Knockdown PEG10 deteriorates H2O2-injury of PC-12 cells by targeting miR-34a-5p/TLX.

abstract：:Attempts to develop peptide vaccines, based on a limited number of peptides face two problems: HLA polymorphism and the high mutation rate of viral epitopes. We have developed a new genomic method that ensures maximal coverage and thus maximal applicability of the peptide vaccine. The same method also promises a large...

journal_title：Molecular immunology

authors： Vider-Shalit T,Raffaeli S,Louzoun Y

更新日期：2007-02-01 00:00:00

abstract：:Asthma is a complex condition in which exposure to environmental antigens induces inflammatory reactions in the airway characterized by activation of mast cells and eosinophils. Mast cells are known to be the main effector cells in eliciting IgE-mediated allergic response. These cells secrete various substances that p...

journal_title：Molecular immunology

authors： Jolly PS,Rosenfeldt HM,Milstien S,Spiegel S

更新日期：2002-09-01 00:00:00

abstract：:A number of fragments derived from acid-treated rabbit IgG by digestion with plasmin have been separated by high-resolution gel filtration. Fragments isolated included a dimer and monomer Facb, named F(acb)2 and Facb, respectively and a heterodimer composed of Facb and Fab subunits, named F(acb)(ab). A C gamma 2 fragm...

journal_title：Molecular immunology

authors： Utsumi S,Okada M,Udaka K,Amano T

更新日期：1985-07-01 00:00:00

abstract：:Effective use of adenovirus-5 (Ad5) in cancer therapy is heavily dependent on the degree to which the virus's natural tropism can be subverted to one that favours tumour cells. This is normally achieved through either engineering of the viral fiber knob or the use of bispecific adaptors that display both adenovirus an...

journal_title：Molecular immunology

authors： Vasiljevic S,Beale EV,Bonomelli C,Easthope IS,Pritchard LK,Seabright GE,Caputo AT,Scanlan CN,Dalziel M,Crispin M

更新日期：2015-12-01 00:00:00

abstract：:Comparative interactions of purified rabbit C1q with 18-2-3, a high affinity (2-3 X 10(10) M-1) anti-fluorescein (anti-F1) murine monoclonal IgM antibody (pentamer) and constitutive monomeric subunits (IgMs) were studied. Using a solid phase radioimmunoassay (SPRIA), based on immobilized polyvalent antigen, it was sho...

journal_title：Molecular immunology

authors： Swanson SM,Dombrink-Kurtzman MA,Voss EW Jr

更新日期：1988-06-01 00:00:00

abstract：:Immunoglobulin heavy chain (Igh) locus rearrangements are controlled in part by an approximately 30 b complex 3' regulatory region located 3' of C alpha: this region contains several enhancers. We report here the comparison of the genomic sequences of the 3' regulatory region and further downstream sequences from mous...

journal_title：Molecular immunology

authors： Sepulveda MA,Garrett FE,Price-Whelan A,Birshtein BK

更新日期：2005-03-01 00:00:00

abstract：:C-reactive protein (CRP) is a pattern recognition molecule that binds several microbial and host ligands. Ligand-bound CRP activates the complement system via the classical pathway. Previously, we identified human complement factor H-related protein 4 (CFHR4), a member of the factor H protein family, as a CRP binding ...

journal_title：Molecular immunology

authors： Hebecker M,Okemefuna AI,Perkins SJ,Mihlan M,Huber-Lang M,Józsi M

更新日期：2010-03-01 00:00:00

abstract：:The scid mutation interferes with normal rearrangement of antigen receptor genes, leading to an absence of T and B lymphocytes in most SCID mice. However, the SCID phenotype is "leaky", with an age- and strain-dependent increase in the incidence of mice with small number of T and B cells and readily detectable serum i...

journal_title：Molecular immunology

authors： Riggs JE,Feeney AJ,Kirven M,Mosier DE

更新日期：1994-08-01 00:00:00

abstract：:The mechanisms of each subset of immune cells contributing to the pathogenesis of viral hepatitis remain incompletely understood. In this study, we examined the role of liver CD4(-) CD8(-) (double negative, DN) T cells during murine hepatitis virus strain 3 (MHV-3)-induced hepatitis in C3H/HeJ mice. We demonstrate tha...

journal_title：Molecular immunology

authors： Lu Y,Wang X,Yan W,Wang H,Wang M,Wu D,Zhu L,Luo X,Ning Q

更新日期：2012-10-01 00:00:00

abstract：:Mannose-binding lectin (MBL) is a recognition molecule of the complement (C) system and binds to carbohydrate ligands present on a wide range of pathogenic bacteria, viruses, fungi, and parasites. MBL has been detected in the cervico-vaginal cavity where it can provide a first-line defence against infectious agents co...

journal_title：Molecular immunology

authors： Bulla R,De Seta F,Radillo O,Agostinis C,Durigutto P,Pellis V,De Santo D,Crovella S,Tedesco F

更新日期：2010-11-01 00:00:00

abstract：:RIP2/RICK/CARDIAK is a member of the receptor interacting protein kinase (RIP) family. RIP2 promotes NF-kappaB activation as well as activation of the MAPKs JNK, ERK1/2 and p38 MAPK, thereby playing an emergent role in the innate immune response and NOD signaling. Moreover, RIP2 has been shown to interact with the CAR...

journal_title：Molecular immunology

authors： Krieg A,Le Negrate G,Reed JC

更新日期：2009-03-01 00:00:00

abstract：:To clarify the different anti-CD26 mAbs corresponding different functions of CD26, the correlation of the epitopes defined by anti-CD26 mAbs and the functions of CD26 have been studied. Using truncated, human-rat CD26 swap mutants and cross-blocking studies, 13 anti-CD26 mAbs were divided into 5 separate groups. These...

journal_title：Molecular immunology

authors： Dong RP,Tachibana K,Hegen M,Scharpé S,Cho D,Schlossman SF,Morimoto C

更新日期：1998-01-01 00:00:00

abstract：:We describe several proteins that are components of the rabbit B cell receptor complex. Two proteins (37 kDa and 42 kDa) were found in non-covalent association with IgM expressed on B cells from peripheral blood. These proteins were also immunoprecipitated by anti-B29 (Ig-beta) and anti-mb1 (Ig-alpha) monoclonal antib...

journal_title：Molecular immunology

authors： Fitts MG,Metzger DW,Hendershot LM,Mage RG

更新日期：1995-07-01 00:00:00

abstract：:The globular C1q heterotrimer is a subunit of the C1 complement factor. Binding of the C1q subunit to the constant (Fc) part of antibody molecules is a first step and key event of complement activation. Although three-dimensional structures of C1q and antibody Fc subunits have been determined experimentally no atomic ...

journal_title：Molecular immunology

authors： Schneider S,Zacharias M

更新日期：2012-05-01 00:00:00

abstract：:The generation of T cell receptor (TCR) sequence diversity can produce 'forbidden' clones able to recognize self-antigens. Here, the structure of the complex between a myelin basic protein peptide (MBP85-99), human leukocyte antigen (HLA)-DR2 (DRB1*1501/DRA) and TCR-Ob.2F3, the dominant autoimmune clone obtained from ...

journal_title：Molecular immunology

authors： Kato Z,Stern JN,Nakamura HK,Miyashita N,Kuwata K,Kondo N,Strominger JL

更新日期：2010-11-01 00:00:00

abstract：:Macrophages are the most abundant cells in tumor stroma and their polarization within tumor microenvironment exert the key roles in tumorigenesis. Astragaloside IV is a natural extract from traditional Chinese herbal Radix Astragali, and fulfills pleiotropic function in several cancers. Nevertheless, its function in o...

journal_title：Molecular immunology

authors： Wang X,Gao S,Song L,Liu M,Sun Z,Liu J

更新日期：2021-02-01 00:00:00

abstract：:Bombyx mori nucleopolyhedrovirus (BmNPV) is one of the main pathogens that seriously affect the sustainable development of sericulture industry. Inhibition of Hsp90 by Hsp90 inhibitor, geldanamycin (GA) significantly suppresses BmNPV proliferation in Bombyx mori, while the functional mechanism is not clear. LncRNA has...

journal_title：Molecular immunology

authors： Yin H,Shang Q,Zhang S,Shen M,Huang H,Zhao W,Xijie G,Wu P

更新日期：2020-11-01 00:00:00

abstract：:White spot syndrome virus (WSSV) has caused great economic damage to shrimp aquaculture. Previous studies have shown that WSSV successfully usurps the immunity system of the host for its own gene regulation. To investigate the role of shrimp high mobility group box (HMGB) proteins in WSSV gene regulation, two Litopena...

journal_title：Molecular immunology

authors： Chen YH,Jia XT,Huang XD,Zhang S,Li M,Xie JF,Weng SP,He JG

更新日期：2011-02-01 00:00:00

abstract：:Idiotype (Id) and autoanti-thyroglobulin were induced in different strains of mice by priming with anti-Id to monoclonal anti-thyroglobulins (D8 and G4) and challenged with a subimmunogenic dose of thyroglobulin (Tg). Both D8.Id and G4.Id were induced in CBA mice by priming with the appropriate anti-Id, but only primi...

journal_title：Molecular immunology

authors： Male D,Pryce G,Roitt I

更新日期：1985-03-01 00:00:00

abstract：:T regulatory (Treg)/T-helper (Th) 17 imbalance has been shown to integrate with epigenetics to result in the development of autoimmune diseases. We aim to investigate the influence of disease staging on Treg/Th17 cells and whether the aberrant DNA methylation is implicated in the development of rheumatoid arthritis (R...

journal_title：Molecular immunology

authors： Huang Y,Wang H,Ba X,Chen Z,Wang Y,Qin K,Huang Y,Shen P,Tu S

更新日期：2020-11-01 00:00:00

abstract：:Viral myocarditis (VMC) is an inflammation of the myocardium closely associated with Coxsackievirus B3 (CVB3) infection. Vγ1+γδT cells, one of early cardiac infiltrated innate population, were reported to protect CVB3 myocarditis while the precise mechanism not fully addressed. To explore cytokine profiles and kinetic...

journal_title：Molecular immunology

authors： Wan F,Yan K,Xu D,Qian Q,Liu H,Li M,Xu W

更新日期：2017-01-01 00:00:00

abstract：:Clonal idiotypic immunoglobulins of follicular lymphomas can be isolated by somatic fusion procedures. Idiotypic IgMs (Id-IgM) were isolated from two patients and used to immunise a strain of mice, deficient in mouse antibody production and engineered with yeast artificial chromosomes (YAC) containing fragments of the...

journal_title：Molecular immunology

authors： Suárez E,Yáñez R,Barrios Y,Díaz-Espada F

更新日期：2004-07-01 00:00:00

abstract：:Peptide gpMBP72-85, containing amino acids 72-85 of guinea pig myelin basic protein is commonly used to induce experimental autoimmune encephalomyelitis in Lewis rats. The N-terminal glutamine in this peptide can cyclize to pyroglutamic acid, leading to loss of the first MHC anchor for binding to MHC class II. Acetyla...

journal_title：Molecular immunology

authors： de Haan EC,Wauben MH,Wagenaar-Hilbers JP,Grosfeld-Stulemeyer MC,Rijkers DT,Moret EE,Liskamp RM

更新日期：2004-02-01 00:00:00

abstract：:Recent studies have shown that aberrant activation of the complement system plays an important role in the pathogenesis of preeclampsia. There is evidence to suggest that aberrant activation of the complement system may already be present during the first trimester. Here, we performed a prospective study in which peri...

journal_title：Molecular immunology

authors： He YD,Xu BN,Wang ML,Wang YQ,Yu F,Chen Q,Zhao MH

更新日期：2020-04-16 00:00:00

abstract：:A first report of an XLA patient with a polymorphism in Btk SH3 domain has been identified after sequencing of the entire gene. SH3 domain variants might not be detected due to well characterized mutations outside the domain. ...

journal_title：Molecular immunology

authors： Pérez de Diego R,Bravo J,Allende LM,López-Granados E,Rivera J,Ferreira A,Fontán G,García Rodríguez MC

更新日期：2008-01-01 00:00:00

abstract：:Amino acid sequences encoded by exon 8 of the H-2K and H-2D/L genes appear to be locus specific. The majority of H-2Kb molecules contain 10 amino acids that are derived from exon 8. In contrast, the H-2Db, -Dd and -Ld molecules contain only one amino acid which is encoded by exon 8, even though the genetic information...

journal_title：Molecular immunology

authors： Maloy WL,Lew AM,Anderson RW,Coligan JE

更新日期：1988-05-01 00:00:00

abstract：:The recognition structure responsible for binding to conventional antigen on target cells has not previously been described for nonspecific cytotoxic cells (NCC) or for mammalian natural killer (NK) cells. Although several biochemical pathways may be available for initiation of the lytic cycle in NCC, evidence present...

journal_title：Molecular immunology

authors： Jaso-Friedmann L,Leary JH 3rd,Evans DL

更新日期：1997-08-01 00:00:00

abstract：:The Pacific oyster (Crassostrea gigas) is farmed globally. Ostreid herpesvirus (OsHV-1) causes severe mortalities of farmed C. gigas. Management of OsHV-1 has proven difficult. Oysters treated with poly(I:C) exhibit enhanced protection (EP) against OsHV-1. This chemical treatment is highly effective, but it is not fea...

journal_title：Molecular immunology

authors： Green TJ,Helbig K,Speck P,Raftos DA

更新日期：2016-10-01 00:00:00

abstract：:In this study, a novel approach for the development of a peptide-based vaccine has been tested. We investigated the possibility of replacing an all-L amino acid peptide sequence corresponding to the protective B-cell epitope hemagglutinin (HA) 91-108 from influenza HA with a retro-inverso analogue encompassing this se...

journal_title：Molecular immunology

authors： Ben-Yedidia T,Beignon AS,Partidos CD,Muller S,Arnon R

更新日期：2002-10-01 00:00:00

abstract：:The complete cDNA sequences of two bovine IgGs were obtained by RT-PCR cloning. The first-strand cDNA was prepared from an animal homozygous (A2/A2) for IgG2a; the resulting sequences of the two bovine IgGs reported here were identified as IgG2a(A2) and IgG1. These sequences, and their deduced amino acid sequences, ar...

journal_title：Molecular immunology

authors： Kacskovics I,Butler JE

更新日期：1996-02-01 00:00:00