Abstract：
:Conserved extended haplotypes (CEHs) are large (>or=1Mb) regions of identical DNA of the major histocompatibility complex (MHC) region of chromosome 6p in unrelated individuals. They are recognized by family studies and constitute nearly half of MHC haplotypes among European Caucasians. We studied 49 Hungarian Caucasian families in comparison with the previous findings in 2675 normal American Caucasian chromosomes from families in the Boston area. Besides HLA-A, -B and HLA-DRB1/-DQB1 alleles, copy number polymorphism of C4A and C4B genes and several SNPs encoded in the central (class III) MHC region were determined. By comparing 188 Caucasian haplotypes in Hungary to 2675 normal Caucasian chromosomes in Boston, we found that 11 of 12 of the most common CEHs (with a frequency of at least 1%) among the Boston chromosomes also occurred in Hungary. Moreover, there was a significant correlation (R=0.789; p=0.0023) in the frequency order of these haplotypes between the two Caucasian populations. Of 10 haplotypes found in >or=2 copies among the Hungarian chromosomes, all but one occurred in one to 14 copies among the Boston haplotypes. These findings indicate that CEHs are commonly shared by distinct European Caucasian populations; however, lower frequency CEHs may differ.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Szilágyi A,Bánlaki Z,Pozsonyi E,Yunis EJ,Awdeh ZL,Hossó A,Rajczy K,Larsen CE,Fici DA,Alper CA,Füst Gdoi
10.1016/j.molimm.2010.03.013subject
Has Abstractpub_date
2010-06-01 00:00:00pages
1899-904issue
10eissn
0161-5890issn
1872-9142pii
S0161-5890(10)00107-0journal_volume
47pub_type
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