当前位置： SCI文献检索 > MOLECULAR IMMUNOLOGY期刊下所有文献 > Quantitation of the immunogenic potential of protein antigens.

Quantitation of the immunogenic potential of protein antigens.

Abstract：

:A procedure to quantitate the immunogenic potential of protein antigens is presented. It is hypothesized that the intrinsic immunogenicity of an accessible region on the protein arises from the overall structural effect of the presence of the particular assemblage of amino acid residues in the given region. Structural parameters previously derived by Grantham [Science 185, 862-864 (1974)] to differentiate the various amino acids are assigned to each residue position. At each point chosen on the molecule, an av. value is computed due to all residues within 8.5 A of this point; it is proposed that this local average is proportional to the immunogenic potential of the region centered at this point. The method can be used to locate the immunodominant regions of a molecule and to compare the antigenicity of related molecules. Test calculations on hen egg-white lysozyme, sperm whale myoglobin and horse cytochrome c show that segments in these molecules, that have been shown in immunochemical studies to possess antigenic activity, are predicted by this method to be immunodominant.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Padlan EA

doi

10.1016/0161-5890(85)90043-4

subject

Has Abstract

pub_date

1985-11-01 00:00:00

pages

1243-54

issue

11

eissn

0161-5890

issn

1872-9142

journal_volume

22

pub_type

杂志文章

相关文献

MOLECULAR IMMUNOLOGY文献大全
  • Bradykinin-induced IL-6 expression through bradykinin B2 receptor, phospholipase C, protein kinase Cdelta and NF-kappaB pathway in human synovial fibroblasts.

    abstract：:Bradykinin (BK) is an inflammatory mediator, and shows elevated levels in regions of severe injury and inflammatory diseases. It has been shown to induce interleukin-6 (IL-6) expression in inflammatory responses in rheumatoid arthritis. We investigated the signaling pathway involved in IL-6 production caused by BK in ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2008.06.007

    authors： Lee CH,Shieh DC,Tzeng CY,Chen CP,Wang SP,Chiu YC,Huang CY,Hsu CJ,Fong YC,Tang CH

    更新日期：2008-08-01 00:00:00

  • The Jak-STAT pathway.

    abstract：:A variety of important cellular functions are regulated by cytokines. The Jak-STAT pathway is one of the important signaling pathways downstream of cytokine receptors. Following binding of a ligand to its cognate receptor, receptor-associated Jaks are activated. STAT proteins are then in turn activated by tyrosine pho...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0161-5890(00)00018-3

    authors： Imada K,Leonard WJ

    更新日期：2000-01-01 00:00:00

  • MD-2 regulates LPS-induced NLRP3 inflammasome activation and IL-1beta secretion by a MyD88/NF-κB-dependent pathway in alveolar macrophages cell line.

    abstract：:Myeloid differentiation protein 2 (MD-2) is required in the recognition of lipopolysaccharide (LPS) by toll-like receptor 4 (TLR4), and participates in LPS-induced alveolar macrophage (AM) inflammation during acute lung injury (ALI). Activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflamm...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2017.06.035

    authors： Luo M,Hu L,Li D,Wang Y,He Y,Zhu L,Ren W

    更新日期：2017-10-01 00:00:00

  • Differences in endocytosis mediated by FcγRIIA and FcγRIIB2.

    abstract：:An important function of Fcγ receptors is the removal of IgG-containing immune complexes from the circulation. The activating receptor FcγRIIA and inhibitory receptor FcγRIIB2 are both expressed on human myeloid cells, and are both capable of mediating endocytosis of immune complexes. We studied endocytosis of these t...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2011.09.003

    authors： Zhang CY,Booth JW

    更新日期：2011-10-01 00:00:00

  • DNA-binding activity of NF-kappaB and phosphorylation of p65 are induced by N-acetylcysteine through phosphatidylinositol (PI) 3-kinase.

    abstract：:N-Acetylcysteine (NAC) has been widely used as an antioxidant in research, however, it has also been found to reduce the binding of TNF to its receptor independent of its antioxidative role. In this study, we investigated the effect of NAC on NF-kappaB activation. In HeLa cells, Hep3B cells, and A549 cells, DNA-bindin...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2008.06.012

    authors： Liu J,Yoshida Y,Yamashita U

    更新日期：2008-09-01 00:00:00

  • Analysis of the structural diversity of monoclonal antibodies to cyclosporine.

    abstract：:The immunosuppressive cyclic undecapeptide cyclosporine (Cs) represents a useful model for studying the molecular basis of antibody-antigen interactions. The three-dimensional structure of the Cs molecule is known and a large panel of monoclonal antibodies (mAbs) to Cs has been well characterized by cross-reactivity s...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(90)90126-k

    authors： Schmitter D,Poch O,Zeder G,Heinrich GF,Kocher HP,Quesniaux VF,Van Regenmortel MH

    更新日期：1990-10-01 00:00:00

  • Fine molecular analysis of the antigenicity of the Androctonus australis hector scorpion neurotoxin II: a new antigenic epitope disclosed by the Pepscan method.

    abstract：:A set of 58 overlapping rod-bound peptides was used to map the antigenic reactivity pattern of a 64-residue neurotoxin (AaH II) from the venom of the scorpion Androctonus australis hector. Five anti-toxin rabbit antisera were assayed serially for their capacity to bind to each peptide in the set. Six regions of antige...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(93)90152-2

    authors： Devaux C,Juin M,Mansuelle P,Granier C

    更新日期：1993-08-01 00:00:00

  • Regulation of BCR- and PKC/Ca(2+)-mediated activation of the Raf1/MEK/MAPK pathway by protein-tyrosine kinase and -tyrosine phosphatase activities.

    abstract：:Ligation of the B cell Ag receptor (BCR) activates a protein-tyrosine kinase (PTK) and CD45 protein-tyrosine phosphatase (PTPase)-dependent signaling cascade that results in the activation of Ras. This pathway of Ras activation can operate independently of protein kinase C (PKC) activity. Activation of Ras may lead to...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(95)00134-4

    authors： Kawauchi K,Lazarus AH,Sanghera JS,Man GL,Pelech SL,Delovitch TL

    更新日期：1996-02-01 00:00:00

  • RIP2-beta: a novel alternative mRNA splice variant of the receptor interacting protein kinase RIP2.

    abstract：:RIP2/RICK/CARDIAK is a member of the receptor interacting protein kinase (RIP) family. RIP2 promotes NF-kappaB activation as well as activation of the MAPKs JNK, ERK1/2 and p38 MAPK, thereby playing an emergent role in the innate immune response and NOD signaling. Moreover, RIP2 has been shown to interact with the CAR...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2008.11.002

    authors： Krieg A,Le Negrate G,Reed JC

    更新日期：2009-03-01 00:00:00

  • Purification and physicochemical properties of C1q from guinea-pig serum.

    abstract：:An efficient method is described for the isolation of highly purified, IgG-free and stable guinea-pig serum C1q. The procedure includes the chromatography of EDTA-treated serum (25 mM EDTA) on CM- and DEAE-cellulose followed by gel filtration on ACA 34-Ultrogel whereby ammonium sulfate precipitation was used for conce...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(83)90133-5

    authors： Hitschold T,Golan MD,Rabs U,Loos M

    更新日期：1983-02-01 00:00:00

  • Constitutive and inflammatory induction of alpha and beta chemokines in human first trimester forebrain astrocytes and neurons.

    abstract：:Chemokine effects on leukocyte infiltration into the central nervous system (CNS) are key events in the inflammatory processes of neuroimmunologic and neuroinfectious diseases. Because, chemokines may play important roles in proliferation and differentiation of brain cells and in the initiation and progression of CNS ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/s0161-5890(02)00019-6

    authors： Bakhiet M,Mousa A,Seiger A,Andersson J

    更新日期：2002-05-01 00:00:00

  • Hepatitis B virus sensitizes hepatocytes to complement-dependent cytotoxicity through downregulating CD59.

    abstract：:Hepatitis B virus (HBV) infection afflicts over 350 million people worldwide and is a leading cause of hepatitis, cirrhosis and hepatocellular carcinoma. HBV replicates noncytopathically in hepatocytes, and most of the hepatic injury is caused by the immune response to the virus. While most studies focused on the adap...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2009.09.022

    authors： Qu Z,Liang X,Liu Y,Du J,Liu S,Sun W

    更新日期：2009-12-01 00:00:00

  • Inhibition of horseradish peroxidase activity by specific antibody: determinant specificity of anticatalytic antibodies.

    abstract：:Rabbit antisera specific for horseradish peroxidase inhibit the catalytic activity of the enzyme. All antibodies prepared against the holoenzyme react with the peroxidase apoenzyme. However, only a minority (30-45%) of the total antiperoxidase pool cross react with reduced and alkylated apoenzymes. The antibodies inhi...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(82)90366-2

    authors： Conroy JM,Salter RD

    更新日期：1982-05-01 00:00:00

  • Allogeneic and syngeneic class I MHC complexes drive the association of CD8 and TCR on 2C T cells.

    abstract：:In most cases, cytotoxic T cell activation is dependent on the interaction of the T cell receptor (TCR) and CD8 with MHC class I molecules. In the CD8(+) T cell system based on the mouse cytotoxic T cell clone 2C, recognition of the allogeneic MHC L(d) exhibits a less significant role for CD8 than recognition of the s...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/s0161-5890(02)00259-6

    authors： Lee PU,Kranz DM

    更新日期：2003-01-01 00:00:00

  • Searching for autoimmunity in "antibiotic-refractory" Lyme arthritis.

    abstract：:In two recent articles published in Molecular Immunology, Steere and colleagues continue their search for an autoimmune mechanism of arthritis in patients who have failed short-course antibiotic therapy for Borrelia burgdorferi, the spirochetal agent of Lyme disease. As in previous attempts, the authors fail to elucid...

    journal_title：Molecular immunology

    pub_type： 评论,信件

    doi：10.1016/j.molimm.2008.02.015

    authors： Stricker RB,Johnson L

    更新日期：2008-06-01 00:00:00

  • Virus-epitope vaccine design: informatic matching the HLA-I polymorphism to the virus genome.

    abstract：:Attempts to develop peptide vaccines, based on a limited number of peptides face two problems: HLA polymorphism and the high mutation rate of viral epitopes. We have developed a new genomic method that ensures maximal coverage and thus maximal applicability of the peptide vaccine. The same method also promises a large...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2006.06.003

    authors： Vider-Shalit T,Raffaeli S,Louzoun Y

    更新日期：2007-02-01 00:00:00

  • Structural variants of Salmonella Typhimurium lipopolysaccharide induce less dimerization of TLR4/MD-2 and reduced pro-inflammatory cytokine production in human monocytes.

    abstract：:Salmonella enterica serovar Typhimurium (S. Typhimurium) changes the structure of its lipopolysaccharide (LPS) in response to the environment. The two main LPS variants found in S. Typhimurium correspond to LPS with a hepta-acylated lipid A (LPS 430) and LPS with modified phosphate groups on its lipid A (LPS 435). We ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2019.03.003

    authors： Aldapa-Vega G,Moreno-Eutimio MA,Berlanga-Taylor AJ,Jiménez-Uribe AP,Nieto-Velazquez G,López-Ortega O,Mancilla-Herrera I,Cortés-Malagón EM,Gunn JS,Isibasi A,Wong-Baeza I,López-Macías C,Pastelin-Palacios R

    更新日期：2019-07-01 00:00:00

  • Blocking oncogenic RAS enhances tumour cell surface MHC class I expression but does not alter susceptibility to cytotoxic lymphocytes.

    abstract：:Mutations in the RAS family of oncogenes are highly prevalent in human cancer and, amongst its manifold effects, oncogenic RAS impairs the expression of components of the antigen presentation pathway. This allows evasion of cytotoxic T lymphocytes (CTL). CTL and natural killer (NK) cells are reciprocally regulated by ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2013.11.020

    authors： El-Jawhari JJ,El-Sherbiny YM,Scott GB,Morgan RS,Prestwich R,Bowles PA,Blair GE,Tanaka T,Rabbitts TH,Meade JL,Cook GP

    更新日期：2014-04-01 00:00:00

  • The immune response to Epstein-Barr nuclear antigen: conformational and structural features of antibody binding to synthetic peptides.

    abstract：:Naturally developing human antibodies to the Epstein-Barr nuclear antigen recognize synthetic peptides containing sequences from the unusual glycine-alanine region of this protein. We tested antibody binding to a series of peptides of from five to 20 amino acids in length. Peptides as small as seven amino acids could ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(84)90114-7

    authors： Rhodes G,Houghten R,Taulane JP,Carson D,Vaughan J

    更新日期：1984-11-01 00:00:00

  • Notch activation in thymic epithelial cells induces development of thymic microenvironments.

    abstract：:The development and maintenance of thymic microenvironments depends on sustained crosstalk signals derived from developing thymocytes. However, the molecular basis for the initial phase in the lymphoid dependent development of thymic epithelial cells (TECs) remains unclear. Here we show that similarly to regular thymo...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2009.01.015

    authors： Masuda K,Germeraad WT,Satoh R,Itoi M,Ikawa T,Minato N,Katsura Y,van Ewijk W,Kawamoto H

    更新日期：2009-05-01 00:00:00

  • Complement: a unique innate immune sensor for danger signals.

    abstract：:The complement (C) inflammatory cascade is part of the phylogenetically ancient innate immune response and is crucial to our natural ability to ward off infection. It has three critical physiologic activities: (i) defending against microbial infections by triggering the generation of a membranolytic complex (C5b9 comp...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2004.06.011

    authors： Gasque P

    更新日期：2004-11-01 00:00:00

  • Discovery and expression of 3 siglecs-like in Oreochromis niloticus neutrophil, and their interaction with group B streptococcal sialylated capsular polysaccharides.

    abstract：:Sialic acid - binding immunoglobulin - like lectins (Siglecs) are members of the largest superfamily of immune receptors; they recognize sialic acid and are mainly expressed in immune cells. Studies on mammals indicate that Streptococcus agalactiae (GBS) evade immune reactions by interacting with the host immune cells...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2016.01.005

    authors： Dong J,Wei Y,Ye X,Sun C,Tian Y,Lu M,Du J,Chen Z

    更新日期：2016-05-01 00:00:00

  • Localisation of three epitopes of the env protein of feline immunodeficiency virus.

    abstract：:The envelope protein of the feline immunodeficiency virus (FIV) was analyzed using several epitope prediction programs based on profiles of hydrophilicity, antigenicity, and probability of residues to lie on the protein surface. Tentative homologies with the immunodominant epitope sites in simian virus (SIV) or human ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(92)90192-z

    authors： Avrameas A,Guillet JG,Chouchane L,Moraillon A,Sonigo P,Strosberg AD

    更新日期：1992-05-01 00:00:00

  • Acute arsenic exposure induces inflammatory responses and CD4+ T cell subpopulations differentiation in spleen and thymus with the involvement of MAPK, NF-kB, and Nrf2.

    abstract：:Increasing lines of evidence indicate that arsenic may be associated with immune related problems, but its detailed effects on immune organs are poorly understood. The objective of this study was to explore inflammatory responses and T cell differentiation of arsenic exposure in spleen and thymus. Female C57BL/6 mice ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2016.12.005

    authors： Duan X,Gao S,Li J,Wu L,Zhang Y,Li W,Zhao L,Chen J,Yang S,Sun G,Li B

    更新日期：2017-01-01 00:00:00

  • Dynamics of CD3gammaepsilon and CD3deltaepsilon dimer expression during murine T cell development.

    abstract：:The preTCR, gammadeltaTCR, and alphabetaTCR are the three isoforms of the T cell antigen receptor that are expressed during thymocyte development. Signaling by these isoforms is required at different stages of T cell development for lineage commitment, thymocyte maturation, and repertoire selection. All three isoforms...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2009.09.015

    authors： Laird RM,Hayes SM

    更新日期：2009-12-01 00:00:00

  • Dysregulation of complement system during pregnancy in patients with preeclampsia: A prospective study.

    abstract：:Recent studies have shown that aberrant activation of the complement system plays an important role in the pathogenesis of preeclampsia. There is evidence to suggest that aberrant activation of the complement system may already be present during the first trimester. Here, we performed a prospective study in which peri...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2020.03.021

    authors： He YD,Xu BN,Wang ML,Wang YQ,Yu F,Chen Q,Zhao MH

    更新日期：2020-04-16 00:00:00

  • IgE epitopes of intact and digested Ara h 1: a comparative study in humans and rats.

    abstract：BACKGROUND:Allergen epitope characterization provides valuable information useful for the understanding of proteins as food allergens. It is believed that IgE epitopes in general are conformational, nevertheless, for food allergens known to sensitize through the gastrointestinal tract linear epitopes have been suggeste...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2012.04.002

    authors： Bøgh KL,Nielsen H,Madsen CB,Mills EN,Rigby N,Eiwegger T,Szépfalusi Z,Roggen EL

    更新日期：2012-07-01 00:00:00

  • Redirecting adenoviruses to tumour cells using therapeutic antibodies: Generation of a versatile human bispecific adaptor.

    abstract：:Effective use of adenovirus-5 (Ad5) in cancer therapy is heavily dependent on the degree to which the virus's natural tropism can be subverted to one that favours tumour cells. This is normally achieved through either engineering of the viral fiber knob or the use of bispecific adaptors that display both adenovirus an...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2015.08.014

    authors： Vasiljevic S,Beale EV,Bonomelli C,Easthope IS,Pritchard LK,Seabright GE,Caputo AT,Scanlan CN,Dalziel M,Crispin M

    更新日期：2015-12-01 00:00:00

  • C-mip interacts physically with RelA and inhibits nuclear factor kappa B activity.

    abstract：:The fine regulation of NF-kappaB activity is crucial for both resting and stimulated cells and relies on complex balance between multiple activators and inhibitors. We report here that c-mip, a recently identified pleckstrin homology (PH) and leucine-rich repeat (LRR)-domain-containing protein, inactivates GSKbeta and...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2008.09.034

    authors： Kamal M,Valanciute A,Dahan K,Ory V,Pawlak A,Lang P,Guellaen G,Sahali D

    更新日期：2009-02-01 00:00:00

  • LEI0258 microsatellite variability and its association with humoral and cell mediated immune responses in broiler chickens.

    abstract：:Major histocompatibility complex (MHC) has a profound influence on disease resistance or susceptibility, productivity and important economic traits in chicken. Association of the MHC with a wide range of immune responses makes it a valuable predictive factor for the disease pathogenesis and outcome. The tandem repeat ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2017.06.027

    authors： Esmailnejad A,Nikbakht Brujeni G,Badavam M

    更新日期：2017-10-01 00:00:00