Receptors for complement C3 on T-lymphocytes: relics of evolution or functional molecules?

Abstract:

:Despite the fact that receptors for complement on T-cells have been described many years ago the function remains unclear as is the role of complement in the T-cell response. In this review we will evaluate how the accumulated wisdom concur with the current concepts of the adaptive T-cell response.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Wagner C,Hänsch GM

doi

10.1016/j.molimm.2005.06.027

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

22-30

issue

1-2

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(05)00200-2

journal_volume

43

pub_type

杂志文章,评审
  • Functional maturation of murine B lymphocyte precursors--III. Soluble factors involved in the regulation of growth and differentiation.

    abstract::When 5-fluorouracil (5-FU) resistant bone marrow (BM) cells are depleted of B-cells and then cultured in insert chambers [separated from a layer of adherent BM (aBM) cells by a nucleopore membrane], no mature, lipopolysaccharide (LPS) reactive B-cells are formed. Factors acting on B-cell precursors are not produced un...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/0161-5890(88)90146-0

    authors: Gisler RH,Schlienger C,Söderberg A,Ledermann F,Lambris JD

    更新日期:1988-11-01 00:00:00

  • The complement system is involved in acute inflammation but not in the hemorrhage produced by a Bothrops atrox snake venom low molecular mass proteinase.

    abstract::Low molecular weight hemorrhagins were purified from crude Bothrops atrox snake venom by gel filtration followed by ionic strength chromatography. The protein fractions obtained, designated HI-1 to HI-8, contained proteins with molecular masses lower than 30 kDa. HI-5, the most representative among of these fractions,...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/j.molimm.2003.11.032

    authors: Rodrigues FG,Petretski JH,Kanashiro MM,Lemos L,da Silva WD,Kipnis TL

    更新日期:2004-03-01 00:00:00

  • Interleukin-1 Receptor-Associated Kinase-1 (IRAK-1) functionally associates with PKCepsilon and VASP in the regulation of macrophage migration.

    abstract::Macrophage migration is mediated by complex cellular signaling processes and cytoskeleton re-arrangement. In particular, recent advances indicate that the innate immunity signaling process plays a key role in the regulation of macrophage migration. In this report, we have provided evidence demonstrating the involvemen...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/j.molimm.2009.12.004

    authors: Gan L,Li L

    更新日期:2010-03-01 00:00:00

  • Interleukin 1 activation of the AP-1 transcription complex in murine T cells is regulated at the level of Jun B protein accumulation.

    abstract::We have examined the regulation of the AP-1 DNA transcription complex during T cell activation in response to interleukin 1 (IL-1) and phorbol ester (TPA) treatment of the IL-1 responsive murine thymoma T cell line, EL4 6.1 C 10. IL-1 synergistically enhances the stimulatory effect of TPA on AP-1-mediated gene express...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/0161-5890(95)00055-j

    authors: Brooks JW,Yoza BK,Mizel SB

    更新日期:1995-08-01 00:00:00

  • Involvement of CTLA-4 in T-cell anergy induced by staphylococcal enterotoxin A in vitro.

    abstract::Superantigens, like staphylococcal enterotoxin A (SEA), induce a strong proliferative response followed by clonal deletion of a substantial portion of defined V(beta) T-cells. The remaining cells display in vitro anergy. Anergy is a major mechanism to ensure antigen-specific tolerance in T-lymphocyte in the adult. Co-...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/j.molimm.2004.03.001

    authors: Xu GL,Zhu XH,Guo B,Wu YZ

    更新日期:2004-05-01 00:00:00

  • Anti-allergic properties of a new all-D synthetic immunoglobulin-binding peptide.

    abstract::Using a combinatorial chemistry approach, we identified a tetrameric tripeptide, denoted Protein A Mimetic (PAM) or TG19318, able to bind to immunoglobulins of different classes and species. The inverso variant, with the tripeptide in the all-D configuration (D-PAM or TG19320), is described as retaining binding proper...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/j.molimm.2007.04.020

    authors: Rossi M,Ruvo M,Marasco D,Colombo M,Cassani G,Verdoliva A

    更新日期:2008-01-01 00:00:00

  • Covalent binding to alpha-macroglobulins of a protein with free SH groups produced by activated B cells: blocking by D-penicillamine and gold compounds.

    abstract::alpha 2-Macroglobulin (alpha 2M) complexed with proteinases or modified by the action of amines has been shown to affect immune responses in vitro, though as yet the mechanisms are poorly understood. Supernates from rabbit lymphoid cells cultured in medium with normal rabbit serum and 35S-methionine (or 14C-leucine) w...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/0161-5890(89)90079-5

    authors: Schlesinger C,McEntire J,Wallman J,Skosey JL,Hanly WC,Teodorescu M

    更新日期:1989-03-01 00:00:00

  • Protection against alpha-bungarotoxin poisoning by immunization with synthetic toxin peptides.

    abstract::The purpose of the present work was to determine the ability of BgTX peptides, corresponding to the various loops and exposed regions of alpha-bungarotoxin (BgTX) and representing regions that are recognized by B and/or T cells, to stimulate protective immunity in mice against in vivo challenge with BgTX. The BgTX LD5...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/0161-5890(96)00014-4

    authors: Dolimbek BZ,Atassi MZ

    更新日期:1996-05-01 00:00:00

  • Germline transcripts of immunoglobulin light chain variable regions are structurally diverse and differentially expressed.

    abstract::The murine pre-B cell line R2-bfl, which can be induced to differentiate in vitro, was used to study germline transcription of variable regions of the light chain loci. RNA from these cells was subjected to a 3'-RACE and germline transcripts from 17 individual Vkappa gene segments belonging to 12 Vkappa families were ...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/s0161-5890(03)00226-8

    authors: Düber S,Engel H,Rolink A,Kretschmer K,Weiss S

    更新日期:2003-12-01 00:00:00

  • Magnolol suppresses NF-kappaB activation and NF-kappaB regulated gene expression through inhibition of IkappaB kinase activation.

    abstract::The mis-regulation of nuclear factor-kappa B (NF-kappaB) signal pathway is involved in a variety of inflammatory diseases that leds to the production of inflammatory mediators. Our studies using human U937 promonocytes cells suggested that magnolol, a low molecular weight lignan isolated from the medicinal plant Magno...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/j.molimm.2006.12.004

    authors: Tse AK,Wan CK,Zhu GY,Shen XL,Cheung HY,Yang M,Fong WF

    更新日期:2007-04-01 00:00:00

  • MBL and C1q compete for interaction with human endothelial cells.

    abstract::C1q, the recognition molecule of the classical pathway of complement, binds to endothelial cells, leading to cell activation. Mannose-binding lectin (MBL), a recognition molecule of the lectin pathway, is structurally and functionally related to C1q. Therefore, we investigated the interaction of MBL with human umbilic...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/j.molimm.2006.06.015

    authors: Oroszlán M,Daha MR,Cervenak L,Prohászka Z,Füst G,Roos A

    更新日期:2007-02-01 00:00:00

  • Maspin inhibits macrophage phagocytosis and enhances inflammatory cytokine production via activation of NF-κB signaling.

    abstract::Maspin (mammary serine protease inhibitor) is a non-inhibitory member of the serine protease inhibitor superfamily and a tumor suppressor in several cancers due to its ability to inhibit cell invasion, angiogenesis, and promote apoptosis. However, its immunomodulatory function remains largely unexplored. Thus, we expl...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/j.molimm.2016.12.021

    authors: Wang Y,Sun L,Song Z,Wang D,Bao Y,Li Y

    更新日期:2017-02-01 00:00:00

  • Quantitation of the immunogenic potential of protein antigens.

    abstract::A procedure to quantitate the immunogenic potential of protein antigens is presented. It is hypothesized that the intrinsic immunogenicity of an accessible region on the protein arises from the overall structural effect of the presence of the particular assemblage of amino acid residues in the given region. Structural...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/0161-5890(85)90043-4

    authors: Padlan EA

    更新日期:1985-11-01 00:00:00

  • A new effector of lipid metabolism: complement factor properdin.

    abstract:BACKGROUND:The complement system is well known for its role in innate immunity via the classical, the alternative and the lectin pathways, although recent investigations suggest expanding roles in adipose tissue. Properdin stabilizes C3 convertase following alternative complement activation. Properdin is also present i...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/j.molimm.2012.02.110

    authors: Gauvreau D,Roy C,Tom FQ,Lu H,Miegueu P,Richard D,Song WC,Stover C,Cianflone K

    更新日期:2012-05-01 00:00:00

  • Polyclonal antibodies specific for liganded active site (metatype) of a high affinity anti-hapten monoclonal antibody.

    abstract::Syngeneic polyclonal antibodies were elicited to an affinity labeled high affinity (2-3 X 10(10) M-1) anti-fluorescein murine IgG2a monoclonal antibody. Hyperimmune ascites fluid was tested for reactivity with homologous liganded, affinity labeled and non-liganded Fab fragments derived from the high affinity antibody....

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/0161-5890(88)90111-3

    authors: Voss EW Jr,Miklasz SD,Petrossian A,Dombrink-Kurtzman MA

    更新日期:1988-08-01 00:00:00

  • The transcription factor Bright plays a role in marginal zone B lymphocyte development and autoantibody production.

    abstract::Previous data suggested that constitutive expression of the transcription factor Bright (B cell regulator of immunoglobulin heavy chain transcription), normally tightly regulated during B cell differentiation, was associated with autoantibody production. Here we show that constitutive Bright expression results in skew...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/j.molimm.2011.09.008

    authors: Oldham AL,Miner CA,Wang HC,Webb CF

    更新日期:2011-10-01 00:00:00

  • Glutaredoxin 1 (GRX1) inhibits oxidative stress and apoptosis of chondrocytes by regulating CREB/HO-1 in osteoarthritis.

    abstract::GRX1 (glutaredoxin1), a sulfhydryl disulfide oxidoreductase, is involved in many cellular processes, including anti-oxidation, anti-apoptosis, and regulation of cell differentiation. However, the role of GRX1 in the oxidative stress and apoptosis of osteoarthritis chondrocytes remains unclear, prompting the current st...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/j.molimm.2017.08.006

    authors: Sun J,Wei X,Lu Y,Cui M,Li F,Lu J,Liu Y,Zhang X

    更新日期:2017-10-01 00:00:00

  • Serologic and molecular characterization of the T15 idiotype--II. Structural basis of independent idiotope expression on phosphorylcholine-specific monoclonal antibodies.

    abstract::We examined the expression of T15 idiotopes (Id) on phosphorylcholine (PC)-binding monoclonal immunoglobulins and defined the structural correlates of these Id. The seven monoclonal anti-Id antibodies used as probes recognize distinct determinants that range from the antigen binding site to the CH1 domain on TEPC15. C...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/0161-5890(87)90045-9

    authors: Strickland FM,Gleason JT,Cerny J

    更新日期:1987-06-01 00:00:00

  • PMS2-deficiency diminishes hypermutation of a lambda1 transgene in young but not older mice.

    abstract::The Pms2 gene is involved in DNA mismatch repair in mammalian cells, and has recently been shown to affect hypermutation of mammalian immunoglobulin genes. We have studied hypermutation of a lambda1 transgene in chronically stimulated Peyer's patch B cells of both young and old mice deficient in function of Pms2. In y...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/s0161-5890(99)00027-9

    authors: Kong Q,Maizels N

    更新日期:1999-02-01 00:00:00

  • PAX2 oncogene negatively regulates the expression of the host defense peptide human beta defensin-1 in prostate cancer.

    abstract::Human beta defensin-1 (hBD1) is a component of the immune system which links the innate and adaptive immune responses. We have demonstrated that hBD1 induces rapid cytolysis of prostate cancer cells and that it may also possess tumor suppressive abilities. In addition, there is a high frequency of cancer-specific loss...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/j.molimm.2008.11.004

    authors: Bose SK,Gibson W,Bullard RS,Donald CD

    更新日期:2009-03-01 00:00:00

  • Discovery and expression of 3 siglecs-like in Oreochromis niloticus neutrophil, and their interaction with group B streptococcal sialylated capsular polysaccharides.

    abstract::Sialic acid - binding immunoglobulin - like lectins (Siglecs) are members of the largest superfamily of immune receptors; they recognize sialic acid and are mainly expressed in immune cells. Studies on mammals indicate that Streptococcus agalactiae (GBS) evade immune reactions by interacting with the host immune cells...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/j.molimm.2016.01.005

    authors: Dong J,Wei Y,Ye X,Sun C,Tian Y,Lu M,Du J,Chen Z

    更新日期:2016-05-01 00:00:00

  • MD-2 regulates LPS-induced NLRP3 inflammasome activation and IL-1beta secretion by a MyD88/NF-κB-dependent pathway in alveolar macrophages cell line.

    abstract::Myeloid differentiation protein 2 (MD-2) is required in the recognition of lipopolysaccharide (LPS) by toll-like receptor 4 (TLR4), and participates in LPS-induced alveolar macrophage (AM) inflammation during acute lung injury (ALI). Activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflamm...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/j.molimm.2017.06.035

    authors: Luo M,Hu L,Li D,Wang Y,He Y,Zhu L,Ren W

    更新日期:2017-10-01 00:00:00

  • Activation of NF-κB induced by TRIMCyp showing a discrepancy between owl monkey and northern pig-tailed macaque.

    abstract::TRIMCyp generated by retrotransposition of a cyclophilin A inserting into TRIM5 locus, has been identified in owl monkey and most of Old World monkeys (OWM). Owl monkey TRIMCyp (omTRIMCyp) inhibits HIV-1 infection by direct interaction with viral capsid and indirect innate immune induction, whereas most of TRIMCyps fr...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/j.molimm.2018.08.001

    authors: Zhu JW,Mu D,Liu FL,Luo MT,Luo RH,Zheng YT

    更新日期:2018-09-01 00:00:00

  • Non-traditional roles of complement in type 2 diabetes: Metabolism, insulin secretion and homeostasis.

    abstract::Type 2 Diabetes (T2D) is a disease of increasing importance and represents a growing burden on global healthcare and human health. In T2D, loss of effectiveness of insulin signaling in peripheral tissues cannot be compensated for by adequate insulin secretion, leading to hyperglycemia and resultant complications. In r...

    journal_title:Molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.molimm.2016.12.009

    authors: King BC,Blom AM

    更新日期:2017-04-01 00:00:00

  • Extracellular, but not intracellular HMGB1, facilitates self-DNA induced macrophage activation via promoting DNA accumulation in endosomes and contributes to the pathogenesis of lupus nephritis.

    abstract::Systemic lupus erythematosus (SLE) is a typical autoimmune disease with unclear etiology. Aberrant self-DNA recognition has been proven critical for the initiation of excessive immune responses in lupus. Consistently, we previously reported that a sort of self-DNA, activated lymphocyte-derived DNA (ALD-DNA) could pote...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/j.molimm.2015.01.023

    authors: Li X,Yue Y,Zhu Y,Xiong S

    更新日期:2015-05-01 00:00:00

  • HPLC purification of the main allergen of Parietaria judaica pollen.

    abstract::A two-step purification procedure of Par j I from the whole Parietaria judaica pollen extract is described. The first step consisted of gel filtration HPLC using a TSKG 3000 SW column, and 0.1% trifluoroacetic acid as the eluant. By this method, proteins were separated from the highly colored material present in the e...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/0161-5890(90)90110-l

    authors: Polo F,Ayuso R,Carreira J

    更新日期:1990-02-01 00:00:00

  • Endogenous ligands of natural killer T cells are alpha-linked glycosylceramides.

    abstract::The nature of the endogenous ligands for natural killer T (NKT) cells has been debated for more than a decade. Because the mammalian glycosylceramide synthases are invertases, it is believed that in mammals all glycosylceramides are β anomers. However, the possibility that an alternative enzymatic pathway, an unfaithf...

    journal_title:Molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.molimm.2015.06.009

    authors: Kain L,Costanzo A,Webb B,Holt M,Bendelac A,Savage PB,Teyton L

    更新日期:2015-12-01 00:00:00

  • Generation of a comprehensive panel of crustacean allergens from the North Sea Shrimp Crangon crangon.

    abstract:BACKGROUND:Published data on crustacean allergens are incomplete. The identification of tropomyosin (TM), arginine kinase (AK), sarcoplasmic Ca-binding protein (SCP) and myosin light chain (MLC) as shrimp allergens are all important contributions but additional allergens are required for the development of a complete s...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/j.molimm.2011.06.216

    authors: Bauermeister K,Wangorsch A,Garoffo LP,Reuter A,Conti A,Taylor SL,Lidholm J,Dewitt AM,Enrique E,Vieths S,Holzhauser T,Ballmer-Weber B,Reese G

    更新日期:2011-09-01 00:00:00

  • Amino acid sequence of a light chain variable region of a human rheumatoid factor of the Wa idiotypic group, in part predicted by its reactivity with antipeptide antibodies.

    abstract::Antipeptide antisera were raised to the second and third complementarity-determining regions of the light chain derived from a human monoclonal IgM (Sie) which had antigammaglobulin activity and belonged to the Wa cross-reactive idiotypic group of human rheumatoid factors, two of whose members (Sie, Wo1) had been prev...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/0161-5890(86)90049-0

    authors: Newkirk M,Chen PP,Carson D,Posnett D,Capra JD

    更新日期:1986-03-01 00:00:00

  • Localization of a hydrophobic domain in human C5.

    abstract::The fifth component of human complement (C5), under physiological salt conditions, bound firmly to phenyl-Sepharose. This indicated the presence of hydrophobic sites on C5. These sites may play an important role in C5 haemolytic activity since this activity was inhibited by chaotropic ions (Mg2+, SCN-, I-) at relative...

    journal_title:Molecular immunology

    pub_type: 杂志文章

    doi:10.1016/0161-5890(88)90031-4

    authors: Al Salihi A,Ripoche J,Fontaine M

    更新日期:1988-04-01 00:00:00