Abstract：
:In an attempt to understand the relationship of amino acid sequence to the formation of primary or multiple myeloma-related amyloid (AL amyloid), we have determined the complete amino acid sequence of amyloid protein BAN. This protein belongs to the kappa I immunoglobulin light chain subgroup and has a polypeptide chain length of 126 amino acids. It encompasses the entire variable region, the joining segment and the first tryptic peptide of the constant region. This protein has two unique features. First, the molecule is glycosylated. At position 61 the usual arginine residue has been replaced by an asparagine with the generation of the signal sequence Asn-Phe-Thr, to which a glucosamine-containing carbohydrate unit is attached. Secondly, the protein is not monoclonal but consists of two chains which have the same variable region but different J-segments. Comparison of the BAN sequence with other amyloid and nonamyloid kappa I proteins reveals a systematic difference between the two groups. In the amyloid proteins, several hydrophilic framework residues have been replaced by hydrophobic residues. These substitutions may provide the nucleation sites for self-aggregation and fibril formation.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Dwulet FE,O'Connor TP,Benson MDdoi
10.1016/0161-5890(86)90173-2subject
Has Abstractpub_date
1986-01-01 00:00:00pages
73-8issue
1eissn
0161-5890issn
1872-9142journal_volume
23pub_type
杂志文章abstract：:Amyloid-beta (Aβ) plaque accumulation in the brain is one of the hallmarks of Alzheimer's disease (AD). Immunotherapy against Aβ was considered a potential strategy for reducing the Aβ load in the brain. However, none of the Aβ immunotherapies have produced clinically meaningful results to date, due to poor safety or ...
journal_title：Molecular immunology
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更新日期：2018-09-01 00:00:00
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journal_title：Molecular immunology
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pub_type： 杂志文章
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更新日期：1987-06-01 00:00:00
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更新日期：2010-03-01 00:00:00
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更新日期：1998-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：1983-12-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
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更新日期：2006-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0161-5890(86)90099-4
更新日期：1986-06-01 00:00:00
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更新日期：2013-01-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(83)90106-2
更新日期：1983-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0161-5890(95)00055-j
更新日期：1995-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-09-01 00:00:00
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pub_type： 杂志文章
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2005-07-01 00:00:00
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abstract：BACKGROUND AND OBJECTIVES:The complement system plays an important role in the development of acute coronary syndrome (ACS). Complement C1q is an important initial component of the classical complement pathway and closely related to many chronic inflammatory diseases, including atherosclerosis (AS). We aimed to determi...
journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2020-04-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2012.01.003
更新日期：2012-04-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
abstract：:The membrane anchored ligand ephrinB2 belongs to the broad Eph/ephrin system and is able to activate different Eph receptors. The Eph receptors belong to the huge group of receptor-tyrosine kinases. Eph receptors as well as their corresponding ephrin ligands are cell-membrane attached proteins. Therefore, direct cell-...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2015.10.009
更新日期：2015-12-01 00:00:00
abstract：:Human C3b as well as native C3 were found to bind to solid phase human and rabbit IgG. Haemolytically active C3 had significantly higher binding capacity to IgG than the C3b fragment. Inhibition experiments proved that C3 and C3b have common binding sites on the Fab and Fc part of the IgG molecule but the character of...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(83)90076-7
更新日期：1983-08-01 00:00:00
