Autophagy and MHC-restricted antigen presentation.

abstract：:Peripheral blood B lymphocytes have been isolated from healthy individuals who were immunized with lymphocytes from HLA-incompatible donors and transformed with Epstein-Barr virus to produce human monoclonal cell lines specific for human HLA molecules. The cell lines have been previously characterized and are known to...

journal_title：Molecular immunology

authors： Andris JS,Abraham SR,Pascual V,Pistillo MP,Mantero S,Ferrara GB,Capra JD

更新日期：1995-10-01 00:00:00

abstract：:The SARS-CoV-2 virus responsible for coronavirus 2019 (COVID-19) poses a significant challenge to healthcare systems worldwide. According to the World Health Organization (WHO), the outbreak of COVID-19 has been a pandemic that infected more than 25.32 million people and caused more than 848.25 thousand deaths worldwi...

journal_title：Molecular immunology

authors： Liu D,Wu F,Cen Y,Ye L,Shi X,Huang Y,Fang S,Ma L

更新日期：2021-01-09 00:00:00

abstract：:A study aiming at cloning and characterizing natural antibodies to human immunodeficiency virus type 1 (HIV-1) targets is described. In particular, we report the molecular cloning of a Fab molecule binding the HIV-1/Tat protein from a seronegative patient. The Fab was characterized for its binding specificity and inve...

journal_title：Molecular immunology

authors： Mancini N,Perotti M,Carletti S,Canducci F,Sampaolo M,Clementi M,Burioni R

更新日期：2006-03-01 00:00:00

abstract：:Although granulocyte colony-stimulating factor(G-CSF) has pathogenic roles in several immune inflammatory diseases, its role in periodontitis has not been investigated. Here we detected local expression of G-CSF using public datasets in the Gene Expression Omnibus (GEO) database, and immune cell infiltration into ging...

journal_title：Molecular immunology

authors： Zhang Z,Yuan W,Deng J,Wang D,Zhang T,Peng L,Tian H,Wang Z,Ma J

更新日期：2020-01-01 00:00:00

abstract：:The development and maintenance of thymic microenvironments depends on sustained crosstalk signals derived from developing thymocytes. However, the molecular basis for the initial phase in the lymphoid dependent development of thymic epithelial cells (TECs) remains unclear. Here we show that similarly to regular thymo...

journal_title：Molecular immunology

authors： Masuda K,Germeraad WT,Satoh R,Itoi M,Ikawa T,Minato N,Katsura Y,van Ewijk W,Kawamoto H

更新日期：2009-05-01 00:00:00

abstract：:In this paper, we performed further biochemical characterization of the CD26 antigen, as defined by the mAbs in anti-1F7 and anti-Ta1, in order to clarify the observed functional differences among these mAbs. For this purpose, we developed a mAb, anti-5F8, which recognizes yet another epitope on the CD26 antigen diffe...

journal_title：Molecular immunology

authors： Torimoto Y,Dang NH,Tanaka T,Prado C,Schlossman SF,Morimoto C

更新日期：1992-02-01 00:00:00

abstract：:Covalent Superose microspheres-bound C3b was used as a model system to simplify the analysis of antigen-bound C3b modifications during antigen processing. The model was set up using purified C3 and Superose-bound trypsin. C3b was covalently bound to Superose through an ester link, as indicated by lability to hydroxyla...

journal_title：Molecular immunology

authors： Rey-Millet CA,Chesne S,Colomb MG

更新日期：1993-07-01 00:00:00

abstract：:The mammalian interleukin (IL)-6 family of cytokines consist of eight class-I helical cytokines and are major players in hematopoiesis, as well as in neuroendocrine and immune systems, and have pro- and anti-inflammatory properties. We have identified a novel fish CNTF-like molecule, for the first time, as well as the...

journal_title：Molecular immunology

authors： Wang T,Secombes CJ

更新日期：2009-07-01 00:00:00

abstract：:This study identified the peptide-binding motif of HLA-DRA/DRB1*1401 (DR1401). First, peptides containing DR1401 restricted epitopes were identified using tetramer-guided epitope mapping. Among these, an influenza B peptide was selected for the motif study. After confirming the binding register for this peptide using ...

journal_title：Molecular immunology

authors： James EA,Moustakas AK,Berger D,Huston L,Papadopoulos GK,Kwok WW

更新日期：2008-05-01 00:00:00

abstract：:The sphingosine-1-phosphate analogue FTY720 is known to alter migration and homing of lymphocytes via sphingosine-1-phosphate receptors. However, several studies indicate that its mode of action is more complex and that FTY720 may also directly influence cytokine effector functions. Therefore, we studied the effect of...

journal_title：Molecular immunology

authors： Daniel C,Sartory NA,Zahn N,Schmidt R,Geisslinger G,Radeke HH,Stein JM

更新日期：2007-07-01 00:00:00

abstract：:To understand the mechanism of action of the chaperone protein tapasin, which mediates loading of high-affinity peptides onto major histocompatibility complex (MHC) class I molecules in the antiviral immune response, we have performed numerical simulations of the class I-peptide binding process with four different mec...

journal_title：Molecular immunology

authors： Schneeweiss C,Garstka M,Smith J,Hütt MT,Springer S

更新日期：2009-06-01 00:00:00

abstract：:Cathepsin L protease belongs to the papain-like cysteine proteases family, plays indispensable roles in animals' pathological and physiological processes. However, little is known about Cathepsin L in silkworm, Bombyx mori. Herein, a novel Cathepsin L-like (Cat L-like) was cloned and identified from silkworm by the ra...

journal_title：Molecular immunology

authors： Pan G,Zhang K,Li C,Hu X,Kausar S,Gu H,Yang L,Cui H

更新日期：2020-12-26 00:00:00

abstract：:CD55 is a key regulator of complement activation, expressed on most tissues and cells in man and other mammals. In the rat, alternative splicing in the gene encoding CD55 yields GPI-anchored (GPI-CD55) and transmembrane (TM-CD55) forms. Published Northern blot analysis indicated that while GPI-CD55 was broadly express...

journal_title：Molecular immunology

authors： Mizuno M,Donev RM,Harris CL,Morgan BP

更新日期：2007-03-01 00:00:00

abstract：:Recombinant IL-2 (rIL-2) produced in prokaryotes, is widely used in lieu of native IL-2, which is secreted by T cells, to assess the functional profile of this cytokine. We provide evidence that a naturally occurring species of post-translationally modified IL-2 (moIL-2) exhibits enhanced bioactivity compared to rIL-2...

journal_title：Molecular immunology

authors： Denis MC,Huber BT

更新日期：2003-09-01 00:00:00

abstract：:We have examined the regulation of the AP-1 DNA transcription complex during T cell activation in response to interleukin 1 (IL-1) and phorbol ester (TPA) treatment of the IL-1 responsive murine thymoma T cell line, EL4 6.1 C 10. IL-1 synergistically enhances the stimulatory effect of TPA on AP-1-mediated gene express...

journal_title：Molecular immunology

authors： Brooks JW,Yoza BK,Mizel SB

更新日期：1995-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNAs that function in diverse biological processes. However, little is known about the precise role of microRNAs in the functioning of airway smooth muscle cells (ASMCs). Here, we investigated the potential role and mechanisms of the miR-143 -3p on proliferation and the extracell...

journal_title：Molecular immunology

authors： Cheng W,Yan K,Xie LY,Chen F,Yu HC,Huang YX,Dang CX

更新日期：2016-10-01 00:00:00

abstract：:The diagnosis and therapy of allergic disorders are usually performed with crude extracts which are a heterogeneous mixture of proteins with different allergenic potency. The knowledge of the allergenic composition is a key step for diagnostic and therapeutic options. Parietaria judaica pollen represents one of the ma...

journal_title：Molecular immunology

authors： Bonura A,Gulino L,Trapani A,Di Felice G,Tinghino R,Amoroso S,Geraci D,Valenta R,Westritschnig K,Scala E,Mari A,Colombo P

更新日期：2008-05-01 00:00:00

abstract：:Leishmania infantum pyridoxal kinase (PK) protein was characterized after an immunoproteomics screening performed with the sera from patients suffering visceral leishmaniasis (VL). Since it was recognized by sera of mammalian hosts infected by a viscerotropic Leishmania species, PK could emerge as a new vaccine candid...

journal_title：Molecular immunology

authors： Oliveira-da-Silva JA,Lage DP,Ramos FF,Machado AS,Tavares GSV,Mendonça DVC,Pereira IAG,Martins VT,Carvalho LM,Ludolf F,Santos TTO,Reis TAR,Oliveira CS,Bandeira RS,Silva AM,Costa LE,Oliveira JS,Duarte MC,Menezes-Souza D

更新日期：2020-08-01 00:00:00

abstract：:Macrophages (Mφ) undergo activation to pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes in response to pathophysiologic stimuli and dysregulation of the M1-M2 balance is often associated with diseases. Therefore, studying mechanisms of macrophage polarization may reveal new drug targets. Human Mφ polarizatio...

journal_title：Molecular immunology

authors： Shiratori H,Feinweber C,Luckhardt S,Linke B,Resch E,Geisslinger G,Weigert A,Parnham MJ

更新日期：2017-08-01 00:00:00

abstract：:Topoisomerase cDNA and various fragments thereof generated by the DNA polymerase chain reaction were cloned into plasmid expression vectors (pET series) and the expressed polypeptides were probed with scleroderma sera from seven different patients immunoreactive with topoisomerase I. All sera reacted selectively with ...

journal_title：Molecular immunology

authors： Piccinini G,Cardellini E,Reimer G,Arnett FC,Durban E

更新日期：1991-04-01 00:00:00

abstract：:SOCS3 is well known to negatively regulate various cytokine-mediated signaling responses, but its direct role in the expression of specific cytokines has not been clearly elucidated. To understand the role of SOCS3 in the expression of IL-4, one of the key Th2 cytokines, RBL-2H3 cells (a rat mast cell line) were engin...

journal_title：Molecular immunology

authors： Kim D,Kim SH,Cho SH,Shin K,Kim S

更新日期：2011-02-01 00:00:00

abstract：:The ability of bovine IgG preparations to bind to the various distinct human leukocyte Fc gamma receptors was studied. In experiments using intact cells and isolated Fc gamma receptors, it was demonstrated that bovine IgG can bind to Fc gamma receptors of four human cell types but not to Fc gamma receptors of human ne...

journal_title：Molecular immunology

authors： Kulczycki A Jr

更新日期：1987-03-01 00:00:00

abstract：:Leucine-rich repeat-containing G-protein-coupled receptors (LGRs) form a subfamily of the large superfamily of G-protein-coupled receptors. LGRs can be divided into three groups. LGR2 from Drosophila melanogaster is involved in cuticle tanning (melanization and sclerotization). In this study, one LGR2 (MnLGR2) was ide...

journal_title：Molecular immunology

authors： Cao X,Zhang C,Zhang R,Wang K,Dai X,Huang X,Ren Q

更新日期：2020-10-01 00:00:00

abstract：:Binding of the catecholamine beta-adrenergic antagonist, l-alprenolol, by the IgGl anti-alprenolol monoclonal antibody 37A4 was examined using the radioligand 3H-dihydroalprenolol as an extrinsic signal and the increase in antibody fluorescence upon l-alprenolol binding as intrinsic signal. Equilibrium binding studies...

journal_title：Molecular immunology

authors： Hoebeke J,Engelborghs Y,Chamat S,Strosberg AD

更新日期：1987-06-01 00:00:00

abstract：:Recent studies suggest that CD8(+) T cells with down-regulated CD8 expression (CD3(+)CD8(low) T cells) represented as a distinct phenotype of CD8(+) T cells are increased and linked to disease severity in some chronically persistent infection, such as chronic HIV and parasite infection. However, the role of CD3(+)CD8(...

journal_title：Molecular immunology

authors： Ouyang L,Li X,Liang Z,Yang D,Gong F,Shen G,Weng X,Wu X

更新日期：2013-12-01 00:00:00

abstract：:Apoptosis can be induced in the human leukemic T-cell line Jurkat when these cells are stimulated by several known T-cell activators. Among the stimuli that activate Jurkat cells, calcium ionophore A23187, phytohemagglutinin and cross-linked monoclonal antibody anti-CD3 are the best inducers of apoptosis. The activato...

journal_title：Molecular immunology

authors： Ruiz-Ruiz MC,Oliver FJ,Izquierdo M,López-Rivas A

更新日期：1995-09-01 00:00:00

abstract：:The capsid protein of hepatitis B virus (P19) is made of 183 amino acids and carries the antigenic sites of hepatitis B core antigen (HBcAg) and hepatitis B e antigen (HBeAg) on the amino-terminal domain. The carboxyl-terminal domain of P19 (amino acids 150-183) is arginine-rich (47%) and faces the interior of the nuc...

journal_title：Molecular immunology

authors： Machida A,Ohnuma H,Takai E,Tsuda F,Tanaka T,Naito M,Munekata E,Miyakawa Y,Mayumi M

更新日期：1989-04-01 00:00:00

abstract：:Rabbit antisera specific for horseradish peroxidase inhibit the catalytic activity of the enzyme. All antibodies prepared against the holoenzyme react with the peroxidase apoenzyme. However, only a minority (30-45%) of the total antiperoxidase pool cross react with reduced and alkylated apoenzymes. The antibodies inhi...

journal_title：Molecular immunology

authors： Conroy JM,Salter RD

更新日期：1982-05-01 00:00:00

abstract：:Endodontic infection is a widespread oral problem. DNA methylation is a key epigenetic modification that plays important roles in various inflammatory responses, but its role in dental pulp inflammation is poorly understood. In this study, we assessed the expression of DNA methyltransferases (DNMTs) in human dental pul...

journal_title：Molecular immunology

authors： Mo Z,Li Q,Cai L,Zhan M,Xu Q

更新日期：2019-07-01 00:00:00

abstract：:The S100A12 gene belongs to the S100 family of genes, which are specific to vertebrates. It is involved in many inflammatory diseases of human and has been considered as a powerful diagnostic gene. In the present study, we identified the porcine S100A12 (pS100A12) gene, provided evidence that pS100A12 is located on ch...

journal_title：Molecular immunology

authors： Chen H,Cheng L,Yang S,Liu X,Liu Y,Tang J,Li X,He Q,Zhao S

更新日期：2010-04-01 00:00:00