Role of STAT3 in glucocorticoid-induced expression of the human IL-10 gene.

abstract：:The immunosuppressive cyclic undecapeptide cyclosporine (Cs) represents a useful model for studying the molecular basis of antibody-antigen interactions. The three-dimensional structure of the Cs molecule is known and a large panel of monoclonal antibodies (mAbs) to Cs has been well characterized by cross-reactivity s...

journal_title：Molecular immunology

authors： Schmitter D,Poch O,Zeder G,Heinrich GF,Kocher HP,Quesniaux VF,Van Regenmortel MH

更新日期：1990-10-01 00:00:00

abstract：:The development of nanoparticles (NPs) for commercial products is undergoing a dramatic expansion. Many sunscreens and cosmetics now use zinc oxide (ZnO) or titania (TiO2) NPs, which are effective ultraviolet (UV) filters. Zinc oxide topical creams are also used in mild anti-inflammatory treatments. In this study we e...

journal_title：Molecular immunology

authors： Feltis BN,Elbaz A,Wright PF,Mackay GA,Turney TW,Lopata AL

更新日期：2015-08-01 00:00:00

abstract：:The role of secondary structures and base mutability at different levels of transcription and supercoiling is analyzed in variable region antibody genes VH5, VH94 and VH186.2. The data are consistent with a model of somatic hypermutation in which increasing levels of transcription and secondary structure stability cor...

journal_title：Molecular immunology

authors： Wright BE,Schmidt KH,Davis N,Hunt AT,Minnick MF

更新日期：2008-08-01 00:00:00

abstract：:The O-antigen of the gram negative bacteria Brucella is composed of an homopolymer of 4,6-dideoxy-4-formamido-alpha-D-mannopyranosyl (or perosamine). Several mAb interact specifically with only the O-antigen of certain Brucella species. Although, many studies show that this specific recognition results mainly from the...

journal_title：Molecular immunology

authors： Laurent TC,Mertens P,Dierick JF,Letesson JJ,Lambert C,De Bolle X

更新日期：2004-03-01 00:00:00

abstract：:The isolation and characterization of two human serum proteins, RHP and N-RHP, are described. N-RHP appears to be the normal counterpart of RHP which is found at elevated levels in sera of patients with rheumatoid arthritis [Rosano et al. (1988b) Inflammation 12, 351 - 360]. Although both proteins crossreact with anti...

journal_title：Molecular immunology

authors： Hurwitz C,Rosano CL,Hechemy KE,Weber P,Parhami N

更新日期：1995-11-01 00:00:00

abstract：:CD4+CD25+ natural Treg cells, which are developed in the thymus, migrate to the periphery to actively maintain self-tolerance. Similar to conventional T cells, TCR signals are critical for the development and activation of Treg cell inhibitory function. While PKC-theta-mediated TCR signals are required for the activat...

journal_title：Molecular immunology

authors： Gupta S,Manicassamy S,Vasu C,Kumar A,Shang W,Sun Z

更新日期：2008-12-01 00:00:00

abstract：:During the last years, intensive research has shed light in the transcriptional networks that shape the invariant NKT (iNKT) cell lineage and guide the choices towards functionally distinct iNKT cell subsets (Constantinides and Bendelac, 2013; Engel and Kronenberg, 2014; Gapin, 2016; Kim et al., 2015). However, the ep...

journal_title：Molecular immunology

authors： Tsagaratou A

更新日期：2018-09-01 00:00:00

abstract：:N-Acetylcysteine (NAC) has been widely used as an antioxidant in research, however, it has also been found to reduce the binding of TNF to its receptor independent of its antioxidative role. In this study, we investigated the effect of NAC on NF-kappaB activation. In HeLa cells, Hep3B cells, and A549 cells, DNA-bindin...

journal_title：Molecular immunology

authors： Liu J,Yoshida Y,Yamashita U

更新日期：2008-09-01 00:00:00

abstract：:CD55 is a key regulator of complement activation, expressed on most tissues and cells in man and other mammals. In the rat, alternative splicing in the gene encoding CD55 yields GPI-anchored (GPI-CD55) and transmembrane (TM-CD55) forms. Published Northern blot analysis indicated that while GPI-CD55 was broadly express...

journal_title：Molecular immunology

authors： Mizuno M,Donev RM,Harris CL,Morgan BP

更新日期：2007-03-01 00:00:00

abstract：:The mis-regulation of nuclear factor-kappa B (NF-kappaB) signal pathway is involved in a variety of inflammatory diseases that leds to the production of inflammatory mediators. Our studies using human U937 promonocytes cells suggested that magnolol, a low molecular weight lignan isolated from the medicinal plant Magno...

journal_title：Molecular immunology

authors： Tse AK,Wan CK,Zhu GY,Shen XL,Cheung HY,Yang M,Fong WF

更新日期：2007-04-01 00:00:00

abstract：:C-reactive protein (CRP) is an acute-phase protein featuring a homopentameric structure and Ca-binding specificity for phosphocholine (PCh). Expression of CRP is regulated mainly at the transcriptional level with interleukin-6 being the principal inducer of the gene during the acute phase. The crystal structure of CRP...

journal_title：Molecular immunology

authors： Volanakis JE

更新日期：2001-08-01 00:00:00

abstract：:Mannose-binding lectin (MBL) and the ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defence. They bind sugar structures or acetylated compounds present on microorganisms and on dying host cells and they initiate activation of the lectin complement pa...

journal_title：Molecular immunology

authors： Garred P,Honoré C,Ma YJ,Munthe-Fog L,Hummelshøj T

更新日期：2009-09-01 00:00:00

abstract：:The ragweed allergens Amb t 5 and Amb a 5 are among the smallest inhaled protein allergens known, containing a single, immunodominant T-cell epitope. In this study we analyzed the B-cell epitope structure of Amb t 5. The three-dimensional structures of Amb t 5 and Amb a 5 have been determined by NMR spectroscopy, prov...

journal_title：Molecular immunology

authors： Rafnar T,Brummet ME,Bassolino-Klimas D,Metzler WJ,Marsh DG

更新日期：1998-06-01 00:00:00

abstract：:The generation of T cell receptor (TCR) sequence diversity can produce 'forbidden' clones able to recognize self-antigens. Here, the structure of the complex between a myelin basic protein peptide (MBP85-99), human leukocyte antigen (HLA)-DR2 (DRB1*1501/DRA) and TCR-Ob.2F3, the dominant autoimmune clone obtained from ...

journal_title：Molecular immunology

authors： Kato Z,Stern JN,Nakamura HK,Miyashita N,Kuwata K,Kondo N,Strominger JL

更新日期：2010-11-01 00:00:00

abstract：:Apo-1/Fas (CD95) is a transmembrane protein expressed on the cell surface that is involved in apoptosis and plays an important role in the function and regulation of the immune system. Aberrant expression of the Apo-1/Fas gene product has been reported in a number of immune-related disorders, such as autoimmune lympho...

journal_title：Molecular immunology

authors： Huang QR,Morris D,Manolios N

更新日期：1997-06-01 00:00:00

abstract：:Hybridomas producing anti-histone monoclonal antibodies were generated from a 2-month old MRL lpr/lpr mouse. Five IgM antibodies showed binding to histone H3 and three of these IgM antibodies also bound histone H1. Two IgG2a antibodies (MRA3 and MRA12) were specific for histone H1 and their binding was further charact...

journal_title：Molecular immunology

authors： Monestier M,Fasy TM,Böhm L

更新日期：1989-08-01 00:00:00

abstract：:The host response to intravascular, Gram-negative bacteria includes profound immunologic, hematologic and physiologic changes. Numerous host defense mechanisms are activated by Gram-negative bacteria, including the complement system. Activation of the complement system leads to cleavage of C5 with subsequent generatio...

journal_title：Molecular immunology

authors： Hollmann TJ,Mueller-Ortiz SL,Braun MC,Wetsel RA

更新日期：2008-04-01 00:00:00

abstract：:Ankylosing spondylitis (AS) is a chronic inflammatory arthritis that affects the spine and sacroiliac joints. It causes significant disability and is associated with a number of other features including peripheral arthritis, anterior uveitis, psoriasis and inflammatory bowel disease (IBD). Significant progress has bee...

journal_title：Molecular immunology

authors： Robinson PC,Brown MA

更新日期：2014-01-01 00:00:00

abstract：:To investigate the IL-6/IL-6 receptor system, we obtained five murine monoclonal antibodies against human IL-6, which neutralize its biological activity. We classified them into two groups (Type I mAb and Type II mAb) according to the epitopes they recognized. These two types of antibodies showed no difference in the ...

journal_title：Molecular immunology

authors： Shimamura T,Taki S,Honda H,Yokota M,Ito S,Takahara Y

更新日期：1991-11-01 00:00:00

abstract：:HLA-B27 (B27) is strongly associated with the spondyloarthritides. B27 is expressed at the cell surface of antigen presenting cells (APC) both as canonical β2m-associated and non-canonical β2m-free heavy chain (FHC) forms which include B27 dimers (termed B272). B27 FHC forms arise in an endosomal compartment from recy...

journal_title：Molecular immunology

authors： Shaw J,Hatano H,Kollnberger S

更新日期：2014-01-01 00:00:00

abstract：:Purified mRNA's encoding the HLA-A and -B antigen heavy chains or beta 2-microglobulin were prepared from human B lymphoid cells by positive hybridization selection procedures. The role of chain association in the biosynthesis and intracellular transport of HLA-A and -B antigens was investigated by injecting these mRN...

journal_title：Molecular immunology

authors： Kinnon C,Owen MJ

更新日期：1986-05-01 00:00:00

abstract：:The SARS-CoV-2 virus responsible for coronavirus 2019 (COVID-19) poses a significant challenge to healthcare systems worldwide. According to the World Health Organization (WHO), the outbreak of COVID-19 has been a pandemic that infected more than 25.32 million people and caused more than 848.25 thousand deaths worldwi...

journal_title：Molecular immunology

authors： Liu D,Wu F,Cen Y,Ye L,Shi X,Huang Y,Fang S,Ma L

更新日期：2021-01-09 00:00:00

abstract：:Antimicrobial peptides (AMPs) are important components of the host's innate immune response against microbial invasion. The cysteine-rich AMPs such as defensin and hepcidin have been extensively studied, but the recently identified cysteine-rich liver-expressed antimicrobial peptide 2 (LEAP-2) has been characterized f...

journal_title：Molecular immunology

authors： Bao B,Peatman E,Xu P,Li P,Zeng H,He C,Liu Z

更新日期：2006-02-01 00:00:00

abstract：:An expression cDNA library was constructed from the helper T cell hybridoma, A.1.1, which has been shown to produce constitutively proteins involved in the down regulation of the immune response. From this library we identified and characterized a cDNA clone, J6B7, by screening with a polyclonal antibody specific for ...

journal_title：Molecular immunology

authors： Lee C,Ghoshal K,Beaman KD

更新日期：1990-11-01 00:00:00

abstract：:N-substituted benzamides are compounds that have recently been reported to inhibit nuclear factor-kappaB (NF-kappaB) activity and induce apoptosis in a pre-B cell line. In this study, we focused on the effects of N-substituted benzamides on transcriptional regulation in Jurkat T cells. We used a model system where the...

journal_title：Molecular immunology

authors： Lindgren H,Pero RW,Ivars F,Leanderson T

更新日期：2001-08-01 00:00:00

abstract：:The p38 mitogen-activated protein kinases (MAPKs) are essential cytoplasmic signal molecules of innate immune pathways that play a vital role in host immune defense responses to pathogenic challenges. In this study, two fish p38 genes (Cip38α and Cip38β) were characterized for the first time from the grass carp Ctenop...

journal_title：Molecular immunology

authors： Sun Y,Xu W,Li D,Zhou H,Qu F,Cao S,Tang J,Zhou Y,He Z,Li H,Zhou Z,Liu Z

更新日期：2020-02-01 00:00:00

abstract：:C-reactive protein (CRP) binds to chromatin, histones, and small nuclear ribonucleoproteins (snRNPs) through a phosphocholine (PC)-inhibitable, calcium-dependent binding site. snRNPs process pre-mRNA to mature mRNA and are composed of small uridine-rich RNAs (designated U1, U2, U5 and U4/U6) and associated proteins. W...

journal_title：Molecular immunology

authors： Jewell WS,Marnell LL,Rokeach LA,Du Clos TW

更新日期：1993-06-01 00:00:00

abstract：:The common variant in the human complement Factor H gene (CFH), with Tyr402His, is linked to age-related macular degeneration (AMD), a prevalent disorder leading to visual impairment and irreversible blindness in elderly patients. Here we show that the risk variant CFH 402His displays reduced binding to C reactive pro...

journal_title：Molecular immunology

authors： Skerka C,Lauer N,Weinberger AA,Keilhauer CN,Sühnel J,Smith R,Schlötzer-Schrehardt U,Fritsche L,Heinen S,Hartmann A,Weber BH,Zipfel PF

更新日期：2007-07-01 00:00:00

abstract：:Artificial Salmonella serogroup B, D or Cl-specific glycolipids were prepared by covalently linking oligosaccharides corresponding to two O-antigen repeating units, obtained by phage enzyme hydrolysis of native O-antigenic polysaccharides, to octyl residues. Sheep erythrocytes coated with the artificial glycolipids we...

journal_title：Molecular immunology

authors： Grossman N,Svenson SB,Leive L,Lindberg AA

更新日期：1990-09-01 00:00:00

abstract：:NKG2D receptor-ligand interaction triggers NK cell-mediated cytolysis and IFN-gamma secretion. IFN-gamma produced by NK cells has been found to promote the interaction between NK cells and monocytes; however, the underlying mechanism remains elusive. We demonstrate here that IFN-gamma exclusively induced or upregulate...

journal_title：Molecular immunology

authors： Wang H,Ruan Z,Wang Y,Han J,Fu X,Zhao T,Yang D,Xu W,Yang Z,Wang L,Chen Y,Wu Y

更新日期：2008-03-01 00:00:00