Identification of Porphyromonas gingivalis lipopolysaccharide-binding proteins in human saliva.

abstract：:The allergenic cross-reactivity of cytochromes c isolated from Kentucky bluegrass (KBG) and ryegrass (RG) pollens was demonstrated by the finding that both cytochromes elicited PCA reactions of comparable titers in rats sensitized with murine reaginic antiserum to either KBG or RG cytochrome c. However, allergenic dif...

journal_title：Molecular immunology

authors： Ekramoddoullah AK,Kisil FT,Sehon AH

更新日期：1982-12-01 00:00:00

abstract：:The capability of NK lymphocytes to kill tumor cells depends on different receptors/ligands interactions. In order to identify the cellular ligands recognized by "orphan" triggering receptors, mice were immunized with NK susceptible target cells. mAbs were selected that inhibited NK cytotoxicity and recognized two dif...

journal_title：Molecular immunology

authors： Pende D,Bottino C,Castriconi R,Cantoni C,Marcenaro S,Rivera P,Spaggiari GM,Dondero A,Carnemolla B,Reymond N,Mingari MC,Lopez M,Moretta L,Moretta A

更新日期：2005-02-01 00:00:00

abstract：:Structural similarities between two members of the immunoglobulin superfamily were explored by making chimeric immunoglobulin/CD4 antigen molecules. A crossover in the middle of the originally proposed J kappa homology unit of the first domain of the CD4 molecule was used to construct a chimeric molecule having human ...

journal_title：Molecular immunology

authors： Frey T,Estess P,Oi VT

更新日期：1993-06-01 00:00:00

abstract：:PKZ, protein kinase containing Z-DNA binding domains, is a novel member of eIF2α kinase in fish. PKZ can be up-regulated in response to Poly I:C or heat stress, and it has a typical eIF2α kinase activity. However, the relationship between fish PKZ and apoptosis remains unclear. In the present study, effects of PKZ on ...

journal_title：Molecular immunology

authors： Wu C,Hu Y,Fan L,Wang H,Sun Z,Deng S,Liu Y,Hu C

更新日期：2016-01-01 00:00:00

abstract：:Autophagy is an intracellular "self-eating" process that is closely related to inflammation and cellular immunity. New studies indicate that autophagy is also involved in tumor suppression. The anti-inflammatory cytokine interleukin-37 (IL-37) has been shown to have tumor-suppressive abilities in hepatocellular carcin...

journal_title：Molecular immunology

authors： Li TT,Zhu D,Mou T,Guo Z,Pu JL,Chen QS,Wei XF,Wu ZJ

更新日期：2017-07-01 00:00:00

abstract：:Bifunctional antigens composed of one L-tyrosine-p-azobenzenearsonate (Tyr-ABA) carrier epitope and one dinitrophenyl (DNP) haptenic epitope separated by 6-aminocaproyl or polyprolyl spacers induced weak IgM anti-DNP plaque-forming cell (PFC) responses in the spleens of mice immunized intraperitoneally, without detect...

journal_title：Molecular immunology

authors： Kaymakcalan Z,Nitecki DE,Lewis GK,Goodman JW

更新日期：1984-06-01 00:00:00

abstract：:In an attempt to understand the relationship of amino acid sequence to the formation of primary or multiple myeloma-related amyloid (AL amyloid), we have determined the complete amino acid sequence of amyloid protein BAN. This protein belongs to the kappa I immunoglobulin light chain subgroup and has a polypeptide cha...

journal_title：Molecular immunology

authors： Dwulet FE,O'Connor TP,Benson MD

更新日期：1986-01-01 00:00:00

abstract：:Large quantities of antibodies are transported into the yolk of the chicken's egg. We have identified several regions within the antibody molecule important for its uptake into the egg yolk. An intact Fc and hinge region but not the Fc-associated carbohydrate are required for transport. Our data suggest that the C(H)2...

journal_title：Molecular immunology

authors： Morrison SL,Mohammed MS,Wims LA,Trinh R,Etches R

更新日期：2002-01-01 00:00:00

abstract：:Pulmonary exposure to innocuous aeroallergens is a common event leading to inhalation tolerance. Distinct subsets of pulmonary dendritic cells (DC) and regulatory T cells (T(Reg)) play critical roles in mediating and maintaining such tolerance. In asthmatics, the same aeroallergens drive a maladaptive, Th2-biased immu...

journal_title：Molecular immunology

authors： Köhl J,Wills-Karp M

更新日期：2007-01-01 00:00:00

abstract：:The insect gut participates in initial local immune responses by producing reactive oxygen and nitrogen species as well as anti-microbial peptides to resist pathogenic invasions. Nitric oxide (NO), a signaling and an immune effector molecule synthesized by the enzyme NO synthase (NOS), mediates an early step of the si...

journal_title：Molecular immunology

authors： Liu W,Wang Y,Leng Z,Wang Q,Duan X,Luo Y,Jiang Y,Qin L

更新日期：2020-10-01 00:00:00

abstract：:Peptide fragments of pertussis toxin subunit 1 (PT-S1) have been synthesized in order to investigate their antigenic and immunogenic activity, and to evaluate their possible use as components of a new vaccine. Two peptides (sequence 73-82, EAERAGRGTG and sequence 107-116, YVDTYGDNAG) were selected for their predictabl...

journal_title：Molecular immunology

authors： Presentini R,Perin F,Ancilli G,Nucci D,Bartoloni A,Rappuoli R,Antoni G

更新日期：1989-01-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I molecules usually present endogenous peptides at the cell surface. This is the result of a cascade of events involving various dedicated proteins like the peptide transporter associated with antigen processing (TAP) and the ER chaperone tapasin. However, alternative ways ...

journal_title：Molecular immunology

authors： Grommé M,Neefjes J

更新日期：2002-10-01 00:00:00

abstract：:The generation and cell surface expression of IL-2 receptors was monitored by: (i) an ELISA that permits quantitative determination of detergent-solubilized or soluble IL-2 receptors; and (ii) detection of the binding of 125I-labelled recombinant IL-2 and of anti-IL-2 receptor antibodies to receptor bearing cells. Upo...

journal_title：Molecular immunology

authors： Diamantstein T,Osawa H,Mouzaki A,Josimovic-Alasevic O

更新日期：1986-11-01 00:00:00

abstract：:Increasing evidence suggests that inflammation and apoptosis are involved in the development of acute myocardial ischemia (AMI). Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) have recently been identified as key mediators of inflammatory responses. The aim of this study was to explore the speci...

journal_title：Molecular immunology

authors： Li H,Zhang S,Li F,Qin L

更新日期：2016-08-01 00:00:00

abstract：:CD9 is a glycoprotein of the transmembrane 4 superfamily (TM4SF) and is involved in various cellular processes. In this study, we describe the isolation of the full-length cDNA encoding for CD9 molecule (daCD9) of red stingray, Dasyatis akajei. This 1252 bp cDNA was isolated from leukocyte cDNA library and contains 68...

journal_title：Molecular immunology

authors： Zhu J,Yan K,Lu L,Peng C,Zhou C,Chen S,Xie X,Dong M,Xu A

更新日期：2006-04-01 00:00:00

abstract：:Humanization of rodent mAbs by CDR-grafting (also called "reshaping") is now a standard procedure for reducing immunogenicity and recruiting human effector functions. However, the design of the humanized mAb can sometimes prove circuitous. Attempts were made to humanize L-25, a mouse antibody against the human alpha-4...

journal_title：Molecular immunology

authors： Saldanha JW,Martin AC,Léger OJ

更新日期：1999-08-01 00:00:00

abstract：:Following measles virus (MV) infection, viral peptides are presented to CTL by MHC class I molecules on infected antigen presenting cells at widely different epitope densities. Whereas three MV epitopes (MV-M(211-219), MV-F(438-446) and MV-H(30-38)) derived from different structural proteins occur at regular densities...

journal_title：Molecular immunology

authors： Herberts CA,Meiring HM,van Gaans-van den Brink JA,van der Heeft E,Poelen MC,Boog CJ,de Jong AP,van Els CA

更新日期：2003-01-01 00:00:00

abstract：:Bcl-2 translocations in follicular lymphomas (FL) are often associated with downstream immunoglobulin class switch recombination (CSR) on the translocated allele. We studied cell lines with different translocations into the IgH locus to gauge any common features associated with downstream CSR events. CSR associated wi...

journal_title：Molecular immunology

authors： Hughes JA,Weckert HA,van Holst Pellekaan C,Benson EM,Dunn IS

更新日期：2003-12-01 00:00:00

abstract：:ANCA associated vasculitis is a serious, very often recurrent disease that despite the current standard treatment with high-dose glucocorticoids and either cyclophosphamide or rituximab, patients have a nine-fold increased mortality risk in the first year compared with healthy controls, attributed to infections, vascu...

journal_title：Molecular immunology

authors： Quintana LF,Kronbichler A,Blasco M,Zhao MH,Jayne D

更新日期：2019-08-01 00:00:00

abstract：:CD55 is a key regulator of complement activation, expressed on most tissues and cells in man and other mammals. In the rat, alternative splicing in the gene encoding CD55 yields GPI-anchored (GPI-CD55) and transmembrane (TM-CD55) forms. Published Northern blot analysis indicated that while GPI-CD55 was broadly express...

journal_title：Molecular immunology

authors： Mizuno M,Donev RM,Harris CL,Morgan BP

更新日期：2007-03-01 00:00:00

abstract：:A highly purified preparation of a monoclonal antibody to vasoactive intestinal peptide (VIP) was analysed by gel filtration. Three peaks of VIP hydrolysing activity were observed, corresponding to the 150 kDa tetramer IgG, 80 kDa dimer of the heavy and light chains (H-L dimer) and 25 kDa L chain monomer. The hydrolyt...

journal_title：Molecular immunology

authors： Li L,Sun M,Gao QS,Paul S

更新日期：1996-05-01 00:00:00

abstract：:Programmed cell death protein 1 (PD1) is a cell-surface receptor that plays a vital regulatory role in suppressing inflammatory T cell activity; therefore, it is an ideal target for T cell-redirecting therapies. Here, we describe a cynomolgus macaque model for studying the transfer of PD1-modified T cells. We develope...

journal_title：Molecular immunology

authors： Gao CE,Song Q,Zhang M,Li J,Miao Y,Li Z,Dong J

更新日期：2020-08-01 00:00:00

abstract：:The effect of antibody affinity on molecular forms of immune complexes was investigated by measuring antigen-antibody interactions using surface plasmon resonance (SPR), electrospray ionization time-of-flight mass spectrometry under non-denaturing conditions (MS), analytical ultracentrifugation (AUC), and transmission...

journal_title：Molecular immunology

authors： Oda M,Uchiyama S,Noda M,Nishi Y,Koga M,Mayanagi K,Robinson CV,Fukui K,Kobayashi Y,Morikawa K,Azuma T

更新日期：2009-12-01 00:00:00

abstract：:An efficient method is described for the isolation of highly purified, IgG-free and stable guinea-pig serum C1q. The procedure includes the chromatography of EDTA-treated serum (25 mM EDTA) on CM- and DEAE-cellulose followed by gel filtration on ACA 34-Ultrogel whereby ammonium sulfate precipitation was used for conce...

journal_title：Molecular immunology

authors： Hitschold T,Golan MD,Rabs U,Loos M

更新日期：1983-02-01 00:00:00

abstract：:Macrophage migration is mediated by complex cellular signaling processes and cytoskeleton re-arrangement. In particular, recent advances indicate that the innate immunity signaling process plays a key role in the regulation of macrophage migration. In this report, we have provided evidence demonstrating the involvemen...

journal_title：Molecular immunology

authors： Gan L,Li L

更新日期：2010-03-01 00:00:00

abstract：:Immature B cell lines transformed with a temperature-sensitive mutant of Abelson murine leukaemia virus undergo preferentially V gamma 2 to J gamma 2 joinings during culture at a non-permissive temperature (39 degrees C). Here we examined nucleotide addition and deletion at the V gamma 2-J gamma 2 junctions in these V...

journal_title：Molecular immunology

authors： Tsukada S,Oka Y,Sugiyama H

更新日期：1992-07-01 00:00:00

abstract：:Elevated level of IgG-type antibodies against Type 1 nuclear antigen (anti-EBNA-1-IgG) of the Epstein-Barr virus is a strong risk factor for certain autoimmune diseases. We measured anti-EBNA-1 IgG titers in 107 patients with hereditary angioedema due to C1-inhibitor deficiency (HAE-C1-INH). In the sera from 33 longit...

journal_title：Molecular immunology

authors： Csuka D,Varga L,Farkas H,Füst G

更新日期：2012-01-01 00:00:00

abstract：:CD1 molecules are MHC-unlinked class Ib molecules consisting of classical (human CD 1a-c) and non-classical subsets (human CD1d and murine CD1). The characterization of non-classical subsets of CD1 is limited due to the lack of reagents. In this study, we have generated two new anti-mouse CD1 monoclonal antibodies, 3H...

journal_title：Molecular immunology

authors： Mandal M,Chen XR,Alegre ML,Chiu NM,Chen YH,Castaño AR,Wang CR

更新日期：1998-06-01 00:00:00

abstract：:Peripheral blood B lymphocytes have been isolated from healthy individuals who were immunized with lymphocytes from HLA-incompatible donors and transformed with Epstein-Barr virus to produce human monoclonal cell lines specific for human HLA molecules. The cell lines have been previously characterized and are known to...

journal_title：Molecular immunology

authors： Andris JS,Abraham SR,Pascual V,Pistillo MP,Mantero S,Ferrara GB,Capra JD

更新日期：1995-10-01 00:00:00

abstract：:The potency of a T cell is determined in large part by two interactions, binding of a cognate peptide to the MHC, and binding of the T cell receptor (TCR) to this pepMHC. Various studies have attempted to assess the relative importance of these interactions, and to correlate the corresponding binding parameters with t...

journal_title：Molecular immunology

authors： Bowerman NA,Crofts TS,Chlewicki L,Do P,Baker BM,Christopher Garcia K,Kranz DM

更新日期：2009-09-01 00:00:00