Abstract:
:Multiple organ dysfunction syndrome (MODS) is a major cause of morbidity and mortality in surgical intensive care units. It is characterized by progressive failure of two or more organs remote from the origin of injury. Since MODS results from a severe generalized inflammatory response, both chemokines and complement have had a proposed role in its pathophysiology. The availability of macrophage inflammatory protein 1 alpha (MIP-1alpha) knockout mice and congenic C5-deficient and C5-sufficient mice allowed us to investigate the individual contribution of these immune modulators in MODS. It has been demonstrated in this assay that MIP-1alpha has a protective role against MODS mortality, while C5a contributes to MODS mortality. Using a zymosan-induced MODS murine model, the absence of MIP-1alpha increased mortality four-fold, whereas the absence of C5 decreased mortality four-fold. Therefore, MIP-1alpha-dependent mediators are essential in the prevention of MODS related deaths, while C5-dependent mediators of inflammation can be considered to be contributing to the development of MODS related deaths.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Miller CG,Cook DN,Kotwal GJdoi
10.1016/s0161-5890(96)00077-6subject
Has Abstractpub_date
1996-10-01 00:00:00pages
1135-7issue
14eissn
0161-5890issn
1872-9142pii
S0161589096000776journal_volume
33pub_type
杂志文章abstract::To understand the mechanism of action of the chaperone protein tapasin, which mediates loading of high-affinity peptides onto major histocompatibility complex (MHC) class I molecules in the antiviral immune response, we have performed numerical simulations of the class I-peptide binding process with four different mec...
journal_title:Molecular immunology
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pub_type: 杂志文章,评审
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journal_title:Molecular immunology
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pub_type: 杂志文章
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journal_title:Molecular immunology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2000-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Molecular immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1988-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2005.10.007
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pub_type: 杂志文章
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journal_title:Molecular immunology
pub_type: 杂志文章,评审
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更新日期:2018-08-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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更新日期:1992-02-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2009.03.008
更新日期:2009-06-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(93)90069-n
更新日期:1993-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0161-5890(84)90094-4
更新日期:1984-01-01 00:00:00
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pub_type: 杂志文章
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