Abstract：
:The specificities of the combining sites of 19 mouse monoclonal antibodies to dextran B1355S have been characterized immunochemically by quantitative precipitin and precipitin inhibition assays; association constants for B1355S were determined by affinity gel electrophoresis. Cross-reactive and individual idiotypes related to the BALB/c B1355S-binding myeloma proteins MOPC104E [IdI(MOPC104E)] and J558 [IdI(J558)], determined by a radioimmunoassay, and heavy-chain variable-region sequences, are presented. Antibodies to B1355S are "alpha (1----3) alpha (1----6)-specific" as determined by precipitin and precipitin inhibition assays with dextrans and oligosaccharides, respectively, containing alternating alpha (1----3) alpha (1----6) linkages compared with oligosaccharides composed solely of alpha (1----3) or alpha (1----6) linkages; all antibodies have low association constants (less than or equal to 10(5) ml/g). However, there is also considerable diversity among the proteins as seen in the five groups of different patterns of reactivity with numerous dextrans having different structures, and the variability in affinity even among antibodies showing the same fine specificity by precipitin assay. There is little observable correlation of heavy-chain variable-region amino-acid sequence with specificity or affinity; however, all proteins having D-region amino acids Tyr,Asp at positions 96,97 express the MOPC104E individual idiotype and belong to precipitin specificity group 5, the group most cross-reactive with numerous dextrans, whereas those proteins having the J558 individual idiotype, Arg,Tyr or Asn,Tyr at 96,97 are found in all five precipitin groups.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Newman BA,Liao J,Gruezo F,Sugii S,Kabat EA,Torii M,Clevinger BL,Davie JM,Schilling J,Bond Mdoi
10.1016/0161-5890(86)90139-2subject
Has Abstract,Author List Incompletepub_date
1986-04-01 00:00:00pages
413-24issue
4eissn
0161-5890issn
1872-9142journal_volume
23pub_type
杂志文章abstract：:Egr-1 is an immediate early gene that is rapidly upregulated in response to mitogenic signals induced by antigen receptor crosslinking on murine B lymphocytes. It has been shown that levels of Egr-1 expression are closely correlated with B cell proliferation in several models of B cell activation and tolerance. We com...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(93)90463-l
更新日期：1993-11-01 00:00:00
abstract：:Of the antioxidant/prooxidant mechanisms mediating the regulation of inflammatory mediators, particularly cytokines, oxidative stress-related pathways remain a cornerstone. It is conspicuous that there is a strong association between free radical accumulation (ROS/RNS; oxidative stress) and the evolution of inflammati...
journal_title：Molecular immunology
pub_type： 杂志文章,评审
doi：10.1016/j.molimm.2004.09.029
更新日期：2005-05-01 00:00:00
abstract：:A procedure to quantitate the immunogenic potential of protein antigens is presented. It is hypothesized that the intrinsic immunogenicity of an accessible region on the protein arises from the overall structural effect of the presence of the particular assemblage of amino acid residues in the given region. Structural...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(85)90043-4
更新日期：1985-11-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
doi：10.1016/j.molimm.2005.06.018
更新日期：2006-01-01 00:00:00
abstract：:Rabbit antisera specific for horseradish peroxidase inhibit the catalytic activity of the enzyme. All antibodies prepared against the holoenzyme react with the peroxidase apoenzyme. However, only a minority (30-45%) of the total antiperoxidase pool cross react with reduced and alkylated apoenzymes. The antibodies inhi...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(82)90366-2
更新日期：1982-05-01 00:00:00
abstract：:Because of its lethal effects, ease of preparation, and ability to be delivered by aerosolization, ricin has been developed as a lethal weapon by various terrorist groups. When introduced into the pulmonary system of rodents, ricin causes pathological changes in the lung that are known to occur in acute respiratory di...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2006.10.025
更新日期：2007-04-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/s0161-5890(97)00109-0
更新日期：1997-08-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(96)00021-1
更新日期：1996-05-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2019.11.012
更新日期：2020-02-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2009.08.015
更新日期：2009-10-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2008.03.007
更新日期：2008-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0161-5890(90)90158-v
更新日期：1990-09-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2005.07.029
更新日期：2006-03-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(85)90088-4
更新日期：1985-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.molimm.2012.09.001
更新日期：2013-04-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2007.08.002
更新日期：2008-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.molimm.2020.05.010
更新日期：2020-08-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2009.06.015
更新日期：2009-09-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2009-02-01 00:00:00
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更新日期：2011-09-01 00:00:00
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journal_title：Molecular immunology
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更新日期：2004-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2015-02-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
doi：10.1016/j.molimm.2013.06.013
更新日期：2014-01-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2020.12.002
更新日期：2020-12-29 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(85)90159-2
更新日期：1985-03-01 00:00:00
abstract：:Major histocompatibility complex (MHC) class I and II proteins have been in the focus of interest for immunologists, biochemists, cell biologists, and structural biologists for decades. With dozens of entries in the Protein Data Bank, their crystal structures are now sufficiently well understood, while their dynamic p...
journal_title：Molecular immunology
pub_type： 杂志文章,评审
doi：10.1016/j.molimm.2009.10.008
更新日期：2010-01-01 00:00:00
abstract：:Rabbits hyperimmunized with fluorescyl-conjugated KLH exhibited bound ligand associated with a high affinity circulating IgG anti-fluorescein population. After cessation of immunogen administration the liganded complexes were eventually spontaneously cleared from the circulation. Individual rabbits synthesized autolog...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(92)90105-7
更新日期：1992-02-01 00:00:00
abstract：:T cell responses are determined by the environment in which antigen is encountered. In the absence of proper costimulation, anergizing stimuli induce the activation of a specific program of gene expression. Proteins encoded by these genes impose a state of functional unresponsiveness in anergic T cells through the act...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2008.09.029
更新日期：2009-02-01 00:00:00
abstract：:Some IgM cattle antibodies are amongst the largest known to exist in jawed vertebrates where CDR3H size may extend up to 61 amino acids. To understand the origin of such an exceptionally long CDR3H, bovine D(H) gene locus was completely characterized from Holstein cattle that revealed the presence of a total of eight ...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2010.02.014
更新日期：2010-07-01 00:00:00
