当前位置： SCI文献检索 > MOLECULAR IMMUNOLOGY期刊下所有文献 > Calcium signaling in B cells: regulation of cytosolic Ca2+ increase and its sensor molecules, STIM1 and STIM2.

Calcium signaling in B cells: regulation of cytosolic Ca2+ increase and its sensor molecules, STIM1 and STIM2.

Abstract：

:Calcium signals are crucial for diverse cellular functions including adhesion, differentiation, proliferation, effector functions and gene expression. After engagement of the B cell receptor, the intracellular calcium ion (Ca(2+)) concentration is increased promoting the activation of various signaling cascades. While elevated Ca(2+) in the cytosol initially comes from the endoplasmic reticulum (ER), a continuous influx of extracellular Ca(2+) is required to maintain the increased level of cytosolic Ca(2+). Store-operated Ca(2+) entry manages this process, which is regulated by an ER calcium sensor, stromal interaction molecule (STIM). STIM proteins sense changes in the levels of Ca(2+) stored within the ER lumen and regulates the Ca(2+)-release activated Ca(2+) channel in the plasma membrane. This review focuses on the signaling pathways leading to Ca(2+) influx and the role of Ca(2+) signals in B cell functions.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Baba Y,Matsumoto M,Kurosaki T

doi

10.1016/j.molimm.2013.10.006

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

339-43

issue

2

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(13)00532-4

journal_volume

62

pub_type

杂志文章,评审

相关文献

MOLECULAR IMMUNOLOGY文献大全
  • Hydrophilic-amphiphilic transition of the terminal SC5b-8 complement complex through tryptic modification: biochemical and ultrastructural studies.

    abstract：:the SC5b-8 complex of human complement is a hydrophilic molecule of mol. wt 800,000-850,000 that is seen in the electron microscope as an elongated, straight or curved structure of 50-55 nm total length and 8-9 nm width. Tryptic attack on the fluid-phase complex exposes lipid-binding surfaces on the molecule. The tryp...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(82)90327-3

    authors： Bhakdi S,Tranum-Jensen J

    更新日期：1982-09-01 00:00:00

  • Monoclonal antibodies directed to the blood group A associated structure, galactosyl-A: specificity and relation to the Thomsen-Friedenreich antigen.

    abstract：:Two monoclonal antibodies, HH8 and HH9, have been established after immunization of mice with galactosyl-A glycolipid antigen having the terminal structure, Gal beta 1----3GalNAc alpha 1----3[Fuc alpha 1----2]Gal beta 1----R, which is the precursor for type 3 chain A (repetitive A) and type 3 chain H (A-associated H)....

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(88)90068-5

    authors： Clausen H,Stroud M,Parker J,Springer G,Hakomori S

    更新日期：1988-02-01 00:00:00

  • Salmonella O antigen-specific oligosaccharide-octyl conjugates activate complement via the alternative pathway at different rates depending on the structure of the O antigen.

    abstract：:Artificial Salmonella serogroup B, D or Cl-specific glycolipids were prepared by covalently linking oligosaccharides corresponding to two O-antigen repeating units, obtained by phage enzyme hydrolysis of native O-antigenic polysaccharides, to octyl residues. Sheep erythrocytes coated with the artificial glycolipids we...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(90)90152-p

    authors： Grossman N,Svenson SB,Leive L,Lindberg AA

    更新日期：1990-09-01 00:00:00

  • A unique Vgamma5-T-cell population in the murine mammary gland.

    abstract：:Mammary epithelia and the epidermis share a common embryologic origin. Like resident epidermal T cells (ETC), a significant number of murine mammary gland T cells (MTC) express Vgamma5-T-cell receptors (TCR). MTC were assessed to see if they express the same invariant Vgamma5/Vdelta1-TCRs as those of ETC. MTC-derived ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2005.05.010

    authors： Reardon C,Born WK,O'Brien RL

    更新日期：2006-03-01 00:00:00

  • The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways.

    abstract：:The innate immune system is the first line of defense against infection and responses are initiated by pattern recognition receptors (PRRs) that detect pathogen-associated molecular patterns (PAMPs). PRRs also detect endogenous danger-associated molecular patterns (DAMPs) that are released by damaged or dying cells. T...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2017.02.012

    authors： Vajjhala PR,Ve T,Bentham A,Stacey KJ,Kobe B

    更新日期：2017-06-01 00:00:00

  • Identification of MHC class IIbeta resistance/susceptibility alleles to Aeromonas salmonicida in brook charr (Salvelinus fontinalis).

    abstract：:Pathogen-driven selection is believed to be important in the evolution and maintenance of the polymorphism of the major histocompatibility complex (MHC) genes but have been tested for very few vertebrates. In this study, we first investigate by SSCP (single strand conformational polymorphism) the diversity found at th...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2008.03.007

    authors： Croisetière S,Tarte PD,Bernatchez L,Belhumeur P

    更新日期：2008-06-01 00:00:00

  • The molecular weight of the endothelial cell IL-1 receptor is 78,000.

    abstract：:Human endothelial cells have been shown to be distinctive from other IL-1 responsive cells (e.g. murine thymocytes), in the equal units of murine and human IL-1 do not have the same endothelial cell stimulatory effect, as measured by increased lymphocyte adherence. In this paper, the cell surface IL-1 receptors of hum...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(89)90078-3

    authors： Thieme TR,Wagner CR

    更新日期：1989-03-01 00:00:00

  • Interferon-inducible p200-family protein IFI16, an innate immune sensor for cytosolic and nuclear double-stranded DNA: regulation of subcellular localization.

    abstract：:The interferon (IFN)-inducible p200-protein family includes structurally related murine (for example, p202a, p202b, p204, and Aim2) and human (for example, AIM2 and IFI16) proteins. All proteins in the family share a partially conserved repeat of 200-amino acid residues (also called HIN-200 domain) in the C-terminus. ...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2011.11.004

    authors： Veeranki S,Choubey D

    更新日期：2012-01-01 00:00:00

  • High concentrations of therapeutic IgG1 antibodies are needed to compensate for inhibition of antibody-dependent cellular cytotoxicity by excess endogenous immunoglobulin G.

    abstract：:A common feature of human IgG1 antibodies used for cancer treatment is that their anti-tumour efficacy requires high serum trough levels and continued therapy for several months. Treatment cycles, thereby, consume several grams of IgG1 translating into significant drug needs and costs. The basis for the low in vivo ef...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2005.07.010

    authors： Preithner S,Elm S,Lippold S,Locher M,Wolf A,da Silva AJ,Baeuerle PA,Prang NS

    更新日期：2006-03-01 00:00:00

  • Involvement of multiple transcription factors in regulation of IL-β-induced MCP-1 expression in alveolar type II epithelial cells.

    abstract：:During acute lung injury, a large number of monocytes are recruited into the pulmonary tissue, which is mainly mediated by local production of monocyte chemotactic protein 1 (MCP-1). As an essential component of the lung tissues, alveolar type II epithelial cells are one of the major sources of MCP-1. Therefore, uncov...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2019.04.013

    authors： Yan C,Li B,Liu X,Deng C,Cai R,Shen Y,Tang H

    更新日期：2019-07-01 00:00:00

  • Studies of the TLR4-associated protein MD-2 using yeast-display and mutational analyses.

    abstract：:Bacterial lipopolysaccharide (LPS) activates the innate immune system by forming a complex with myeloid differentiation factor 2 (MD-2) and Toll-like receptor 4 (TLR4), which is present on antigen presenting cells. MD-2 plays an essential role in this activation of the innate immune system as a member of the ternary c...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2015.08.008

    authors： Mattis DM,Chervin AS,Ranoa DR,Kelley SL,Tapping RI,Kranz DM

    更新日期：2015-12-01 00:00:00

  • Inhibition of PIM1 kinase attenuates bleomycin-induced pulmonary fibrosis in mice by modulating the ZEB1/E-cadherin pathway in alveolar epithelial cells.

    abstract：:PIM1 is serine/threonine protein kinase that is involved in numerous biological processes. Pulmonary fibrosis (PF) is a chronic pathological result of the dysfunctional repair of lung injury without effective therapeutic treatments. In the current study, we investigated whether PIM1 inhibition would improve bleomycin ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2020.06.013

    authors： Zhang X,Zou Y,Liu Y,Cao Y,Zhu J,Zhang J,Chen X,Zhang R,Li J

    更新日期：2020-09-01 00:00:00

  • Acute arsenic exposure induces inflammatory responses and CD4+ T cell subpopulations differentiation in spleen and thymus with the involvement of MAPK, NF-kB, and Nrf2.

    abstract：:Increasing lines of evidence indicate that arsenic may be associated with immune related problems, but its detailed effects on immune organs are poorly understood. The objective of this study was to explore inflammatory responses and T cell differentiation of arsenic exposure in spleen and thymus. Female C57BL/6 mice ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2016.12.005

    authors： Duan X,Gao S,Li J,Wu L,Zhang Y,Li W,Zhao L,Chen J,Yang S,Sun G,Li B

    更新日期：2017-01-01 00:00:00

  • Antiapoptotic and immunomodulatory effects of chlorophyllin.

    abstract：:Chlorophyllin (CHL) was earlier shown to reduce the level of intracellular ROS and apoptosis induced by ionizing radiation and 2,2'-azobis(2-propionimidinedihydrochloride) (AAPH). In the present studies, the effect of CHL on radiation-induced immunosuppression and modulation of immune responses in mice was examined. C...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2006.02.031

    authors： Sharma D,Kumar SS,Sainis KB

    更新日期：2007-01-01 00:00:00

  • Comparative properties of monoclonal antibodies comprising a high-affinity anti-fluorescyl idiotype family.

    abstract：:The T-dependent BALB/c murine immune response to fluorescein (F1) is characterized by structural heterogeneity at the protein level exemplified in part by a significantly wide range of affinities (Ka), and apparent lack of dominant idiotypes. In order to generate an idiotype family, xenogenic anti-idiotype (anti-ID) a...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(85)90072-0

    authors： Bates RM,Ballard DW,Voss EW Jr

    更新日期：1985-08-01 00:00:00

  • Allergenic cross-reactivity of cytochromes c of Kentucky bluegrass and perennial ryegrass pollens.

    abstract：:The allergenic cross-reactivity of cytochromes c isolated from Kentucky bluegrass (KBG) and ryegrass (RG) pollens was demonstrated by the finding that both cytochromes elicited PCA reactions of comparable titers in rats sensitized with murine reaginic antiserum to either KBG or RG cytochrome c. However, allergenic dif...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(82)90263-2

    authors： Ekramoddoullah AK,Kisil FT,Sehon AH

    更新日期：1982-12-01 00:00:00

  • Three different hepcidins from tilapia, Oreochromis mossambicus: analysis of their expressions and biological functions.

    abstract：:Hepcidins are antimicrobial peptides that play important roles in resisting pathogenic infection. Through hybridization of a phage library, the cDNA sequences of three hepcidin-like antimicrobial peptides (named TH1-5, TH2-2, and TH2-3) in tilapia, Oreochromis mossambicus, were determined. The complete hepcidin cDNA s...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2006.09.031

    authors： Huang PH,Chen JY,Kuo CM

    更新日期：2007-03-01 00:00:00

  • The synthesis and expression of HLA-A and -B antigens in Xenopus laevis oocytes.

    abstract：:Purified mRNA's encoding the HLA-A and -B antigen heavy chains or beta 2-microglobulin were prepared from human B lymphoid cells by positive hybridization selection procedures. The role of chain association in the biosynthesis and intracellular transport of HLA-A and -B antigens was investigated by injecting these mRN...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(86)90115-x

    authors： Kinnon C,Owen MJ

    更新日期：1986-05-01 00:00:00

  • Activation of NF-κB induced by TRIMCyp showing a discrepancy between owl monkey and northern pig-tailed macaque.

    abstract：:TRIMCyp generated by retrotransposition of a cyclophilin A inserting into TRIM5 locus, has been identified in owl monkey and most of Old World monkeys (OWM). Owl monkey TRIMCyp (omTRIMCyp) inhibits HIV-1 infection by direct interaction with viral capsid and indirect innate immune induction, whereas most of TRIMCyps fr...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2018.08.001

    authors： Zhu JW,Mu D,Liu FL,Luo MT,Luo RH,Zheng YT

    更新日期：2018-09-01 00:00:00

  • Mechanisms of killing by anti-CD20 monoclonal antibodies.

    abstract：:CD20 is a cell-surface marker expressed on mature B cells and most malignant B cells, but not stem or plasma cells. It is an ideal target for monoclonal antibodies (mAb), such as rituximab and ofatumumab, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the p...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2007.06.151

    authors： Glennie MJ,French RR,Cragg MS,Taylor RP

    更新日期：2007-09-01 00:00:00

  • T-lymphocyte specificity differences to horse cytochrome c in different lymphoid cell compartments.

    abstract：:T-lymphocyte proliferative responses were determined with peripheral blood lymphocytes (PBL), peritoneal exudate lymphocytes (PEL) and lymph node lymphocytes (LNL) of guinea pigs immunized with horse cytochrome c (HCytc). The proliferative response of PBL activated by peptide 81-104 from animals immunized with HCytc w...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(88)90115-0

    authors： Wang KM,Reichlin M

    更新日期：1988-08-01 00:00:00

  • Cloning, expression analysis and functional characterization of an interleukin-1 receptor-associated kinase 4 from Apostichopus japonicus.

    abstract：:Interleukin 1 receptor-associated kinase 4 (IRAK4) is a key factor in TLR-mediated host immune function. In this study, an IRAK4 homologue molecule was identified from Apostichopus japonicus (designated as AjIRAK4) by RACE approach. The full-length cDNA of AjIRAK4 was of 2024 bp containing an open reading frame of 131...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2018.08.006

    authors： Cui Y,Jiang L,Xing R,Wang Z,Wang Z,Shao Y,Zhang W,Zhao X,Li C

    更新日期：2018-09-01 00:00:00

  • Comprehensive analysis of lncRNA-mRNA regulatory network in BmNPV infected cells treated with Hsp90 inhibitor.

    abstract：:Bombyx mori nucleopolyhedrovirus (BmNPV) is one of the main pathogens that seriously affect the sustainable development of sericulture industry. Inhibition of Hsp90 by Hsp90 inhibitor, geldanamycin (GA) significantly suppresses BmNPV proliferation in Bombyx mori, while the functional mechanism is not clear. LncRNA has...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2020.09.014

    authors： Yin H,Shang Q,Zhang S,Shen M,Huang H,Zhao W,Xijie G,Wu P

    更新日期：2020-11-01 00:00:00

  • Prohibitin binds to C3 and enhances complement activation.

    abstract：:Prohibitin (PHB1) is a multifunction protein that is released in lipid droplets from adipocytes and possibly other cells and is detectable in the circulation. We used crosslinking, immunoprecipitation and proteomic analysis to investigate binding partners for circulating PHB1. Crosslinking of PHB1 to serum resulted in...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2006.09.025

    authors： Mishra S,Moulik S,Murphy LJ

    更新日期：2007-03-01 00:00:00

  • Genetic analysis of the complement factor H related 5 gene in haemolytic uraemic syndrome.

    abstract：:Several mutations in the CFH gene have been described in non-Shiga-toxin-associated haemolytic uraemic syndrome (non-Stx-HUS), a rare syndrome characterized by haemolytic anaemia, thrombocytopenia and acute renal failure. Mutations in genes encoding other complement regulatory proteins, membrane cofactor protein (CD46...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2006.08.004

    authors： Monteferrante G,Brioschi S,Caprioli J,Pianetti G,Bettinaglio P,Bresin E,Remuzzi G,Noris M

    更新日期：2007-03-01 00:00:00

  • Effects of surfactant protein D on growth, adhesion and epithelial invasion of intestinal Gram-negative bacteria.

    abstract：:Surfactant protein D (SP-D) interacts with various different microorganisms and plays an important role in pulmonary innate immunity. SP-D expression has also been detected in extrapulmonary tissues, including the gastro-intestinal tract. However, its function in the intestine is unknown and may differ considerably fr...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2007.03.013

    authors： Hogenkamp A,Herías MV,Tooten PC,Veldhuizen EJ,Haagsman HP

    更新日期：2007-07-01 00:00:00

  • The N- and C-terminal carbohydrate recognition domains of galectin-9 contribute differently to its multiple functions in innate immunity and adaptive immunity.

    abstract：:By binding to T cell Ig mucin-3 (Tim-3) expressed on different cells, galectin-9 (Gal-9) mediates two important functions, triggering T cell death and activating innate immune cells. The mechanisms by which ligation of the same molecule on different cell types mediates different effects are largely unclear. Gal-9 cont...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2010.11.011

    authors： Li Y,Feng J,Geng S,Geng S,Wei H,Chen G,Li X,Wang L,Wang R,Peng H,Han G,Shen B,Li Y

    更新日期：2011-01-01 00:00:00

  • Comparison of the antigenicities of native human growth hormone (hGH) and three forms of recombinant hGHs using monoclonal antibodies.

    abstract：:A panel of hybridomas producing antibodies specific for human growth hormone (hGH) were prepared by using a recombinant hGH [methionylsomatotropin (r-hGH)] as an immunogen. Thirteen representative monoclonal antibodies which showed different reactivity patterns were used to analyze the antigenicities of four different...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(86)90099-4

    authors： Sawada J,Wada N,Irie M,Tokunaga-Doi T,Ohtsuka E,Ikehara M,Terao T

    更新日期：1986-06-01 00:00:00

  • Inhibition of phosphatidylserine synthesis induced by triggering CD2 or the CD3-TCR complex in a human T cell line. Relationships with G proteins and receptors modulation.

    abstract：:Activation of Jurkat T cells with phytohemagglutinin, CD3 or CD2 mAbs results in a marked inhibition of phosphatidylserine (PS) synthesis. Monitoring PS synthesis in T cells shows that: (i) after modulation of CD3 molecules the cells become refractory to further treatment with CD3 mAbs as well as to a further challeng...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(89)90072-2

    authors： Pelassy C,Dallanegra A,Aussel C,Fehlmann M

    更新日期：1989-11-01 00:00:00

  • Triptolide inhibits B7-H1 expression on proinflammatory factor activated renal tubular epithelial cells by decreasing NF-kappaB transcription.

    abstract：:Triptolide has been used extensively in China for the treatment of autoimmune diseases and tumor for many centuries. Nevertheless, little is known about its exact immunosuppressive and anti-inflammatory properties. Increasing recognition of the importance of renal tubular epithelial cells (TECs) in renal diseases rais...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2005.07.026

    authors： Chen Y,Zhang J,Li J,Zhao T,Zou L,Tang Y,Zhang X,Wu Y

    更新日期：2006-03-01 00:00:00