LEI0258 microsatellite variability and its association with humoral and cell mediated immune responses in broiler chickens.

abstract：:During B and T lymphocyte development, immunoglobulin and T cell receptor genes are assembled from the germline V, (D) and J gene segments (Lewis, S.M., 1994. The mechanism of V(D)J joining: lessons from molecular, immunological and comparative analyses. Adv. Immunol. 56, 27-150). These DNA rearrangements, responsible...

journal_title：Molecular immunology

authors： Sun T,Ezekiel UR,Erskine L,Agulo R,Bozek G,Roth D,Storb U

更新日期：1999-06-01 00:00:00

abstract：:The insect gut participates in initial local immune responses by producing reactive oxygen and nitrogen species as well as anti-microbial peptides to resist pathogenic invasions. Nitric oxide (NO), a signaling and an immune effector molecule synthesized by the enzyme NO synthase (NOS), mediates an early step of the si...

journal_title：Molecular immunology

authors： Liu W,Wang Y,Leng Z,Wang Q,Duan X,Luo Y,Jiang Y,Qin L

更新日期：2020-10-01 00:00:00

abstract：:Of the antioxidant/prooxidant mechanisms mediating the regulation of inflammatory mediators, particularly cytokines, oxidative stress-related pathways remain a cornerstone. It is conspicuous that there is a strong association between free radical accumulation (ROS/RNS; oxidative stress) and the evolution of inflammati...

journal_title：Molecular immunology

authors： Haddad JJ,Harb HL

更新日期：2005-05-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I and II proteins have been in the focus of interest for immunologists, biochemists, cell biologists, and structural biologists for decades. With dozens of entries in the Protein Data Bank, their crystal structures are now sufficiently well understood, while their dynamic p...

journal_title：Molecular immunology

authors： Yaneva R,Schneeweiss C,Zacharias M,Springer S

更新日期：2010-01-01 00:00:00

abstract：:MAIT cells are innate-like T cells that are enriched in mucosal sites and tissues including adipose tissue and liver. They play an important role in immunity against microbial pathogens. Recently, it has been reported that MAIT cells could also be important in metabolic diseases and can be involved in setting up and m...

journal_title：Molecular immunology

authors： Toubal A,Lehuen A

更新日期：2021-02-01 00:00:00

abstract：:Adiponectin can protect against inflammation; one of the mechanisms involves direct, inhibition of macrophages (MΦ). We postulated that adiponectin anti-sense transgenic (AsTg) mice raised in our laboratory are prone to inflammation because of systemic low adiponectin levels. The writhing response to acetic acid was u...

journal_title：Molecular immunology

authors： Negoro T,Kin M,Takuma A,Saito K,Shimizu S,Nakano Y

更新日期：2014-02-01 00:00:00

abstract：:The variables regions of three syngeneic anti-idiotypic antibodies (Ab2s) were cloned and sequenced. They are encoded by different VL genes, two are from different members of V kappa-Ox1 superfamily. The H chains are encoded by VH genes belonging to three different VH families, J558, Q52 and 7183. Together with a prev...

journal_title：Molecular immunology

authors： Chen J,Borden P,Liao J,Kabat EA

更新日期：1992-09-01 00:00:00

abstract：:The binding of CD40 ligand on activated T cells to CD40 on resting B cells induces the expression of costimulatory molecules B7-1 (CD80) and B7-2 (CD86). The induction of B7 molecules by CD40 ligand-CD40 interaction represents a critical step in rendering B cells competent for antigen presentation. The CBA/N mouse has...

journal_title：Molecular immunology

authors： Goldstein MD,Debenedette MA,Hollenbaugh D,Watts TH

更新日期：1996-04-01 00:00:00

abstract：:High glucose- induced endothelial dysregulation has been recognized as an initiation of vascular complications in Type 2 diabetes mellitus (T2DM). Anagliptin is a novel licensed dipeptidyl peptidase-4 (DPP-4) inhibitor for the treatment of T2DM. The effects of anagliptin in high glucose- induced endothelial dysfunctio...

journal_title：Molecular immunology

authors： Jiang T,Jiang D,Zhang L,Ding M,Zhou H

更新日期：2019-03-01 00:00:00

abstract：:The translation of mRNA within total RNA of German (Blattella germanica) cockroaches was performed using a rabbit reticulocyte lysate system. Analysis of the translation products by SDS-PAGE and combined autoradiography revealed several synthesized proteins with apparent molecular weights ranging from 20 kD to 110 kD....

journal_title：Molecular immunology

authors： Helm R,Cockrell G,Sharkey P,Brenner R,Burks AW

更新日期：1993-12-01 00:00:00

abstract：:In humans, three distinct but closely related classes of receptors that bind the Fc portion of IgG (FcgammaRI, II and III) have been identified. FcgammaRI can bind monomeric IgG with high affinity and has a unique third extracellular domain (EC3). Three very similar genes have been characterized for FcgammaRI (A, B, C...

journal_title：Molecular immunology

authors： Ernst LK,Duchemin AM,Miller KL,Anderson CL

更新日期：1998-10-01 00:00:00

abstract：:Pathogen-driven selection is believed to be important in the evolution and maintenance of the polymorphism of the major histocompatibility complex (MHC) genes but have been tested for very few vertebrates. In this study, we first investigate by SSCP (single strand conformational polymorphism) the diversity found at th...

journal_title：Molecular immunology

authors： Croisetière S,Tarte PD,Bernatchez L,Belhumeur P

更新日期：2008-06-01 00:00:00

abstract：:Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor-inducible 14 (Fn14) have been associated with liver disease. Hepatic stellate cells (HSCs) play a critical role in the hepatic wound-healing response after liver injury, but there is little information available on t...

journal_title：Molecular immunology

authors： Wang A,Zhang F,Xu H,Xu M,Cao Y,Wang C,Xu Y,Su M,Zhang M,Zhuge Y

更新日期：2017-07-01 00:00:00

abstract：:In this work, we show that P2 nucleotide receptors control lipopolysaccharide (LPS)-induced neutrophil migration in the mouse air pouch model. Neutrophil infiltration in LPS-treated air pouches was reduced by the intravenous (iv) administration of the non-selective P2 receptor antagonist PPADS but not by suramin and R...

journal_title：Molecular immunology

authors： Kukulski F,Ben Yebdri F,Bahrami F,Lévesque SA,Martín-Satué M,Sévigny J

更新日期：2010-01-01 00:00:00

abstract：:Aging is an irreversible physiological process characterized by increased risk of diseases, reduced effectiveness of vaccines, and decreased immune responses. One of the most prominent paradigms of aging and age related conditions is the progressive accumulation of un-repaired DNA breaks leading to apoptosis and exhau...

journal_title：Molecular immunology

authors： Puthiyaveetil AG,Caudell DL

更新日期：2013-01-01 00:00:00

abstract：:A quantitative analysis of the frequencies of autoantibody producing B-cells has been undertaken by producing and analyzing random hybridoma collections generated in fusions with activated B-cells. Activated B-cells were derived from mice injected with LPS and SRBC and normal mice. They were compared to those derived ...

journal_title：Molecular immunology

authors： Rolink AG,Thalmann P,Berger C,Radaszkiewicz T,Melchers F

更新日期：1988-11-01 00:00:00

abstract：:In two recent articles published in Molecular Immunology, Steere and colleagues continue their search for an autoimmune mechanism of arthritis in patients who have failed short-course antibiotic therapy for Borrelia burgdorferi, the spirochetal agent of Lyme disease. As in previous attempts, the authors fail to elucid...

journal_title：Molecular immunology

authors： Stricker RB,Johnson L

更新日期：2008-06-01 00:00:00

abstract：:The paradigm that B cells mainly play a central role in adaptive immunity may have to be reevaluated because B-1 lineage cells have been found to exhibit innate-like functions, such as phagocytic and bactericidal activities. Therefore, the evolutionary connection of B-1 lineage cells between innate and adaptive immuni...

journal_title：Molecular immunology

authors： Zhu LY,Shao T,Nie L,Zhu LY,Xiang LX,Shao JZ

更新日期：2016-01-01 00:00:00

abstract：:The generation of T cell receptor (TCR) sequence diversity can produce 'forbidden' clones able to recognize self-antigens. Here, the structure of the complex between a myelin basic protein peptide (MBP85-99), human leukocyte antigen (HLA)-DR2 (DRB1*1501/DRA) and TCR-Ob.2F3, the dominant autoimmune clone obtained from ...

journal_title：Molecular immunology

authors： Kato Z,Stern JN,Nakamura HK,Miyashita N,Kuwata K,Kondo N,Strominger JL

更新日期：2010-11-01 00:00:00

abstract：:Human endothelial cells have been shown to be distinctive from other IL-1 responsive cells (e.g. murine thymocytes), in the equal units of murine and human IL-1 do not have the same endothelial cell stimulatory effect, as measured by increased lymphocyte adherence. In this paper, the cell surface IL-1 receptors of hum...

journal_title：Molecular immunology

authors： Thieme TR,Wagner CR

更新日期：1989-03-01 00:00:00

abstract：:An attempt was made to obtain fragments containing the C gamma 2 region by selectively cleaving human Fc fragments prepared from pooled IgG at Met residues using cyanogen bromide. Based on the known locations of Met residues in the Fc regions of human IgG subclasses, fragments between Met 252 and 358, comprising the C...

journal_title：Molecular immunology

authors： Boulware DW,Goldsworthy PD,Nardella FA,Mannik M

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:Allergen epitope characterization provides valuable information useful for the understanding of proteins as food allergens. It is believed that IgE epitopes in general are conformational, nevertheless, for food allergens known to sensitize through the gastrointestinal tract linear epitopes have been suggeste...

journal_title：Molecular immunology

authors： Bøgh KL,Nielsen H,Madsen CB,Mills EN,Rigby N,Eiwegger T,Szépfalusi Z,Roggen EL

更新日期：2012-07-01 00:00:00

abstract：:Mus m 1.0102 is a member of the mouse Major Urinary Protein family, belonging to the Lipocalins superfamily. Major Urinary Proteins (MUPs) are characterized by highly conserved structural motifs. These include a disulphide bond, involved in protein oxidative folding and protein structure stabilization, and a free cyst...

journal_title：Molecular immunology

authors： Ferrari E,Corsini R,Burastero SE,Tanfani F,Spisni A

更新日期：2020-04-01 00:00:00

abstract：:Tremendous advances in our understanding of the thrombotic microangiopathies (TMAs) have revealed distinct disease mechanisms within this heterogeneous group of diseases. As a direct result of this knowledge, both children and adults with complement-mediated TMA now enjoy higher expectations for long-term health. In t...

journal_title：Molecular immunology

authors： Nester CM,Barbour T,de Cordoba SR,Dragon-Durey MA,Fremeaux-Bacchi V,Goodship TH,Kavanagh D,Noris M,Pickering M,Sanchez-Corral P,Skerka C,Zipfel P,Smith RJ

更新日期：2015-09-01 00:00:00

abstract：:Recombinant IL-2 (rIL-2) produced in prokaryotes, is widely used in lieu of native IL-2, which is secreted by T cells, to assess the functional profile of this cytokine. We provide evidence that a naturally occurring species of post-translationally modified IL-2 (moIL-2) exhibits enhanced bioactivity compared to rIL-2...

journal_title：Molecular immunology

authors： Denis MC,Huber BT

更新日期：2003-09-01 00:00:00

abstract：:Immune-mediated glomerular diseases (glomerulonephritis) encompass a heterogeneous collection of diseases that cause inflammation within the glomerulus and other renal compartments with significant morbidity and mortality. In general, CD4+ T cells orchestrate the immune response and play a unique role in autoimmune an...

journal_title：Molecular immunology

authors： Schmidt T,Luebbe J,Paust HJ,Panzer U

更新日期：2018-12-01 00:00:00

abstract：:The allergenic cross-reactivity of cytochromes c isolated from Kentucky bluegrass (KBG) and ryegrass (RG) pollens was demonstrated by the finding that both cytochromes elicited PCA reactions of comparable titers in rats sensitized with murine reaginic antiserum to either KBG or RG cytochrome c. However, allergenic dif...

journal_title：Molecular immunology

authors： Ekramoddoullah AK,Kisil FT,Sehon AH

更新日期：1982-12-01 00:00:00

abstract：:Major histocompatibility complex (MHC) molecules present peptide antigens to T lymphocytes and initiate immune responses. The peptides loaded onto MHC class I or MHC class II molecules can be derived from cytosolic proteins, both self and foreign. A variety of cellular processes, including endocytosis, vesicle traffic...

journal_title：Molecular immunology

authors： Valečka J,Almeida CR,Su B,Pierre P,Gatti E

更新日期：2018-07-01 00:00:00

abstract：:We have previously developed a number of monoclonal antibodies (Mabs) that bind to protamine. One of these antibodies, Hup1N, binds to human protamine 1 but not to protamine 2. In contrast, Mab HupA binds both protamine 1 and protamine 2. The epitopes for these two Mabs were observed to overlap, and were localized to ...

journal_title：Molecular immunology

authors： Stanker LH,Wyrobek A,McKeown C,Balhorn R

更新日期：1993-12-01 00:00:00

abstract：UNLABELLED:C5L2, a G-protein-coupled receptor (GPCR), has been identified as an ASP (C3adesArg) and C5a receptor. Controversy exists regarding both ligand binding and functionality. ASP activation of C5L2 is proposed to regulate fat storage. C5L2 is also proposed as a decoy receptor for C5a, an inflammatory mediator, b...

journal_title：Molecular immunology

authors： Cui W,Simaan M,Laporte S,Lodge R,Cianflone K

更新日期：2009-09-01 00:00:00