Protective KIR-HLA interactions for HCV infection in intravenous drug users.

abstract：:Although granulocyte colony-stimulating factor(G-CSF) has pathogenic roles in several immune inflammatory diseases, its role in periodontitis has not been investigated. Here we detected local expression of G-CSF using public datasets in the Gene Expression Omnibus (GEO) database, and immune cell infiltration into ging...

journal_title：Molecular immunology

authors： Zhang Z,Yuan W,Deng J,Wang D,Zhang T,Peng L,Tian H,Wang Z,Ma J

更新日期：2020-01-01 00:00:00

abstract：:Purified human C5 was converted non-enzymically to an activated form as defined by its ability to participate in reactive lysis. This conversion occurred following exposure to systems that generate oxygen radicals, namely addition of H2O2 in the presence of ascorbic acid and iron or the addition of xanthine oxidase, a...

journal_title：Molecular immunology

authors： Vogt W,Damerau B,von Zabern I,Nolte R,Brunahl D

更新日期：1989-12-01 00:00:00

abstract：:This report demonstrates that a marker of human embryonic endoderm and embryonal carcinoma cells recognized by a hybridoma antibody FC 10.2, involves Type 1 blood group chains with the sequence Gal beta 1 leads to 3G1cNAc beta 1 leads to 3Gal beta 1 leads to 4G1c. This conclusion has been reached from antigenic analys...

journal_title：Molecular immunology

authors： Gooi HC,Williams LK,Uemura K,Hounsell EF,McIlhinney RA,Feizi T

更新日期：1983-06-01 00:00:00

abstract：:Since secretion of IgE antibodies is known to be blocked by tunicamycin, the first aim of the present study was to determine at which step of glycosylation or processing secretion was restored. For this purpose, murine hybridoma cells secreting an anti beta-lactoglobulin IgE were incubated either in the presence of in...

journal_title：Molecular immunology

authors： Granato DA,Neeser JR

更新日期：1987-08-01 00:00:00

abstract：:alpha 2-Macroglobulin (alpha 2M) complexed with proteinases or modified by the action of amines has been shown to affect immune responses in vitro, though as yet the mechanisms are poorly understood. Supernates from rabbit lymphoid cells cultured in medium with normal rabbit serum and 35S-methionine (or 14C-leucine) w...

journal_title：Molecular immunology

authors： Schlesinger C,McEntire J,Wallman J,Skosey JL,Hanly WC,Teodorescu M

更新日期：1989-03-01 00:00:00

abstract：:Of the antioxidant/prooxidant mechanisms mediating the regulation of inflammatory mediators, particularly cytokines, oxidative stress-related pathways remain a cornerstone. It is conspicuous that there is a strong association between free radical accumulation (ROS/RNS; oxidative stress) and the evolution of inflammati...

journal_title：Molecular immunology

authors： Haddad JJ,Harb HL

更新日期：2005-05-01 00:00:00

abstract：:The T cell stimulatory activity of peptides is known to be associated with the cell surface stability and lifetime of the peptide-MHC (pepMHC) complex. In this report, soluble high-affinity T cell receptors (TCRs) that are specific for pepMHC complexes recognized by the mouse CD8+ clone 2C were used to monitor the cel...

journal_title：Molecular immunology

authors： Brophy SE,Jones LL,Holler PD,Kranz DM

更新日期：2007-03-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) are important components of the host's innate immune response against microbial invasion. The cysteine-rich AMPs such as defensin and hepcidin have been extensively studied, but the recently identified cysteine-rich liver-expressed antimicrobial peptide 2 (LEAP-2) has been characterized f...

journal_title：Molecular immunology

authors： Bao B,Peatman E,Xu P,Li P,Zeng H,He C,Liu Z

更新日期：2006-02-01 00:00:00

abstract：:Fcα/μR (CD351) is an Fc receptor for both IgA and IgM and forms an atypical dimer that is resistant to reduction by 2-mercaptoethanol or boiling. We previously demonstrated that the cytoplasmic portion of Fcα/μR is required for dimer formation and for its efficient cell-surface expression. However, the biochemical nat...

journal_title：Molecular immunology

authors： Takagaki K,Satoh K,Honda S,Shibuya A

更新日期：2013-11-01 00:00:00

abstract：:The effect of fragment B of staphylococcal protein A on the binding of rabbit IgG to human granulocytes has been examined. When rabbit IgG sensitized sheep erythrocytes (EA) were preincubated with increasing amounts of fragment B, a dose dependent inhibition of rosette formation between the human granulocytes and the ...

journal_title：Molecular immunology

authors： Barnett Foster DE,Sjoquist J,Painter RH

更新日期：1982-03-01 00:00:00

abstract：:A quantitative analysis of the frequencies of autoantibody producing B-cells has been undertaken by producing and analyzing random hybridoma collections generated in fusions with activated B-cells. Activated B-cells were derived from mice injected with LPS and SRBC and normal mice. They were compared to those derived ...

journal_title：Molecular immunology

authors： Rolink AG,Thalmann P,Berger C,Radaszkiewicz T,Melchers F

更新日期：1988-11-01 00:00:00

abstract：:Cardamonin, a chalcone isolated from the fruits of a local plant Alpinia rafflesiana, has demonstrated anti-inflammatory activity in cellular models of inflammation. In this report, we evaluated the ability of cardamonin to suppress both NO and PGE2 synthesis, iNOS and COX-2 expression and enzymatic activity, and key ...

journal_title：Molecular immunology

authors： Israf DA,Khaizurin TA,Syahida A,Lajis NH,Khozirah S

更新日期：2007-02-01 00:00:00

abstract：:Endogenous mouse mammary tumor proviruses (MMTV; Mtv loci) deletes Vbeta6 expressing T cells in the thymus of Mtv-7(+) DBA/2 (H2(d)) mice through negative selection. We found that in Mtv-7(-) BALB/c (H2(d)) mice, Vbeta6 is a dominant V gene used in T cell responses to an 18 amino acid long peptide antigen: EYKEYAEYAEY...

journal_title：Molecular immunology

authors： Kilgannon P,Novak Z,Fotedar A,Singh B

更新日期：2010-02-01 00:00:00

abstract：:NKG2D receptor-ligand interaction triggers NK cell-mediated cytolysis and IFN-gamma secretion. IFN-gamma produced by NK cells has been found to promote the interaction between NK cells and monocytes; however, the underlying mechanism remains elusive. We demonstrate here that IFN-gamma exclusively induced or upregulate...

journal_title：Molecular immunology

authors： Wang H,Ruan Z,Wang Y,Han J,Fu X,Zhao T,Yang D,Xu W,Yang Z,Wang L,Chen Y,Wu Y

更新日期：2008-03-01 00:00:00

abstract：:We have previously generated human IgG1 antibodies that were engineered for reduced binding to the classical Fcγ receptors (FcγRI-III) and C1q, thereby eliminating their destructive effector functions (constant region G1Δnab). In their potential use as blocking agents, favorable binding to the neonatal Fc receptor (Fc...

journal_title：Molecular immunology

authors： Stapleton NM,Armstrong-Fisher SS,Andersen JT,van der Schoot CE,Porter C,Page KR,Falconer D,de Haas M,Williamson LM,Clark MR,Vidarsson G,Armour KL

更新日期：2018-03-01 00:00:00

abstract：:The DNA vaccine based on the glycoprotein gene of Infectious hematopoietic necrosis virus induces a non-specific anti-viral immune response and long-term specific immunity against IHNV. This study characterized gene expression responses associated with the early anti-viral response. Homozygous rainbow trout were injec...

journal_title：Molecular immunology

authors： Purcell MK,Nichols KM,Winton JR,Kurath G,Thorgaard GH,Wheeler P,Hansen JD,Herwig RP,Park LK

更新日期：2006-05-01 00:00:00

abstract：:A transplanted organ suffers inherently from an ischaemic insult and subsequent reperfusion injury. The severity of such early events is thought to influence the success of the transplant procedure, not only in the immediate post-transplant period, but also to predispose the graft to both acute and chronic rejection. ...

journal_title：Molecular immunology

authors： Dong J,Pratt JR,Smith RA,Dodd I,Sacks SH

更新日期：1999-09-01 00:00:00

abstract：:Specific IgE antibodies have been affinity-purified from recombinant grass pollen allergens, and used to identify isoforms of the two major allergens of rye-grass pollen, Lol p I and Lol p V and cross-reactive allergens in other grasses. Lol p I-specific IgE (affinity-purified from the recombinant protein expressed by...

journal_title：Molecular immunology

authors： Smith PM,Ong EK,Knox RB,Singh MB

更新日期：1994-04-01 00:00:00

abstract：:The mechanism by which heparin inhibits the alternative complement pathway (ACP) by a fluid-phase activator, CoVF, has been studied. Results presented here indicate that heparin's major (rate-limiting) effect on the fluid-phase activation of the ACP was to potentiate Factor H activity. Such an effect results in a very...

journal_title：Molecular immunology

authors： Boackle RJ,Caughman GB,Vesely J,Medgyesi G,Fudenberg HH

更新日期：1983-11-01 00:00:00

abstract：:Tumor-associated macrophages (TAMs) are preferentially M2 skewed and promote tumor growth, angiogenesis, invasion, and/or metastasis. In this study, we have analyzed the in vitro immunomodulatory potential of a non-toxic neem leaf glycoprotein (NLGP) in reprogramming Stage III supraglottic laryngeal tumor cell lysate ...

journal_title：Molecular immunology

authors： Goswami KK,Barik S,Sarkar M,Bhowmick A,Biswas J,Bose A,Baral R

更新日期：2014-06-01 00:00:00

abstract：:Structurally diverse dextrans from Leuconostoc mesenteroides and related bacteria have been used extensively in fundamental immunochemical studies such as induction and characterization of anti-dextran antibodies, as well as in studies of their interaction with pneumococcal antisera, normal bovine serum, concanavalin ...

journal_title：Molecular immunology

authors： Jeanes A

更新日期：1986-09-01 00:00:00

abstract：:The anti-cytokeratin (CK) 8 monoclonal antibody (mab) TS1 has been shown to efficiently bind to CK8 expressed in carcinomas in vivo. The anti-idiotypic antibody of TS1, alphaTS1, can be used to regulate the tumor:non-tumor ratio of TS1 by clearing non-tumor binding TS1 from the circulation. If the interaction of TS1 t...

journal_title：Molecular immunology

authors： Holm P,Jafari R,Sundström BE

更新日期：2007-02-01 00:00:00

abstract：:Complement per se has been shown to play an important role in demyelinating disease but controversy remains regarding the role of C3 in the development and progression of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis. In this study, we used C3(-/-) mice to confirm previous fi...

journal_title：Molecular immunology

authors： Szalai AJ,Hu X,Adams JE,Barnum SR

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:Spinal cord injury (SCI) is a neurological disease with high incidence and disability. In this paper, we made a foundational study in long non-coding RNA paternally expressed gene 10 (lncRNA PEG10) at PC-12 cells. METHODS:We used CCK8, flow cytometry, migration and invasion assay to detect changes at the cel...

journal_title：Molecular immunology

authors： Niu S,Ni Y,Niu T,Gao J

更新日期：2020-02-01 00:00:00

abstract：:Natural killer cells fail to lyse target cells expressing sufficient levels of self MHC class I molecules, providing one mechanism to secure self tolerance. Inhibition of lysis is mediated by inhibitory receptors expressed by NK cells, such as the murine Ly49 receptors, human KIR receptors and CD94/NKG2A, expressed by...

journal_title：Molecular immunology

authors： Salmon-Divon M,Höglund P,Johansson MH,Johansson S,Mehr R

更新日期：2005-02-01 00:00:00

abstract：:Natural resistance to infection with intracellular parasites, such as Leishmania, Salmonella, and Mycobacterium, is controlled in mice by the expression of a single dominant gene locus designated Lsh/Ity/Bcg. Natural resistance-associated macrophage protein gene 1 (NRAMP1) was isolated as a candidate gene. NRAMP1 enco...

journal_title：Molecular immunology

authors： Kishi F,Yoshida T,Aiso S

更新日期：1996-11-01 00:00:00

abstract：:Aberrant O-glycosylation of cell surface mucin antigens is characteristic of epithelial cancer cells. For example, Thomsen-Friedenreich disaccharide (TFD) is a chemically well-defined carbohydrate antigen with a documented link to malignancy. There have been many attempts to improve immune response to carbohydrate ant...

journal_title：Molecular immunology

authors： Irazoqui FJ,Lopez PH,Mandel U,Nores GA

更新日期：2002-03-01 00:00:00

abstract：:An efficient method is described for the isolation of highly purified, IgG-free and stable guinea-pig serum C1q. The procedure includes the chromatography of EDTA-treated serum (25 mM EDTA) on CM- and DEAE-cellulose followed by gel filtration on ACA 34-Ultrogel whereby ammonium sulfate precipitation was used for conce...

journal_title：Molecular immunology

authors： Hitschold T,Golan MD,Rabs U,Loos M

更新日期：1983-02-01 00:00:00

abstract：:Mouse monoclonal antibody AUK12-20 binds to human IL-6 receptor and inhibits IL-6 functions. It has been humanized by CDR-grafting for therapeutic use. In the design of reshaped human AUK12-20 VL region, the human framework regions (FRs) from the human Bence-Jones protein REI were used. The reshaped human AUK12-20 lig...

journal_title：Molecular immunology

authors： Sato K,Tsuchiya M,Saldanha J,Koishihara Y,Ohsugi Y,Kishimoto T,Bendig MM

更新日期：1994-04-01 00:00:00

abstract：:The immunological role of exosomes in autoimmune encephalitis (AE) remains uncharacterized and not examined. In this study we ought to determine whether exosomes are generated in AE and to define the presence of cell surface neuronal autoantigens (autoAgs) in the cargo. Exosomes were isolated from cerebrospinal fluid ...

journal_title：Molecular immunology

authors： Gu J,Jin T,Li Z,Chen H,Xia H,Xu X,Gui Y

更新日期：2021-01-11 00:00:00