Th17 activation by dendritic cells stimulated with gamma-irradiated Streptococcus pneumoniae.

abstract：:The insect gut participates in initial local immune responses by producing reactive oxygen and nitrogen species as well as anti-microbial peptides to resist pathogenic invasions. Nitric oxide (NO), a signaling and an immune effector molecule synthesized by the enzyme NO synthase (NOS), mediates an early step of the si...

journal_title：Molecular immunology

authors： Liu W,Wang Y,Leng Z,Wang Q,Duan X,Luo Y,Jiang Y,Qin L

更新日期：2020-10-01 00:00:00

abstract：:Triptolide has been used extensively in China for the treatment of autoimmune diseases and tumor for many centuries. Nevertheless, little is known about its exact immunosuppressive and anti-inflammatory properties. Increasing recognition of the importance of renal tubular epithelial cells (TECs) in renal diseases rais...

journal_title：Molecular immunology

authors： Chen Y,Zhang J,Li J,Zhao T,Zou L,Tang Y,Zhang X,Wu Y

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Tumor necrosis factor-α (TNF-α) is involved in inflammatory responses in atherosclerosis. We propose an in vitro cellular assay to evaluate the anti-inflammatory mechanisms of potential modifiers such as food extracts. In the current model we assessed an anti-inflammatory effect of polyphenol-rich peanut ext...

journal_title：Molecular immunology

authors： Catalán Ú,Fernández-Castillejo S,Anglès N,Morelló JR,Yebras M,Solà R

更新日期：2012-10-01 00:00:00

abstract：:Malignant transformation of hepatocytes is frequently associated with upregulation of HLA-A expression. Currently there is no information available regarding the mechanisms underlying this phenotypic change. We investigated HLA-A expression in 165 paraffin embedded tissues and 21 fresh tissues from liver cancer patien...

journal_title：Molecular immunology

authors： Shen Y,Xia M,Zhang J,Xu L,Yang J,Chen A,Miao F,Ferrone S,Xie W

更新日期：2009-06-01 00:00:00

abstract：:Fibroblast-like synoviocyte (FLS) is the ultimate effectual cells in the pathogenesis of rheumatoid arthritis (RA). The current study was undertaken to investigate whether a proliferation-inducing ligand (APRIL) mediates the function of FLS in an animal model of RA. Rat adjuvant-induced arthritis (AA) was induced by i...

journal_title：Molecular immunology

authors： Chang Y,Jia X,Sun X,Xu S,Wu Y,Zhang L,Wei W

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Dendritic cells (DCs) and regulatory T (Treg) cells are crucial for inducing immune tolerance. However, the suppressive function of infused Treg cells and immature DCs (imDCs) following solid organ transplantation remains unclear. METHODS:ImDCs derived from DA-donor rats and Treg cells isolated from spleens...

journal_title：Molecular immunology

authors： He W,Chen L,Zheng L,Luo L,Gao L

更新日期：2016-11-01 00:00:00

abstract：:Adiponectin can protect against inflammation; one of the mechanisms involves direct, inhibition of macrophages (MΦ). We postulated that adiponectin anti-sense transgenic (AsTg) mice raised in our laboratory are prone to inflammation because of systemic low adiponectin levels. The writhing response to acetic acid was u...

journal_title：Molecular immunology

authors： Negoro T,Kin M,Takuma A,Saito K,Shimizu S,Nakano Y

更新日期：2014-02-01 00:00:00

abstract：:The development of nanoparticles (NPs) for commercial products is undergoing a dramatic expansion. Many sunscreens and cosmetics now use zinc oxide (ZnO) or titania (TiO2) NPs, which are effective ultraviolet (UV) filters. Zinc oxide topical creams are also used in mild anti-inflammatory treatments. In this study we e...

journal_title：Molecular immunology

authors： Feltis BN,Elbaz A,Wright PF,Mackay GA,Turney TW,Lopata AL

更新日期：2015-08-01 00:00:00

abstract：:The antigenicity of Human Immunodeficiency Virus type 1 (HIV-1) matrix p18 protein was evaluated by analyzing the specificity of anti-p18 antibodies elicited either in HIV-1 infected humans, or in HIV-1 infected or immunized chimpanzees, against a panel of long and short overlapping synthetic peptides [from 12 to 46 a...

journal_title：Molecular immunology

authors： Mabrouk K,Moulard M,Gluckman JC,Romi R,Rochat H,Van Rietschoten J,Bahraoui E

更新日期：1993-04-01 00:00:00

abstract：:CD20 is an important target for monoclonal antibody therapy of B-cell malignancies and for some autoimmune disorders. Though there is interest in evaluating the induction of active immunity to CD20 in the mouse model, the CD20 extracellular domain (ECD) has significant secondary and tertiary structure which make it di...

journal_title：Molecular immunology

authors： Oscherwitz J,Gribbin TE,Cease KB

更新日期：2010-04-01 00:00:00

abstract：:Endogenous mouse mammary tumor proviruses (MMTV; Mtv loci) deletes Vbeta6 expressing T cells in the thymus of Mtv-7(+) DBA/2 (H2(d)) mice through negative selection. We found that in Mtv-7(-) BALB/c (H2(d)) mice, Vbeta6 is a dominant V gene used in T cell responses to an 18 amino acid long peptide antigen: EYKEYAEYAEY...

journal_title：Molecular immunology

authors： Kilgannon P,Novak Z,Fotedar A,Singh B

更新日期：2010-02-01 00:00:00

abstract：:During acute lung injury, a large number of monocytes are recruited into the pulmonary tissue, which is mainly mediated by local production of monocyte chemotactic protein 1 (MCP-1). As an essential component of the lung tissues, alveolar type II epithelial cells are one of the major sources of MCP-1. Therefore, uncov...

journal_title：Molecular immunology

authors： Yan C,Li B,Liu X,Deng C,Cai R,Shen Y,Tang H

更新日期：2019-07-01 00:00:00

abstract：:Immunoglobulins are important elements of the adaptive immune system that bind to an immense variety of microbial antigens to neutralize infectivity and specify effector functions. In the present study, the immunoglobulin heavy chain constant region (IGHC) genes from marine mammals were identified and compared with th...

journal_title：Molecular immunology

authors： Li L,Rong X,Li G,Wang Y,Chen B,Ren W,Yang G,Xu S

更新日期：2018-07-01 00:00:00

abstract：:Conserved extended haplotypes (CEHs) are large (>or=1Mb) regions of identical DNA of the major histocompatibility complex (MHC) region of chromosome 6p in unrelated individuals. They are recognized by family studies and constitute nearly half of MHC haplotypes among European Caucasians. We studied 49 Hungarian Caucasi...

journal_title：Molecular immunology

authors： Szilágyi A,Bánlaki Z,Pozsonyi E,Yunis EJ,Awdeh ZL,Hossó A,Rajczy K,Larsen CE,Fici DA,Alper CA,Füst G

更新日期：2010-06-01 00:00:00

abstract：:Genetic and functional studies suggest that polymorphism in cytotoxic T lymphocyte-associated antigen-4 (CTLA4) and inducible costimulator (ICOS) genes, both reported to harbour autoimmune susceptibility loci, could regulate the immune activation through affecting their expression and splicing of CTLA4. To address thi...

journal_title：Molecular immunology

authors： Kaartinen T,Lappalainen J,Haimila K,Autero M,Partanen J

更新日期：2007-03-01 00:00:00

abstract：:Osteopontin (OPN) is a cytokine with multiple functions, including the regulation of innate immune response. However, the detailed function and mechanism of OPN in host defense against invaded microorganisms remain unclear. In this report, we revealed that OPN could affect the clearance of Propionibacterium acnes in k...

journal_title：Molecular immunology

authors： Yang H,Guo H,Fan K,Zhang B,Zhao L,Hou S,Qian W,Zhang D,Wang H,Dai J,Guo Y

更新日期：2011-09-01 00:00:00

abstract：:Secreted glycoproteins generally contain oligosaccharides of the complex type. However, several molecules have been described in which individual glycans are processed differently from one another. Folding, assembly and oligomerization could affect the maturation of certain glycans by hindering them to the Golgi proce...

journal_title：Molecular immunology

authors： Cals MM,Guenzi S,Carelli S,Simmen T,Sparvoli A,Sitia R

更新日期：1996-01-01 00:00:00

abstract：:Recombinant DNA techniques now allow the production of "mini-antibodies" called Fv fragments. These have been produced either as the independent variable domains of the heavy and light chains non-covalently associated in one-to-one stoichiometry or as single-chain gene products with the two domains linked by an interv...

journal_title：Molecular immunology

authors： Webber KO,Reiter Y,Brinkmann U,Kreitman R,Pastan I

更新日期：1995-03-01 00:00:00

abstract：:Dendritic cells (DC) are capable of capturing and processing antigens and can stimulate co-cultured effector cells in a specific manner. Here, we pulsed DC with apoptotic bodies (apb) from colorectal carcinoma. For enhancement of the immunogenic potential of apb, we transduced the tumor cells with the MHC class II gen...

journal_title：Molecular immunology

authors： Märten A,Renoth S,Schmidt-Wolf IG

更新日期：2002-11-01 00:00:00

abstract：:Tunicamycin inhibited the synthesis of glycosylated mu-chains and kappa-chains in the human lymphoblastoid cell line, Daudi. Nonglycosylated IgM could not be detected on the surface of tunicamycin-treated cells by cell surface iodination techniques even under conditions where membrane IgM was re-expressed in control c...

journal_title：Molecular immunology

authors： Kubo RT,Pelanne ML

更新日期：1983-01-01 00:00:00

abstract：:Major histocompatibility complex (MHC) molecules present peptide antigens to T lymphocytes and initiate immune responses. The peptides loaded onto MHC class I or MHC class II molecules can be derived from cytosolic proteins, both self and foreign. A variety of cellular processes, including endocytosis, vesicle traffic...

journal_title：Molecular immunology

authors： Valečka J,Almeida CR,Su B,Pierre P,Gatti E

更新日期：2018-07-01 00:00:00

abstract：:Dendritic cells (DC) are comprised of several subsets with distinct functions, differing in their capacity to respond to pathogen products. To gain novel insights into their pathogen specificity, we compared the protein composition of the plasma membrane of CD8+ and CD8- DC, directly isolated from mouse spleens. Diffe...

journal_title：Molecular immunology

authors： Segura E,Kapp E,Gupta N,Wong J,Lim J,Ji H,Heath WR,Simpson R,Villadangos JA

更新日期：2010-05-01 00:00:00

abstract：:Bradykinin (BK) is an inflammatory mediator, and shows elevated levels in regions of severe injury and inflammatory diseases. It has been shown to induce interleukin-6 (IL-6) expression in inflammatory responses in rheumatoid arthritis. We investigated the signaling pathway involved in IL-6 production caused by BK in ...

journal_title：Molecular immunology

authors： Lee CH,Shieh DC,Tzeng CY,Chen CP,Wang SP,Chiu YC,Huang CY,Hsu CJ,Fong YC,Tang CH

更新日期：2008-08-01 00:00:00

abstract：:A bovine papilloma virus-derived vector was used to direct the high level expression in mouse C127 cells of three different cDNAs encoding the human interleukin-2 receptor. These were: the previously described cDNA clone isolated from the T-cell lymphoma, HUT-102; a cDNA clone isolated from mitogen-activated, normal p...

journal_title：Molecular immunology

authors： Cosman D,Wignall J,Lewis A,Alpert A,Cerretti DP,Park L,Dower SK,Gillis S,Urdal DL

更新日期：1986-09-01 00:00:00

abstract：:Prolactin has several immune functions in fish however, the effects on innate and specific components of rainbow trout immunity are currently unknown. Therefore in this study, prolactin peptide (pPRL) injection in rainbow trout generated anti-PRL antibodies that were confirmed through Western blot assays of fish brain...

journal_title：Molecular immunology

authors： Villalba M,Gómez G,Torres L,Maldonado N,Espiñeira C,Payne G,Vargas-Chacoff L,Figueroa J,Yáñez A,Olavarría VH

更新日期：2020-11-01 00:00:00

abstract：:Dendritic cells (DCs) are suspected to be involved in the development of atherogenesis, but their role is still unclear. The aim of this study was to characterize circulating DCs and monocyte-derived DCs (Mo-DCs) of obese and diabetic patients (T2D), and to study their interaction with human coronary smooth muscle cel...

journal_title：Molecular immunology

authors： Musilli C,Paccosi S,Pala L,Gerlini G,Ledda F,Mugelli A,Rotella CM,Parenti A

更新日期：2011-10-01 00:00:00

abstract：:The synovial sarcoma X breakpoint (SSX) gene family contains nine members. The SSX proteins are CT (cancer/testis) antigens and can be expressed in many tumor types. T cell immune response against SSX protein can be detected in tumor patients and mice expressing any SSX. Screening predominant protective epitopes might...

journal_title：Molecular immunology

authors： He Y,Mao L,Lin Z,Deng Y,Tang Y,Jiang M,Li W,Jia Z,Wang J,Ni B,Wu Y

更新日期：2008-05-01 00:00:00

abstract：:During T-cell regulation, T-cell receptors and CD28 lead to signaling activation, while T-lymphocyte antigen 4 (CTLA-4) is known to lead to downregulation, similar to programmed cell death-1 (PD-1). In the cytoplasmic tails of CD28 and CTLA-4, phosphoinositide 3-kinase (PI3K) binds to the consensus sequence including ...

journal_title：Molecular immunology

authors： Iiyama M,Numoto N,Ogawa S,Kuroda M,Morii H,Abe R,Ito N,Oda M

更新日期：2020-12-29 00:00:00

abstract：:Recent studies suggest that CD8(+) T cells with down-regulated CD8 expression (CD3(+)CD8(low) T cells) represented as a distinct phenotype of CD8(+) T cells are increased and linked to disease severity in some chronically persistent infection, such as chronic HIV and parasite infection. However, the role of CD3(+)CD8(...

journal_title：Molecular immunology

authors： Ouyang L,Li X,Liang Z,Yang D,Gong F,Shen G,Weng X,Wu X

更新日期：2013-12-01 00:00:00

abstract：:Toll-like receptors (TLR) are expressed on the surface or intracellularly by dendritic cells (DC) and recognize specifically different pathogen-associated molecular patterns (PAMPs). Increasing evidence suggests that TLR expressed by DC can cooperate to synergize their functions. Here, we describe the cooperation of T...

journal_title：Molecular immunology

authors： Theiner G,Rössner S,Dalpke A,Bode K,Berger T,Gessner A,Lutz MB

更新日期：2008-01-01 00:00:00