当前位置： SCI文献检索 > MOLECULAR IMMUNOLOGY期刊下所有文献 > The catfish liver-expressed antimicrobial peptide 2 (LEAP-2) gene is expressed in a wide range of tissues and developmentally regulated.

The catfish liver-expressed antimicrobial peptide 2 (LEAP-2) gene is expressed in a wide range of tissues and developmentally regulated.

Abstract：

:Antimicrobial peptides (AMPs) are important components of the host's innate immune response against microbial invasion. The cysteine-rich AMPs such as defensin and hepcidin have been extensively studied, but the recently identified cysteine-rich liver-expressed antimicrobial peptide 2 (LEAP-2) has been characterized from only a few organisms. Here we cloned and sequenced the LEAP-2 cDNAs from both Channel catfish and Blue catfish. The LEAP-2 gene from Channel catfish was also sequenced and characterized. Channel catfish LEAP-2 gene consists of two introns and three exons that encode a peptide of 94 amino acids with a 28 amino acid signal peptide and a mature peptide of 41 amino acids. The amino acid sequences and gene organization were conserved between catfish and other organisms. The Channel catfish LEAP-2 gene is expressed in a wide range of tissues except brain and stomach. Its expression is developmentally regulated with no detection of mature mRNA in early stages of development. It appears that the catfish LEAP-2 gene is regulated at the level of splicing; it is constitutively transcribed, but remains unspliced until 6 days after hatching. The expression of LEAP-2 was induced in a tissue-specific manner. Its expression was upregulated in the spleen, but not in the liver and head kidney, after challenge with Edwardsiella ictaluri, the causative agent of enteric septicemia of catfish (ESC).

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Bao B,Peatman E,Xu P,Li P,Zeng H,He C,Liu Z

doi

10.1016/j.molimm.2005.02.014

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

367-77

issue

4

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(05)00043-X

journal_volume

43

pub_type

杂志文章

相关文献

MOLECULAR IMMUNOLOGY文献大全
  • Food antigens and Transglutaminase 2 in IgA nephropathy: Molecular links between gut and kidney.

    abstract：:The transglutaminase 2 (TG2) is one of the enigmatic enzymes with important functional diversity. It plays an important role in several pathologies such as celiac disease (CD). In patients with active CD, the abnormal retrotranscytosis of IgA/gliadin complexes is mediated by Transferrin Receptor 1 (TfR1). This triad a...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2020.02.019

    authors： Abbad L,Monteiro RC,Berthelot L

    更新日期：2020-05-01 00:00:00

  • Knockdown PEG10 deteriorates H2O2-injury of PC-12 cells by targeting miR-34a-5p/TLX.

    abstract：OBJECTIVE:Spinal cord injury (SCI) is a neurological disease with high incidence and disability. In this paper, we made a foundational study in long non-coding RNA paternally expressed gene 10 (lncRNA PEG10) at PC-12 cells. METHODS:We used CCK8, flow cytometry, migration and invasion assay to detect changes at the cel...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2019.11.012

    authors： Niu S,Ni Y,Niu T,Gao J

    更新日期：2020-02-01 00:00:00

  • Isoform identification and characterization of Art v 3, the lipid-transfer protein of mugwort pollen.

    abstract：:Art v 3, the lipid-transfer protein (LTP) of Artemisia vulgaris pollen is a relevant allergen showing frequent cross-reactivity with homologues in other plants. Here we report the identification of four full-length Art v 3 sequences obtained by cDNA cloning using mass spectrometry-based sequencing. Two isoforms, Art v...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2009.03.021

    authors： Gadermaier G,Harrer A,Girbl T,Palazzo P,Himly M,Vogel L,Briza P,Mari A,Ferreira F

    更新日期：2009-06-01 00:00:00

  • Production and characterization of monoclonal antibodies to staphylococcal enterotoxins: use in immunodetection and immunopurification.

    abstract：:Four cell lines producing monoclonal antibodies were obtained by fusion of NS1 myeloma cells with splenocytes of BALB/C mice immunized with only 1 microgram of each staphylococcal enterotoxin A, B, C1 and D by a modified technique of intrasplenic boosting. This procedure was considerably more efficient than the more c...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(87)90118-0

    authors： Lapeyre C,Kaveri SV,Janin F,Strosberg AD

    更新日期：1987-12-01 00:00:00

  • Exogenous interleukin-2 does not reverse the immunoinhibitory effects of 1,25-dihydroxyvitamin D3 on human peripheral blood lymphocyte immunoglobulin production.

    abstract：:1,25-Dihydroxyvitamin D3 (1,25-D3) is known to have potent inhibitory effects on human peripheral blood mononuclear cell (PBMC) functions. Previous experiments suggest that addition of interleukin-2 (IL-2) to cell cultures can reverse the antiproliferative action of 1,25-D3. Previous studies have also shown that the C...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(90)90064-7

    authors： Jordan SC,Lemire JM,Sakai RS,Toyoda M,Adams JS

    更新日期：1990-01-01 00:00:00

  • The function of MITF and associated proteins in mast cells.

    abstract：:Mutation of microphthalmia transcription factor (MITF) results in deafness, bone loss, small eyes, and poorly pigmented eyes and skin. The primary cell types affected in MITF-deficient mice are melanocytes, osteoclasts and mast cells. A search for MITF-associated proteins, using a mast cell library that was screened w...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0161-5890(02)00059-7

    authors： Nechushtan H,Razin E

    更新日期：2002-09-01 00:00:00

  • Complement escape of human pathogenic bacteria by acquisition of complement regulators.

    abstract：:Pathogenic micro-organisms employ a broad range of strategies to survive in and to persistently infect the human host. Far from being completely understood by which highly sophisticated means invading pathogens overcome the host's destructive immune defence, there is a growing body of evidence on particular mechanisms...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2005.06.016

    authors： Kraiczy P,Würzner R

    更新日期：2006-01-01 00:00:00

  • IL-2 regulates the expression of the NK-TR gene via an alternate RNA splicing mechanism.

    abstract：:We have recently isolated and characterized human and mouse genes of a putative natural killer (NK) cell tumour-recognition protein (NK-TR) that is specifically expressed in NK cells. This gene codes for a 150 kD protein with a cyclophilin-related amino terminus followed by several positively charged domains. We repor...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(93)90047-f

    authors： Rinfret A,Anderson SK

    更新日期：1993-10-01 00:00:00

  • Inactivation of the KSRP gene modifies collagen antibody induced arthritis.

    abstract：:The KH type splicing regulatory protein (KSRP) is a nucleic acid binding protein, which negatively regulates the stability and/or translatability of many mRNA species encoding immune-relevant proteins. As KSRP is expressed in immune cells including T and B cells, neutrophils, macrophages and dendritic cells, we wanted...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2017.05.003

    authors： Käfer R,Schrick K,Schmidtke L,Montermann E,Hobernik D,Bros M,Chen CY,Kleinert H,Pautz A

    更新日期：2017-07-01 00:00:00

  • Molecular characterization of the dimer formation of Fcα/μ receptor (CD351).

    abstract：:Fcα/μR (CD351) is an Fc receptor for both IgA and IgM and forms an atypical dimer that is resistant to reduction by 2-mercaptoethanol or boiling. We previously demonstrated that the cytoplasmic portion of Fcα/μR is required for dimer formation and for its efficient cell-surface expression. However, the biochemical nat...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2013.04.003

    authors： Takagaki K,Satoh K,Honda S,Shibuya A

    更新日期：2013-11-01 00:00:00

  • Infectious salmon anaemia virus (ISAV) isolates induce distinct gene expression responses in the Atlantic salmon (Salmo salar) macrophage/dendritic-like cell line TO, assessed using genomic techniques.

    abstract：:Infectious salmon anaemia virus (ISAV) is a marine orthomyxovirus of significant interest not only as a cause of a fatal disease of farmed Atlantic salmon resulting in severe economic losses to the aquaculture industry, but also as the only poikilothermic orthomyxovirus. ISAV targets vascular endothelial cells and mac...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2009.06.015

    authors： Workenhe ST,Hori TS,Rise ML,Kibenge MJ,Kibenge FS

    更新日期：2009-09-01 00:00:00

  • Topology of the membrane-bound form of complement protein C9 probed by glycosylation mapping, anti-peptide antibody binding, and disulfide modification.

    abstract：:The two N-linked oligosaccharides in native human C9 were deleted by site-specific mutagenesis. This aglycosyl-C9 did not differ from its native form in hemolytic and bactericidal activity. A new N-glycosylation site (K311N/E313T) was introduced into the turn of a helix-turn-helix [HTH] fold that had been postulated t...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2010.01.013

    authors： Rossi V,Wang Y,Esser AF

    更新日期：2010-04-01 00:00:00

  • Epitope analysis of the allergen ovalbumin (Gal d II) with monoclonal antibodies and patients' IgE.

    abstract：:Ovalbumin (OVA) is a major allergen (Gal d II) of hen egg white and is often the cause of hypersensitivity reactions to food. Further knowledge of the antigenic and allergenic epitopes of allergens will provide better treatment of this disease. To analyse these epitopes we produced a panel of monoclonal antibodies (mA...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(92)90055-3

    authors： Kahlert H,Petersen A,Becker WM,Schlaak M

    更新日期：1992-10-01 00:00:00

  • In silico prediction of FVIII epitopes recognised by natural autoantibodies in polyvalent immunoglobulin concentrates.

    abstract：:Inhibitory antibodies directed against blood coagulation factor VIII (FVIII) impair FVIII replacement therapy, constituting a serious complication in haemophilic and autoimmune patients. Identifying B-cell FVIII epitopes and mapping them on the molecule remain important challenges. Using a combination of different alg...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2006.09.034

    authors： Di Giambattista M,Branckaert T,Hougardy V,Kemball-Cook G,Laub R

    更新日期：2007-03-01 00:00:00

  • Binding specificity of a monoclonal anti-DNA antibody.

    abstract：:To investigate the interaction of DNA and anti-DNA antibodies in the immune complex disease of systemic lupus erythematosus, the fine specificity of binding of a monoclonal anti-DNA antibody was determined. This antibody, termed Cll, was derived from the fusion of spleen cells from an autoimmune MRL-lpr/lpr mouse with...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(82)90364-9

    authors： Pisetsky DS,Caster SA

    更新日期：1982-05-01 00:00:00

  • Antigen degradation or presentation by MHC class I molecules via classical and non-classical pathways.

    abstract：:Major histocompatibility complex (MHC) class I molecules usually present endogenous peptides at the cell surface. This is the result of a cascade of events involving various dedicated proteins like the peptide transporter associated with antigen processing (TAP) and the ER chaperone tapasin. However, alternative ways ...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0161-5890(02)00101-3

    authors： Grommé M,Neefjes J

    更新日期：2002-10-01 00:00:00

  • Species-specific inhibition by glycophorins of complement activation via the alternative pathway.

    abstract：:Glycophorin, one of the major glycoproteins of erythrocytes (E), was extracted from human E (glycophorin-Hu) and guinea pig E (glycophorin-GP) and adsorbed to rabbit-E. The adsorption of glycophorin-Hu and glycophorin-GP to rabbit-E made the E resistant to hemolysis by human serum and guinea pig serum, respectively, v...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(83)90148-7

    authors： Okada H,Tanaka H

    更新日期：1983-11-01 00:00:00

  • Src-family kinases: rheostats of immune cell signaling.

    abstract：:In immune cells, Src-family kinases have been implicated as critical regulators of a large number of intracellular signaling pathways. Studies of gene knockout mice lacking various family members have both confirmed the requirement for these kinases in some pathways and provided surprising insight into their roles in ...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2004.04.010

    authors： Lowell CA

    更新日期：2004-07-01 00:00:00

  • HIV-1 gp41 binds to several proteins on the human B-cell line, Raji.

    abstract：:Based on our findings that HIV-1 gp41 independently of CD4, can bind to the helper T-cell line H9, we characterized putative binding of HIV-1 gp41 to B-cell lines, Raji, Bjab and Ramos. Using fluorescence-activated cell sorter (FACS) we examined the binding of soluble gp41 (sgp41; Env amino acid 539-684) to these B-ce...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(93)90134-w

    authors： Chen YH,Böck G,Vornhagen R,Steindl F,Katinger H,Dierich MP

    更新日期：1993-09-01 00:00:00

  • Analysis of human IgE epitope of Der f 2 with anti-Der f 2 mouse monoclonal antibodies.

    abstract：:Der f 2 is one of the major mite allergens recognized by human IgE antibodies of allergic patients. Using five anti-Der f 2 mouse monoclonal antibodies, human IgE epitopes of Der f 2 were analyzed. Among them, two monoclonal antibodies 15E11 and 13A4 inhibited the binding between Der f 2 and human IgE antibodies. To d...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/s0161-5890(98)00112-6

    authors： Nishiyama C,Hatanaka H,Ichikawa S,Fukada M,Akagawa-Chihara M,Yuuki T,Yokota T,Inagaki F,Okumura Y

    更新日期：1999-01-01 00:00:00

  • The binding of anti-DNA antibodies to phosphorothioate oligonucleotides in a solid phase immunoassay.

    abstract：:Phosphorothioate oligonucleotides (S-oligos) are nucleic acid derivatives that are commonly used as antisense agents. These compounds, similar to bacterial DNA and CpG oligonucleotides, display a variety of immunological activities in vitro and in vivo. To assess further these activities, the antigenicity of a series ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/s0161-5890(98)00108-4

    authors： Pisetsky DS,Reich CF 3rd

    更新日期：1998-12-01 00:00:00

  • Complement deficiencies and dysregulation: Pathophysiological consequences, modern analysis, and clinical management.

    abstract：:Complement defects are associated with an enhanced risk of a broad spectrum of infectious as well as systemic or local inflammatory and thrombotic disorders. Inherited complement deficiencies have been described for virtually all complement components but can be mimicked by autoantibodies, interfering with the activit...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2019.08.002

    authors： Schröder-Braunstein J,Kirschfink M

    更新日期：2019-10-01 00:00:00

  • C-reactive protein (CRP) binding to the Sm-D protein of snRNPS. Identification of a short polypeptide binding region.

    abstract：:C-reactive protein (CRP) binds to chromatin, histones, and small nuclear ribonucleoproteins (snRNPs) through a phosphocholine (PC)-inhibitable, calcium-dependent binding site. snRNPs process pre-mRNA to mature mRNA and are composed of small uridine-rich RNAs (designated U1, U2, U5 and U4/U6) and associated proteins. W...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(93)90141-w

    authors： Jewell WS,Marnell LL,Rokeach LA,Du Clos TW

    更新日期：1993-06-01 00:00:00

  • Effects of the dietary fibre inulin and Trichuris suis products on inflammatory responses in lipopolysaccharide-stimulated macrophages.

    abstract：:Consumption of fermentable dietary fibres, such as inulin, or administration of helminth products (e.g. Trichuris suis ova) have independently been shown to alleviate inflammation in vivo. We recently found that dietary inulin and T. suis infection in pigs co-operatively suppressed type-1 inflammatory responses in the...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2020.03.006

    authors： Myhill LJ,Jensen P,Zakeri A,Nielsen LF,Jakobsen SR,Mejer H,Thamsborg SM,Nejsum P,Williams AR

    更新日期：2020-05-01 00:00:00

  • Sequence analysis of porcine immunoglobulin light chain cDNAs.

    abstract：:A porcine cDNA library was constructed using poly(A)+ RNA isolated from the spleen of an adult Minnesota miniature swine. Screening the library with antisera specific for porcine immunoglobulin light chains resulted in the selection and isolation of two recombinant clones, PLC18 and PLC3, which encode for kappa and la...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(91)90051-k

    authors： Lammers BM,Beaman KD,Kim YB

    更新日期：1991-08-01 00:00:00

  • The Jak-STAT pathway.

    abstract：:A variety of important cellular functions are regulated by cytokines. The Jak-STAT pathway is one of the important signaling pathways downstream of cytokine receptors. Following binding of a ligand to its cognate receptor, receptor-associated Jaks are activated. STAT proteins are then in turn activated by tyrosine pho...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0161-5890(00)00018-3

    authors： Imada K,Leonard WJ

    更新日期：2000-01-01 00:00:00

  • The rabbit B cell antigen receptor is non-covalently associated with unique heteromeric protein complexes: possible insights into the membrane IgM/IgD coexpression paradox.

    abstract：:We describe several proteins that are components of the rabbit B cell receptor complex. Two proteins (37 kDa and 42 kDa) were found in non-covalent association with IgM expressed on B cells from peripheral blood. These proteins were also immunoprecipitated by anti-B29 (Ig-beta) and anti-mb1 (Ig-alpha) monoclonal antib...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(95)00028-d

    authors： Fitts MG,Metzger DW,Hendershot LM,Mage RG

    更新日期：1995-07-01 00:00:00

  • Inhibition of PIM1 kinase attenuates bleomycin-induced pulmonary fibrosis in mice by modulating the ZEB1/E-cadherin pathway in alveolar epithelial cells.

    abstract：:PIM1 is serine/threonine protein kinase that is involved in numerous biological processes. Pulmonary fibrosis (PF) is a chronic pathological result of the dysfunctional repair of lung injury without effective therapeutic treatments. In the current study, we investigated whether PIM1 inhibition would improve bleomycin ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2020.06.013

    authors： Zhang X,Zou Y,Liu Y,Cao Y,Zhu J,Zhang J,Chen X,Zhang R,Li J

    更新日期：2020-09-01 00:00:00

  • PMS2-deficiency diminishes hypermutation of a lambda1 transgene in young but not older mice.

    abstract：:The Pms2 gene is involved in DNA mismatch repair in mammalian cells, and has recently been shown to affect hypermutation of mammalian immunoglobulin genes. We have studied hypermutation of a lambda1 transgene in chronically stimulated Peyer's patch B cells of both young and old mice deficient in function of Pms2. In y...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/s0161-5890(99)00027-9

    authors： Kong Q,Maizels N

    更新日期：1999-02-01 00:00:00

  • HPLC purification of the main allergen of Parietaria judaica pollen.

    abstract：:A two-step purification procedure of Par j I from the whole Parietaria judaica pollen extract is described. The first step consisted of gel filtration HPLC using a TSKG 3000 SW column, and 0.1% trifluoroacetic acid as the eluant. By this method, proteins were separated from the highly colored material present in the e...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(90)90110-l

    authors： Polo F,Ayuso R,Carreira J

    更新日期：1990-02-01 00:00:00