Abstract:
:During the last years, intensive research has shed light in the transcriptional networks that shape the invariant NKT (iNKT) cell lineage and guide the choices towards functionally distinct iNKT cell subsets (Constantinides and Bendelac, 2013; Engel and Kronenberg, 2014; Gapin, 2016; Kim et al., 2015). However, the epigenetic players that regulate gene expression and orchestrate the iNKT cell lineage choices remain poorly understood. Here, we summarize recent advances in our understanding of epigenetic regulation of iNKT cell development and lineage choice. Particular emphasis is placed on DNA modifications and the Ten Eleven Translocation (TET) family of DNA demethylases.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Tsagaratou Adoi
10.1016/j.molimm.2018.08.020subject
Has Abstractpub_date
2018-09-01 00:00:00pages
564-573eissn
0161-5890issn
1872-9142pii
S0161-5890(18)30684-9journal_volume
101pub_type
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