Abstract：
:CD9 is a glycoprotein of the transmembrane 4 superfamily (TM4SF) and is involved in various cellular processes. In this study, we describe the isolation of the full-length cDNA encoding for CD9 molecule (daCD9) of red stingray, Dasyatis akajei. This 1252 bp cDNA was isolated from leukocyte cDNA library and contains 681 bp open reading frame encoding 226 amino acid residues. Amino acid sequences analysis and structure prediction display approximately 50% identity to higher vertebrates with the presence of conserved structures, including the four transmembrane domains and certain characteristic residues. Southern blot analysis shows that daCD9 exists as a single copy gene. Northern blot analysis reveals that daCD9 is highly expressed in gill and spleen although its expression can be found in other tissues suggesting daCD9 might play an important role in immune defense in this fish.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Zhu J,Yan K,Lu L,Peng C,Zhou C,Chen S,Xie X,Dong M,Xu Adoi
10.1016/j.molimm.2005.10.005subject
Has Abstractpub_date
2006-04-01 00:00:00pages
1534-40issue
10eissn
0161-5890issn
1872-9142pii
S0161-5890(05)00361-5journal_volume
43pub_type
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更新日期：1999-06-01 00:00:00
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