The immunoglobulin heavy chain locus in the reptile Anolis carolinensis.

Abstract:

:We describe the entire immunoglobulin heavy chain (IgH) locus from the reptile Anolis carolinensis. The heavy chain constant (C(H)) region includes C mu, C delta and C upsilon genes. This is the first description of a C upsilon gene in the reptilian class. Variable (V(H)), diversity (D(H)) and joining (J(H)) genes are located 5' from the constant (C(H)) chain complex locus. The C mu and C upsilon genes encode antibodies with four immunoglobulin domains. The C delta gene encoded an 11 domain delta heavy chain as in Eublepharis macularius. Seventy V(H) genes, belonging to 28 families, were identified, and they can be sorted into five broader groups. The similarity of the organization of the reptilian genes with those of amphibians and mammals suggests the existence of a process of heavy chain genomic reorganization before the radiation of tetrapod vertebrates.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Gambón Deza F,Sánchez Espinel C,Magadán Mompó S

doi

10.1016/j.molimm.2009.02.019

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

1679-87

issue

8-9

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(09)00096-0

journal_volume

46

pub_type

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