The catfish liver-expressed antimicrobial peptide 2 (LEAP-2) gene is expressed in a wide range of tissues and developmentally regulated.

abstract：:The potency of a T cell is determined in large part by two interactions, binding of a cognate peptide to the MHC, and binding of the T cell receptor (TCR) to this pepMHC. Various studies have attempted to assess the relative importance of these interactions, and to correlate the corresponding binding parameters with t...

journal_title：Molecular immunology

authors： Bowerman NA,Crofts TS,Chlewicki L,Do P,Baker BM,Christopher Garcia K,Kranz DM

更新日期：2009-09-01 00:00:00

abstract：:Following measles virus (MV) infection, viral peptides are presented to CTL by MHC class I molecules on infected antigen presenting cells at widely different epitope densities. Whereas three MV epitopes (MV-M(211-219), MV-F(438-446) and MV-H(30-38)) derived from different structural proteins occur at regular densities...

journal_title：Molecular immunology

authors： Herberts CA,Meiring HM,van Gaans-van den Brink JA,van der Heeft E,Poelen MC,Boog CJ,de Jong AP,van Els CA

更新日期：2003-01-01 00:00:00

abstract：:The T-dependent BALB/c murine immune response to fluorescein (F1) is characterized by structural heterogeneity at the protein level exemplified in part by a significantly wide range of affinities (Ka), and apparent lack of dominant idiotypes. In order to generate an idiotype family, xenogenic anti-idiotype (anti-ID) a...

journal_title：Molecular immunology

authors： Bates RM,Ballard DW,Voss EW Jr

更新日期：1985-08-01 00:00:00

abstract：:Activation of p38 MAP kinase in T cells leads to increased interferon-gamma production in CD4+ and CD8+ T cells, and the selective cell death of CD8+ T cells. To address the role of p38 MAP kinase activation in T cells during an in vivo immune response, we examined the response against the influenza virus in transgeni...

journal_title：Molecular immunology

authors： Conze D,Lumsden J,Enslen H,Davis RJ,Le Gros G,Rincón M

更新日期：2000-06-01 00:00:00

abstract：:The specificities of the combining sites of 19 mouse monoclonal antibodies to dextran B1355S have been characterized immunochemically by quantitative precipitin and precipitin inhibition assays; association constants for B1355S were determined by affinity gel electrophoresis. Cross-reactive and individual idiotypes re...

journal_title：Molecular immunology

authors： Newman BA,Liao J,Gruezo F,Sugii S,Kabat EA,Torii M,Clevinger BL,Davie JM,Schilling J,Bond M

更新日期：1986-04-01 00:00:00

abstract：:It has been developed an HIV type 1 transgenic rat model (HIV-1 Tg Rat) which contains a gag-pol-deleted HIV-1 provirus regulated by the viral LTR promoter. Although it harbors a non infectious provirus, efficient viral expression occurs in different tissues and disease manifestations as well as immune-response altera...

journal_title：Molecular immunology

authors： Mazzucchelli R,Amadio M,Curreli S,Denaro F,Bemis K,Reid W,Bryant J,Riva A,Galli M,Zella D

更新日期：2004-08-01 00:00:00

abstract：:The mast cell function-associated antigen (MAFA) is a type II membranal glycoprotein that was first identified on the surface of rat mucosal-type mast cells of the RBL-2H3 line. A C-type lectin domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM) are located in the extracellular and intracellular domain...

journal_title：Molecular immunology

authors： Abramson J,Xu R,Pecht I

更新日期：2002-09-01 00:00:00

abstract：:Antipeptide antisera were raised to the second and third complementarity-determining regions of the light chain derived from a human monoclonal IgM (Sie) which had antigammaglobulin activity and belonged to the Wa cross-reactive idiotypic group of human rheumatoid factors, two of whose members (Sie, Wo1) had been prev...

journal_title：Molecular immunology

authors： Newkirk M,Chen PP,Carson D,Posnett D,Capra JD

更新日期：1986-03-01 00:00:00

abstract：:GRX1 (glutaredoxin1), a sulfhydryl disulfide oxidoreductase, is involved in many cellular processes, including anti-oxidation, anti-apoptosis, and regulation of cell differentiation. However, the role of GRX1 in the oxidative stress and apoptosis of osteoarthritis chondrocytes remains unclear, prompting the current st...

journal_title：Molecular immunology

authors： Sun J,Wei X,Lu Y,Cui M,Li F,Lu J,Liu Y,Zhang X

更新日期：2017-10-01 00:00:00

abstract：:Most of the complement proteins in circulation are, by and large, synthesized in the liver. However data accumulated over the past several decades provide incontrovertible evidence that some if not most of the individual complement proteins are also synthesized extrahepatically by activated as well as non-activated ce...

journal_title：Molecular immunology

authors： Ghebrehiwet B,Hosszu KH,Peerschke EI

更新日期：2017-04-01 00:00:00

abstract：:The dynamics of human antigen-specific immunoglobulin (Ig) responses in early life are not well characterized. We have previously observed an inverse relationship between allergen-specific Ig concentration and allergen-Ig-binding affinity in allergen-sensitive atopic adults, suggesting a possible feedback relationship...

journal_title：Molecular immunology

authors： Jackola DR,Liebeler CL,Lin CY,Chiu YK,Blumenthal MN,Rosenberg A

更新日期：2005-01-01 00:00:00

abstract：:Histocompatibility Leukocyte Antigens, or HLAs, are one of the most polymorphic molecules in humans. This high degree of polymorphism endows HLA molecules with the ability to present a vast array of peptides, an essential trait for responding to ever-evolving pathogens. Unlike classical HLA molecules (HLA-Ia), some no...

journal_title：Molecular immunology

authors： Grant EJ,Nguyen AT,Lobos CA,Szeto C,Chatzileontiadou DSM,Gras S

更新日期：2020-04-01 00:00:00

abstract：:The EGF receptor is an important target of cancer immunotherapies. The 7A7 monoclonal antibody has been raised against the murine EGFR, but it cross-reacts with the human receptor. The results from experiments using immune-competent mice can therefore, in principle, be extrapolated to the corresponding scenario in hum...

journal_title：Molecular immunology

authors： Talavera A,Mackenzie J,Garrido G,Friemann R,López-Requena A,Moreno E,Krengel U

更新日期：2011-07-01 00:00:00

abstract：:The complement system is a vital component of the immune-priveliged human eye that is always active at a low-grade level, preventing harmful intraocular injuries caused by accumulation of turnover products and controlling pathogens to preserve eye homeostasis and vision. The complement system is a double-edged sword t...

journal_title：Molecular immunology

authors： Mohlin C,Sandholm K,Ekdahl KN,Nilsson B

更新日期：2017-09-01 00:00:00

abstract：:The membrane anchored ligand ephrinB2 belongs to the broad Eph/ephrin system and is able to activate different Eph receptors. The Eph receptors belong to the huge group of receptor-tyrosine kinases. Eph receptors as well as their corresponding ephrin ligands are cell-membrane attached proteins. Therefore, direct cell-...

journal_title：Molecular immunology

authors： Poitz DM,Ende G,Stütz B,Augstein A,Friedrichs J,Brunssen C,Werner C,Strasser RH,Jellinghaus S

更新日期：2015-12-01 00:00:00

abstract：:The general thinking about the phylogenic distribution of vertebrate Ig classes is that fish and urodele amphibians are only able to synthesize polymeric IgM-like molecules and that the emergence of a new class of LMW Ig occurs for the first time in anouran species. Following immunization of the Mexican axolotl (Ambys...

journal_title：Molecular immunology

authors： Fellah JS,Charlemagne J

更新日期：1988-12-01 00:00:00

abstract：:When mouse dendritic cells (DCs) are isolated from tissues, purified and placed in a nutritive culture they die more rapidly than would be expected from their normal turnover in vivo. This can distort culture assays of DC function. We therefore tested several approaches to prolonging DC survival in culture. Of several...

journal_title：Molecular immunology

authors： Vremec D,Hansen J,Strasser A,Acha-Orbea H,Zhan Y,O'Keeffe M,Shortman K

更新日期：2015-02-01 00:00:00

abstract：:The development and maintenance of thymic microenvironments depends on sustained crosstalk signals derived from developing thymocytes. However, the molecular basis for the initial phase in the lymphoid dependent development of thymic epithelial cells (TECs) remains unclear. Here we show that similarly to regular thymo...

journal_title：Molecular immunology

authors： Masuda K,Germeraad WT,Satoh R,Itoi M,Ikawa T,Minato N,Katsura Y,van Ewijk W,Kawamoto H

更新日期：2009-05-01 00:00:00

abstract：:A new sulfhydryl redox model of antibody-dependent endocytosis is proposed. This model synthesizes many previous studies employing a variety of experimental approaches. Predictions of this model can be tested experimentally. ...

journal_title：Molecular immunology

authors： Petty HR

更新日期：1985-08-01 00:00:00

abstract：:T regulatory (Treg)/T-helper (Th) 17 imbalance has been shown to integrate with epigenetics to result in the development of autoimmune diseases. We aim to investigate the influence of disease staging on Treg/Th17 cells and whether the aberrant DNA methylation is implicated in the development of rheumatoid arthritis (R...

journal_title：Molecular immunology

authors： Huang Y,Wang H,Ba X,Chen Z,Wang Y,Qin K,Huang Y,Shen P,Tu S

更新日期：2020-11-01 00:00:00

abstract：:The immunoglobulin JHC mu intron was cloned from genomic DNA of a VHa3 rabbit and a 1257 bp sequence which contains conserved enhancer and splice sites was determined. From positions 315 to 1257, there is approximately 72 and 67% similarity to available sequences of man and mouse, respectively (counting gaps as single...

journal_title：Molecular immunology

authors： Mage RG,Newman BA,Harindranath N,Bernstein KE,Becker RS,Knight KL

更新日期：1989-10-01 00:00:00

abstract：UNLABELLED:C5L2, a G-protein-coupled receptor (GPCR), has been identified as an ASP (C3adesArg) and C5a receptor. Controversy exists regarding both ligand binding and functionality. ASP activation of C5L2 is proposed to regulate fat storage. C5L2 is also proposed as a decoy receptor for C5a, an inflammatory mediator, b...

journal_title：Molecular immunology

authors： Cui W,Simaan M,Laporte S,Lodge R,Cianflone K

更新日期：2009-09-01 00:00:00

abstract：:A computerized method for predicting the locations of protein antigenic determinants is presented, which requires only the amino acid sequence of a protein, and no other information. This procedure has been used to predict the major antigenic determinant of the hepatitis B surface antigen, as well as antigenic sites o...

journal_title：Molecular immunology

authors： Hopp TP,Woods KR

更新日期：1983-04-01 00:00:00

abstract：:The concomitant effects of trans-chromosomal allotype suppression of both an a VH and an n Cmu locus allotype in multiheterozygous rabbits were investigated. For example of the expression of the a2 VH and n81 Cmu allotypes were suppressed in a multiheterozygous rabbit having the a1 chi-y-n81de12,15f73g74/a2 chi 32y33n...

journal_title：Molecular immunology

authors： Horng WJ,Roux KH,Gilman-Sachs A,Dray S

更新日期：1982-01-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) to the hinge region of human IgG1 immunoglobulins were prepared by immunization with a proteolytic fragment of hinge segment coupled to keyhole limpet hemocyanin. A mAb, 4G3, was obtained capable of binding to intact IgG but not to partially reduced IgG. Using this mAb, inter-heavy (H) cha...

journal_title：Molecular immunology

authors： Azuma T,Takeda J,Motoyama N,Okada H

更新日期：1992-01-01 00:00:00

abstract：:The isolation and characterization of two human serum proteins, RHP and N-RHP, are described. N-RHP appears to be the normal counterpart of RHP which is found at elevated levels in sera of patients with rheumatoid arthritis [Rosano et al. (1988b) Inflammation 12, 351 - 360]. Although both proteins crossreact with anti...

journal_title：Molecular immunology

authors： Hurwitz C,Rosano CL,Hechemy KE,Weber P,Parhami N

更新日期：1995-11-01 00:00:00

abstract：:The NLRP3 inflammasome constitutes a major antiviral host defense mechanism during influenza virus infection. Inflammasome assembly in virus-infected cells facilitates autocatalytic processing of pro-caspase-1 and subsequent cleavage and secretion of proinflammatory cytokines IL-1β and IL-18. The NLRP3 inflammasome is...

journal_title：Molecular immunology

authors： Kuriakose T,Kanneganti TD

更新日期：2017-06-01 00:00:00

abstract：:The KH type splicing regulatory protein (KSRP) is a nucleic acid binding protein, which negatively regulates the stability and/or translatability of many mRNA species encoding immune-relevant proteins. As KSRP is expressed in immune cells including T and B cells, neutrophils, macrophages and dendritic cells, we wanted...

journal_title：Molecular immunology

authors： Käfer R,Schrick K,Schmidtke L,Montermann E,Hobernik D,Bros M,Chen CY,Kleinert H,Pautz A

更新日期：2017-07-01 00:00:00

abstract：:Anaerobic reduction of purified rabbit IgG antibody (Ab) with 1.5 moles of dithiothreitol per mole of Ab at pH 8.0, followed by alkylation, cleaves 39% of the inter-heavy-chain (H-H) disulfide (SS) bonds. This treatment has the following effects on the ability of the Ab to activate the classical pathway of complement....

journal_title：Molecular immunology

authors： Johnson BA,Hoffmann LG

更新日期：1984-01-01 00:00:00

abstract：:Increasing lines of evidence indicate that arsenic may be associated with immune related problems, but its detailed effects on immune organs are poorly understood. The objective of this study was to explore inflammatory responses and T cell differentiation of arsenic exposure in spleen and thymus. Female C57BL/6 mice ...

journal_title：Molecular immunology

authors： Duan X,Gao S,Li J,Wu L,Zhang Y,Li W,Zhao L,Chen J,Yang S,Sun G,Li B

更新日期：2017-01-01 00:00:00