thus far and the following chapter reviews our current understanding of how the expression and ...

journal_title：Molecular immunology

authors： O'Neil DA

更新日期：2003-11-01 00:00:00

abstract：:Antibacterial responses have been studied in Atlantic salmon following an acute intra peritoneal injection of a genetically attenuated (aroA(-)) strain of Aeromonas salmonicida known to elicit protective immunity. Three tissues were studied for transcriptional changes, the liver, head kidney and the gill. RNA was coll...

journal_title：Molecular immunology

authors： Martin SA,Blaney SC,Houlihan DF,Secombes CJ

更新日期：2006-04-01 00:00:00

abstract：:GK-1 is an immunomodulatory, 18-aa-long peptide that has been proved to promote the activation of mouse peritoneal macrophages and LPS-pulsed mouse bone marrow-derived dendritic cells (BM-DCs). This study is aimed to explore the mechanisms underlying the activation of these antigen-presenting cells (APCs) by GK-1. In ...

journal_title：Molecular immunology

authors： Montero L,Cervantes-Torres J,Sciutto E,Fragoso G

更新日期：2020-12-01 00:00:00

abstract：:Human C3b as well as native C3 were found to bind to solid phase human and rabbit IgG. Haemolytically active C3 had significantly higher binding capacity to IgG than the C3b fragment. Inhibition experiments proved that C3 and C3b have common binding sites on the Fab and Fc part of the IgG molecule but the character of...

journal_title：Molecular immunology

authors： Kulics J,Rajnavölgyi E,Füst G,Gergely J

更新日期：1983-08-01 00:00:00

abstract：:The migration of dendritic cells (DCs) from the site of antigen-encounter to regional lymphoid organs is crucial for DCs to function as potent antigen-presenting cells. Matrix metalloproteinase-9 (MMP-9) is critically for DCs migration across extracellular matrix (ECM). We verified in previous studies that hypoxia dim...

journal_title：Molecular immunology

authors： Zhao P,Li XG,Yang M,Shao Q,Wang D,Liu S,Song H,Song B,Zhang Y,Qu X

更新日期：2008-04-01 00:00:00

abstract：:Lysozyme is an important component of the insect non-specific immune response against bacteria that is characterized by its ability to break down bacterial cell-walls. By searching an EST database from the fall armyworm, Spodoptera frugiperda (Negre et al., 2006), we identified five sequences encoding proteins of the ...

journal_title：Molecular immunology

authors： Chapelle M,Girard PA,Cousserans F,Volkoff NA,Duvic B

更新日期：2009-12-01 00:00:00

abstract：:Degenerate PCR was used to isolate a 221-base pair nucleotide sequence of a new crustin-like antibacterial peptide from the haemocytes of the European lobster, Homarus gammarus. Rapid amplification of cDNA ends was used to extend the sequence to determine the complete open reading frame and un-translated regions. The ...

journal_title：Molecular immunology

authors： Hauton C,Brockton V,Smith VJ

更新日期：2006-03-01 00:00:00

abstract：:We considered the possibility that the greater the distance between an immune receptor V and J, the more likely the V usage. Such a hypothesis is supported by results from mouse experiments. And, such a hypothesis is consistent with the fundamental nature of recombination and genomic distance: the further the distance...

journal_title：Molecular immunology

authors： Pakasticali N,Gill T,Chobrutskiy BI,Tong WL,Ramsamooj M,Blanck G

更新日期：2019-12-01 00:00:00

abstract：:Mycobacterium leprae, the causative agent of leprosy, challenges host defense mechanism by impairing the signal transduction of T cells which leads to downregulation of T cell proliferation, mainly as a consequence of interference with IL-2 production. In this study we sought to identify how soluble forms of M. leprae...

journal_title：Molecular immunology

authors： Chattree V,Khanna N,Rao DN

更新日期：2007-03-01 00:00:00

abstract：:MiRNAs are a class of endogenous tiny RNAs that act as inhibitors of translation or promote RNA degradation by duplex-formation within the 3'-UTR of target mRNAs. They play an important role during a wide range of cellular processes by fine-tuning of gene expression. The differentiation of monocytes to macrophages pla...

journal_title：Molecular immunology

authors： Poitz DM,Augstein A,Gradehand C,Ende G,Schmeisser A,Strasser RH

更新日期：2013-12-01 00:00:00

abstract：:The complement system is very tightly regulated by fluid-phase and membrane-bound factors that prevent injury to self-tissues. The study of genetically engineered animals with targeted deletion or gain of function mutations has highlighted the important role that many of the complement inhibitors play in vivo. The adv...

journal_title：Molecular immunology

authors： Turnberg D,Botto M

更新日期：2003-09-01 00:00:00

abstract：:Activation-induced cell death (AICD) in T lymphocytes depends on the expression of Fas-ligand, which triggers the apoptotic process after binding to its receptor Fas. This leads to the activation of cysteine proteases of the caspase family and especially of caspase-3, a critical effector protein during AICD. We have p...

journal_title：Molecular immunology

authors： Sabbagh L,Bourbonnière M,Sékaly RP,Cohen LY

更新日期：2005-07-01 00:00:00

abstract：:Sepsis is a life-threatening disease characterized by uncontrolled inflammatory responses upon pathogen infections, especially for the antibiotic-resistant strains, such as Methicillin-resistant S. aureus (MRSA). Here we demonstrated that a Mitochondria-derived peptide (MOTS-c) could significantly improve the survival...

journal_title：Molecular immunology

authors： Zhai D,Ye Z,Jiang Y,Xu C,Ruan B,Yang Y,Lei X,Xiang A,Lu H,Zhu Z,Yan Z,Wei D,Li Q,Wang L,Lu Z

更新日期：2017-12-01 00:00:00

abstract：:Despite the fact that was one of the first systems to be discovered and investigated in the innate immunity, Complement is continuing to receive growing attention by the scientific community. Complement is involved in several diseases such as diabetes, atherosclerosis or Systemic Lupus Erythematous. Successful therape...

journal_title：Molecular immunology

authors： Castellano G

更新日期：2015-11-01 00:00:00

abstract：:The binding of a T cell-presented peptide to MHC class II alpha,beta chains occurs as a concurrent process with the release of the associated invariant chain (Ii) by cathepsin B. Ii was digested by cathepsin B from solubilized, MHC class II alpha,beta,Ii complexes in the presence of N-hydroxysuccinimidyl-4-azidobenzoa...

journal_title：Molecular immunology

authors： Daibata M,Xu M,Humphreys RE,Reyes VE

更新日期：1994-03-01 00:00:00

abstract：:Somatic hypermutation (SHM) in immunoglobulin gene (Ig) variable (V) regions is critical for the maturation of the antibody response. It is dependent on the expression of activation-induced cytidine deaminase (AID) and translesion DNA polymerases in germinal center B cells as well as Ig V transcription, as regulated b...

journal_title：Molecular immunology

authors： Komori A,Xu Z,Wu X,Zan H,Casali P

更新日期：2006-04-01 00:00:00

abstract：:Keratin is a cytoskeletal protein that constitutes the intermediate filament. Its distribution is restricted to epithelial tissues in mammals, but is wider in fish. An interesting feature of fish keratin is that it is abundant in the cutaneous mucus. However, the biological function of keratin in the mucus has not bee...

journal_title：Molecular immunology

authors： Shibuya K,Tsutsui S,Nakamura O

更新日期：2019-12-01 00:00:00

abstract：:Host-derived macrophage migration inhibitory factor (MIF) has been implicated in the pathogenesis of malaria infection, especially in malarial anemia. Although two Plasmodium parasite-derived MIF orthologs, Plasmodium falciparum MIF and P. berghei MIF were identified recently, the crystal structure and the precise rol...

journal_title：Molecular immunology

authors： Shao D,Zhong X,Zhou YF,Han Z,Lin Y,Wang Z,Bu L,Zhang L,Su XD,Wang H

更新日期：2010-01-01 00:00:00

abstract：:Light chains of 426 randomly selected myelomas from BALB/c and NZB mice were characterized by isoelectric focusing (IF) and electrophoresis at pH 3. Approximately 50% of the light chains in each strain were found to have unique electrophoretic properties. The remaining 50% of light chains fell into groups of two or mo...

journal_title：Molecular immunology

authors： Gibson DM

更新日期：1984-05-01 00:00:00

abstract：:Aggregation of therapeutic proteins is a key factor in the generation of unwanted immunogenicity, and can result in reduced serum half-life, neutralization of function and adverse health effects. There is currently little information regarding how aggregates interact with B-cell receptors or cognate antibodies at the ...

journal_title：Molecular immunology

authors： Eyes TJ,Austerberry JI,Dearman RJ,Johannissen LO,Kimber I,Smith N,Thistlethwaite A,Derrick JP

更新日期：2019-01-01 00:00:00

abstract：:Most of the complement proteins in circulation are, by and large, synthesized in the liver. However data accumulated over the past several decades provide incontrovertible evidence that some if not most of the individual complement proteins are also synthesized extrahepatically by activated as well as non-activated ce...

journal_title：Molecular immunology

authors： Ghebrehiwet B,Hosszu KH,Peerschke EI

更新日期：2017-04-01 00:00:00

abstract：:In this paper, we performed further biochemical characterization of the CD26 antigen, as defined by the mAbs in anti-1F7 and anti-Ta1, in order to clarify the observed functional differences among these mAbs. For this purpose, we developed a mAb, anti-5F8, which recognizes yet another epitope on the CD26 antigen diffe...

journal_title：Molecular immunology

authors： Torimoto Y,Dang NH,Tanaka T,Prado C,Schlossman SF,Morimoto C

更新日期：1992-02-01 00:00:00

abstract：:The protective antigen (PA(83)) of Bacillus anthracis is the dominant antigen in natural and vaccine-induced immunity to anthrax infection. Three human single-chain variable fragments (scFvs) against cell bound PA were isolated from an antibody phage display library. Specifically, the antibodies were evaluated for the...

journal_title：Molecular immunology

authors： Steiniger SC,Altobell LJ 3rd,Zhou B,Janda KD

更新日期：2007-04-01 00:00:00

abstract：:Peptide gpMBP72-85, containing amino acids 72-85 of guinea pig myelin basic protein is commonly used to induce experimental autoimmune encephalomyelitis in Lewis rats. The N-terminal glutamine in this peptide can cyclize to pyroglutamic acid, leading to loss of the first MHC anchor for binding to MHC class II. Acetyla...

journal_title：Molecular immunology

authors： de Haan EC,Wauben MH,Wagenaar-Hilbers JP,Grosfeld-Stulemeyer MC,Rijkers DT,Moret EE,Liskamp RM

更新日期：2004-02-01 00:00:00

abstract：:Der f 2 is one of the major mite allergens recognized by human IgE antibodies of allergic patients. Using five anti-Der f 2 mouse monoclonal antibodies, human IgE epitopes of Der f 2 were analyzed. Among them, two monoclonal antibodies 15E11 and 13A4 inhibited the binding between Der f 2 and human IgE antibodies. To d...

journal_title：Molecular immunology

authors： Nishiyama C,Hatanaka H,Ichikawa S,Fukada M,Akagawa-Chihara M,Yuuki T,Yokota T,Inagaki F,Okumura Y

更新日期：1999-01-01 00:00:00

abstract：:We showed that nucleotide sequences coding for linear B-cell epitopes of human immunodeficiency virus type 1 (HIV1) gp120 protein are enriched with codons containing cytosine and guanine in their first and second codon positions. Guanine and cytosine are the most mutable nucleotides in HIV1 genes (due to APOBEC3 and A...

journal_title：Molecular immunology

authors： Khrustalev VV

更新日期：2010-04-01 00:00:00

abstract：:Scygonadin is a novel antimicrobial peptide, which was originally isolated from the seminal plasma of the mud crab, Scylla serrata. Based on the partial 20-residue NH(2)-terminal sequence of the peptide, H-Gly-Gln-Ala-Leu-Asn-Lys-Leu-Met-Pro-Lys-Ile-Val-Ser-Ala-Ile-Ile-Tyr-Met-Val-Gly-OH, scygonadin was cloned from th...

journal_title：Molecular immunology

authors： Wang KJ,Huang WS,Yang M,Chen HY,Bo J,Li SJ,Wang GZ

更新日期：2007-03-01 00:00:00

abstract：:During the last years, intensive research has shed light in the transcriptional networks that shape the invariant NKT (iNKT) cell lineage and guide the choices towards functionally distinct iNKT cell subsets (Constantinides and Bendelac, 2013; Engel and Kronenberg, 2014; Gapin, 2016; Kim et al., 2015). However, the ep...

journal_title：Molecular immunology

authors： Tsagaratou A

更新日期：2018-09-01 00:00:00