Abstract：
:The Pms2 gene is involved in DNA mismatch repair in mammalian cells, and has recently been shown to affect hypermutation of mammalian immunoglobulin genes. We have studied hypermutation of a lambda1 transgene in chronically stimulated Peyer's patch B cells of both young and old mice deficient in function of Pms2. In young (3-4 months) mice, somatic hypermutation is fourfold lower in PMS2-deficient mice than in control mice. This difference is statistically significant (P < 0.05). In contrast, in older mice (9 months of age), hypermutation levels are indistinguishable in the Pms2-/- and Pms2+/+ backgrounds. In the older mice, there was no clear difference in the fraction of clones carrying either any mutations or at least two mutations when PMS2-deficient mice were compared with their wild-type littermates. As genomic instability increases with age, this observation is difficult to reconcile with the hypothesis that highly mutated B cells cannot survive in Peyer's patches. Moreover, there were clear differences apparent in the mutation spectra of the Pms2-/- and Pms2+/+ mice. In the PMS2-deficient background, deletion and insertion mutations were found, and there was a significant decrease in the ratio of A mutations to T mutations in comparison with the Pms2+/+ controls. Our data support the hypothesis that PMS2 functions in somatic hypermutation, and are most consistent with the hypothesis that the role of PMS2 is direct rather than indirect.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Kong Q,Maizels Ndoi
10.1016/s0161-5890(99)00027-9subject
Has Abstractpub_date
1999-02-01 00:00:00pages
83-91issue
2eissn
0161-5890issn
1872-9142pii
S0161589099000279journal_volume
36pub_type
杂志文章abstract：:Leprosy is a bacterial disease caused by M. leprae. Its clinical spectrum reflects the host's immune response to the M. leprae and provide an ideal model to investigate the host pathogen interaction and immunological dysregulation. Tregs are high in leprosy patients and responsible for immune suppression of the host b...
journal_title：Molecular immunology
pub_type： 杂志文章
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abstract：:Following measles virus (MV) infection, viral peptides are presented to CTL by MHC class I molecules on infected antigen presenting cells at widely different epitope densities. Whereas three MV epitopes (MV-M(211-219), MV-F(438-446) and MV-H(30-38)) derived from different structural proteins occur at regular densities...
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更新日期：2003-01-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2006-03-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2008-01-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：1985-09-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1993-06-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2006-03-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2004.06.034
更新日期：2005-01-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2011.02.002
更新日期：2011-05-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2016-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2010.02.018
更新日期：2010-04-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(83)90005-6
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2003.10.015
更新日期：2004-02-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2009-06-01 00:00:00
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更新日期：2017-12-01 00:00:00
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更新日期：2016-10-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(95)00118-2
更新日期：1995-12-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/s0161-5890(00)00039-0
更新日期：2000-02-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2017.08.017
更新日期：2017-11-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
doi：10.1016/j.molimm.2016.12.009
更新日期：2017-04-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2008.11.004
更新日期：2009-03-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(95)00016-8
更新日期：1995-07-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(94)90175-9
更新日期：1994-06-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/s0161-5890(01)00095-5
更新日期：2002-01-01 00:00:00
abstract：:Optineurin (Optn) is an adaptor protein with homology to NF-κB essential modulator (NEMO), the regulatory subunit of the IκB kinase (IKK) complex. Dysregulation of Optn has been linked to neurodegenerative, autoimmune and bone diseases. Optn shares a high degree of homology with NEMO, but is not part of the same high-...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2017.01.027
更新日期：2017-05-01 00:00:00
