Atomic resolution model of the antibody Fc interaction with the complement C1q component.

abstract：:The outer membrane protein A (OmpA) is one of the intra-species conserved proteins with immunogenicity widely found in the family of Enterobacteriaceae. Here we first confirmed OmpA is conserved in the three pathogenic Yersinia: Yersinia pestis, Yersinia pseudotuberculosis and pathogenic Yersinia enterocolitica, with ...

journal_title：Molecular immunology

authors： Chen Y,Duan R,Li X,Li K,Liang J,Liu C,Qiu H,Xiao Y,Jing H,Wang X

更新日期：2015-12-01 00:00:00

abstract：:Antigen-stimulated B lymphocytes undergo genetic and phenotypic changes in germinal centers (GCs), including affinity maturation of immunoglobulin (Ig) genes and Ig heavy chain isotype switching. Expression of the Germinal Center Expressed Transcript (GCET) gene is up-regulated in murine GC B cells. The human homolog ...

journal_title：Molecular immunology

authors： Steinke JW,Hodsdon W,Parenti S,Ostraat R,Lutz R,Borish L,Hagman J

更新日期：2004-11-01 00:00:00

abstract：:Coinfection with leishmaniasis and schistosomiasis has been associated with increased time to healing of cutaneous lesions of leishmaniasis. The objective of this study was to evaluate the effect of Leishmania braziliensis infection on co-cultures of monocyte-derived dendritic cells (MoDCs) with autologous lymphocytes...

journal_title：Molecular immunology

authors： Lopes DM,de Almeida TVVS,de Souza RDP,Ribeiro LEV,Page B,Fernandes JS,Carvalho EM,Cardoso LS

更新日期：2018-01-01 00:00:00

abstract：:The synovial sarcoma X breakpoint (SSX) gene family contains nine members. The SSX proteins are CT (cancer/testis) antigens and can be expressed in many tumor types. T cell immune response against SSX protein can be detected in tumor patients and mice expressing any SSX. Screening predominant protective epitopes might...

journal_title：Molecular immunology

authors： He Y,Mao L,Lin Z,Deng Y,Tang Y,Jiang M,Li W,Jia Z,Wang J,Ni B,Wu Y

更新日期：2008-05-01 00:00:00

abstract：:Very sensitive assays of IgE are required for determining prevalence of allergic reactions in children. In order to develop a sensitive two-site IRMA two kinds of mAb were produced. Antibodies specific for D epsilon 1 determinants were derived from immunization with a 40 kDa papain Fc fragment. They bound equally nati...

journal_title：Molecular immunology

authors： Anfosso F,Demeure C,Delaage M,Cheballah R,Bellot F,Bourgois A

更新日期：1987-11-01 00:00:00

abstract：:In an attempt to understand the relationship of amino acid sequence to the formation of primary or multiple myeloma-related amyloid (AL amyloid), we have determined the complete amino acid sequence of amyloid protein BAN. This protein belongs to the kappa I immunoglobulin light chain subgroup and has a polypeptide cha...

journal_title：Molecular immunology

authors： Dwulet FE,O'Connor TP,Benson MD

更新日期：1986-01-01 00:00:00

abstract：:Dense deposit disease (DDD) is strongly associated with the uncontrolled activation of the complement alternative pathway. Factor H (CFH)-deficient (Cfh(-/-)) mice spontaneously develop C3 deposition along the glomerular basement membrane (GBM) with subsequent development of glomerulonephritis with features of DDD, a ...

journal_title：Molecular immunology

authors： Paixão-Cavalcante D,Hanson S,Botto M,Cook HT,Pickering MC

更新日期：2009-06-01 00:00:00

abstract：:A relatively large number of variable region genes (V) contribute, via gene rearrangements with smaller numbers of additional gene elements (D and J), to generate diversity in the immune response. While some VH gene families are thought to contain 100- 1000 members, the VH10 family has only two known functioning membe...

journal_title：Molecular immunology

authors： Chao M,Voss EW Jr

更新日期：1992-03-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) are important components of the host's innate immune response against microbial invasion. The cysteine-rich AMPs such as defensin and hepcidin have been extensively studied, but the recently identified cysteine-rich liver-expressed antimicrobial peptide 2 (LEAP-2) has been characterized f...

journal_title：Molecular immunology

authors： Bao B,Peatman E,Xu P,Li P,Zeng H,He C,Liu Z

更新日期：2006-02-01 00:00:00

abstract：:Age-related macular degeneration (AMD) and membranoproliferative glomerulonephritis type II (MPGN2) are dense deposit diseases that share a genetic association with complement genes and have complement proteins as important components of the dense deposits. Here, we present the case of a 64-year-old smoker male who de...

journal_title：Molecular immunology

authors： Montes T,Goicoechea de Jorge E,Ramos R,Gomà M,Pujol O,Sánchez-Corral P,Rodríguez de Córdoba S

更新日期：2008-05-01 00:00:00

abstract：:Human cell lines and blood lymphocytes were treated for short time periods with IFN-gamma. This treatment increased the amount of the assembled MHC class I molecules on the plasma membrane after 30 min. This early increase of the membrane expression subsided in the next few hours. A second wave of elevation occurred a...

journal_title：Molecular immunology

authors： Végh Z,Wang P,Vánky F,Klein E

更新日期：1993-06-01 00:00:00

abstract：:Although the etiology of rheumatoid arthritis (RA) remains unknown, it has been widely suggested that RA has a genetic background. In humans, a copy number loss of 22q11.2, a region harboring the VPREB1 gene, has been suggested to be associated with several immunologic disorders, but there has been no study on the cop...

journal_title：Molecular immunology

authors： Yim SH,Chung YJ,Jin EH,Shim SC,Kim JY,Kim YS,Hu HJ,Shin SH,Pae HO,Zouali M,Chung HT

更新日期：2011-06-01 00:00:00

abstract：INTRODUCTION:Previous studies have suggested the importance of somatic mutations and arginine, asparagine and lysine residues in the complementarity determining regions (CDRs) of antiphospholipid antibodies (aPL) implicated in the pathogenesis of the antiphospholipid antibody syndrome. The relative contributions of the...

journal_title：Molecular immunology

authors： Giles IP,Haley J,Nagl S,Latchman DS,Chen PP,Chukwuocha RU,Isenberg DA,Rahman A

更新日期：2003-09-01 00:00:00

abstract：:Based on our findings that HIV-1 gp41 independently of CD4, can bind to the helper T-cell line H9, we characterized putative binding of HIV-1 gp41 to B-cell lines, Raji, Bjab and Ramos. Using fluorescence-activated cell sorter (FACS) we examined the binding of soluble gp41 (sgp41; Env amino acid 539-684) to these B-ce...

journal_title：Molecular immunology

authors： Chen YH,Böck G,Vornhagen R,Steindl F,Katinger H,Dierich MP

更新日期：1993-09-01 00:00:00

abstract：:Bifunctional antigens composed of one L-tyrosine-p-azobenzenearsonate (Tyr-ABA) carrier epitope and one dinitrophenyl (DNP) haptenic epitope separated by 6-aminocaproyl or polyprolyl spacers induced weak IgM anti-DNP plaque-forming cell (PFC) responses in the spleens of mice immunized intraperitoneally, without detect...

journal_title：Molecular immunology

authors： Kaymakcalan Z,Nitecki DE,Lewis GK,Goodman JW

更新日期：1984-06-01 00:00:00

abstract：:Because of its lethal effects, ease of preparation, and ability to be delivered by aerosolization, ricin has been developed as a lethal weapon by various terrorist groups. When introduced into the pulmonary system of rodents, ricin causes pathological changes in the lung that are known to occur in acute respiratory di...

journal_title：Molecular immunology

authors： Korcheva V,Wong J,Lindauer M,Jacoby DB,Iordanov MS,Magun B

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:The complement system is well known for its role in innate immunity via the classical, the alternative and the lectin pathways, although recent investigations suggest expanding roles in adipose tissue. Properdin stabilizes C3 convertase following alternative complement activation. Properdin is also present i...

journal_title：Molecular immunology

authors： Gauvreau D,Roy C,Tom FQ,Lu H,Miegueu P,Richard D,Song WC,Stover C,Cianflone K

更新日期：2012-05-01 00:00:00

abstract：:Multiple organ dysfunction syndrome (MODS) is a major cause of morbidity and mortality in surgical intensive care units. It is characterized by progressive failure of two or more organs remote from the origin of injury. Since MODS results from a severe generalized inflammatory response, both chemokines and complement ...

journal_title：Molecular immunology

authors： Miller CG,Cook DN,Kotwal GJ

更新日期：1996-10-01 00:00:00

abstract：:During acute lung injury, a large number of monocytes are recruited into the pulmonary tissue, which is mainly mediated by local production of monocyte chemotactic protein 1 (MCP-1). As an essential component of the lung tissues, alveolar type II epithelial cells are one of the major sources of MCP-1. Therefore, uncov...

journal_title：Molecular immunology

authors： Yan C,Li B,Liu X,Deng C,Cai R,Shen Y,Tang H

更新日期：2019-07-01 00:00:00

abstract：:A porcine cDNA library was constructed using poly(A)+ RNA isolated from the spleen of an adult Minnesota miniature swine. Screening the library with antisera specific for porcine immunoglobulin light chains resulted in the selection and isolation of two recombinant clones, PLC18 and PLC3, which encode for kappa and la...

journal_title：Molecular immunology

authors： Lammers BM,Beaman KD,Kim YB

更新日期：1991-08-01 00:00:00

abstract：:The interaction between a single-chain Fv (sFv) of the monoclonal antibody 3A21 and its antigen, bovine pancreatic ribonuclease A (RNase A), was studied by site-directed mutagenesis of the hypervariable regions and fluorescence polarization analysis. The affinity constants of wild-type sFv and a mutant sFv D31A (Asp31...

journal_title：Molecular immunology

authors： Katakura Y,Kumamoto T,Iwai Y,Kurokawa Y,Omasa T,Suga K

更新日期：1997-07-01 00:00:00

abstract：:The complete cDNA sequences of two bovine IgGs were obtained by RT-PCR cloning. The first-strand cDNA was prepared from an animal homozygous (A2/A2) for IgG2a; the resulting sequences of the two bovine IgGs reported here were identified as IgG2a(A2) and IgG1. These sequences, and their deduced amino acid sequences, ar...

journal_title：Molecular immunology

authors： Kacskovics I,Butler JE

更新日期：1996-02-01 00:00:00

abstract：:The etiology of multiple sclerosis (MS), particularly the environmental component of the disease, remains speculative. Recent reports have suggested that alterations in the gut microbiota of MS patients could contribute to the etiology or pathophysiology of the disease. In this Viewpoint, using PICRUSt (Phylogenetic I...

journal_title：Molecular immunology

authors： Montassier E,Berthelot L,Soulillou JP

更新日期：2018-01-01 00:00:00

abstract：:The binding specificity of rat alveolar macrophages (AM phi) for sheep erythrocytes (E) coated with gangliosides GM1, GM2, GM3, GD1a, GD1b or GT1b was analyzed in a rosette assay by studying the inhibitory effect of gangliosides, various carbohydrates, IgG, C3b-like C3, and fibronectin in this assay. The uptake of gan...

journal_title：Molecular immunology

authors： Förster O,Boltz-Nitulescu G,Holzinger C,Wiltschke C,Riedl M,Ortel B,Fellinger A,Bernheimer H

更新日期：1986-11-01 00:00:00

abstract：:Macrophages are the most abundant cells in tumor stroma and their polarization within tumor microenvironment exert the key roles in tumorigenesis. Astragaloside IV is a natural extract from traditional Chinese herbal Radix Astragali, and fulfills pleiotropic function in several cancers. Nevertheless, its function in o...

journal_title：Molecular immunology

authors： Wang X,Gao S,Song L,Liu M,Sun Z,Liu J

更新日期：2021-02-01 00:00:00

abstract：:Heparin and two dextran sulphate preparations with a low or high average molecular mass (M(r) 5000 and 5 x 10(5), respectively) enhanced binding of radioactively labelled complement factor H to the complement protein C3b, coupled to Sepharose 4B, maximally 2.5-4-fold within a polyanion concn range of 12.5-400 microgra...

journal_title：Molecular immunology

authors： Koistinen V

更新日期：1993-02-01 00:00:00

abstract：:Abs reactive to DNA and DNA/histone complexes are a distinguished characteristic of primary immunoglobulin repertoires in autoimmune B6.MRL-Faslpr and MRL/MpJ-Faslpr mice. These mice are defective in Fas receptor, which is critical for the apoptosis of autoreactive B cells by an extrinsic pathway. In the present study...

journal_title：Molecular immunology

authors： Li S,Liu W,Li Y,Zhao S,Liu C,Hu M,Yue W,Liu Y,Wang Y,Yang R,Xiang R,Liu F

更新日期：2016-10-01 00:00:00

abstract：:MHC class I molecules present short peptides, usually 8-10 amino acids in length, to CD8(+) T cells. These peptides are typically generated from full-length endogenously synthesized proteins degraded by the antigen processing machinery of the target cell. However, exogenous proteins, whether originating from intracell...

journal_title：Molecular immunology

authors： Wolf BJ,Princiotta MF

更新日期：2011-01-01 00:00:00

abstract：:Mutation of microphthalmia transcription factor (MITF) results in deafness, bone loss, small eyes, and poorly pigmented eyes and skin. The primary cell types affected in MITF-deficient mice are melanocytes, osteoclasts and mast cells. A search for MITF-associated proteins, using a mast cell library that was screened w...

journal_title：Molecular immunology

authors： Nechushtan H,Razin E

更新日期：2002-09-01 00:00:00

abstract：:Stimulation of cells of the rat basophilic leukemia line RBL-2H3, which are used as a model in biochemical studies of mast cells, by antigen or by the calcium ionophore ionomycin, are known to cause secretion of mediators of inflammation. These stimuli have now been found to cause a decrease in the cells' cytosolic pH...

journal_title：Molecular immunology

authors： Gertler R,Pecht I

更新日期：1988-11-01 00:00:00