A new extra sequence at the amino terminal of a mu heavy chain disease protein (DAG).

abstract：:Major histocompatibility complex (MHC) molecules present peptide antigens to T lymphocytes and initiate immune responses. The peptides loaded onto MHC class I or MHC class II molecules can be derived from cytosolic proteins, both self and foreign. A variety of cellular processes, including endocytosis, vesicle traffic...

journal_title：Molecular immunology

authors： Valečka J,Almeida CR,Su B,Pierre P,Gatti E

更新日期：2018-07-01 00:00:00

abstract：:Topoisomerase cDNA and various fragments thereof generated by the DNA polymerase chain reaction were cloned into plasmid expression vectors (pET series) and the expressed polypeptides were probed with scleroderma sera from seven different patients immunoreactive with topoisomerase I. All sera reacted selectively with ...

journal_title：Molecular immunology

authors： Piccinini G,Cardellini E,Reimer G,Arnett FC,Durban E

更新日期：1991-04-01 00:00:00

abstract：:Previous investigation have demonstrated the presence of the Rho(D) antigen in Rh negative erythrocytes. The intact Rh negative cell, however, does not bind anti-D IgG. Presently we have shown that an anti-D binding antigen resides on the cytoplasmic surface of Rh negative erythrocyte membranes. Unsealed Rh negative m...

journal_title：Molecular immunology

authors： Evans JP,Brown PJ,Sinor LT,Tilzer LL,Beck M,Plapp FV

更新日期：1983-05-01 00:00:00

abstract：:Serotonin release from rat basophilic leukemia (RBL) cells, sensitized with a DNP-binding monoclonal IgE, was stimulated with solid surface (polystyrene)-bound DNP-amino acids. The stimulatory potency of DNP-amino acids was dependent on the structure of amino acid attached to DNP. Generally, DNP-amino acids with high ...

journal_title：Molecular immunology

authors： Varga JM,Kalchschmid G,Klein GF,Fritsch P

更新日期：1991-06-01 00:00:00

abstract：:Glucocorticoids down regulate the inducible nitric oxide synthase (iNOS) gene both transcriptionally and post-transcriptionally. The post-transcriptional events are suggested to involve destabilization of the iNOS transcript although the molecular mechanisms for this effect are not known. Recently, our laboratory demo...

journal_title：Molecular immunology

authors： Söderberg M,Raffalli-Mathieu F,Lang MA

更新日期：2007-05-01 00:00:00

abstract：:Complement plays a dual role in the progression of systemic lupus erythematosus since it has important protective functions, such as the clearance of immune complexes and apoptotic cells, but is also a mediator of renal inflammation. To investigate this balance in a clinically relevant setting, we investigated how tar...

journal_title：Molecular immunology

authors： Sekine H,Ruiz P,Gilkeson GS,Tomlinson S

更新日期：2011-10-01 00:00:00

abstract：:Cell-cell signaling represents an essential hallmark of multicellular organisms, which necessarily require a means of communicating between different cell populations, particularly immune cells. Cytokine receptor signaling through the Janus kinase/Signal Transducer and Activator of Transcription/Suppressor of Cytokine...

journal_title：Molecular immunology

authors： Liongue C,Taznin T,Ward AC

更新日期：2016-03-01 00:00:00

abstract：:Candida albicans the most frequently isolated clinical fungal pathogen can cause local as well as systemic and life-threatening infections particularly in immune-compromised individuals. A better and more detailed understanding how C. albicans evades human immune attack is therefore needed for identifying fungal immun...

journal_title：Molecular immunology

authors： Luo S,Dasari P,Reiher N,Hartmann A,Jacksch S,Wende E,Barz D,Niemiec MJ,Jacobsen I,Beyersdorf N,Hünig T,Klos A,Skerka C,Zipfel PF

更新日期：2018-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are now recognized as important regulators of all cellular processes, including immune function and cancer survival. These evolutionary preserved, single-stranded, non-coding RNA molecules mediate important functional effects primarily through post-transcriptional regulation of protein expression. M...

journal_title：Molecular immunology

authors： Saultz JN,Freud AG,Mundy-Bosse BL

更新日期：2019-11-01 00:00:00

abstract：:The T-cell surface proteins CD4 (L3T4) and CD8 (Lyt2) are first expressed on thymocytes as they undergo maturation in the thymus. Two immature T-lymphoma cell clones SL12.4 and RS4.2 which constitutively express low or undetectable levels of CD4 and CD8 were used to investigate the activation of CD4 and CD8 gene expre...

journal_title：Molecular immunology

authors： Wilkinson MF,Fong AM,Huynh H,Hays EF,MacLeod CL

更新日期：1991-01-01 00:00:00

abstract：:T-cell receptor (TCR) repertoire diversity, thymic output, clonal size and peripheral T-lymphocyte numbers largely depend on intra-thymic and post-thymic T-lymphocyte proliferation. However, quantitative insight into thymocyte and T-lymphocyte proliferation is still lacking. We developed a new TCRG-based TCR excision ...

journal_title：Molecular immunology

authors： van der Weerd K,Dik WA,Schrijver B,Bogers AJ,Maat AP,van Nederveen FH,van Hagen PM,van Dongen JJ,Langerak AW,Staal FJ

更新日期：2013-03-01 00:00:00

abstract：:Mugwort (Artemisia vulgaris) belongs to the Compositae family, and is one of the main causes of allergy in late summer and autumn. The aim of the study was to characterize the allergen Art v 2 from mugwort pollen. Skin prick tests, performed in 19 patients allergic to mugwort and 10 control patients, showed an Art v 2...

journal_title：Molecular immunology

authors： Arilla MC,Ibarrola I,Puente Y,Daza JC,Martínez A,Asturias JA

更新日期：2007-07-01 00:00:00

abstract：:Suppressor of cytokine signaling 3 (SOCS3) is a negative regulator of TBK1 and interferon pathway and the expression of SOCS3 is closely correlated with symptoms of influenza patients. However, whether deletion of Socs3 in the lung epithelial cells would affect influenza lung replication and inflammation in vivo is un...

journal_title：Molecular immunology

authors： Li L,Wu H,Li Q,Chen J,Xu K,Xu J,Su X

更新日期：2020-09-01 00:00:00

abstract：:The host response to intravascular, Gram-negative bacteria includes profound immunologic, hematologic and physiologic changes. Numerous host defense mechanisms are activated by Gram-negative bacteria, including the complement system. Activation of the complement system leads to cleavage of C5 with subsequent generatio...

journal_title：Molecular immunology

authors： Hollmann TJ,Mueller-Ortiz SL,Braun MC,Wetsel RA

更新日期：2008-04-01 00:00:00

abstract：:Jackfruit lectin, jacalin, prepared from two batches of jackfruit seeds showed a different specificity in precipitating reaction in Agarose gel with various purified immunoglobulins and secretory components. Jacalin-P, extracted from jackfruit seeds from the Philippines, reacts only with serum IgA and secretory IgA of...

journal_title：Molecular immunology

authors： Kondoh H,Kobayashi K,Hagiwara K

更新日期：1987-11-01 00:00:00

abstract：:The role of glycosylation in membrane expression and secretion of IgM and IgA was investigated in murine lymphoma and hybridoma cell lines, derived from I.29 tumor, which synthesize IgM or IgA with identical variable regions. Tunicamycin, a selective inhibitor of N-linked glycosylation, prevented the membrane expressi...

journal_title：Molecular immunology

authors： Sitia R,Rubartelli A,Hämmerling U

更新日期：1984-08-01 00:00:00

abstract：:The complement system is a vital component of the immune-priveliged human eye that is always active at a low-grade level, preventing harmful intraocular injuries caused by accumulation of turnover products and controlling pathogens to preserve eye homeostasis and vision. The complement system is a double-edged sword t...

journal_title：Molecular immunology

authors： Mohlin C,Sandholm K,Ekdahl KN,Nilsson B

更新日期：2017-09-01 00:00:00

abstract：:We have previously used immunoelectron microscopy (IEM) to generate a three-dimensional map of idiotypic (Id) and isotypic epitopes on the Fab arms of HGAC 39 (Roux et al., 1987, Proc. natn. Acad. Sci. U.S.A. 84, 4984-4988), a mouse IgG3 monoclonal antibody (Mab). In this report, we analyse the geometry of the various...

journal_title：Molecular immunology

authors： Roux KH,Greenspan NS

更新日期：1994-06-01 00:00:00

abstract：:We recently identified IgE-binding epitopes of bovine serum albumin (BSA), the major beef allergen, and found that the major epitope structure contains an EXXV motif. Here we report hypoallergenic analogue peptides of BSA that preserve T cell reactivity to retain the capacity to induce immunotolerance. Substitution of...

journal_title：Molecular immunology

authors： Tanabe S,Shibata R,Nishimura T

更新日期：2004-07-01 00:00:00

abstract：:Dendritic cells (DCs) play an important role in antigen presentation, which is an essential step for the induction of antigen-specific adaptive immunity. Inactivated bacterial whole cell vaccines have been widely used to prevent many bacterial infections because they elicit good immunogenicity due to the presence of v...

journal_title：Molecular immunology

authors： Kim HY,Kim SK,Seo HS,Jeong S,Ahn KB,Yun CH,Han SH

更新日期：2018-09-01 00:00:00

abstract：:Mangiferin is the major bioactive ingredient in the leaves of Mangifera indica L., Aqueous extract of such leaves have been traditionally used as an indigenous remedy for respiratory diseases including cough and asthma in Traditional Chinese Medicine. Mangiferin was shown to exert its anti-asthmatic effect by modulati...

journal_title：Molecular immunology

authors： Yun C,Chang M,Hou G,Lan T,Yuan H,Su Z,Zhu D,Liang W,Li Q,Zhu H,Zhang J,Lu Y,Deng J,Guo H

更新日期：2019-10-01 00:00:00

abstract：:Monoclonal antibodies to cyclosporine A (Cs), a potent immunosuppressant, were generated in BALB/c mice using a novel antigen prepared by linking Cs to a protein carrier via a photoactive cross-linking reagent, 4-benzoylbenzoic acid (BBa). Twenty-two monoclonal anti-Cs antibodies were generated, using Cs-BBa-bovine se...

journal_title：Molecular immunology

authors： Cacalano NA,Aggarwal R,Quesniaux VF,Cleveland WL,Erlanger BF

更新日期：1992-01-01 00:00:00

abstract：:We have investigated the chemical structure of the antigenic determinant of Candida krusei cell-wall mannan. Acetolysis of the mannan, obtained by extraction with alkali and purified as copper complex, gave five oligosaccharides (from mono- to pentasaccharide) and a minor amount of an octasaccharide. Partial acetolysi...

journal_title：Molecular immunology

authors： Nishikawa A,Shinoda T,Fukazawa Y

更新日期：1982-03-01 00:00:00

abstract：:Toll-like receptors (TLRs) are a family of highly conserved germline-encoded pattern-recognition receptors (PRRs) and are essential for host immune response. Little is known regarding the activation mechanism of TLRs especially of the TLR7/8/9 subfamily. Here we cloned and characterized bovine TLR8 (bTLR8) and found t...

journal_title：Molecular immunology

authors： Zhu J,Brownlie R,Liu Q,Babiuk LA,Potter A,Mutwiri GK

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Dendritic cells (DCs) and regulatory T (Treg) cells are crucial for inducing immune tolerance. However, the suppressive function of infused Treg cells and immature DCs (imDCs) following solid organ transplantation remains unclear. METHODS:ImDCs derived from DA-donor rats and Treg cells isolated from spleens...

journal_title：Molecular immunology

authors： He W,Chen L,Zheng L,Luo L,Gao L

更新日期：2016-11-01 00:00:00

abstract：:Tunicamycin inhibited the synthesis of glycosylated mu-chains and kappa-chains in the human lymphoblastoid cell line, Daudi. Nonglycosylated IgM could not be detected on the surface of tunicamycin-treated cells by cell surface iodination techniques even under conditions where membrane IgM was re-expressed in control c...

journal_title：Molecular immunology

authors： Kubo RT,Pelanne ML

更新日期：1983-01-01 00:00:00

abstract：:T-cell-replacing factor (TRF)/IL-5 is a T-cell-derived glycoprotein which has pleiotropic activity on lymphoid and myeloid cells. IL-5 polypeptide translated into Xenopus oocytes are heterogeneous in molecular size (40,000 to 60,000 under nonreducing conditions) and yields a monomeric form (Mr of 25,000 to 30,000) und...

journal_title：Molecular immunology

authors： Takahashi T,Yamaguchi N,Mita S,Yamaguchi Y,Suda T,Tominaga A,Kikuchi Y,Miura Y,Takatsu K

更新日期：1990-09-01 00:00:00

abstract：:Based on our findings that HIV-1 gp41 independently of CD4, can bind to the helper T-cell line H9, we characterized putative binding of HIV-1 gp41 to B-cell lines, Raji, Bjab and Ramos. Using fluorescence-activated cell sorter (FACS) we examined the binding of soluble gp41 (sgp41; Env amino acid 539-684) to these B-ce...

journal_title：Molecular immunology

authors： Chen YH,Böck G,Vornhagen R,Steindl F,Katinger H,Dierich MP

更新日期：1993-09-01 00:00:00

abstract：:ANCA associated vasculitis is a serious, very often recurrent disease that despite the current standard treatment with high-dose glucocorticoids and either cyclophosphamide or rituximab, patients have a nine-fold increased mortality risk in the first year compared with healthy controls, attributed to infections, vascu...

journal_title：Molecular immunology

authors： Quintana LF,Kronbichler A,Blasco M,Zhao MH,Jayne D

更新日期：2019-08-01 00:00:00

abstract：:Increasing lines of evidence indicate that arsenic may be associated with immune related problems, but its detailed effects on immune organs are poorly understood. The objective of this study was to explore inflammatory responses and T cell differentiation of arsenic exposure in spleen and thymus. Female C57BL/6 mice ...

journal_title：Molecular immunology

authors： Duan X,Gao S,Li J,Wu L,Zhang Y,Li W,Zhao L,Chen J,Yang S,Sun G,Li B

更新日期：2017-01-01 00:00:00