Abstract：
:Elevated level of IgG-type antibodies against Type 1 nuclear antigen (anti-EBNA-1-IgG) of the Epstein-Barr virus is a strong risk factor for certain autoimmune diseases. We measured anti-EBNA-1 IgG titers in 107 patients with hereditary angioedema due to C1-inhibitor deficiency (HAE-C1-INH). In the sera from 33 longitudinally tested patients, we found a very strong correlation (R>0.75, p=0.0005) between anti-EBNA-1-IgG titers measured in 2004 and 2010, respectively. High (>200 U/ml) anti-EBNA-1 levels were strongly correlated with the frequency of upper airway attacks (p=0.003) and the dose requirement of C1-inhibitor concentrate (p=0.008), while no significant association with the frequency of subcutaneous and abdominal attacks was found. These novel findings indicate that the underlying/triggering mechanisms of upper airway attacks in HAE-C1-INH may differ from that of other types of attacks and measurement of the anti-EBNA-1 IgG levels may be suitable for the prediction of upper airway attacks and C1-inhibitor concentrate requirement in HAE-C1-INH patients.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Csuka D,Varga L,Farkas H,Füst Gdoi
10.1016/j.molimm.2011.11.005subject
Has Abstractpub_date
2012-01-01 00:00:00pages
649-54issue
4eissn
0161-5890issn
1872-9142pii
S0161-5890(11)00801-7journal_volume
49pub_type
杂志文章abstract：:The 3-D complex structures of extracellular domain of human CD16 (FcgammaRIII) and hIgG1 or B88-9 were obtained by means of computer-guided molecular modeling, respectively. The binding epitopes were predicted and binding energy was calculated theoretically. The epitopes of human CD16 interacted with hIgG1 and B88-9 w...
journal_title：Molecular immunology
pub_type： 杂志文章
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abstract：:T cell responses are determined by the environment in which antigen is encountered. In the absence of proper costimulation, anergizing stimuli induce the activation of a specific program of gene expression. Proteins encoded by these genes impose a state of functional unresponsiveness in anergic T cells through the act...
journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2009-02-01 00:00:00
abstract：:In addition to the antigen receptor, resting T cells express a number of receptors that can be stimulated to generate proliferative signals. These "accessory" receptors require co-expression of the T cell receptor (TCR), suggesting that they channel their signals via secondary activation of the signal transduction fun...
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pub_type： 杂志文章
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更新日期：1995-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.molimm.2006.08.001
更新日期：2007-02-01 00:00:00
abstract：:Cimetidine, a histamine type-2 receptor antagonist, is known to inhibit the growth of several tumors in human and animals, however the mechanism of action underlying this effect remains largely unknown. Here, in the mice model of 3LL lung tumor, cimetidine showed significant inhibition of tumor growth. However, an in ...
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pub_type： 杂志文章
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更新日期：2013-05-01 00:00:00
abstract：:Hepcidins are antimicrobial peptides that play important roles in resisting pathogenic infection. Through hybridization of a phage library, the cDNA sequences of three hepcidin-like antimicrobial peptides (named TH1-5, TH2-2, and TH2-3) in tilapia, Oreochromis mossambicus, were determined. The complete hepcidin cDNA s...
journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2007-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：1992-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：1985-08-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2004-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：1993-06-01 00:00:00
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pub_type： 历史文章,杂志文章,评审
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更新日期：2020-03-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1992-04-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(93)90156-6
更新日期：1993-08-01 00:00:00
abstract：:Salmonella enterica serovar Typhimurium (S. Typhimurium) changes the structure of its lipopolysaccharide (LPS) in response to the environment. The two main LPS variants found in S. Typhimurium correspond to LPS with a hepta-acylated lipid A (LPS 430) and LPS with modified phosphate groups on its lipid A (LPS 435). We ...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2019.03.003
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The complement system plays an important role in the development of acute coronary syndrome (ACS). Complement C1q is an important initial component of the classical complement pathway and closely related to many chronic inflammatory diseases, including atherosclerosis (AS). We aimed to determi...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2020.02.012
更新日期：2020-04-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2011.06.435
更新日期：2011-09-01 00:00:00
abstract：:Structurally diverse dextrans from Leuconostoc mesenteroides and related bacteria have been used extensively in fundamental immunochemical studies such as induction and characterization of anti-dextran antibodies, as well as in studies of their interaction with pneumococcal antisera, normal bovine serum, concanavalin ...
journal_title：Molecular immunology
pub_type： 杂志文章,评审
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更新日期：1986-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：1991-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2014-05-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2014-06-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2008-04-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2005-07-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2001-08-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2017-06-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2020-10-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2008-01-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
doi：10.1016/j.molimm.2014.03.013
更新日期：2015-01-01 00:00:00
