Complement control protein factor H: the good, the bad, and the inadequate.

abstract：:Bradykinin (BK) is an inflammatory mediator, and shows elevated levels in regions of severe injury and inflammatory diseases. It has been shown to induce interleukin-6 (IL-6) expression in inflammatory responses in rheumatoid arthritis. We investigated the signaling pathway involved in IL-6 production caused by BK in ...

journal_title：Molecular immunology

authors： Lee CH,Shieh DC,Tzeng CY,Chen CP,Wang SP,Chiu YC,Huang CY,Hsu CJ,Fong YC,Tang CH

更新日期：2008-08-01 00:00:00

abstract：:Most of the complement proteins in circulation are, by and large, synthesized in the liver. However data accumulated over the past several decades provide incontrovertible evidence that some if not most of the individual complement proteins are also synthesized extrahepatically by activated as well as non-activated ce...

journal_title：Molecular immunology

authors： Ghebrehiwet B,Hosszu KH,Peerschke EI

更新日期：2017-04-01 00:00:00

abstract：:As an initial step towards the molecular analysis of the murine V kappa locus, a cosmid library from BALB/cJ mouse liver DNA was screened with probes representing 10 V kappa families. Of eight cosmids that were isolated from the initial screen, five contained a single restriction fragment that hybridized to the probes...

journal_title：Molecular immunology

authors： Lawler AM,Umar A,Gearhart PJ

更新日期：1992-03-01 00:00:00

abstract：:Degenerate PCR was used to isolate a 221-base pair nucleotide sequence of a new crustin-like antibacterial peptide from the haemocytes of the European lobster, Homarus gammarus. Rapid amplification of cDNA ends was used to extend the sequence to determine the complete open reading frame and un-translated regions. The ...

journal_title：Molecular immunology

authors： Hauton C,Brockton V,Smith VJ

更新日期：2006-03-01 00:00:00

abstract：:The porcine complement proteins C3 and C4 have been isolated and then characterized using small-angle scattering methods. Within the limits of experimental errors, the porcine proteins are virtually identical with the corresponding human proteins as measured in terms of mol. wt, Mr and radius of gyration, R,: Mr(C3) =...

journal_title：Molecular immunology

authors： Osterberg R,Malmensten B,Boive T,Nilsson U,Stigbrand T,Mortensen K

更新日期：1991-09-01 00:00:00

abstract：:Apo-1/Fas (CD95) is a transmembrane protein expressed on the cell surface that is involved in apoptosis and plays an important role in the function and regulation of the immune system. Aberrant expression of the Apo-1/Fas gene product has been reported in a number of immune-related disorders, such as autoimmune lympho...

journal_title：Molecular immunology

authors： Huang QR,Morris D,Manolios N

更新日期：1997-06-01 00:00:00

abstract：:The major product of digestion of bovine IgG2a(A1) with immobilized pepsin is F(ab')2 while similar treatment of IgG2a(A2) yields Fab, Fc and other products. It is postulated that structural differences in the hinge region, including the absence of the most N-terminal disulfide bridge in IgG2a(A2) and a displacement o...

journal_title：Molecular immunology

authors： Heyermann H,Butler JE

更新日期：1987-12-01 00:00:00

abstract：:We investigated the antibody (Ab) and cytotoxic T lymphocyte (CTL) responses to gene gun (GG)-mediated DNA immunization via the intramuscular (i.m.) and intradermal (i.d.) routes. BALB/c mice were immunized five times at weekly intervals with plasmid DNA encoding enhanced green fluorescent protein (EGFP). EGFP product...

journal_title：Molecular immunology

authors： Ito K,Ito K,Shinohara N,Kato S

更新日期：2003-05-01 00:00:00

abstract：:We have designed a 39 amino acid peptide mimic of the conformation-dependent main immunogenic region (MIR) of the Torpedo acetylcholine receptor (TAChR) that joins three discontinuous segments of the Torpedo α-subunit, α(1-12), α(65-79), and α(110 - 115) with two GS linkers: This 39MIR-mimic was expressed in E. coli a...

journal_title：Molecular immunology

authors： Trinh VB,Foster AJ,Fairclough RH

更新日期：2014-05-01 00:00:00

abstract：:A first report of an XLA patient with a polymorphism in Btk SH3 domain has been identified after sequencing of the entire gene. SH3 domain variants might not be detected due to well characterized mutations outside the domain. ...

journal_title：Molecular immunology

authors： Pérez de Diego R,Bravo J,Allende LM,López-Granados E,Rivera J,Ferreira A,Fontán G,García Rodríguez MC

更新日期：2008-01-01 00:00:00

abstract：:Concanavalin A (Con A)section-binding proteins from mouse spleen leukocytes were characterised by two-dimensional electrophoresis of material precipitated, by Con A plus anti-Con A, from lysates of biosynthetically-labelled cells. Although most cell surface (iodinatable) proteins are known to bind Con A, some of the m...

journal_title：Molecular immunology

authors： Pink JR,Hoessli D,Tartakoff A,Hooghe R

更新日期：1983-04-01 00:00:00

abstract：:Chemokine effects on leukocyte infiltration into the central nervous system (CNS) are key events in the inflammatory processes of neuroimmunologic and neuroinfectious diseases. Because, chemokines may play important roles in proliferation and differentiation of brain cells and in the initiation and progression of CNS ...

journal_title：Molecular immunology

authors： Bakhiet M,Mousa A,Seiger A,Andersson J

更新日期：2002-05-01 00:00:00

abstract：:The mast cell function-associated antigen (MAFA) is a type II membranal glycoprotein that was first identified on the surface of rat mucosal-type mast cells of the RBL-2H3 line. A C-type lectin domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM) are located in the extracellular and intracellular domain...

journal_title：Molecular immunology

authors： Abramson J,Xu R,Pecht I

更新日期：2002-09-01 00:00:00

abstract：:Macrophages play an important role both in innate and adaptive immune responses. Treatment with interferon (IFN) γ together with lipopolysaccharide (LPS) activates pro-inflammatory macrophages which secrete various pro-inflammatory cytokines including IL-12. IL-12 promotes a Th1 type immune response by directly contro...

journal_title：Molecular immunology

authors： Boonyatecha N,Sangphech N,Wongchana W,Kueanjinda P,Palaga T

更新日期：2012-07-01 00:00:00

abstract：:Human neutrophil peptides (HNPs) are cysteine-rich antimicrobial peptides stored in neutrophils. The similar structure of HNPs -1, -2, and -3 renders them impossible to study individually in biological samples. For the first time, we describe a method of individually identifying the HNPs -1-3 from exudative neutrophil...

journal_title：Molecular immunology

authors： Thompson L,Turko I,Murad F

更新日期：2006-03-01 00:00:00

abstract：:Human IgE against helminths is a normal component of the whole protective response elicitesd during infection, when specific IgE to a great number of antigens is produced; however, few of those IgE binding components are actually allergens. In general, considering the strong Th2/IgE responses during helminth infection...

journal_title：Molecular immunology

authors： Caraballo L,Coronado S

更新日期：2018-08-01 00:00:00

abstract：:Forty different PCR clones encoding a llama variable heavy chain domain were analysed. The majority of these clones are derived from heavy-chain antibody cDNA in which the entire CH1 exon is absent. It appears from the amino acid within the VHH framework 1 and 3 that all the llama clones belong to the VH III family. H...

journal_title：Molecular immunology

authors： Vu KB,Ghahroudi MA,Wyns L,Muyldermans S

更新日期：1997-11-01 00:00:00

abstract：:Immunoglobulins (Ig) require correct folding and assembly of both heavy (H) and light (L) chains to form a functional H2L2 dimer that is secreted from plasma cells. This process is dependent upon the endoplasmic reticulum (ER) chaperone BiP, which targets improperly, folded or assembled Ig molecules for degradation. W...

journal_title：Molecular immunology

authors： McLean GR,Torres M,Trotter B,Noseda M,Bryson S,Pai EF,Schrader JW,Casadevall A

更新日期：2005-05-01 00:00:00

abstract：:Purified mRNA's encoding the HLA-A and -B antigen heavy chains or beta 2-microglobulin were prepared from human B lymphoid cells by positive hybridization selection procedures. The role of chain association in the biosynthesis and intracellular transport of HLA-A and -B antigens was investigated by injecting these mRN...

journal_title：Molecular immunology

authors： Kinnon C,Owen MJ

更新日期：1986-05-01 00:00:00

abstract：:Cathepsin L protease belongs to the papain-like cysteine proteases family, plays indispensable roles in animals' pathological and physiological processes. However, little is known about Cathepsin L in silkworm, Bombyx mori. Herein, a novel Cathepsin L-like (Cat L-like) was cloned and identified from silkworm by the ra...

journal_title：Molecular immunology

authors： Pan G,Zhang K,Li C,Hu X,Kausar S,Gu H,Yang L,Cui H

更新日期：2020-12-26 00:00:00

abstract：:Egr-1 is an immediate early gene that is rapidly upregulated in response to mitogenic signals induced by antigen receptor crosslinking on murine B lymphocytes. It has been shown that levels of Egr-1 expression are closely correlated with B cell proliferation in several models of B cell activation and tolerance. We com...

journal_title：Molecular immunology

authors： Klaus SJ,Phillips NE,Parker DC

更新日期：1993-11-01 00:00:00

abstract：:T-cell receptor (TCR) repertoire diversity, thymic output, clonal size and peripheral T-lymphocyte numbers largely depend on intra-thymic and post-thymic T-lymphocyte proliferation. However, quantitative insight into thymocyte and T-lymphocyte proliferation is still lacking. We developed a new TCRG-based TCR excision ...

journal_title：Molecular immunology

authors： van der Weerd K,Dik WA,Schrijver B,Bogers AJ,Maat AP,van Nederveen FH,van Hagen PM,van Dongen JJ,Langerak AW,Staal FJ

更新日期：2013-03-01 00:00:00

abstract：:The three-dimensional structure of the Mcg lambda-type Bence-Jones dimer crystallized in ammonium sulfate is known at 2.3-A resolution. A series of nine other human lambda-chains and two kappa-chains did not crystallize under the same conditions. After these proteins were hybridized with the Mcg light chain by the met...

journal_title：Molecular immunology

authors： Ely KR,Peabody DS,Holm TR,Cheson BD,Edmundson AB

更新日期：1985-02-01 00:00:00

abstract：:In most cases, cytotoxic T cell activation is dependent on the interaction of the T cell receptor (TCR) and CD8 with MHC class I molecules. In the CD8(+) T cell system based on the mouse cytotoxic T cell clone 2C, recognition of the allogeneic MHC L(d) exhibits a less significant role for CD8 than recognition of the s...

journal_title：Molecular immunology

authors： Lee PU,Kranz DM

更新日期：2003-01-01 00:00:00

abstract：:Integrin-mediated adhesion of human monocytes to fibrinogen regulated by CD11b/CD18 and the closely related integrin CD11c/CD18, play a key role in inflammation. Peripheral blood monocytes isolated from human donors despite expressing CD11c primarily utilized CD11b to mediate adhesion to fibrinogen upon stimulation wi...

journal_title：Molecular immunology

authors： Georgakopoulos T,Moss ST,Kanagasundaram V

更新日期：2008-08-01 00:00:00

abstract：:In a recent article published in Molecular Immunology [Furukawa, K., Shimizu, T., Murakami, A., Kono, R., Nakagawa, M., Sagawa, T., Yamato, I., Azuma, T., 2007. Strategy for affinity maturation of an antibody with high evolvability to (4-hydroxy-3-nitrophenyl) acetyl hapten. Mol. Immunol. 44, 2436-2445], the authors m...

journal_title：Molecular immunology

authors： Kang J,Warren AS

更新日期：2008-01-01 00:00:00

abstract：:Endodontic infection is a widespread oral problem. DNA methylation is a key epigenetic modification that plays important roles in various inflammatory responses, but its role in dental pulp inflammation is poorly understood. In this study, we assessed the expression of DNA methyltransferases (DNMTs) in human dental pul...

journal_title：Molecular immunology

authors： Mo Z,Li Q,Cai L,Zhan M,Xu Q

更新日期：2019-07-01 00:00:00

abstract：:The C-terminal domain of protein 4.1G was identified to interact with the cytosolic tail of the high affinity IgG receptor, Fc gamma RI, in yeast two-hybrid screens. Proteins of the 4.1 family have previously been found to mediate receptor/cytoskeleton interactions. In the study presented here, we show an alternativel...

journal_title：Molecular immunology

authors： Beekman JM,Bakema JE,van der Poel CE,van der Linden JA,van de Winkel JG,Leusen JH

更新日期：2008-04-01 00:00:00

abstract：:Sepsis-induced inflammatory damage is a crucial cause of acute kidney injury (AKI), and AKI is an ecumenical fearful complication in approximately half of patients with sepsis. CCAAT/enhancer-binding protein β (C/EBPβ) plays roles in regulating acute phase responses and inflammation. However, the role and mechanism of...

journal_title：Molecular immunology

authors： Dai XG,Li Q,Li T,Huang WB,Zeng ZH,Yang Y,Duan ZP,Wang YJ,Ai YH

更新日期：2020-11-01 00:00:00

abstract：:Low molecular weight hemorrhagins were purified from crude Bothrops atrox snake venom by gel filtration followed by ionic strength chromatography. The protein fractions obtained, designated HI-1 to HI-8, contained proteins with molecular masses lower than 30 kDa. HI-5, the most representative among of these fractions,...

journal_title：Molecular immunology

authors： Rodrigues FG,Petretski JH,Kanashiro MM,Lemos L,da Silva WD,Kipnis TL

更新日期：2004-03-01 00:00:00