当前位置： SCI文献检索 > MOLECULAR IMMUNOLOGY期刊下所有文献 > Induction of costimulatory molecules B7-1 and B7-2 in murine B cells. the CBA/N mouse reveals a role for Bruton's tyrosine kinase in CD40-mediated B7 induction.

Induction of costimulatory molecules B7-1 and B7-2 in murine B cells. the CBA/N mouse reveals a role for Bruton's tyrosine kinase in CD40-mediated B7 induction.

Abstract：

:The binding of CD40 ligand on activated T cells to CD40 on resting B cells induces the expression of costimulatory molecules B7-1 (CD80) and B7-2 (CD86). The induction of B7 molecules by CD40 ligand-CD40 interaction represents a critical step in rendering B cells competent for antigen presentation. The CBA/N mouse has a defect in CD40 signalling which has been attributed to a mutation in Bruton's tyrosine kinase. We have compared the ability of murine CD40 ligand to induce B7-1 and B7-2 expression on B cells isolated from CBA/N and wild-type CBA/J mice. We find that the CBA/N defect partially impairs both B7-1 and B7-2 induction via CD40. Subsequent experiments investigated the roles of different second messenger systems in B7-1 and B7-2 induction in normal B cells. In M12 B lymphomas either CD40 cross-linking or cAMP treatment can induce B7 molecules. Here we report that treatment with dibutyryl-cAMP also induces B7 molecules in normal B cells provided that they have been preactivated by CD40 cross-linking. We also find that PMA and ionomycin treatment of B cells induces B7-2 but not B7-1 expression. Our data therefore show roles for BTK, cAMP and PMA/ionomycin in B7 induction, as well as providing further evidence for differential regulation of B7-1 and B7-2 induction in B cells.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Goldstein MD,Debenedette MA,Hollenbaugh D,Watts TH

doi

10.1016/0161-5890(96)00005-3

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

541-52

issue

6

eissn

0161-5890

issn

1872-9142

pii

0161589096000053

journal_volume

33

pub_type

杂志文章

相关文献

MOLECULAR IMMUNOLOGY文献大全
  • Identification of Porphyromonas gingivalis lipopolysaccharide-binding proteins in human saliva.

    abstract：:Porphyromonas gingivalis causes periodontal diseases and its lipopolysaccharide (LPS) is considered as a major virulence factor responsible for pathogenesis. Since initial recognition of P. gingivalis LPS (Pg.LPS) in the oral cavity might be crucial for the host response, we identified Pg.LPS-binding proteins (Pg.LPS-...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2011.06.434

    authors： Choi S,Baik JE,Jeon JH,Cho K,Seo DG,Kum KY,Yun CH,Han SH

    更新日期：2011-09-01 00:00:00

  • LEI0258 microsatellite variability and its association with humoral and cell mediated immune responses in broiler chickens.

    abstract：:Major histocompatibility complex (MHC) has a profound influence on disease resistance or susceptibility, productivity and important economic traits in chicken. Association of the MHC with a wide range of immune responses makes it a valuable predictive factor for the disease pathogenesis and outcome. The tandem repeat ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2017.06.027

    authors： Esmailnejad A,Nikbakht Brujeni G,Badavam M

    更新日期：2017-10-01 00:00:00

  • Prevention and control of reciprocal T-B cell diversification: implications for lupus-like autoimmunity.

    abstract：:Autoimmunity is fundamentally a continuously evolving process. The autoimmune responses shift, drift and diversify with time not only to other epitopes in the original antigen but also to other related and sometimes to unrelated antigens. We have described a form of immune diversification--reciprocal T-B epitope sprea...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2003.11.029

    authors： Singh RR

    更新日期：2004-02-01 00:00:00

  • TRAV gene segments further away from the TRAJ gene segment cluster appear more commonly in human tumor and blood samples.

    abstract：:We considered the possibility that the greater the distance between an immune receptor V and J, the more likely the V usage. Such a hypothesis is supported by results from mouse experiments. And, such a hypothesis is consistent with the fundamental nature of recombination and genomic distance: the further the distance...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2019.10.010

    authors： Pakasticali N,Gill T,Chobrutskiy BI,Tong WL,Ramsamooj M,Blanck G

    更新日期：2019-12-01 00:00:00

  • Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a.

    abstract：:The host response to intravascular, Gram-negative bacteria includes profound immunologic, hematologic and physiologic changes. Numerous host defense mechanisms are activated by Gram-negative bacteria, including the complement system. Activation of the complement system leads to cleavage of C5 with subsequent generatio...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2007.10.037

    authors： Hollmann TJ,Mueller-Ortiz SL,Braun MC,Wetsel RA

    更新日期：2008-04-01 00:00:00

  • Antibodies against glutaraldehyde-modified albumin in normal mouse sera.

    abstract：:An antigen-coated plate radioimmunoassay was used to detect antibodies against homologous glutaraldehyde-modified albumin (in monomeric or polymeric form) in normal mouse sera. Mouse antibodies reacted also with heterologous glutaraldehyde-treated albumin; for instance human albumin. Immunoelectrophoresis of purified ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(82)90310-8

    authors： Onică D,Mărgineanu I,Medeşan C,Călugăru A,Manciulea M

    更新日期：1982-08-01 00:00:00

  • Junctional diversity prevents negative selection of an antigen-specific T cell repertoire.

    abstract：:Endogenous mouse mammary tumor proviruses (MMTV; Mtv loci) deletes Vbeta6 expressing T cells in the thymus of Mtv-7(+) DBA/2 (H2(d)) mice through negative selection. We found that in Mtv-7(-) BALB/c (H2(d)) mice, Vbeta6 is a dominant V gene used in T cell responses to an 18 amino acid long peptide antigen: EYKEYAEYAEY...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2009.11.006

    authors： Kilgannon P,Novak Z,Fotedar A,Singh B

    更新日期：2010-02-01 00:00:00

  • A retro-inverso peptide analogue of influenza virus hemagglutinin B-cell epitope 91-108 induces a strong mucosal and systemic immune response and confers protection in mice after intranasal immunization.

    abstract：:In this study, a novel approach for the development of a peptide-based vaccine has been tested. We investigated the possibility of replacing an all-L amino acid peptide sequence corresponding to the protective B-cell epitope hemagglutinin (HA) 91-108 from influenza HA with a retro-inverso analogue encompassing this se...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/s0161-5890(02)00095-0

    authors： Ben-Yedidia T,Beignon AS,Partidos CD,Muller S,Arnon R

    更新日期：2002-10-01 00:00:00

  • Interleukin-1 receptor associated kinase 1 is a potential therapeutic target of anti-inflammatory therapy for systemic lupus erythematosus.

    abstract：:Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease and currently has no effective therapy. The genome-wide analyses indicate that interleukin-1 receptor associated kinase 1 (IRAK1) is associated with the susceptibility of SLE in humans. In the present study, we identified that IRAK1 was ov...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2017.03.018

    authors： Li M,Yu D,Ni B,Hao F

    更新日期：2017-07-01 00:00:00

  • Liver stroma enhances activation of TLR3-triggered NK cells through fibronectin.

    abstract：:Recent studies demonstrate that tissue microenvironments may regulate development and functions of immune cells including dendritic cells, monocytes and T cells. However, there is no report about functional regulation of innate NK cells by tissue microenvironment. The liver is an organ abundant in NK cells and suscept...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2008.01.035

    authors： Xia S,Guo Z,Yao Y,Xu X,Yi H,Xia D,Cao X

    更新日期：2008-05-01 00:00:00

  • Antiapoptotic and immunomodulatory effects of chlorophyllin.

    abstract：:Chlorophyllin (CHL) was earlier shown to reduce the level of intracellular ROS and apoptosis induced by ionizing radiation and 2,2'-azobis(2-propionimidinedihydrochloride) (AAPH). In the present studies, the effect of CHL on radiation-induced immunosuppression and modulation of immune responses in mice was examined. C...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2006.02.031

    authors： Sharma D,Kumar SS,Sainis KB

    更新日期：2007-01-01 00:00:00

  • Purification and physicochemical properties of C1q from guinea-pig serum.

    abstract：:An efficient method is described for the isolation of highly purified, IgG-free and stable guinea-pig serum C1q. The procedure includes the chromatography of EDTA-treated serum (25 mM EDTA) on CM- and DEAE-cellulose followed by gel filtration on ACA 34-Ultrogel whereby ammonium sulfate precipitation was used for conce...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(83)90133-5

    authors： Hitschold T,Golan MD,Rabs U,Loos M

    更新日期：1983-02-01 00:00:00

  • Methotrexate regulates the expression of glucocorticoid receptor alpha and beta isoforms in normal human peripheral mononuclear cells and human lymphocyte cell lines in vitro.

    abstract：:MTX is an effective therapy for autoimmune-inflammatory diseases. The mechanisms that mediate these actions are not completely clear. It is accepted that many of these effects are mediated through the release of adenosine with the activation of the adenosine receptor A2. MTX is used as a steroid sparing agent. An impr...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2006.07.303

    authors： Goecke IA,Alvarez C,Henríquez J,Salas K,Molina ML,Ferreira A,Gatica H

    更新日期：2007-03-01 00:00:00

  • Identification of conformational core epitope Lys⁶⁸ in C5a based on the 3-D modeling complex C5a and its functional antibody F20.

    abstract：:Inhibition of C5a by antibodies has been demonstrated to dramatically improve survival in various sepsis models in mice and rats. The structural basis of C5a mediated bioactivity and C5a antibody mediated neutralization are of interesting to be investigated. In the previous study, we obtained a novel functional mouse ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2011.03.013

    authors： Wei H,Lin Z,Feng J,Peng H,Guo R,Han G,Geng S,Lang X,Sun Y,Shen B,Li Y

    更新日期：2011-07-01 00:00:00

  • Analysis of two acidic P6 pocket residues in the pH dependency of peptide binding by I-E(k).

    abstract：:Peptide binding to major histocompatibility complex (MHC) class II molecules is optimal at mildly acidic pH. X-ray crystal structures solved for the murine class II molecule I-E(k) revealed an interesting localization of negatively charged residues within the P6 pocket, which may have implications in the pH dependency...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/s0161-5890(02)00010-x

    authors： Dao CT,Weber DA,Jensen PE

    更新日期：2002-06-01 00:00:00

  • Correlation of the epitopes defined by anti-CD26 mAbs and CD26 function.

    abstract：:To clarify the different anti-CD26 mAbs corresponding different functions of CD26, the correlation of the epitopes defined by anti-CD26 mAbs and the functions of CD26 have been studied. Using truncated, human-rat CD26 swap mutants and cross-blocking studies, 13 anti-CD26 mAbs were divided into 5 separate groups. These...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/s0161-5890(98)00015-7

    authors： Dong RP,Tachibana K,Hegen M,Scharpé S,Cho D,Schlossman SF,Morimoto C

    更新日期：1998-01-01 00:00:00

  • Evolution of low molecular weight immunoglobulins--IV. IgY-like immunoglobulins of birds, reptiles and amphibians, precursors of mammalian IgA.

    abstract：:Radioimmunochemical studies on the comparison of the immunological cross-reactivity between the 7-S Igs of birds, reptiles and amphibians (IgY-like Igs) and the IgA of mammals (man and pig) using 125I-chicken IgY and anti-chicken IgY(Fc) or anti-chicken IgY(H) antibodies from rabbits and carp for the detection led to ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(84)90022-1

    authors： Hädge D,Ambrosius H

    更新日期：1984-08-01 00:00:00

  • The dual specificity phosphatase transcriptome of the murine thymus.

    abstract：:Properly regulated mitogen-activated protein (MAP) kinase activity is critical for normal thymocyte development. MAP kinases are activated by phosphorylation of tyrosine and threonine, and dual specificity phosphatases (DUSPs) can inactivate MAP kinases by dephosphorylating both tyrosine and threonine. However, a role...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2005.03.006

    authors： Tanzola MB,Kersh GJ

    更新日期：2006-02-01 00:00:00

  • Involvement of Notch signaling pathway in regulating IL-12 expression via c-Rel in activated macrophages.

    abstract：:Macrophages play an important role both in innate and adaptive immune responses. Treatment with interferon (IFN) γ together with lipopolysaccharide (LPS) activates pro-inflammatory macrophages which secrete various pro-inflammatory cytokines including IL-12. IL-12 promotes a Th1 type immune response by directly contro...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2012.03.017

    authors： Boonyatecha N,Sangphech N,Wongchana W,Kueanjinda P,Palaga T

    更新日期：2012-07-01 00:00:00

  • Anti-neuroinflammatory effects of 20C from Gastrodia elata via regulating autophagy in LPS-activated BV-2 cells through MAPKs and TLR4/Akt/mTOR signaling pathways.

    abstract：:20C, a novel bibenzyl compound, is isolated from Gastrodia elata. In our previous study, 20C showed protective effects on tunicamycin-induced endoplasmic reticulum stress, rotenone-induced apoptosis and rotenone-induced oxidative damage. However, the anti-neuroinflammatory effect of 20C is still with limited acquainta...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2018.04.014

    authors： Shao QH,Zhang XL,Chen Y,Zhu CG,Shi JG,Yuan YH,Chen NH

    更新日期：2018-07-01 00:00:00

  • Specificity of ganglioside binding to rat macrophages.

    abstract：:The binding specificity of rat alveolar macrophages (AM phi) for sheep erythrocytes (E) coated with gangliosides GM1, GM2, GM3, GD1a, GD1b or GT1b was analyzed in a rosette assay by studying the inhibitory effect of gangliosides, various carbohydrates, IgG, C3b-like C3, and fibronectin in this assay. The uptake of gan...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(86)90163-x

    authors： Förster O,Boltz-Nitulescu G,Holzinger C,Wiltschke C,Riedl M,Ortel B,Fellinger A,Bernheimer H

    更新日期：1986-11-01 00:00:00

  • The human gamma/delta + and alpha/beta + T cells: a branched pathway of differentiation.

    abstract：:In human peripheral blood, most of the CD3+ cells express the alpha/beta T cell receptor. A smaller fraction of CD3+ T cells express the gamma/delta T cell receptor (from 1 to 10% depending the individuals, with an average of 3-5%). Interestingly, although the alpha/beta + T cells never express the gamma chain at the ...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/0161-5890(92)90001-e

    authors： Alexandre D,Lefranc MP

    更新日期：1992-04-01 00:00:00

  • Identification of potential transcriptomic markers in developing asthma: An integrative analysis of gene expression profiles.

    abstract：:The goal of this study was to identify potential transcriptomic markers in developing asthma by an integrative analysis of multiple public microarray data sets. Using the R software and bioconductor packages, we performed a statistical analysis to identify differentially expressed (DE) genes in asthma, and further per...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2017.09.021

    authors： Fang F,Pan J,Li Y,Li Y,Feng X,Wang J

    更新日期：2017-12-01 00:00:00

  • T cell dependent differentiation of human B cells: direct switch from IgM to IgE, and sequential switch from IgM via IgG to IgA production.

    abstract：:Ig production by splenic human B cells that express different surface Ig isotypes were analysed in limiting dilution cultures. Therefore, FACS sorted IgM+, IgG+ and IgA1+ B cells were stimulated with PMA-activated EL4 thymoma cells as helper cells in the presence of IL-2 and IL-4. We found that at least every second B...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(92)90051-x

    authors： Brinkmann V,Müller S,Heusser CH

    更新日期：1992-10-01 00:00:00

  • Novel putative protein kinase clones from a rat large granular lymphocyte tumor cell line.

    abstract：:Protein kinases have been implicated in a number of regulatory mechanisms including signal transduction in many cells. To address the possibility that the large granular lymphocyte (LGL) also uses one or more unique protein kinases for LGL functions, an efficient method was developed to obtain partial cDNA clones for ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(91)90153-b

    authors： Yue CC

    更新日期：1991-04-01 00:00:00

  • Immunochemical studies of tobacco mosaic virus--VII. Use of comparative surface accessibility of residues in antigenically related viruses for delineating epitopes recognized by monoclonal antibodies.

    abstract：:The binding properties of 18 monoclonal antibodies (MAbs) directed against the tobacco mosaic virus (TMV) coat protein were studied with five related tobamoviruses and seven mutant viruses, as well as with the dissociated coat proteins of these variants. Ten of the antibodies bound to both TMV and TMV protein, but the...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(87)90131-3

    authors： Dore I,Altschuh D,Al Moudallal Z,Van Regenmortel MH

    更新日期：1987-12-01 00:00:00

  • Molecular analysis of induced idiotypes associated with autoanti-thyroglobulin.

    abstract：:Idiotype (Id) and autoanti-thyroglobulin were induced in different strains of mice by priming with anti-Id to monoclonal anti-thyroglobulins (D8 and G4) and challenged with a subimmunogenic dose of thyroglobulin (Tg). Both D8.Id and G4.Id were induced in CBA mice by priming with the appropriate anti-Id, but only primi...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(85)90159-2

    authors： Male D,Pryce G,Roitt I

    更新日期：1985-03-01 00:00:00

  • More efficient peptide binding to MHC class II molecules during cathepsin B digestion of Ii than after Ii release.

    abstract：:The binding of a T cell-presented peptide to MHC class II alpha,beta chains occurs as a concurrent process with the release of the associated invariant chain (Ii) by cathepsin B. Ii was digested by cathepsin B from solubilized, MHC class II alpha,beta,Ii complexes in the presence of N-hydroxysuccinimidyl-4-azidobenzoa...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(94)90122-8

    authors： Daibata M,Xu M,Humphreys RE,Reyes VE

    更新日期：1994-03-01 00:00:00

  • Delineation of four carcinoembryonic antigen (CEA) related antigens in normal plasma by transblot studies using monoclonal anti-CEA antibodies with different epitope specificities.

    abstract：:Antigens related to the carcinoembryonic antigen (CEA) were isolated from normal human plasma by perchloric acid extraction, gel permeation chromatography and immunoaffinity chromatography using a monoclonal antibody with broad specificity and high affinity. The antigens were separated by SDS-polyacrylamide gel electr...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(85)90046-x

    authors： Neumaier M,Fenger U,Wagener C

    更新日期：1985-11-01 00:00:00

  • Homology modelling and conformational analysis of IgE-binding epitopes of Ara h 3 and other legumin allergens with a cupin fold from tree nuts.

    abstract：:Linear IgE-binding epitopes identified in legumin allergens of peanut (Ara h 3) and other allergenic tree nuts (Jug r 4 of walnut, Cor a 9 of hazelnut, Ana o 2 cashew nut) were mapped on three-dimensional models of the proteins built up by homology modelling. A conformational analysis revealed that consensual surface-...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2007.01.023

    authors： Barre A,Jacquet G,Sordet C,Culerrier R,Rougé P

    更新日期：2007-05-01 00:00:00