BRAF splice variants in rheumatoid arthritis synovial fibroblasts activate MAPK through CRAF.

abstract：:Porcine deltacoronavirus (PDCoV) is an emerging swine coronavirus causing diarrhea and intestinal damage in nursing piglets. Previous work showed that PDCoV infection inhibits type I interferon (IFN) production. To further identify and characterize the PDCoV-encoded IFN antagonists will broaden our understanding of it...

journal_title：Molecular immunology

authors： Liu X,Fang P,Fang L,Hong Y,Zhu X,Wang D,Peng G,Xiao S

更新日期：2019-10-01 00:00:00

abstract：:Human complement components C6 and C7 have been purified and characterized. Component C6 is a single-chain plasma protein of mol. wt 104,800 containing 3.8% carbohydrate and it has alanine as the amino terminal residue. Component C7 is a single-chain plasma protein of mol. wt 92,400 containing 6.4% carbohydrate and it...

journal_title：Molecular immunology

authors： Discipio RG,Gagnon J

更新日期：1982-11-01 00:00:00

abstract：:Rabbit antisera specific for horseradish peroxidase inhibit the catalytic activity of the enzyme. All antibodies prepared against the holoenzyme react with the peroxidase apoenzyme. However, only a minority (30-45%) of the total antiperoxidase pool cross react with reduced and alkylated apoenzymes. The antibodies inhi...

journal_title：Molecular immunology

authors： Conroy JM,Salter RD

更新日期：1982-05-01 00:00:00

abstract：:Anti-DNP activity was found in normal human immunoglobulins with average affinities (10(4)-10(6) l/mole) and frequencies (15-2%) that correlate well with those expected from multispecific binding sites. ...

journal_title：Molecular immunology

authors： Ortega E,Kostovetzky M,Larralde C

更新日期：1984-10-01 00:00:00

abstract：:The membrane anchored ligand ephrinB2 belongs to the broad Eph/ephrin system and is able to activate different Eph receptors. The Eph receptors belong to the huge group of receptor-tyrosine kinases. Eph receptors as well as their corresponding ephrin ligands are cell-membrane attached proteins. Therefore, direct cell-...

journal_title：Molecular immunology

authors： Poitz DM,Ende G,Stütz B,Augstein A,Friedrichs J,Brunssen C,Werner C,Strasser RH,Jellinghaus S

更新日期：2015-12-01 00:00:00

abstract：:The expression and ligand binding activity of Fc receptors for IgG (Fc gamma R) on guinea-pig peripheral blood polymorphonuclear leukocytes (blood PMN) have been compared with those on casein-elicited peritoneal PMN (exudate PMN). Both the PMN were found to express two distinct types of Fc gamma R, one specific for Ig...

journal_title：Molecular immunology

authors： Fukuchi Y,Sato M,Yamashita T,Koyama J

更新日期：1992-05-01 00:00:00

abstract：:Following measles virus (MV) infection, viral peptides are presented to CTL by MHC class I molecules on infected antigen presenting cells at widely different epitope densities. Whereas three MV epitopes (MV-M(211-219), MV-F(438-446) and MV-H(30-38)) derived from different structural proteins occur at regular densities...

journal_title：Molecular immunology

authors： Herberts CA,Meiring HM,van Gaans-van den Brink JA,van der Heeft E,Poelen MC,Boog CJ,de Jong AP,van Els CA

更新日期：2003-01-01 00:00:00

abstract：:The potency of a T cell is determined in large part by two interactions, binding of a cognate peptide to the MHC, and binding of the T cell receptor (TCR) to this pepMHC. Various studies have attempted to assess the relative importance of these interactions, and to correlate the corresponding binding parameters with t...

journal_title：Molecular immunology

authors： Bowerman NA,Crofts TS,Chlewicki L,Do P,Baker BM,Christopher Garcia K,Kranz DM

更新日期：2009-09-01 00:00:00

abstract：:Infection of ruminants and humans with Fasciola gigantica is attracting increasing attention due to its economic impact and public health significance. However, little is known of innate immune responses during F. gigantica infection. Here, we investigated the expression profiles of genes involved in Toll-like recepto...

journal_title：Molecular immunology

authors： Zhang FK,Hou JL,Guo AJ,Tian AL,Sheng ZA,Zheng WB,Huang WY,Elsheikha HM,Zhu XQ

更新日期：2018-02-01 00:00:00

abstract：:The development and progression of systemic lupus erythematosus (SLE) is strongly associated with complement activation and deposition. The anaphylatoxin C3a is a product of complement activation with immunomodulatory properties, and the receptor for C3a (C3aR) is not only expressed by granulocytes and antigen present...

journal_title：Molecular immunology

authors： Wenderfer SE,Wang H,Ke B,Wetsel RA,Braun MC

更新日期：2009-04-01 00:00:00

abstract：:Asthma is a chronic respiratory disease which is susceptible to children and causes great harm to them. Recently, Interferon-related developmental regulator 1 (IFRD1) was proved to be participant in regulating lung diseases, and its abnormal expression was shown in pathological airway tissues. Our study aimed to demon...

journal_title：Molecular immunology

authors： Chang M,Zhang Y,Hui Z,Wang D,Guo H

更新日期：2020-11-01 00:00:00

abstract：:Symmetry in antibody plus complement mediated killing between a T15 idiotype-bearing monoclonal antibody (HPC-M2) and an anti-T15 monoclonal antibody (B36-82) is demonstrated. The HPC-M2 antibody is also shown to be multispecific in its effector function, since it lyses both phosphorylcholine coated erythrocytes, and ...

journal_title：Molecular immunology

authors： Cooper-Willis A,Hoffmann GW

更新日期：1983-08-01 00:00:00

abstract：:The cell-surface receptor ST2L triggers cytokine release by immune cells upon exposure to its ligand IL-33. To study the effect of ST2L-dependent signaling in different cell types, we generated antagonist antibodies that bind different receptor domains. We sought to characterize their activities in vitro using both tr...

journal_title：Molecular immunology

authors： Fursov N,Lu J,Healy C,Wu SJ,Lacy E,Filer A,Li Y,Liu C,Lamb R,Jones B,Reddy R,Petley T,Duffy K

更新日期：2016-07-01 00:00:00

abstract：:In this work, we show that P2 nucleotide receptors control lipopolysaccharide (LPS)-induced neutrophil migration in the mouse air pouch model. Neutrophil infiltration in LPS-treated air pouches was reduced by the intravenous (iv) administration of the non-selective P2 receptor antagonist PPADS but not by suramin and R...

journal_title：Molecular immunology

authors： Kukulski F,Ben Yebdri F,Bahrami F,Lévesque SA,Martín-Satué M,Sévigny J

更新日期：2010-01-01 00:00:00

abstract：:Major histocompatibility complex (MHC) has a profound influence on disease resistance or susceptibility, productivity and important economic traits in chicken. Association of the MHC with a wide range of immune responses makes it a valuable predictive factor for the disease pathogenesis and outcome. The tandem repeat ...

journal_title：Molecular immunology

authors： Esmailnejad A,Nikbakht Brujeni G,Badavam M

更新日期：2017-10-01 00:00:00

abstract：:Bombyx mori nucleopolyhedrovirus (BmNPV) is one of the main pathogens that seriously affect the sustainable development of sericulture industry. Inhibition of Hsp90 by Hsp90 inhibitor, geldanamycin (GA) significantly suppresses BmNPV proliferation in Bombyx mori, while the functional mechanism is not clear. LncRNA has...

journal_title：Molecular immunology

authors： Yin H,Shang Q,Zhang S,Shen M,Huang H,Zhao W,Xijie G,Wu P

更新日期：2020-11-01 00:00:00

abstract：:A major goal in HIV-1 vaccine research is to develop an immunogen that can elicit broadly neutralizing antibodies that efficiently neutralize a wide range of the HIV-1 subtypes. Using biopanning procedure we have selected linear peptide VGAFGSFYRLSVLQS mimicking the structure of discontinuous binding sites of broadly ...

journal_title：Molecular immunology

authors： Karpenko LI,Scherbakova NS,Chikaev AN,Tumanova OY,Lebedev LR,Shalamova LA,Pyankova OG,Ryzhikov AB,Ilyichev AA

更新日期：2012-04-01 00:00:00

abstract：:The aim of the study was to explore whether fever-range hyperthermia (FRH) might enhance the anticancer and immunoregulatory activities of protein-bound polysaccharides (PBP), a class of fungus derived immunomodifiers used in the cancer adjuvant therapy. Blood lymphocytes and breast cancer cells (MCF-7) were cultured ...

journal_title：Molecular immunology

authors： Pawlikowska M,Jędrzejewski T,Piotrowski J,Kozak W

更新日期：2016-12-01 00:00:00

abstract：:The mast cell function-associated antigen (MAFA) is a type II membranal glycoprotein that was first identified on the surface of rat mucosal-type mast cells of the RBL-2H3 line. A C-type lectin domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM) are located in the extracellular and intracellular domain...

journal_title：Molecular immunology

authors： Abramson J,Xu R,Pecht I

更新日期：2002-09-01 00:00:00

abstract：:The B1 molecule (CD20) is a phosphoprotein expressed only by B-lymphocytes. In this study, analysis of B1 immunoprecipitated from surface iodinated B-cell lines and B-lymphocytes has shown that there are several expressed forms of B1. A predominant species of Mr 33,000 represents 75-80% of the iodinated cell surface B...

journal_title：Molecular immunology

authors： Tedder TF,McIntyre G,Schlossman SF

更新日期：1988-12-01 00:00:00

abstract：:In this paper, we performed further biochemical characterization of the CD26 antigen, as defined by the mAbs in anti-1F7 and anti-Ta1, in order to clarify the observed functional differences among these mAbs. For this purpose, we developed a mAb, anti-5F8, which recognizes yet another epitope on the CD26 antigen diffe...

journal_title：Molecular immunology

authors： Torimoto Y,Dang NH,Tanaka T,Prado C,Schlossman SF,Morimoto C

更新日期：1992-02-01 00:00:00

abstract：:The insect gut participates in initial local immune responses by producing reactive oxygen and nitrogen species as well as anti-microbial peptides to resist pathogenic invasions. Nitric oxide (NO), a signaling and an immune effector molecule synthesized by the enzyme NO synthase (NOS), mediates an early step of the si...

journal_title：Molecular immunology

authors： Liu W,Wang Y,Leng Z,Wang Q,Duan X,Luo Y,Jiang Y,Qin L

更新日期：2020-10-01 00:00:00

abstract：:With the exception of a few strains such as BuB/BnJ, complement activity in most inbred strains of mice is remarkably similar. The BuB/BnJ strain reportedly has high levels of complement activity and elevated serum levels of C3 and other complement proteins. However, we observed that BuB/BnJ mice have serum C3 levels ...

journal_title：Molecular immunology

authors： Osmers I,Szalai AJ,Tenner AJ,Barnum SR

更新日期：2006-04-01 00:00:00

abstract：:The Fc region of IgG antibodies is crucial for binding to Fc receptors expressed on the surfaces of various immune leukocytes and eliciting therapeutic effector functions such as clearance of antibody-opsonized tumor cells. Despite abrogated Fc gamma receptor (FcγR) binding and therapeutic effector function in the abs...

journal_title：Molecular immunology

authors： Yoon HW,Jo M,Ko S,Kwon HS,Lim CS,Ko BJ,Lee JC,Jung ST

更新日期：2019-10-01 00:00:00

abstract：:Bcl-2 translocations in follicular lymphomas (FL) are often associated with downstream immunoglobulin class switch recombination (CSR) on the translocated allele. We studied cell lines with different translocations into the IgH locus to gauge any common features associated with downstream CSR events. CSR associated wi...

journal_title：Molecular immunology

authors： Hughes JA,Weckert HA,van Holst Pellekaan C,Benson EM,Dunn IS

更新日期：2003-12-01 00:00:00

abstract：:We have determined the cDNA sequence encoding J chain, a polypeptide accessory molecule associated with polymeric Ig, from the anuran amphibian, Xenopus laevis (South African clawed frog). The translated polypeptide consists of 164 amino acid residues, including the signal sequence, and is somewhat longer than the cor...

journal_title：Molecular immunology

authors： Hohman VS,Stewart SE,Willett CE,Steiner LA

更新日期：1997-10-01 00:00:00

abstract：:Human IgE against helminths is a normal component of the whole protective response elicitesd during infection, when specific IgE to a great number of antigens is produced; however, few of those IgE binding components are actually allergens. In general, considering the strong Th2/IgE responses during helminth infection...

journal_title：Molecular immunology

authors： Caraballo L,Coronado S

更新日期：2018-08-01 00:00:00

abstract：:Ligation of the B cell Ag receptor (BCR) activates a protein-tyrosine kinase (PTK) and CD45 protein-tyrosine phosphatase (PTPase)-dependent signaling cascade that results in the activation of Ras. This pathway of Ras activation can operate independently of protein kinase C (PKC) activity. Activation of Ras may lead to...

journal_title：Molecular immunology

authors： Kawauchi K,Lazarus AH,Sanghera JS,Man GL,Pelech SL,Delovitch TL

更新日期：1996-02-01 00:00:00

abstract：:Gene regulatory network (GRN) subcircuits have been described for cell fate progressions in animal development. The hallmark of these subcircuits is the integration of promoters, and positive- and negative-acting promoter binding proteins, such that an alteration in function of any one member of the defined subcircuit...

journal_title：Molecular immunology

authors： Xu L,Niesen MI,Blanck G

更新日期：2009-02-01 00:00:00

abstract：:A 30,000 mol. wt component (beta) is associated in a 1:1 ratio with the 50,000 mol. wt glycoprotein (alpha) which binds immunoglobulin E (IgE) on mast cells and related tumor cells. We show that alpha and beta are associated in membrane preparations. This is consistent with previous results which showed labeling of be...

journal_title：Molecular immunology

authors： Holowka D,Metzger H

更新日期：1982-02-01 00:00:00