An afucosylated anti-CD20 monoclonal antibody with greater antibody-dependent cellular cytotoxicity and B-cell depletion and lower complement-dependent cytotoxicity than rituximab.

abstract：:RIP2/RICK/CARDIAK is a member of the receptor interacting protein kinase (RIP) family. RIP2 promotes NF-kappaB activation as well as activation of the MAPKs JNK, ERK1/2 and p38 MAPK, thereby playing an emergent role in the innate immune response and NOD signaling. Moreover, RIP2 has been shown to interact with the CAR...

journal_title：Molecular immunology

authors： Krieg A,Le Negrate G,Reed JC

更新日期：2009-03-01 00:00:00

abstract：:Zinc finger protein regulator of apoptosis and cell cycle arrest (Zac1) is a transcription factor able to induce apoptosis or cell cycle arrest through independent pathways. In spite of the important potential functions attributed to Zac1, little is known of its physiological regulation and biological function. We dis...

journal_title：Molecular immunology

authors： Warzée B,Mesnil C,Hober D,Caloone D,Pirottin D,Garigliany MM,Desmecht D,Drion PV,Journot L,Lekeux P,Bureau F,Desmet CJ

更新日期：2010-11-01 00:00:00

abstract：:The complement system is important for protection from invading pathogens, removal of waste products and guidance of the immune response. Furthermore, complement can be also targeted to cancer cells. However, membrane-bound inhibitors over-expressed by certain types of tumor cells restrict the cytotoxic activity of co...

journal_title：Molecular immunology

authors： Okroj M,Hsu YF,Ajona D,Pio R,Blom AM

更新日期：2008-01-01 00:00:00

abstract：:We showed that nucleotide sequences coding for linear B-cell epitopes of human immunodeficiency virus type 1 (HIV1) gp120 protein are enriched with codons containing cytosine and guanine in their first and second codon positions. Guanine and cytosine are the most mutable nucleotides in HIV1 genes (due to APOBEC3 and A...

journal_title：Molecular immunology

authors： Khrustalev VV

更新日期：2010-04-01 00:00:00

abstract：:Topoisomerase cDNA and various fragments thereof generated by the DNA polymerase chain reaction were cloned into plasmid expression vectors (pET series) and the expressed polypeptides were probed with scleroderma sera from seven different patients immunoreactive with topoisomerase I. All sera reacted selectively with ...

journal_title：Molecular immunology

authors： Piccinini G,Cardellini E,Reimer G,Arnett FC,Durban E

更新日期：1991-04-01 00:00:00

abstract：:The murine pre-B cell line R2-bfl, which can be induced to differentiate in vitro, was used to study germline transcription of variable regions of the light chain loci. RNA from these cells was subjected to a 3'-RACE and germline transcripts from 17 individual Vkappa gene segments belonging to 12 Vkappa families were ...

journal_title：Molecular immunology

authors： Düber S,Engel H,Rolink A,Kretschmer K,Weiss S

更新日期：2003-12-01 00:00:00

abstract：:A number of fragments derived from acid-treated rabbit IgG by digestion with plasmin have been separated by high-resolution gel filtration. Fragments isolated included a dimer and monomer Facb, named F(acb)2 and Facb, respectively and a heterodimer composed of Facb and Fab subunits, named F(acb)(ab). A C gamma 2 fragm...

journal_title：Molecular immunology

authors： Utsumi S,Okada M,Udaka K,Amano T

更新日期：1985-07-01 00:00:00

abstract：:The A/J murine hybridoma cell line 40-150 secretes antidigoxin antibodies with high affinity for digoxin. A first-order spontaneous mutant (40-150 A2.4) produces antibodies containing a mutation at heavy chain position 94 resulting in reduced affinity for digoxin. A second-order mutant (40-150 A2.4 P.10) derived from ...

journal_title：Molecular immunology

authors： Shaw SY,Margolies MN

更新日期：1992-04-01 00:00:00

abstract：:Candida albicans is an opportunistic human-pathogenic fungus, which can cause superficial but also life-threatening invasive infections. The pH-regulated antigen 1 (Pra1) of C. albicans is a surface-associated and secreted protein highly expressed in the hyphal form. Pra1 can bind to complement receptor 3 (CD11b/CD18)...

journal_title：Molecular immunology

authors： Losse J,Svobodová E,Heyken A,Hube B,Zipfel PF,Józsi M

更新日期：2011-09-01 00:00:00

abstract：:The innate immune response is critical to enteric disease resistance and the induction of mucosal adaptive immunity. In mucosae of the small intestine, Peyer's patches play a central role in immune surveillance and sampling of bacteria by specialized M cells. The innate immune response to Salmonella enterica serovar C...

journal_title：Molecular immunology

authors： Hyland KA,Kohrt L,Vulchanova L,Murtaugh MP

更新日期：2006-04-01 00:00:00

abstract：:The five-year survival rate of melanoma worsens significantly with advancing tumor stage. We hypothesized that regulatory B cells (Breg) might have participated in the pathogenesis of melanoma. In this study, the PD-L1+ Breg cells were investigated. The expression of PD-L1 by circulating B cells was very low in health...

journal_title：Molecular immunology

authors： Wu H,Xia L,Jia D,Zou H,Jin G,Qian W,Xu H,Li T

更新日期：2020-03-01 00:00:00

abstract：:It has been developed an HIV type 1 transgenic rat model (HIV-1 Tg Rat) which contains a gag-pol-deleted HIV-1 provirus regulated by the viral LTR promoter. Although it harbors a non infectious provirus, efficient viral expression occurs in different tissues and disease manifestations as well as immune-response altera...

journal_title：Molecular immunology

authors： Mazzucchelli R,Amadio M,Curreli S,Denaro F,Bemis K,Reid W,Bryant J,Riva A,Galli M,Zella D

更新日期：2004-08-01 00:00:00

abstract：:Mice deficient for SPI-group ETS transcription factors PU.1 or SPI-B fail to generate lymphocytes or do not mount normal antibody mediated immune responses, respectively. PU.1 expression is restricted to B-, T-lymphocytes and macrophages, while SPI-B is expressed in B- and T-lymphocytes. SPI-C is an ETS transcription ...

journal_title：Molecular immunology

authors： Carlsson R,Persson C,Leanderson T

更新日期：2003-06-01 00:00:00

abstract：:Kappa light chains were investigated in sera of several groups of wild derived mouse strains by radioimmunological analysis using xenogeneic anti-mouse kappa light chain antibodies. Although the majority of strains tested expressed serologically indistinguishable kappa chains, several significant exceptions were obser...

journal_title：Molecular immunology

authors： Mami F,Gris C,Guenet JL,Bonhomme F,Cazenave PA

更新日期：1986-08-01 00:00:00

abstract：:We have sequenced the TCRs from Ld-specific alloreactive T cell hybridomas, whose reactivities we have found to be quite representative of those of a primary dm2 anti-BALB/cJ mixed lymphocyte reaction. We find V beta 6, V beta 7, V beta 8 and V beta 10 gene segments. V alpha usage is diverse, although closely related ...

journal_title：Molecular immunology

authors： Louie KA,Ochoa-Garay J,Chen PJ,McKinney D,Groshen S,McMillan M

更新日期：1996-06-01 00:00:00

abstract：:When human serum is diluted and pre-incubated at 37 degrees C in low ionic strength buffer (LIS, u = 0.07; made iso-osmotic with dextrose), a spontaneous activation of complement (C) is observed as determined by C4 and C3 electrophoretic conversion. In this paper it is postulated that most species of glycosaminoglycan...

journal_title：Molecular immunology

authors： Chang NS,Boackle RJ

更新日期：1986-08-01 00:00:00

abstract：:N-substituted benzamides are compounds that have recently been reported to inhibit nuclear factor-kappaB (NF-kappaB) activity and induce apoptosis in a pre-B cell line. In this study, we focused on the effects of N-substituted benzamides on transcriptional regulation in Jurkat T cells. We used a model system where the...

journal_title：Molecular immunology

authors： Lindgren H,Pero RW,Ivars F,Leanderson T

更新日期：2001-08-01 00:00:00

abstract：:A monoclonal human IgG1, Campath-1H, was digested with glycosidases to assess the effect of carbohydrate on the functional activities of an IgG1. Removal of the complete carbohydrate moiety abolished complement lysis activity and antibody-dependent cell-mediated cytotoxicity, but left antigen binding activity and prot...

journal_title：Molecular immunology

authors： Boyd PN,Lines AC,Patel AK

更新日期：1995-12-01 00:00:00

abstract：:We previously demonstrated that some fish have unique response in the form of reactive oxygen species (ROS) production. In the present study, we cloned and sequenced the full-length cDNAs for carp (Cyprinus carpio) phagocyte NADPH oxidase components: gp91phox, p22phox, p47phox, p67phox and p40phox. These amino acid se...

journal_title：Molecular immunology

authors： Mayumi M,Takeda Y,Hoshiko M,Serada K,Murata M,Moritomo T,Takizawa F,Kobayashi I,Araki K,Nakanishi T,Sumimoto H

更新日期：2008-03-01 00:00:00

abstract：:Proteolytic processing of transmembrane receptors and ligands can have a dramatic impact on cell signaling processes and subsequent cellular responses, including activation and differentiation. A member of the disintegrin and metalloproteinase family, ADAM10, has emerged as a prominent regulator of numerous receptors ...

journal_title：Molecular immunology

authors： Gibb DR,Saleem SJ,Chaimowitz NS,Mathews J,Conrad DH

更新日期：2011-06-01 00:00:00

abstract：:the SC5b-8 complex of human complement is a hydrophilic molecule of mol. wt 800,000-850,000 that is seen in the electron microscope as an elongated, straight or curved structure of 50-55 nm total length and 8-9 nm width. Tryptic attack on the fluid-phase complex exposes lipid-binding surfaces on the molecule. The tryp...

journal_title：Molecular immunology

authors： Bhakdi S,Tranum-Jensen J

更新日期：1982-09-01 00:00:00

abstract：:Activation-induced cell death (AICD) in T lymphocytes depends on the expression of Fas-ligand, which triggers the apoptotic process after binding to its receptor Fas. This leads to the activation of cysteine proteases of the caspase family and especially of caspase-3, a critical effector protein during AICD. We have p...

journal_title：Molecular immunology

authors： Sabbagh L,Bourbonnière M,Sékaly RP,Cohen LY

更新日期：2005-07-01 00:00:00

abstract：:The host response to intravascular, Gram-negative bacteria includes profound immunologic, hematologic and physiologic changes. Numerous host defense mechanisms are activated by Gram-negative bacteria, including the complement system. Activation of the complement system leads to cleavage of C5 with subsequent generatio...

journal_title：Molecular immunology

authors： Hollmann TJ,Mueller-Ortiz SL,Braun MC,Wetsel RA

更新日期：2008-04-01 00:00:00

abstract：:During acute lung injury, a large number of monocytes are recruited into the pulmonary tissue, which is mainly mediated by local production of monocyte chemotactic protein 1 (MCP-1). As an essential component of the lung tissues, alveolar type II epithelial cells are one of the major sources of MCP-1. Therefore, uncov...

journal_title：Molecular immunology

authors： Yan C,Li B,Liu X,Deng C,Cai R,Shen Y,Tang H

更新日期：2019-07-01 00:00:00

abstract：:Physicochemical techniques were used to verify previous immunochemical studies showing homology of the human Thy-1 (formerly p25) antigen and the murine Thy-1 or theta antigen. Peptide maps and amino acid compositions showed close similarity between these two proteins; however, they were not identical. These data conf...

journal_title：Molecular immunology

authors： Bonewald L,Wang AC,Terry E,Zwerner R,Balch CM,Ades EW

更新日期：1982-03-01 00:00:00

abstract：:It is widely believed that migrating immune cells utilise the intercellular junctions as routes of passage, and in doing so cause the transient disruption of junctional structures. Thus there is much interest in the molecules that have been identified at cell-cell contact points and their potential involvement in the ...

journal_title：Molecular immunology

authors： Williams LA,Martin-Padura I,Dejana E,Hogg N,Simmons DL

更新日期：1999-12-01 00:00:00

abstract：:HCA2 is a widely used monoclonal antibody, thought to be highly selective for HLA-A and -G heavy chains. We demonstrate here that it also shows affinity to HLA-B73 and HLA-E molecules on intact cells. By comparing the differences in the amino acid (AA) sequences of several HLA class I alleles that are either recognise...

journal_title：Molecular immunology

authors： Seitz C,Uchanska-Ziegler B,Zank A,Ziegler A

更新日期：1998-09-01 00:00:00

abstract：:The primary structure of a human mu heavy chain (DAG) protein is described. The native protein is a circular decamer with a molecular weight (Mr) of 500 kDa, each decamer being constituted of the constant domains C mu 2, C mu 3 and C mu4 and interlinked by 15 disulfide bridges. At its NH2-terminal each monomeric chain...

journal_title：Molecular immunology

authors： Mihaesco C,Ferrara P,Guillemot JC,Congy N,Gendron MC,Roy JP,Sizaret PY,Mihaesco E

更新日期：1990-08-01 00:00:00

abstract：:Monoclonal antibodies were prepared against synthetic peptides synthetized on the basis of nucleotide sequence from cDNA and genomic clones encoding a class I antigen expressed by the rabbit RL-5 cell line. Using a peptide corresponding to positions 61-73 of the N domain, we were able to obtain an hybridoma producing ...

journal_title：Molecular immunology

authors： Le Guern A,Wetterskog D,Marche PN,Kindt TJ

更新日期：1987-05-01 00:00:00

abstract：:The fifth component of human complement (C5), under physiological salt conditions, bound firmly to phenyl-Sepharose. This indicated the presence of hydrophobic sites on C5. These sites may play an important role in C5 haemolytic activity since this activity was inhibited by chaotropic ions (Mg2+, SCN-, I-) at relative...

journal_title：Molecular immunology

authors： Al Salihi A,Ripoche J,Fontaine M

更新日期：1988-04-01 00:00:00