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MHC class I chain-related molecules induced on monocytes by IFN-gamma promote NK cell activation.

Abstract：

:NKG2D receptor-ligand interaction triggers NK cell-mediated cytolysis and IFN-gamma secretion. IFN-gamma produced by NK cells has been found to promote the interaction between NK cells and monocytes; however, the underlying mechanism remains elusive. We demonstrate here that IFN-gamma exclusively induced or upregulated the expression of MHC class I chain-related (MIC) molecules, which are ligands of the NKG2D receptor, on the surface of human monocytes of the PBMC population. The IFN-gamma-induced MIC molecules on monocytes played an essential role in triggering the activation of NK cells because mAb-mediated masking of the MIC molecules and the inhibition of cell-to-cell contact using transwell inserts significantly abolished NK cell activation. Meanwhile, membrane-bound IL-15 (mIL-15) was concomitantly induced with MIC molecules on IFN-gamma-treated monocytes and played an essential role in protecting NK cells cocultured with monocytes from MIC-induced NKG2D down-modulation. Therefore, we conclude that the IFN-gamma-induced MIC molecules participated in monocyte/NK cell interaction and that this interaction also involved mIL-15.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Wang H,Ruan Z,Wang Y,Han J,Fu X,Zhao T,Yang D,Xu W,Yang Z,Wang L,Chen Y,Wu Y

doi

10.1016/j.molimm.2007.10.007

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

1548-56

issue

6

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(07)00801-2

journal_volume

45

pub_type

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