Abstract：
:Tumor-associated macrophages (TAMs) are preferentially M2 skewed and promote tumor growth, angiogenesis, invasion, and/or metastasis. In this study, we have analyzed the in vitro immunomodulatory potential of a non-toxic neem leaf glycoprotein (NLGP) in reprogramming Stage III supraglottic laryngeal tumor cell lysate (SLTCL) induced M2 TAMs to their classical anti-tumor shape (M1). Data generated from this study support that NLGP is effective in preventing the SLTCL induced generation (CD68(+)CD206(+)IL-10(high) to CD68(+)CD206(-)IL-10(low) TAMs) and functions (NO(low) to NO(high), MHC-I(low) to MHC-I(high), CD80(low) to CD80(high)) of pro-tumorous M2 macrophages, which in turn associated with sustained anti-tumor effector functions by promoting cytotoxic T cell activities and suppressing regulatory T cells. Furthermore, our data also suggest that NLGP prevents M2 skewness of TAMs by downregulating phosphorylation of targeted STAT3.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Goswami KK,Barik S,Sarkar M,Bhowmick A,Biswas J,Bose A,Baral Rdoi
10.1016/j.molimm.2014.01.015subject
Has Abstractpub_date
2014-06-01 00:00:00pages
119-27issue
2eissn
0161-5890issn
1872-9142pii
S0161-5890(14)00025-Xjournal_volume
59pub_type
杂志文章abstract：:Emerging evidence has indicated that vascular endothelial cells (ECs) not only form the barrier between blood and the vessel wall but also serve as conditional innate immune cells. Our previous study found that SIRT1, a class III histone deacetylase, inhibits the inflammatory response in ECs. Recent studies revealed t...
journal_title：Molecular immunology
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abstract：:TNFα converting enzyme (TACE) is responsible for converting membrane-anchored TNFα to its soluble form in mammalian. However, the function and characteristics of TACE in teleosts is unclear. In this study, we report the cloning of a cDNA sequence of the PaTACE from ayu, Plecoglossus altivelis. PaTACE encodes an 865-aa...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2014.10.010
更新日期：2015-02-01 00:00:00
abstract：:Four cell lines producing monoclonal antibodies were obtained by fusion of NS1 myeloma cells with splenocytes of BALB/C mice immunized with only 1 microgram of each staphylococcal enterotoxin A, B, C1 and D by a modified technique of intrasplenic boosting. This procedure was considerably more efficient than the more c...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(87)90118-0
更新日期：1987-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0161-5890(95)00107-7
更新日期：1996-02-01 00:00:00
abstract：:The binding of CD40 ligand on activated T cells to CD40 on resting B cells induces the expression of costimulatory molecules B7-1 (CD80) and B7-2 (CD86). The induction of B7 molecules by CD40 ligand-CD40 interaction represents a critical step in rendering B cells competent for antigen presentation. The CBA/N mouse has...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(96)00005-3
更新日期：1996-04-01 00:00:00
abstract：:We have investigated the chemical structure of the antigenic determinant of Candida krusei cell-wall mannan. Acetolysis of the mannan, obtained by extraction with alkali and purified as copper complex, gave five oligosaccharides (from mono- to pentasaccharide) and a minor amount of an octasaccharide. Partial acetolysi...
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pub_type： 杂志文章
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更新日期：1982-03-01 00:00:00
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更新日期：1992-11-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2005.05.010
更新日期：2006-03-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
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更新日期：2004-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2000-02-01 00:00:00
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更新日期：2009-08-01 00:00:00
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更新日期：1994-10-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2020-03-01 00:00:00
abstract：:Invertebrate cells lack the p53 recombination checkpoint but contain mobile DNA sequences that transpose by a mechanism in part shared with excision of the V(D)J recombination signal sequences (RSS). In this work, inversion, deletion, and duplication of sequences associated with an invertebrate C. elegans Tc6 element ...
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更新日期：1999-05-01 00:00:00
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doi：10.1016/j.molimm.2009.06.015
更新日期：2009-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.molimm.2015.02.021
更新日期：2015-08-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2010.08.011
更新日期：2010-11-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2008-01-01 00:00:00
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journal_title：Molecular immunology
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更新日期：2019-03-01 00:00:00
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pub_type： 杂志文章
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1990-10-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2010-03-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2002-11-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2010.01.013
更新日期：2010-04-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2003.11.037
更新日期：2004-03-01 00:00:00
abstract：:The immunoglobulin JHC mu intron was cloned from genomic DNA of a VHa3 rabbit and a 1257 bp sequence which contains conserved enhancer and splice sites was determined. From positions 315 to 1257, there is approximately 72 and 67% similarity to available sequences of man and mouse, respectively (counting gaps as single...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(89)90119-3
更新日期：1989-10-01 00:00:00
