TET mediated epigenetic regulation of iNKT cell lineage fate choice and function.

Abstract:

:During the last years, intensive research has shed light in the transcriptional networks that shape the invariant NKT (iNKT) cell lineage and guide the choices towards functionally distinct iNKT cell subsets (Constantinides and Bendelac, 2013; Engel and Kronenberg, 2014; Gapin, 2016; Kim et al., 2015). However, the epigenetic players that regulate gene expression and orchestrate the iNKT cell lineage choices remain poorly understood. Here, we summarize recent advances in our understanding of epigenetic regulation of iNKT cell development and lineage choice. Particular emphasis is placed on DNA modifications and the Ten Eleven Translocation (TET) family of DNA demethylases.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Tsagaratou A

doi

10.1016/j.molimm.2018.08.020

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

564-573

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(18)30684-9

journal_volume

101

pub_type

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