Interleukin-1 receptor associated kinase 1 is a potential therapeutic target of anti-inflammatory therapy for systemic lupus erythematosus.

abstract：:Monoclonal antibodies were prepared against synthetic peptides synthetized on the basis of nucleotide sequence from cDNA and genomic clones encoding a class I antigen expressed by the rabbit RL-5 cell line. Using a peptide corresponding to positions 61-73 of the N domain, we were able to obtain an hybridoma producing ...

journal_title：Molecular immunology

authors： Le Guern A,Wetterskog D,Marche PN,Kindt TJ

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:Interleukin-1 beta (IL-1β) plays pivotal roles in the progression of allergic airway inflammation. This study aims to determine whether the blockade of IL-1β can inhibit airway inflammation in guinea pigs with allergic asthma induced by the inhalation of aerosolized ovalbumin (OVA). METHODS:Healthy guinea p...

journal_title：Molecular immunology

authors： Wei-xu H,Qin X,Zhu W,Yuan-yi C,Li-feng Z,Zhi-yong L,Dan H,Xiao-mu W,Guo-zhu H

更新日期：2014-03-01 00:00:00

abstract：:The major product of digestion of bovine IgG2a(A1) with immobilized pepsin is F(ab')2 while similar treatment of IgG2a(A2) yields Fab, Fc and other products. It is postulated that structural differences in the hinge region, including the absence of the most N-terminal disulfide bridge in IgG2a(A2) and a displacement o...

journal_title：Molecular immunology

authors： Heyermann H,Butler JE

更新日期：1987-12-01 00:00:00

abstract：:A 30,000 mol. wt component (beta) is associated in a 1:1 ratio with the 50,000 mol. wt glycoprotein (alpha) which binds immunoglobulin E (IgE) on mast cells and related tumor cells. We show that alpha and beta are associated in membrane preparations. This is consistent with previous results which showed labeling of be...

journal_title：Molecular immunology

authors： Holowka D,Metzger H

更新日期：1982-02-01 00:00:00

abstract：:Recent studies suggest that CD8(+) T cells with down-regulated CD8 expression (CD3(+)CD8(low) T cells) represented as a distinct phenotype of CD8(+) T cells are increased and linked to disease severity in some chronically persistent infection, such as chronic HIV and parasite infection. However, the role of CD3(+)CD8(...

journal_title：Molecular immunology

authors： Ouyang L,Li X,Liang Z,Yang D,Gong F,Shen G,Weng X,Wu X

更新日期：2013-12-01 00:00:00

abstract：:Syngeneic polyclonal antibodies were elicited to an affinity labeled high affinity (2-3 X 10(10) M-1) anti-fluorescein murine IgG2a monoclonal antibody. Hyperimmune ascites fluid was tested for reactivity with homologous liganded, affinity labeled and non-liganded Fab fragments derived from the high affinity antibody....

journal_title：Molecular immunology

authors： Voss EW Jr,Miklasz SD,Petrossian A,Dombrink-Kurtzman MA

更新日期：1988-08-01 00:00:00

abstract：:Bombyx mori nucleopolyhedrovirus (BmNPV) is one of the main pathogens that seriously affect the sustainable development of sericulture industry. Inhibition of Hsp90 by Hsp90 inhibitor, geldanamycin (GA) significantly suppresses BmNPV proliferation in Bombyx mori, while the functional mechanism is not clear. LncRNA has...

journal_title：Molecular immunology

authors： Yin H,Shang Q,Zhang S,Shen M,Huang H,Zhao W,Xijie G,Wu P

更新日期：2020-11-01 00:00:00

abstract：:Grass pollens are amongst the most important aeroallergen sources world-wide triggering allergic rhinoconjunctivitis and asthma in sensitised patients. Much of what we know about the allergen components of grasses is informed by research on pollen of temperate (Pooideae) species that are abundant in the temperate clim...

journal_title：Molecular immunology

authors： Kailaivasan T,Davies JM

更新日期：2018-08-01 00:00:00

abstract：:Properly regulated mitogen-activated protein (MAP) kinase activity is critical for normal thymocyte development. MAP kinases are activated by phosphorylation of tyrosine and threonine, and dual specificity phosphatases (DUSPs) can inactivate MAP kinases by dephosphorylating both tyrosine and threonine. However, a role...

journal_title：Molecular immunology

authors： Tanzola MB,Kersh GJ

更新日期：2006-02-01 00:00:00

abstract：:C1q, the recognition molecule of the classical pathway of complement, binds to endothelial cells, leading to cell activation. Mannose-binding lectin (MBL), a recognition molecule of the lectin pathway, is structurally and functionally related to C1q. Therefore, we investigated the interaction of MBL with human umbilic...

journal_title：Molecular immunology

authors： Oroszlán M,Daha MR,Cervenak L,Prohászka Z,Füst G,Roos A

更新日期：2007-02-01 00:00:00

abstract：:The migration of dendritic cells (DCs) from the site of antigen-encounter to regional lymphoid organs is crucial for DCs to function as potent antigen-presenting cells. Matrix metalloproteinase-9 (MMP-9) is critically for DCs migration across extracellular matrix (ECM). We verified in previous studies that hypoxia dim...

journal_title：Molecular immunology

authors： Zhao P,Li XG,Yang M,Shao Q,Wang D,Liu S,Song H,Song B,Zhang Y,Qu X

更新日期：2008-04-01 00:00:00

abstract：:Recognition of double-stranded RNA (dsRNA) activates interferon-regulatory factor 3 (IRF3)-dependent expression of anti-viral factors. The innate immune system recognizes viral dsRNA through two distinct pathways. First, the Toll-like receptor 3 (TLR3) detects dsRNA phagocytosed in endosomes. In addition, the helicase...

journal_title：Molecular immunology

authors： Dong LW,Kong XN,Yan HX,Yu LX,Chen L,Yang W,Liu Q,Huang DD,Wu MC,Wang HY

更新日期：2008-06-01 00:00:00

abstract：:Dense deposit disease (DDD) is strongly associated with the uncontrolled activation of the complement alternative pathway. Factor H (CFH)-deficient (Cfh(-/-)) mice spontaneously develop C3 deposition along the glomerular basement membrane (GBM) with subsequent development of glomerulonephritis with features of DDD, a ...

journal_title：Molecular immunology

authors： Paixão-Cavalcante D,Hanson S,Botto M,Cook HT,Pickering MC

更新日期：2009-06-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D3 (1,25-D3) is known to have potent inhibitory effects on human peripheral blood mononuclear cell (PBMC) functions. Previous experiments suggest that addition of interleukin-2 (IL-2) to cell cultures can reverse the antiproliferative action of 1,25-D3. Previous studies have also shown that the C...

journal_title：Molecular immunology

authors： Jordan SC,Lemire JM,Sakai RS,Toyoda M,Adams JS

更新日期：1990-01-01 00:00:00

abstract：:Candida albicans is an opportunistic human-pathogenic fungus, which can cause superficial but also life-threatening invasive infections. The pH-regulated antigen 1 (Pra1) of C. albicans is a surface-associated and secreted protein highly expressed in the hyphal form. Pra1 can bind to complement receptor 3 (CD11b/CD18)...

journal_title：Molecular immunology

authors： Losse J,Svobodová E,Heyken A,Hube B,Zipfel PF,Józsi M

更新日期：2011-09-01 00:00:00

abstract：:Apoptosis can be induced in the human leukemic T-cell line Jurkat when these cells are stimulated by several known T-cell activators. Among the stimuli that activate Jurkat cells, calcium ionophore A23187, phytohemagglutinin and cross-linked monoclonal antibody anti-CD3 are the best inducers of apoptosis. The activato...

journal_title：Molecular immunology

authors： Ruiz-Ruiz MC,Oliver FJ,Izquierdo M,López-Rivas A

更新日期：1995-09-01 00:00:00

abstract：:Age-related macular degeneration (AMD) and membranoproliferative glomerulonephritis type II (MPGN2) are dense deposit diseases that share a genetic association with complement genes and have complement proteins as important components of the dense deposits. Here, we present the case of a 64-year-old smoker male who de...

journal_title：Molecular immunology

authors： Montes T,Goicoechea de Jorge E,Ramos R,Gomà M,Pujol O,Sánchez-Corral P,Rodríguez de Córdoba S

更新日期：2008-05-01 00:00:00

abstract：:High glucose- induced endothelial dysregulation has been recognized as an initiation of vascular complications in Type 2 diabetes mellitus (T2DM). Anagliptin is a novel licensed dipeptidyl peptidase-4 (DPP-4) inhibitor for the treatment of T2DM. The effects of anagliptin in high glucose- induced endothelial dysfunctio...

journal_title：Molecular immunology

authors： Jiang T,Jiang D,Zhang L,Ding M,Zhou H

更新日期：2019-03-01 00:00:00

abstract：:The lymphocyte antigen CD6 has been extensively studied in humans, but has not been reported in mouse. Here we describe the isolation and characterization of a cDNA clone encoding the murine homologue of the human lymphocyte antigen CD6. Comparison of the predicted amino acid sequence of human and murine CD6 shows tha...

journal_title：Molecular immunology

authors： Whitney G,Bowen M,Neubauer M,Aruffo A

更新日期：1995-01-01 00:00:00

abstract：:We have developed a method for use in investigating factors controlling the binding and cross-linking by bivalent haptens of immunoglobulin E (IgE) bound to receptors on rat basophilic leukemia (RBL) cells. This method employs monoclonal anti-2,4-dinitrophenyl (DNP) IgE that is labeled with fluorescein-5-isothiocyanat...

journal_title：Molecular immunology

authors： Erickson J,Kane P,Goldstein B,Holowka D,Baird B

更新日期：1986-07-01 00:00:00

abstract：:Mannose-binding lectin (MBL) is a recognition molecule of the complement (C) system and binds to carbohydrate ligands present on a wide range of pathogenic bacteria, viruses, fungi, and parasites. MBL has been detected in the cervico-vaginal cavity where it can provide a first-line defence against infectious agents co...

journal_title：Molecular immunology

authors： Bulla R,De Seta F,Radillo O,Agostinis C,Durigutto P,Pellis V,De Santo D,Crovella S,Tedesco F

更新日期：2010-11-01 00:00:00

abstract：:A high affinity C5 convertase is generated when a C3 convertase deposits additional C3b molecules on and around itself thereby switching the substrate specificity of C3 convertase from C3 to C5. In the present study the role of the additional C3b molecules in influencing the regulation of classical pathway C5 converta...

journal_title：Molecular immunology

authors： Rawal N,Pangburn MK

更新日期：2007-02-01 00:00:00

abstract：:Cleavage by the proteasome is responsible for generating the C terminus of T-cell epitopes. Modeling the process of proteasome cleavage as part of a multi-step algorithm for T-cell epitope prediction will reduce the number of non-binders and increase the overall accuracy of the predictive algorithm. Quantitative matri...

journal_title：Molecular immunology

authors： Doytchinova IA,Flower DR

更新日期：2006-05-01 00:00:00

abstract：:ASF1a (anti-silencing function 1a), an evolutionarily conserved protein and a histone chaperone, is required for a variety of chromatin-mediated cellular processes. However, the function of ASF1a in innate immune response remains unclear. Here, we find that ASF1a is induced in Vesicular Stomatitis Virus (VSV)-infected...

journal_title：Molecular immunology

authors： Liu Z,Yang L,Sun Y,Xie X,Huang J

更新日期：2016-10-01 00:00:00

abstract：:The primary immune response against Staphylococcus aureus is mediated by neutrophils. In response to S. aureus and its proteins, neutrophil shows two different kinds of NETosis, viz. suicidal and vesicular NETosis. Glucose is the major energy source of neutrophils for performing NETosis. However, NETosis was found alt...

journal_title：Molecular immunology

authors： V Shaji B,Shaji S,V H H,S P,Y A

更新日期：2020-08-01 00:00:00

abstract：:Autophagy is an intracellular "self-eating" process that is closely related to inflammation and cellular immunity. New studies indicate that autophagy is also involved in tumor suppression. The anti-inflammatory cytokine interleukin-37 (IL-37) has been shown to have tumor-suppressive abilities in hepatocellular carcin...

journal_title：Molecular immunology

authors： Li TT,Zhu D,Mou T,Guo Z,Pu JL,Chen QS,Wei XF,Wu ZJ

更新日期：2017-07-01 00:00:00

abstract：:TRIMCyp generated by retrotransposition of a cyclophilin A inserting into TRIM5 locus, has been identified in owl monkey and most of Old World monkeys (OWM). Owl monkey TRIMCyp (omTRIMCyp) inhibits HIV-1 infection by direct interaction with viral capsid and indirect innate immune induction, whereas most of TRIMCyps fr...

journal_title：Molecular immunology

authors： Zhu JW,Mu D,Liu FL,Luo MT,Luo RH,Zheng YT

更新日期：2018-09-01 00:00:00

abstract：:Dendritic cells (DC) are comprised of several subsets with distinct functions, differing in their capacity to respond to pathogen products. To gain novel insights into their pathogen specificity, we compared the protein composition of the plasma membrane of CD8+ and CD8- DC, directly isolated from mouse spleens. Diffe...

journal_title：Molecular immunology

authors： Segura E,Kapp E,Gupta N,Wong J,Lim J,Ji H,Heath WR,Simpson R,Villadangos JA

更新日期：2010-05-01 00:00:00

abstract：:Using the non-crossreactive mAb MRC-OX3 and MRC-OX6, two serologically distinct RT1.B-specific (I-A equivalent) alpha, beta heterodimers have previously been described by us as residing at the cell surface of LEW rat spleen cells. The two-chain elements were suggested to represent stable conformation isomers, diverged...

journal_title：Molecular immunology

authors： Henkes W,Reske K

更新日期：1989-02-01 00:00:00

abstract：:Phosphocholine (PC)-specific antibodies that arise in the mouse in response to Proteus morganii (PM) and use V1-DFL16.1-JH1 are characterized by a number of recurring mutations. Most striking is an invariant A for G substitution in codon 95 of VH which results in an asparagine instead of aspartate at that position. Be...

journal_title：Molecular immunology

authors： George J,Sheehan KM,Brodeur PH,Claflin JL

更新日期：1993-03-01 00:00:00