Abstract:
:Zinc finger protein regulator of apoptosis and cell cycle arrest (Zac1) is a transcription factor able to induce apoptosis or cell cycle arrest through independent pathways. In spite of the important potential functions attributed to Zac1, little is known of its physiological regulation and biological function. We discovered that variant Zac1b was expressed in murine embryonic fibroblasts (MEFs) treated with polyriboinosinic polyribocytidylic acid [poly(I:C)], a synthetic double-stranded RNA. This regulation occurred mainly through Toll-Like Receptor 3 (TLR3)- and Interferon Regulatory Factor 3 (IRF3)-dependent pathways. As TLR3 and IRF3 are central activators of antiviral immunity, we hypothesized that Zac1 may be implicated in antiviral responses. In line with this notion, we observed that Zac1b was expressed in MEFs infected with Encephalomyocarditis virus (EMCV). We also observed that Zac1-deficient MEFs were less sensitive to EMCV-induced cell death than wild-type MEFs. However, Zac1 gene inactivation had no effect on the survival of mice infected with EMCV. In conclusion, this study describes for the first time a transcriptional regulation of Zac1b, induced by synthetic dsRNA and RNA viruses, the functional significance of which remains to be further investigated.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Warzée B,Mesnil C,Hober D,Caloone D,Pirottin D,Garigliany MM,Desmecht D,Drion PV,Journot L,Lekeux P,Bureau F,Desmet CJdoi
10.1016/j.molimm.2010.09.004subject
Has Abstractpub_date
2010-11-01 00:00:00pages
119-27issue
1-3eissn
0161-5890issn
1872-9142pii
S0161-5890(10)00565-1journal_volume
48pub_type
杂志文章abstract::Macrophages (Mφ) undergo activation to pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes in response to pathophysiologic stimuli and dysregulation of the M1-M2 balance is often associated with diseases. Therefore, studying mechanisms of macrophage polarization may reveal new drug targets. Human Mφ polarizatio...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2017.05.027
更新日期:2017-08-01 00:00:00
abstract::RIP2/RICK/CARDIAK is a member of the receptor interacting protein kinase (RIP) family. RIP2 promotes NF-kappaB activation as well as activation of the MAPKs JNK, ERK1/2 and p38 MAPK, thereby playing an emergent role in the innate immune response and NOD signaling. Moreover, RIP2 has been shown to interact with the CAR...
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pub_type: 杂志文章
doi:10.1016/j.molimm.2008.11.002
更新日期:2009-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.molimm.2006.08.022
更新日期:2007-03-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/s0161-5890(00)00055-9
更新日期:2000-04-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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更新日期:2010-04-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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更新日期:2021-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0161-5890(89)90078-3
更新日期:1989-03-01 00:00:00
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pub_type: 历史文章,杂志文章,评审
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更新日期:2020-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.molimm.2007.12.002
更新日期:2008-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0161-5890(91)90087-z
更新日期:1991-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0161-5890(93)90152-2
更新日期:1993-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0161-5890(92)90120-m
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.molimm.2009.11.016
更新日期:2010-02-01 00:00:00
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pub_type: 杂志文章
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journal_title:Molecular immunology
pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0161-5890(91)90181-i
更新日期:1991-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0161-5890(95)00019-b
更新日期:1995-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-06-01 00:00:00