An antigenic region of topoisomerase I in DNA polymerase chain reaction-generated fragments recognized by autoantibodies of scleroderma patients.

abstract：:Phosphorothioate oligonucleotides (S-oligos) are nucleic acid derivatives that are commonly used as antisense agents. These compounds, similar to bacterial DNA and CpG oligonucleotides, display a variety of immunological activities in vitro and in vivo. To assess further these activities, the antigenicity of a series ...

journal_title：Molecular immunology

authors： Pisetsky DS,Reich CF 3rd

更新日期：1998-12-01 00:00:00

abstract：:Mannose-binding lectin (MBL) is a recognition molecule of the complement (C) system and binds to carbohydrate ligands present on a wide range of pathogenic bacteria, viruses, fungi, and parasites. MBL has been detected in the cervico-vaginal cavity where it can provide a first-line defence against infectious agents co...

journal_title：Molecular immunology

authors： Bulla R,De Seta F,Radillo O,Agostinis C,Durigutto P,Pellis V,De Santo D,Crovella S,Tedesco F

更新日期：2010-11-01 00:00:00

abstract：:MAIT cells are innate-like T cells that are enriched in mucosal sites and tissues including adipose tissue and liver. They play an important role in immunity against microbial pathogens. Recently, it has been reported that MAIT cells could also be important in metabolic diseases and can be involved in setting up and m...

journal_title：Molecular immunology

authors： Toubal A,Lehuen A

更新日期：2021-02-01 00:00:00

abstract：:Serotonin release from rat basophilic leukemia (RBL) cells, sensitized with a DNP-binding monoclonal IgE, was stimulated with solid surface (polystyrene)-bound DNP-amino acids. The stimulatory potency of DNP-amino acids was dependent on the structure of amino acid attached to DNP. Generally, DNP-amino acids with high ...

journal_title：Molecular immunology

authors： Varga JM,Kalchschmid G,Klein GF,Fritsch P

更新日期：1991-06-01 00:00:00

abstract：:We discovered that some bovine antibodies are amongst the largest known to exist due to the presence of an exceptionally long CDR3H (≥49 amino acids) with multiple cysteines that provide a unique knob and stalk structure to the antigen binding site. The large CDR3H size, unlike mouse and human, provides a suitable pla...

journal_title：Molecular immunology

authors： Pasman Y,Soliman C,Ramsland PA,Kaushik AK

更新日期：2016-09-01 00:00:00

abstract：:Chagas' disease, caused by Trypanosoma cruzi, is an inflammatory disorder leading to chronic Chagas cardiomyopathy (CCC). Only one third of T. cruzi-infected individuals progress to CCC while the others are considered asymptomatic (ASY). The human inhibitory kappaB-like gene (IKBL/NFKBIL1), homologous to the IkappaB f...

journal_title：Molecular immunology

authors： Ramasawmy R,Faé KC,Cunha-Neto E,Borba SC,Ianni B,Mady C,Goldberg AC,Kalil J

更新日期：2008-01-01 00:00:00

abstract：:The potential biochemical mechanisms that mediate the 'shedding' of soluble IL-6 RI (80-kDa) receptor fragments in populations of adherent macrophages were explored. Stimulated macrophages displayed proportional increases in both the expression of membrane-associated IL-6 RI (80-kDa) and the release of soluble recepto...

journal_title：Molecular immunology

authors： Coyne CP,Howell T 3rd,Baravick J,Baravick E,Willetto C,Fenwick BW

更新日期：2001-09-01 00:00:00

abstract：:Dense deposit disease (DDD) is strongly associated with the uncontrolled activation of the complement alternative pathway. Factor H (CFH)-deficient (Cfh(-/-)) mice spontaneously develop C3 deposition along the glomerular basement membrane (GBM) with subsequent development of glomerulonephritis with features of DDD, a ...

journal_title：Molecular immunology

authors： Paixão-Cavalcante D,Hanson S,Botto M,Cook HT,Pickering MC

更新日期：2009-06-01 00:00:00

abstract：:White spot syndrome virus (WSSV) has caused great economic damage to shrimp aquaculture. Previous studies have shown that WSSV successfully usurps the immunity system of the host for its own gene regulation. To investigate the role of shrimp high mobility group box (HMGB) proteins in WSSV gene regulation, two Litopena...

journal_title：Molecular immunology

authors： Chen YH,Jia XT,Huang XD,Zhang S,Li M,Xie JF,Weng SP,He JG

更新日期：2011-02-01 00:00:00

abstract：:Most studies of the immune responses in allergic rhinitis have focused on IgE antibodies to mixtures of allergenic proteins. Based on our previous studies of the major mountain cedar allergen Jun a 1, we sought to describe a broader assessment of the humoral immune responses to a single, dominant allergen, in three gr...

journal_title：Molecular immunology

authors： Goldblum RM,Madagoda-Desilva RS,Zhang Y,van Bavel J,Midoro-Horiuti T

更新日期：2018-09-01 00:00:00

abstract：:Increasing indication is unveiling a role for poly(ADP-ribose) polymerase (PARP)-1 in the regulation of inflammatory/immune responses. The aim of the present study was to determine the potential anti-inflammatory effects of PARP-1 inhibitor 5-aminoisoquinolinone (5-AIQ) to explore the role of PARP-1 inhibitor in a mou...

journal_title：Molecular immunology

authors： Ahmad SF,Zoheir KM,Ansari MA,Korashy HM,Bakheet SA,Ashour AE,Al-Shabanah OA,Al-harbi MM,Attia SM

更新日期：2015-02-01 00:00:00

abstract：:Tumors exploit immunoregulatory checkpoints that serve to attenuate T cell responses as a means of circumventing immunologic rejection. Programmed death ligand 1 (PD-L1) is a negative regulator of T cell function and is frequently expressed by solid tumors. By engaging programmed death 1 (PD-1) on activated T cells, P...

journal_title：Molecular immunology

authors： Prosser ME,Brown CE,Shami AF,Forman SJ,Jensen MC

更新日期：2012-07-01 00:00:00

abstract：:Apoptosis can be induced in the human leukemic T-cell line Jurkat when these cells are stimulated by several known T-cell activators. Among the stimuli that activate Jurkat cells, calcium ionophore A23187, phytohemagglutinin and cross-linked monoclonal antibody anti-CD3 are the best inducers of apoptosis. The activato...

journal_title：Molecular immunology

authors： Ruiz-Ruiz MC,Oliver FJ,Izquierdo M,López-Rivas A

更新日期：1995-09-01 00:00:00

abstract：:As demonstrated by others, diisopropyl fluorophosphate (DFP) markedly inhibits the O2- generation from guinea-pig polymorphonuclear leukocytes (PMN) stimulated by an antibody complex with ovalbumin (Ag-Ab complex), and also the intracellular uptake of antibody-sensitized erythrocytes by the cells. However, when PMN we...

journal_title：Molecular immunology

authors： Kudoh M,Nakamura T,Koyama J

更新日期：1985-09-01 00:00:00

abstract：:Toll-like receptors (TLRs) are a family of highly conserved germline-encoded pattern-recognition receptors (PRRs) and are essential for host immune response. Little is known regarding the activation mechanism of TLRs especially of the TLR7/8/9 subfamily. Here we cloned and characterized bovine TLR8 (bTLR8) and found t...

journal_title：Molecular immunology

authors： Zhu J,Brownlie R,Liu Q,Babiuk LA,Potter A,Mutwiri GK

更新日期：2009-02-01 00:00:00

abstract：:A monoclonal human IgG1, Campath-1H, was digested with glycosidases to assess the effect of carbohydrate on the functional activities of an IgG1. Removal of the complete carbohydrate moiety abolished complement lysis activity and antibody-dependent cell-mediated cytotoxicity, but left antigen binding activity and prot...

journal_title：Molecular immunology

authors： Boyd PN,Lines AC,Patel AK

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Bladder cancer (BC) can be successfully treated by manipulating immune responses with intravesical Bacillus Calmette-Guerin instillation or targeting the PD-1/PD-L signaling pathway. In the present study we investigated the prognostic significance of the immune checkpoint inhibitor PD-1 and its ligands PD-L1...

journal_title：Molecular immunology

authors： Ariafar A,Ghaedi M,Rezaeifard S,Shahriari S,Zeighami S,Ghaderi A,Faghih Z

更新日期：2020-08-01 00:00:00

abstract：:The five-year survival rate of melanoma worsens significantly with advancing tumor stage. We hypothesized that regulatory B cells (Breg) might have participated in the pathogenesis of melanoma. In this study, the PD-L1+ Breg cells were investigated. The expression of PD-L1 by circulating B cells was very low in health...

journal_title：Molecular immunology

authors： Wu H,Xia L,Jia D,Zou H,Jin G,Qian W,Xu H,Li T

更新日期：2020-03-01 00:00:00

abstract：:Human cell lines and blood lymphocytes were treated for short time periods with IFN-gamma. This treatment increased the amount of the assembled MHC class I molecules on the plasma membrane after 30 min. This early increase of the membrane expression subsided in the next few hours. A second wave of elevation occurred a...

journal_title：Molecular immunology

authors： Végh Z,Wang P,Vánky F,Klein E

更新日期：1993-06-01 00:00:00

abstract：:Binding of the catecholamine beta-adrenergic antagonist, l-alprenolol, by the IgGl anti-alprenolol monoclonal antibody 37A4 was examined using the radioligand 3H-dihydroalprenolol as an extrinsic signal and the increase in antibody fluorescence upon l-alprenolol binding as intrinsic signal. Equilibrium binding studies...

journal_title：Molecular immunology

authors： Hoebeke J,Engelborghs Y,Chamat S,Strosberg AD

更新日期：1987-06-01 00:00:00

abstract：:Subunits of the mitochondrial ATP synthase complex are expressed on the surface of tumors, bind the TCR of human Vgamma9/Vdelta2 lymphocytes and promote their cytotoxicity. Present experiments show that detection of the complex (called ecto-F1-ATPase) at the cell surface by immunofluorescence correlates with low MHC-c...

journal_title：Molecular immunology

authors： Vantourout P,Martinez LO,Fabre A,Collet X,Champagne E

更新日期：2008-01-01 00:00:00

abstract：:BST-2 (also known as tetherin, CD317, or HM1.24) was first described as a potent interferon-inducible host antiviral factor nearly five years ago. Since that time, numerous reports have been published regarding the antiviral activity and immunological properties of this protein. BST-2 blocks viral replication by inhib...

journal_title：Molecular immunology

authors： Swiecki M,Omattage NS,Brett TJ

更新日期：2013-06-01 00:00:00

abstract：:We investigated the structure and expression of immunoglobulin genes in the pufferfish, Takifugu rubripes, a highly prized and economically important fish species. The cDNA fragment that partially encodes the constant region of the IgM heavy chain was isolated in these animals by RACE using degenerate primers after wh...

journal_title：Molecular immunology

authors： Saha NR,Suetake H,Suzuki Y

更新日期：2005-01-01 00:00:00

abstract：:p38 mitogen-actived protein kinases (MAPKs) broadly exist from yeast to mammals and participate in diverse cellular responses to various stimuli, whose activation can be induced by the MAPK kinase 6 (MKK6). In this study, a novel MKK6 homolog from Litopenaeus vannamei (LvMKK6) was cloned and characterized. The transcr...

journal_title：Molecular immunology

authors： Li H,Wang S,Qian Z,Wu Z,Lǚ K,Weng S,He J,Li C

更新日期：2016-02-01 00:00:00

abstract：:Integrin-mediated adhesion of human monocytes to fibrinogen regulated by CD11b/CD18 and the closely related integrin CD11c/CD18, play a key role in inflammation. Peripheral blood monocytes isolated from human donors despite expressing CD11c primarily utilized CD11b to mediate adhesion to fibrinogen upon stimulation wi...

journal_title：Molecular immunology

authors： Georgakopoulos T,Moss ST,Kanagasundaram V

更新日期：2008-08-01 00:00:00

abstract：:Immunoglobulin heavy chain (Igh) locus rearrangements are controlled in part by an approximately 30 b complex 3' regulatory region located 3' of C alpha: this region contains several enhancers. We report here the comparison of the genomic sequences of the 3' regulatory region and further downstream sequences from mous...

journal_title：Molecular immunology

authors： Sepulveda MA,Garrett FE,Price-Whelan A,Birshtein BK

更新日期：2005-03-01 00:00:00

abstract：:Covalent Superose microspheres-bound C3b was used as a model system to simplify the analysis of antigen-bound C3b modifications during antigen processing. The model was set up using purified C3 and Superose-bound trypsin. C3b was covalently bound to Superose through an ester link, as indicated by lability to hydroxyla...

journal_title：Molecular immunology

authors： Rey-Millet CA,Chesne S,Colomb MG

更新日期：1993-07-01 00:00:00

abstract：:A first report of an XLA patient with a polymorphism in Btk SH3 domain has been identified after sequencing of the entire gene. SH3 domain variants might not be detected due to well characterized mutations outside the domain. ...

journal_title：Molecular immunology

authors： Pérez de Diego R,Bravo J,Allende LM,López-Granados E,Rivera J,Ferreira A,Fontán G,García Rodríguez MC

更新日期：2008-01-01 00:00:00

abstract：:Glucocorticoids down regulate the inducible nitric oxide synthase (iNOS) gene both transcriptionally and post-transcriptionally. The post-transcriptional events are suggested to involve destabilization of the iNOS transcript although the molecular mechanisms for this effect are not known. Recently, our laboratory demo...

journal_title：Molecular immunology

authors： Söderberg M,Raffalli-Mathieu F,Lang MA

更新日期：2007-05-01 00:00:00

abstract：:HLA-B27 (B27) is strongly associated with the spondyloarthritides. B27 is expressed at the cell surface of antigen presenting cells (APC) both as canonical β2m-associated and non-canonical β2m-free heavy chain (FHC) forms which include B27 dimers (termed B272). B27 FHC forms arise in an endosomal compartment from recy...

journal_title：Molecular immunology

authors： Shaw J,Hatano H,Kollnberger S

更新日期：2014-01-01 00:00:00