当前位置： SCI文献检索 > MOLECULAR IMMUNOLOGY期刊下所有文献 > NLRX1 attenuates apoptosis and inflammatory responses in myocardial ischemia by inhibiting MAVS-dependent NLRP3 inflammasome activation.

NLRX1 attenuates apoptosis and inflammatory responses in myocardial ischemia by inhibiting MAVS-dependent NLRP3 inflammasome activation.

Abstract：

:Increasing evidence suggests that inflammation and apoptosis are involved in the development of acute myocardial ischemia (AMI). Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) have recently been identified as key mediators of inflammatory responses. The aim of this study was to explore the specific role and the underlying regulatory mechanism of NLRX1 in myocardial ischemic injury. The results show that NLRX1, located in mitochondria, was significantly down-regulated in AMI tissues and hypoxia-induced H9c2 cells. Overexpression of NLRX1 markedly decreased the levels of lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB) and cardiac troponin-I (cTn-I), down-regulated the production of IL-1β，IL-18 and IL-6, and reduced apoptosis induced by hypoxia. Conversely, depletion of NLRX1 with small interfering RNA (siRNA) aggravated hypoxia-induced ischemic injury. We then demonstrated that NLRX1 was associated with the mitochondrial antiviral signaling protein (MAVS) and regulated MAVS-dependent NLRP3 inflammasome activation. NLRX1 overexpression significantly inhibited hypoxia-induced up-regulation of MAVS, NLRP3 and Caspase-1 expression. Additionally, the negative effects of NLRX1 overexpression on hypoxia-induced inflammatory factor production and apoptosis were neutralized by MAVS or NLRP3 overexpression. Taken together, these findings suggest that NLRX1 may function as a cardiac-protective molecule in myocardial ischemic injury by repressing inflammation and apoptosis; the biological effects appear to be mediated by the inhibition of MAVS-dependent NLRP3 inflammasome activation.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Li H,Zhang S,Li F,Qin L

doi

10.1016/j.molimm.2016.06.013

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

90-7

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(16)30115-8

journal_volume

76

pub_type

杂志文章

相关文献

MOLECULAR IMMUNOLOGY文献大全
  • Effects of surfactant protein D on growth, adhesion and epithelial invasion of intestinal Gram-negative bacteria.

    abstract：:Surfactant protein D (SP-D) interacts with various different microorganisms and plays an important role in pulmonary innate immunity. SP-D expression has also been detected in extrapulmonary tissues, including the gastro-intestinal tract. However, its function in the intestine is unknown and may differ considerably fr...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2007.03.013

    authors： Hogenkamp A,Herías MV,Tooten PC,Veldhuizen EJ,Haagsman HP

    更新日期：2007-07-01 00:00:00

  • Leucine-rich repeat-containing G-protein-coupled receptor 2 (LGR2) can regulate PO activity and AMP genes expression in Macrobrachium nipponense.

    abstract：:Leucine-rich repeat-containing G-protein-coupled receptors (LGRs) form a subfamily of the large superfamily of G-protein-coupled receptors. LGRs can be divided into three groups. LGR2 from Drosophila melanogaster is involved in cuticle tanning (melanization and sclerotization). In this study, one LGR2 (MnLGR2) was ide...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2020.07.013

    authors： Cao X,Zhang C,Zhang R,Wang K,Dai X,Huang X,Ren Q

    更新日期：2020-10-01 00:00:00

  • Demonstration of two distinct antigenic determinants on human alpha-foetoprotein by monoclonal antibodies.

    abstract：:Mice were immunized with a purified preparation of human alpha-foetoprotein (AFP) and their spleen cells were hybridized with mouse myeloma cells. Eleven hybridoma cell lines secreting antibody to AFP were obtained. These antibodies were classified into two groups on the basis of different antigenic determinants they ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(82)90281-4

    authors： Nomura M,Imai M,Nakamura T,Miyakawa Y,Mayumi M

    更新日期：1982-12-01 00:00:00

  • Influence of gut microbiota on mouse B2 B cell ontogeny and function.

    abstract：:A complex interplay between the microbiota and the host immune system is evidenced to shape the immune system throughout life, but little is known about the microbial effect on key players of the adaptive immune system, the B2 B cells. In the presented study, we have evaluated the effect of commensal bacteria on B cel...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2011.02.002

    authors： Hansson J,Bosco N,Favre L,Raymond F,Oliveira M,Metairon S,Mansourian R,Blum S,Kussmann M,Benyacoub J

    更新日期：2011-05-01 00:00:00

  • Constitutive and inflammatory induction of alpha and beta chemokines in human first trimester forebrain astrocytes and neurons.

    abstract：:Chemokine effects on leukocyte infiltration into the central nervous system (CNS) are key events in the inflammatory processes of neuroimmunologic and neuroinfectious diseases. Because, chemokines may play important roles in proliferation and differentiation of brain cells and in the initiation and progression of CNS ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/s0161-5890(02)00019-6

    authors： Bakhiet M,Mousa A,Seiger A,Andersson J

    更新日期：2002-05-01 00:00:00

  • Increase of the stimulatory effect of dendritic cells by pulsing with apoptotic bodies transfected with the MHC class II gene.

    abstract：:Dendritic cells (DC) are capable of capturing and processing antigens and can stimulate co-cultured effector cells in a specific manner. Here, we pulsed DC with apoptotic bodies (apb) from colorectal carcinoma. For enhancement of the immunogenic potential of apb, we transduced the tumor cells with the MHC class II gen...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/s0161-5890(02)00142-6

    authors： Märten A,Renoth S,Schmidt-Wolf IG

    更新日期：2002-11-01 00:00:00

  • Conversion of trichosanthin-induced CD95 (Fas) type I into type II apoptotic signaling during Herpes simplex virus infection.

    abstract：:Trichosanthin (TCS) is a type I ribosome-inactivating protein with wide spectrum of pharmacological activities. It inhibits human immunodeficiency virus type 1 (HIV-1) and Herpes simplex virus type 1 (HSV-1) replication but the mechanism is not clear. From a previous study, TCS was found to be more cytotoxic to HIV-1 ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2011.06.217

    authors： He D,Yau K,He X,Shi H,Zheng Y,Tam S

    更新日期：2011-09-01 00:00:00

  • A priori delineation of a peptide which mimics a discontinuous antigenic determinant.

    abstract：:A technique was developed for identifying peptides with high affinity for a given antibody. By testing a monoclonal antibody directed against a discontinuous antigenic determinant on foot-and-mouth disease virus, peptides mimicking the determinant were identified even though the tertiary structure of the proteins comp...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(86)90081-7

    authors： Geysen HM,Rodda SJ,Mason TJ

    更新日期：1986-07-01 00:00:00

  • The N-linked oligosaccharides of the Fc epsilon receptors of rat basophilic leukemia cells.

    abstract：:This study was undertaken to investigate the nature and microheterogeneity of the carbohydrate moiety of the Fc epsilon receptors of RBL-CA10 and RBL-CA10.7 cells. Treatment using the glycosylation processing inhibitors, castanospermine (CN), 1-deoxymannojirimycin (DMJ), and swainsonine (SW) resulted in a decrease of ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(93)90060-o

    authors： LaCroix EL,Froese A

    更新日期：1993-02-01 00:00:00

  • Definition of the peptide binding motif within DRB1*1401 restricted epitopes by peptide competition and structural modeling.

    abstract：:This study identified the peptide-binding motif of HLA-DRA/DRB1*1401 (DR1401). First, peptides containing DR1401 restricted epitopes were identified using tetramer-guided epitope mapping. Among these, an influenza B peptide was selected for the motif study. After confirming the binding register for this peptide using ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2007.12.013

    authors： James EA,Moustakas AK,Berger D,Huston L,Papadopoulos GK,Kwok WW

    更新日期：2008-05-01 00:00:00

  • pH dependent binding of high and low affinity myelin basic protein peptides to purified HLA-DR2.

    abstract：:Major histocompatibility complex (MHC) class II molecules are cell surface glycoproteins and are known to display processed antigens on the surface of antigen presenting cells (APC). Within the APC, the loading of processed antigenic peptides to MHC class II molecules is known to take place in the endosomal compartmen...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(95)00030-i

    authors： Mukku PV,Passmore D,Phan D,Nag B

    更新日期：1995-06-01 00:00:00

  • Effect of C1-INH on ischemia/reperfusion injury in a porcine limb ex vivo perfusion model.

    abstract：:Revascularization of an amputated limb within 4-6h is essential to avoid extensive ischemia/reperfusion (I/R) injury leading to vascular leakage, edema and tissue necrosis. I/R injury is a pathological inflammatory condition that occurs during reperfusion of an organ or tissue after prolonged ischemia. It is character...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2017.06.021

    authors： Abdelhafez MM,Shaw J,Sutter D,Schnider J,Banz Y,Jenni H,Voegelin E,Constantinescu MA,Rieben R

    更新日期：2017-08-01 00:00:00

  • Non-immunized natural human heavy chain CDR3 repertoires allow the isolation of high affinity peptides mimicking a human influenza hemagglutinin epitope.

    abstract：:In this study we constructed two phage libraries displaying non-immunized natural human IgM derived HCDR3 repertoires. One library was structurally constrained by a Gly to Cys substitution at position 104 enabling the formation of a disulfide bridge with the Cys at position 92. Panning of these libraries on an anti-hu...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2007.09.001

    authors： Deroo S,Fischer A,Beaupain N,Counson M,Boutonnet N,Pletinckx J,Loverix S,Beirnaert E,De Haard H,Schmit JC,Lasters I

    更新日期：2008-03-01 00:00:00

  • Combined TCRG and TCRA TREC analysis reveals increased peripheral T-lymphocyte but constant intra-thymic proliferative history upon ageing.

    abstract：:T-cell receptor (TCR) repertoire diversity, thymic output, clonal size and peripheral T-lymphocyte numbers largely depend on intra-thymic and post-thymic T-lymphocyte proliferation. However, quantitative insight into thymocyte and T-lymphocyte proliferation is still lacking. We developed a new TCRG-based TCR excision ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2012.08.019

    authors： van der Weerd K,Dik WA,Schrijver B,Bogers AJ,Maat AP,van Nederveen FH,van Hagen PM,van Dongen JJ,Langerak AW,Staal FJ

    更新日期：2013-03-01 00:00:00

  • Complement escape of human pathogenic bacteria by acquisition of complement regulators.

    abstract：:Pathogenic micro-organisms employ a broad range of strategies to survive in and to persistently infect the human host. Far from being completely understood by which highly sophisticated means invading pathogens overcome the host's destructive immune defence, there is a growing body of evidence on particular mechanisms...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2005.06.016

    authors： Kraiczy P,Würzner R

    更新日期：2006-01-01 00:00:00

  • A monoclonal antibody (RH1-38) which inhibits multiple systems of cell-mediated cytotoxicity--I. Identification of a novel epitope on a killer cell surface bimolecular complex important in the cytotoxic response.

    abstract：:This paper presents the initial characterization of a mouse monoclonal antibody (RH1-38) which blocks, in the absence of complement, three different systems of cell-mediated cytotoxicity. This monoclonal antibody markedly inhibits cytotoxicity mediated by human natural killer cells, a monocyte-like cell [phorbol myris...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(85)90140-3

    authors： Hall RE

    更新日期：1985-07-01 00:00:00

  • Differences in endocytosis mediated by FcγRIIA and FcγRIIB2.

    abstract：:An important function of Fcγ receptors is the removal of IgG-containing immune complexes from the circulation. The activating receptor FcγRIIA and inhibitory receptor FcγRIIB2 are both expressed on human myeloid cells, and are both capable of mediating endocytosis of immune complexes. We studied endocytosis of these t...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2011.09.003

    authors： Zhang CY,Booth JW

    更新日期：2011-10-01 00:00:00

  • Novel monoclonal antibodies to cyclosporine A: characterization and epitope mapping with cyclosporine analogs and cyclophilin.

    abstract：:Monoclonal antibodies to cyclosporine A (Cs), a potent immunosuppressant, were generated in BALB/c mice using a novel antigen prepared by linking Cs to a protein carrier via a photoactive cross-linking reagent, 4-benzoylbenzoic acid (BBa). Twenty-two monoclonal anti-Cs antibodies were generated, using Cs-BBa-bovine se...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(92)90162-q

    authors： Cacalano NA,Aggarwal R,Quesniaux VF,Cleveland WL,Erlanger BF

    更新日期：1992-01-01 00:00:00

  • The TNFα converting enzyme (TACE) from ayu (Plecoglossus altivelis) exhibits TNFα shedding activity.

    abstract：:TNFα converting enzyme (TACE) is responsible for converting membrane-anchored TNFα to its soluble form in mammalian. However, the function and characteristics of TACE in teleosts is unclear. In this study, we report the cloning of a cDNA sequence of the PaTACE from ayu, Plecoglossus altivelis. PaTACE encodes an 865-aa...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2014.10.010

    authors： Lu XJ,Chen Q,Yang GJ,Chen J

    更新日期：2015-02-01 00:00:00

  • Establishment of an ex vivo model of monocytes-derived macrophages differentiated from peripheral blood mononuclear cells (PBMCs) from HIV-1 transgenic rats.

    abstract：:It has been developed an HIV type 1 transgenic rat model (HIV-1 Tg Rat) which contains a gag-pol-deleted HIV-1 provirus regulated by the viral LTR promoter. Although it harbors a non infectious provirus, efficient viral expression occurs in different tissues and disease manifestations as well as immune-response altera...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2004.06.023

    authors： Mazzucchelli R,Amadio M,Curreli S,Denaro F,Bemis K,Reid W,Bryant J,Riva A,Galli M,Zella D

    更新日期：2004-08-01 00:00:00

  • Comparative molecular modelling of the Fas-ligand and other members of the TNF family.

    abstract：:A number of proteins with significant similarity to the tumour necrosis factor (TNF) have been identified over the last years. Upon interaction with their cognate receptor (members of the TNF-receptor family), all members of this protein family induce either cell death or proliferation/differentiation of the receptor-...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(95)00016-8

    authors： Peitsch MC,Tschopp J

    更新日期：1995-07-01 00:00:00

  • Identification and characterisation of human Junctional Adhesion Molecule (JAM).

    abstract：:It is widely believed that migrating immune cells utilise the intercellular junctions as routes of passage, and in doing so cause the transient disruption of junctional structures. Thus there is much interest in the molecules that have been identified at cell-cell contact points and their potential involvement in the ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/s0161-5890(99)00122-4

    authors： Williams LA,Martin-Padura I,Dejana E,Hogg N,Simmons DL

    更新日期：1999-12-01 00:00:00

  • Identification of chicken cathelicidin-2 core elements involved in antibacterial and immunomodulatory activities.

    abstract：:Chicken host defense peptide cathelicidin-2 (CATH-2) is known to exert antimicrobial and immunomodulatory activities and consists of two alpha-helices connected by a hinge region. Here we report the biological properties of the separate alpha-helical segments and the importance of the proline residue in the hinge regi...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2009.05.019

    authors： van Dijk A,Molhoek EM,Veldhuizen EJ,Bokhoven JL,Wagendorp E,Bikker F,Haagsman HP

    更新日期：2009-08-01 00:00:00

  • Antibody repertoire development in fetal and neonatal piglets. V. VDJ gene chimeras resembling gene conversion products are generated at high frequency by PCR in vitro.

    abstract：:The recovery of VDJ rearrangement is most often accomplished by PCR amplification of DNA extracted from mixtures of B-cells. Using this procedure in swine, VDJs containing chimeric V(H) genes that resemble gene-conversion products, are frequently encountered. To examine whether these chimeras could be the result of PC...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0161-5890(01)00022-0

    authors： Sinkora M,Sun J,Butler JE

    更新日期：2000-12-01 00:00:00

  • Helper role of NK cells during the induction of anticancer responses by dendritic cells.

    abstract：:Recent reports demonstrate that natural killer (NK) cells and dendritic cells (DC) support each other's activity in a positive feedback. We observed that activated NK cells induce the maturation of DCs into stable type-1 polarized DCs (DC1), characterized by up to 100-fold enhanced ability to produce IL-12p70 in respo...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2004.07.038

    authors： Kalinski P,Giermasz A,Nakamura Y,Basse P,Storkus WJ,Kirkwood JM,Mailliard RB

    更新日期：2005-02-01 00:00:00

  • Theoretical analysis of the accuracy of calibrated immunoassays for measuring antibody concentration.

    abstract：:The accuracy of calibrated immunoassays for measuring antibody concentration was analysed from a theoretical perspective. The study shows that there are theoretical limits on the accuracy of antibody immunoassays, which are determined by the affinity of the standard and unknown antibodies and the conditions chosen for...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(91)90115-z

    authors： Griswold WR,Chalquest RR

    更新日期：1991-07-01 00:00:00

  • Interaction of C3 and C3b with immunoglobulin G.

    abstract：:Human C3b as well as native C3 were found to bind to solid phase human and rabbit IgG. Haemolytically active C3 had significantly higher binding capacity to IgG than the C3b fragment. Inhibition experiments proved that C3 and C3b have common binding sites on the Fab and Fc part of the IgG molecule but the character of...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(83)90076-7

    authors： Kulics J,Rajnavölgyi E,Füst G,Gergely J

    更新日期：1983-08-01 00:00:00

  • IgM polymerization inhibits the Golgi-mediated processing of the mu-chain carboxy-terminal glycans.

    abstract：:Secreted glycoproteins generally contain oligosaccharides of the complex type. However, several molecules have been described in which individual glycans are processed differently from one another. Folding, assembly and oligomerization could affect the maturation of certain glycans by hindering them to the Golgi proce...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(95)00132-8

    authors： Cals MM,Guenzi S,Carelli S,Simmen T,Sparvoli A,Sitia R

    更新日期：1996-01-01 00:00:00

  • Identification and characterization of a novel nanobody against human placental growth factor to modulate angiogenesis.

    abstract：:Placental growth factor (PlGF), a member of vascular endothelial growth factors (VEGF) family, is considered as an important antigen associated with pathological conditions such as cancer cell growth, and metastasis. PlGF-targeting via nanobody (Nb) therefore could be beneficial to modulate these pathologies. In this ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2016.09.012

    authors： Arezumand R,Mahdian R,Zeinali S,Hassanzadeh-Ghassabeh G,Mansouri K,Khanahmad H,Namvar-Asl N,Rahimi H,Behdani M,Cohan RA,Eavazalipour M,Ramazani A,Muyldermans S

    更新日期：2016-10-01 00:00:00

  • Stenotrophomonas-maltophilia inhibits host cellular immunity by activating PD-1/PD-L1 signaling pathway to induce T-cell exhaustion.

    abstract：BACKGROUND:Smalotrophomonas maltophilia(S. maltophilia) is common in nosocomial infections. However, few studies have revealed the effect of S. maltophilia on cellular immunity in the host's immune system up to now. In clinical work, we accidentally discovered that S. maltophilia directly stimulated T cells to secrete ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2020.12.019

    authors： Wang M,Yin S,Qin Q,Peng Y,Hu Z,Zhu X,Liu L,Li X

    更新日期：2021-02-01 00:00:00