Genomic organization and adaptive evolution of IGHC genes in marine mammals.

abstract：:This study aimed to co-culture Jurkat T lymphocytes with inactivated Mycobacterium tuberculosis (Mtb H37Ra), explore whether T lymphocytes could phagocytose H37Ra cells, and determine the underlying mechanism. Jurkat T lymphocytes were co-cultured with H37Ra cells, and confocal laser scanning microscopy, electron micr...

journal_title：Molecular immunology

authors： Zhang M,Zhu Q,Shi M,Liu Y,Ma L,Yang Y,Feng D,Dai W,Zhang L,Kang T,Chen P,He Y,Liu T,Zhao Q,Wang W,Zhi J,Feng G,Zhao G

更新日期：2015-08-01 00:00:00

abstract：:The fine regulation of NF-kappaB activity is crucial for both resting and stimulated cells and relies on complex balance between multiple activators and inhibitors. We report here that c-mip, a recently identified pleckstrin homology (PH) and leucine-rich repeat (LRR)-domain-containing protein, inactivates GSKbeta and...

journal_title：Molecular immunology

authors： Kamal M,Valanciute A,Dahan K,Ory V,Pawlak A,Lang P,Guellaen G,Sahali D

更新日期：2009-02-01 00:00:00

abstract：:A common feature of human IgG1 antibodies used for cancer treatment is that their anti-tumour efficacy requires high serum trough levels and continued therapy for several months. Treatment cycles, thereby, consume several grams of IgG1 translating into significant drug needs and costs. The basis for the low in vivo ef...

journal_title：Molecular immunology

authors： Preithner S,Elm S,Lippold S,Locher M,Wolf A,da Silva AJ,Baeuerle PA,Prang NS

更新日期：2006-03-01 00:00:00

abstract：:When 5-fluorouracil (5-FU) resistant bone marrow (BM) cells are depleted of B-cells and then cultured in insert chambers [separated from a layer of adherent BM (aBM) cells by a nucleopore membrane], no mature, lipopolysaccharide (LPS) reactive B-cells are formed. Factors acting on B-cell precursors are not produced un...

journal_title：Molecular immunology

authors： Gisler RH,Schlienger C,Söderberg A,Ledermann F,Lambris JD

更新日期：1988-11-01 00:00:00

abstract：:The peptide editor HLA-DM (DM) catalyzes the exchange of peptides bound to MHC class II molecules within antigen presenting cells by generating a "peptide-receptive" MHC class II conformation (MHC(receptive)) to which peptides readily bind and rapidly unbind. While recent work has uncovered the determinants of DM reco...

journal_title：Molecular immunology

authors： Narayan K,Su KW,Chou CL,Khoruzhenko S,Sadegh-Nasseri S

更新日期：2009-09-01 00:00:00

abstract：:The purpose of this study was to evaluate the effects of GATA-6 on airway inflammation and remodeling and the underlying mechanisms in a murine model of chronic asthma. Female BALB/c mice were randomly divided into four groups: phosphate-buffered saline control (PBS), ovalbumin (OVA)-induced asthma group (OVA), OVA+ s...

journal_title：Molecular immunology

authors： Fang P,Shi HY,Wu XM,Zhang YH,Zhong YJ,Deng WJ,Zhang YP,Xie M

更新日期：2016-07-01 00:00:00

abstract：:Structural similarities between two members of the immunoglobulin superfamily were explored by making chimeric immunoglobulin/CD4 antigen molecules. A crossover in the middle of the originally proposed J kappa homology unit of the first domain of the CD4 molecule was used to construct a chimeric molecule having human ...

journal_title：Molecular immunology

authors： Frey T,Estess P,Oi VT

更新日期：1993-06-01 00:00:00

abstract：:A monoclonal antibody (vpg15) has been described which can block infection with feline immunodeficiency virus (FIV) and which recognizes the feline homologue of CD9. In order to study the role of feline CD9 in infection with FIV we have molecularly cloned a cDNA encoding feline CD9 by R.A.C.E (rapid amplification of c...

journal_title：Molecular immunology

authors： Willett BJ,Neil JC

更新日期：1995-04-01 00:00:00

abstract：:The purpose of the present work was to determine the ability of BgTX peptides, corresponding to the various loops and exposed regions of alpha-bungarotoxin (BgTX) and representing regions that are recognized by B and/or T cells, to stimulate protective immunity in mice against in vivo challenge with BgTX. The BgTX LD5...

journal_title：Molecular immunology

authors： Dolimbek BZ,Atassi MZ

更新日期：1996-05-01 00:00:00

abstract：:Ovalbumin (OVA) is a major allergen (Gal d II) of hen egg white and is often the cause of hypersensitivity reactions to food. Further knowledge of the antigenic and allergenic epitopes of allergens will provide better treatment of this disease. To analyse these epitopes we produced a panel of monoclonal antibodies (mA...

journal_title：Molecular immunology

authors： Kahlert H,Petersen A,Becker WM,Schlaak M

更新日期：1992-10-01 00:00:00

abstract：:Leucine-rich repeat-containing G-protein-coupled receptors (LGRs) form a subfamily of the large superfamily of G-protein-coupled receptors. LGRs can be divided into three groups. LGR2 from Drosophila melanogaster is involved in cuticle tanning (melanization and sclerotization). In this study, one LGR2 (MnLGR2) was ide...

journal_title：Molecular immunology

authors： Cao X,Zhang C,Zhang R,Wang K,Dai X,Huang X,Ren Q

更新日期：2020-10-01 00:00:00

abstract：:C-reactive protein (CRP) is an acute-phase protein featuring a homopentameric structure and Ca-binding specificity for phosphocholine (PCh). Expression of CRP is regulated mainly at the transcriptional level with interleukin-6 being the principal inducer of the gene during the acute phase. The crystal structure of CRP...

journal_title：Molecular immunology

authors： Volanakis JE

更新日期：2001-08-01 00:00:00

abstract：:Evidence for the central role that intestinal beta-defensins play in maintaining gut health continues to accumulate within the literature. Two epithelially-derived enteric beta-defensins, hBD1 and hBD2, have been identified thus far and the following chapter reviews our current understanding of how the expression and ...

journal_title：Molecular immunology

authors： O'Neil DA

更新日期：2003-11-01 00:00:00

abstract：:Most of the complement proteins in circulation are, by and large, synthesized in the liver. However data accumulated over the past several decades provide incontrovertible evidence that some if not most of the individual complement proteins are also synthesized extrahepatically by activated as well as non-activated ce...

journal_title：Molecular immunology

authors： Ghebrehiwet B,Hosszu KH,Peerschke EI

更新日期：2017-04-01 00:00:00

abstract：:Interleukin 1β (IL-1β) is a pro-inflammatory cytokine secreted by activated macrophages and monocytes. Previously, we have reported that bone morphogenetic protein-6 (BMP-6) induces inducible nitric oxide synthase (iNOS) expression via IL-1β in macrophages. In the present study, we demonstrate that BMP-6 increases IL-...

journal_title：Molecular immunology

authors： Lee GT,Jung YS,Lee JH,Kim WJ,Kim IY

更新日期：2011-07-01 00:00:00

abstract：:Humanization of monoclonal antibodies by complementary determinant region (CDR)-grafting has become a standard procedure to improve the clinical usage of animal antibodies. However, antibody humanization may result in loss of activity that has been attributed to structural constraints in the framework structure. In th...

journal_title：Molecular immunology

authors： Caldas C,Coelho V,Kalil J,Moro AM,Maranhão AQ,Brígido MM

更新日期：2003-05-01 00:00:00

abstract：:The objective of this study was to characterize the in vitro and in vivo activity of a novel afucosylated rituximab (BLX-300) expressed in a Lemna aquatic plant-based system free of zoonotic pathogens. The glycosylation of BLX-300 was shown to be homogeneous, composed of a single major N-glycan species without detecta...

journal_title：Molecular immunology

authors： Gasdaska JR,Sherwood S,Regan JT,Dickey LF

更新日期：2012-03-01 00:00:00

abstract：:Human complement components C6 and C7 have been purified and characterized. Component C6 is a single-chain plasma protein of mol. wt 104,800 containing 3.8% carbohydrate and it has alanine as the amino terminal residue. Component C7 is a single-chain plasma protein of mol. wt 92,400 containing 6.4% carbohydrate and it...

journal_title：Molecular immunology

authors： Discipio RG,Gagnon J

更新日期：1982-11-01 00:00:00

abstract：:The insect gut participates in initial local immune responses by producing reactive oxygen and nitrogen species as well as anti-microbial peptides to resist pathogenic invasions. Nitric oxide (NO), a signaling and an immune effector molecule synthesized by the enzyme NO synthase (NOS), mediates an early step of the si...

journal_title：Molecular immunology

authors： Liu W,Wang Y,Leng Z,Wang Q,Duan X,Luo Y,Jiang Y,Qin L

更新日期：2020-10-01 00:00:00

abstract：:The development and progression of systemic lupus erythematosus (SLE) is strongly associated with complement activation and deposition. The anaphylatoxin C3a is a product of complement activation with immunomodulatory properties, and the receptor for C3a (C3aR) is not only expressed by granulocytes and antigen present...

journal_title：Molecular immunology

authors： Wenderfer SE,Wang H,Ke B,Wetsel RA,Braun MC

更新日期：2009-04-01 00:00:00

abstract：:Human IgE against helminths is a normal component of the whole protective response elicitesd during infection, when specific IgE to a great number of antigens is produced; however, few of those IgE binding components are actually allergens. In general, considering the strong Th2/IgE responses during helminth infection...

journal_title：Molecular immunology

authors： Caraballo L,Coronado S

更新日期：2018-08-01 00:00:00

abstract：:Mastocytosis is an incurable and sometimes fatal haematological disorder grossly described as the accumulation of abnormal mast cells in the bone marrow and other organs causing tissue and organ damage. The clinical manifestations of this disease are extremely variable; disease phenotypes range from indolent to aggres...

journal_title：Molecular immunology

authors： Soucie E,Brenet F,Dubreuil P

更新日期：2015-01-01 00:00:00

abstract：:Human neutrophil peptides (HNPs) are cysteine-rich antimicrobial peptides stored in neutrophils. The similar structure of HNPs -1, -2, and -3 renders them impossible to study individually in biological samples. For the first time, we describe a method of individually identifying the HNPs -1-3 from exudative neutrophil...

journal_title：Molecular immunology

authors： Thompson L,Turko I,Murad F

更新日期：2006-03-01 00:00:00

abstract：:Binding of the catecholamine beta-adrenergic antagonist, l-alprenolol, by the IgGl anti-alprenolol monoclonal antibody 37A4 was examined using the radioligand 3H-dihydroalprenolol as an extrinsic signal and the increase in antibody fluorescence upon l-alprenolol binding as intrinsic signal. Equilibrium binding studies...

journal_title：Molecular immunology

authors： Hoebeke J,Engelborghs Y,Chamat S,Strosberg AD

更新日期：1987-06-01 00:00:00

abstract：:A relatively large number of variable region genes (V) contribute, via gene rearrangements with smaller numbers of additional gene elements (D and J), to generate diversity in the immune response. While some VH gene families are thought to contain 100- 1000 members, the VH10 family has only two known functioning membe...

journal_title：Molecular immunology

authors： Chao M,Voss EW Jr

更新日期：1992-03-01 00:00:00

abstract：:Discordant xenografts surviving the initial hyperacute rejection phase may be subject to cellular rejection processes mediated by infiltrating leukocytes including T cells, NK cells and monocytes. The stable adhesion of these cell types to endothelial cells is due to the molecular interaction of the integrins VLA-4 an...

journal_title：Molecular immunology

authors： Mueller JP,Giannoni MA,Hartman SL,Elliott EA,Squinto SP,Matis LA,Evans MJ

更新日期：1997-04-01 00:00:00

abstract：:The T cell receptor (TCR) detects the presence of infectious pathogens and activates numerous intracellular signaling pathways. Protein tyrosine phosphorylation and ubiquitination serve as key regulatory mechanisms downstream of the TCR. Negative regulation of TCR signaling pathways is important in controlling the imm...

journal_title：Molecular immunology

authors： Carpino N,Chen Y,Nassar N,Oh HW

更新日期：2009-10-01 00:00:00

abstract：:The xenotransplantation research is driven by the shortage of allografts for transplantation of patients with end-stage organ failure and by lack of success in developing suitable artificial organs. Pigs are now generally accepted to be the donor species of choice, although a possible risk for transmission of xenozoon...

journal_title：Molecular immunology

authors： Mollnes TE,Fiane AE

更新日期：1999-03-01 00:00:00

abstract：:Increasing indication is unveiling a role for poly(ADP-ribose) polymerase (PARP)-1 in the regulation of inflammatory/immune responses. The aim of the present study was to determine the potential anti-inflammatory effects of PARP-1 inhibitor 5-aminoisoquinolinone (5-AIQ) to explore the role of PARP-1 inhibitor in a mou...

journal_title：Molecular immunology

authors： Ahmad SF,Zoheir KM,Ansari MA,Korashy HM,Bakheet SA,Ashour AE,Al-Shabanah OA,Al-harbi MM,Attia SM

更新日期：2015-02-01 00:00:00

abstract：:Although granulocyte colony-stimulating factor(G-CSF) has pathogenic roles in several immune inflammatory diseases, its role in periodontitis has not been investigated. Here we detected local expression of G-CSF using public datasets in the Gene Expression Omnibus (GEO) database, and immune cell infiltration into ging...

journal_title：Molecular immunology

authors： Zhang Z,Yuan W,Deng J,Wang D,Zhang T,Peng L,Tian H,Wang Z,Ma J

更新日期：2020-01-01 00:00:00