Complement in BuB/BnJ mice revisited: serum C3 levels and complement opsonic activity are not elevated.


:With the exception of a few strains such as BuB/BnJ, complement activity in most inbred strains of mice is remarkably similar. The BuB/BnJ strain reportedly has high levels of complement activity and elevated serum levels of C3 and other complement proteins. However, we observed that BuB/BnJ mice have serum C3 levels comparable to those seen in C57BL/6, Balb/c and several other strains of inbred mice. More importantly, using bacteria as a substrate for activation and deposition of complement as a direct biological assay to assess serum complement opsonic activity, we found that BuB/BnJ mice do not have elevated complement activity compared to other inbred mouse strains. In contrast hemolytic assays indicate BuB/BnJ sera to be most active. These results indicate that accepted views regarding mouse serum complement activity need to be re-examined.


Mol Immunol


Molecular immunology


Osmers I,Szalai AJ,Tenner AJ,Barnum SR




Has Abstract


2006-04-01 00:00:00














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    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Ramasawmy R,Faé KC,Cunha-Neto E,Borba SC,Ianni B,Mady C,Goldberg AC,Kalil J

    更新日期:2008-01-01 00:00:00

  • Demonstration of two distinct antigenic determinants on human alpha-foetoprotein by monoclonal antibodies.

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    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Nomura M,Imai M,Nakamura T,Miyakawa Y,Mayumi M

    更新日期:1982-12-01 00:00:00

  • Cellular uptake followed by class I MHC presentation of some exogenous peptides contributes to T cell stimulatory capacity.

    abstract::The T cell stimulatory activity of peptides is known to be associated with the cell surface stability and lifetime of the peptide-MHC (pepMHC) complex. In this report, soluble high-affinity T cell receptors (TCRs) that are specific for pepMHC complexes recognized by the mouse CD8+ clone 2C were used to monitor the cel...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Brophy SE,Jones LL,Holler PD,Kranz DM

    更新日期:2007-03-01 00:00:00

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    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Hitschold T,Golan MD,Rabs U,Loos M

    更新日期:1983-02-01 00:00:00

  • Fine molecular analysis of the antigenicity of the Androctonus australis hector scorpion neurotoxin II: a new antigenic epitope disclosed by the Pepscan method.

    abstract::A set of 58 overlapping rod-bound peptides was used to map the antigenic reactivity pattern of a 64-residue neurotoxin (AaH II) from the venom of the scorpion Androctonus australis hector. Five anti-toxin rabbit antisera were assayed serially for their capacity to bind to each peptide in the set. Six regions of antige...

    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Devaux C,Juin M,Mansuelle P,Granier C

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    journal_title:Molecular immunology

    pub_type: 杂志文章


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    更新日期:2013-12-01 00:00:00

  • HIV-1 gp41 binds to several proteins on the human B-cell line, Raji.

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    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Chen YH,Böck G,Vornhagen R,Steindl F,Katinger H,Dierich MP

    更新日期:1993-09-01 00:00:00

  • Immunochemical determinant and serological specificity of Candida krusei.

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    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Nishikawa A,Shinoda T,Fukazawa Y

    更新日期:1982-03-01 00:00:00

  • Role of MAIT cells in metabolic diseases.

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    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Toubal A,Lehuen A

    更新日期:2021-02-01 00:00:00

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    pub_type: 杂志文章


    authors: Cacalano NA,Aggarwal R,Quesniaux VF,Cleveland WL,Erlanger BF

    更新日期:1992-01-01 00:00:00

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    journal_title:Molecular immunology

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    authors: Goswami KK,Barik S,Sarkar M,Bhowmick A,Biswas J,Bose A,Baral R

    更新日期:2014-06-01 00:00:00

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    journal_title:Molecular immunology

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


    authors: Schmidt T,Luebbe J,Paust HJ,Panzer U

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    authors: Costa MM,Maehr T,Diaz-Rosales P,Secombes CJ,Wang T

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    pub_type: 评论,信件


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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Xia S,Guo Z,Yao Y,Xu X,Yi H,Xia D,Cao X

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    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


    authors: Pouw RB,Vredevoogd DW,Kuijpers TW,Wouters D

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    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Fukuchi Y,Sato M,Yamashita T,Koyama J

    更新日期:1992-05-01 00:00:00

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    pub_type: 杂志文章


    authors: Ren J,Nettleship JE,Harris G,Mwangi W,Rhaman N,Grant C,Kotecha A,Fry E,Charleston B,Stuart DI,Hammond J,Owens RJ

    更新日期:2019-08-01 00:00:00

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    journal_title:Molecular immunology

    pub_type: 杂志文章


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    更新日期:1994-05-01 00:00:00

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    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Saldanha JW,Martin AC,Léger OJ

    更新日期:1999-08-01 00:00:00

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    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Shenker BJ,Boesze-Battaglia K,Zekavat A,Walker L,Besack D,Ali H

    更新日期:2010-11-01 00:00:00

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    journal_title:Molecular immunology

    pub_type: 杂志文章


    authors: Vremec D,Hansen J,Strasser A,Acha-Orbea H,Zhan Y,O'Keeffe M,Shortman K

    更新日期:2015-02-01 00:00:00