当前位置： SCI文献检索 > MOLECULAR IMMUNOLOGY期刊下所有文献 > Protein kinase C-associated kinase is not required for the development of peripheral B lymphocyte populations.

Protein kinase C-associated kinase is not required for the development of peripheral B lymphocyte populations.

Abstract：

:Protein kinase C-associated kinase (PKK; DIK/RIP4) is an ankyrin-repeat containing serine/threonine receptor-interacting protein (RIP)-family kinase that can activate NFkappaB, and is required for keratinocyte development. In earlier studies, the expression of a catalytically inactive mutant of PKK in the B cell lineage resulted in a marked decrease in peripheral B cells in the spleen and a severe reduction of B-1 B cells. Here we explore the consequences of a null mutation in PKK with respect to the generation of peripheral B cell lineages and the activation of NFkappaB. We show that PKK is not required for the production of B cells in the bone marrow or for the development and maintenance of all mature B lymphocyte populations. We also show that PKK is not required for the activation of NFkappaB downstream of the BCR, CD40, or TLR-4 in B cells. Taken together, these data demonstrate that the loss of this RIP-family kinase does not compromise B lymphocyte development and maintenance, but leaves open the possibility that PKK may have a redundant role in these processes.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Moran ST,Cariappa A,Liu H,Boboila C,Shi HN,Holland PM,Peschon JJ,Pillai S

doi

10.1016/j.molimm.2005.09.009

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

1694-9

issue

10

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(05)00341-X

journal_volume

43

pub_type

杂志文章

相关文献

MOLECULAR IMMUNOLOGY文献大全
  • A light-scattering method for measuring the sizes of insoluble immune complexes.

    abstract：:A turbidimetric method for measuring the diameters of insoluble immune complexes, based on the wavelength dependence of their ability to scatter light, was developed. The method was validated by demonstrating that it gave experimental values for the diameters of polystyrene microspheres which were in good agreement wi...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(93)90074-l

    authors： Easterbrook-Smith SB

    更新日期：1993-05-01 00:00:00

  • Regulation of human neutrophil guanylate cyclase by metal ions, free radicals and the muscarinic cholinergic receptor.

    abstract：:We have examined the properties of soluble guanylate cyclase activity in the human neutrophil. The enzyme showed complex regulation by metal ions. A 10-fold higher activity was observed in the presence of Mn2+ than Mg2+, while Ca2+ caused an increase in activity only in the presence of Mg2+ ion. Sodium nitroprusside (...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(85)90138-5

    authors： Lad PM,Glovsky MM,Richards JH,Smiley PA,Backstrom B

    更新日期：1985-07-01 00:00:00

  • Evolution of the MHC: antigenicity and unusual tissue distribution of Xenopus (frog) class II molecules.

    abstract：:Antibodies that recognize Xenopus class II molecules have been developed. Mouse monoclonal antibodies were prepared by immunizing BALB/c mice with frog MHC antigens that had been partially purified with alloantisera, and by immunizing mouse spleen cells in vitro with activated Xenopus T lymphocytes. In addition, five ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(90)90170-5

    authors： Flajnik MF,Ferrone S,Cohen N,Du Pasquier L

    更新日期：1990-05-01 00:00:00

  • C-mip interacts physically with RelA and inhibits nuclear factor kappa B activity.

    abstract：:The fine regulation of NF-kappaB activity is crucial for both resting and stimulated cells and relies on complex balance between multiple activators and inhibitors. We report here that c-mip, a recently identified pleckstrin homology (PH) and leucine-rich repeat (LRR)-domain-containing protein, inactivates GSKbeta and...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2008.09.034

    authors： Kamal M,Valanciute A,Dahan K,Ory V,Pawlak A,Lang P,Guellaen G,Sahali D

    更新日期：2009-02-01 00:00:00

  • Oligomeric proanthocyanidins attenuate airway inflammation in asthma by inhibiting dendritic cells maturation.

    abstract：:To date, although a promising anti-inflammatory activity of oligomeric proanthocyanidins (OPCs) has been observed in asthma, the mechanism responsible for these immunomodulatory properties remains obscure. Dendritic cells (DCs) that reside in the airway have been widely perceived as an important contributor to asthma....

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2017.09.012

    authors： Li Y,Yu Q,Zhao W,Zhang J,Liu W,Huang M,Zeng X

    更新日期：2017-11-01 00:00:00

  • Major mountain cedar allergen, Jun a 1, contains conformational as well as linear IgE epitopes.

    abstract：:We have previously identified four linear IgE epitopes on Jun a 1, the dominant allergen in mountain cedar pollen, and mapped these to the surfaces of a molecular model and to the crystal structure of this glycoprotein. The aim of the present study was to determine if Jun a 1 also displays conformational IgE epitopes....

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2005.12.001

    authors： Varshney S,Goldblum RM,Kearney C,Watanabe M,Midoro-Horiuti T

    更新日期：2007-04-01 00:00:00

  • Effect of C1-INH on ischemia/reperfusion injury in a porcine limb ex vivo perfusion model.

    abstract：:Revascularization of an amputated limb within 4-6h is essential to avoid extensive ischemia/reperfusion (I/R) injury leading to vascular leakage, edema and tissue necrosis. I/R injury is a pathological inflammatory condition that occurs during reperfusion of an organ or tissue after prolonged ischemia. It is character...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2017.06.021

    authors： Abdelhafez MM,Shaw J,Sutter D,Schnider J,Banz Y,Jenni H,Voegelin E,Constantinescu MA,Rieben R

    更新日期：2017-08-01 00:00:00

  • Identification of the cytoskeletal regulatory protein alpha-adducin as a target of T cell receptor signaling.

    abstract：:Quiescent T lymphocytes reorganize the actin cytoskeleton subsequent to interaction with antigen presenting cells bearing the appropriate peptide antigen. Although both biochemical and genetic evidence indicate that T cell receptor-dependent cytoskeletal reorganization is critical to T cell activation, the mechanisms ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2004.03.028

    authors： Lu Q,Liu X,Trama J,Roti MA,Go WY,Ho SN

    更新日期：2004-06-01 00:00:00

  • cDNA cloning and eukaryotic expression of feline CD9.

    abstract：:A monoclonal antibody (vpg15) has been described which can block infection with feline immunodeficiency virus (FIV) and which recognizes the feline homologue of CD9. In order to study the role of feline CD9 in infection with FIV we have molecularly cloned a cDNA encoding feline CD9 by R.A.C.E (rapid amplification of c...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(95)00008-3

    authors： Willett BJ,Neil JC

    更新日期：1995-04-01 00:00:00

  • Interaction of C3 and C3b with immunoglobulin G.

    abstract：:Human C3b as well as native C3 were found to bind to solid phase human and rabbit IgG. Haemolytically active C3 had significantly higher binding capacity to IgG than the C3b fragment. Inhibition experiments proved that C3 and C3b have common binding sites on the Fab and Fc part of the IgG molecule but the character of...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(83)90076-7

    authors： Kulics J,Rajnavölgyi E,Füst G,Gergely J

    更新日期：1983-08-01 00:00:00

  • A Wnt/β-catenin negative feedback loop represses TLR-triggered inflammatory responses in alveolar epithelial cells.

    abstract：:Increasing evidence has demonstrated that the epithelial cells in the lung play crucial roles in regulating certain inflammatory responses by modulating Wnt signaling during microbial infection. However, the anti-microbial functions of Wnt signaling in alveolar epithelial cells remain elusive. In this report, we show ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2014.02.002

    authors： Li Y,Shi J,Yang J,Ma Y,Cheng L,Zeng J,Hao X,Ma C,Wang Y,Liu X

    更新日期：2014-06-01 00:00:00

  • Isolation and characterization of the rat beta-subunit gene of the high affinity receptor for immunoglobulin E.

    abstract：:The high affinity receptor for IgE, which mediates allergic reactions, is found exclusively on mast cells, basophils and epidermal Langerhans cells. It is composed of an alpha, beta and two gamma-polypeptide chains, inserted as a complex into the plasma membrane. The alpha and beta-subunits are produced only by these ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(96)84614-1

    authors： Witthuhn BA,Faust C

    更新日期：1996-07-01 00:00:00

  • Regulation and functions of NLRP3 inflammasome during influenza virus infection.

    abstract：:The NLRP3 inflammasome constitutes a major antiviral host defense mechanism during influenza virus infection. Inflammasome assembly in virus-infected cells facilitates autocatalytic processing of pro-caspase-1 and subsequent cleavage and secretion of proinflammatory cytokines IL-1β and IL-18. The NLRP3 inflammasome is...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2017.01.023

    authors： Kuriakose T,Kanneganti TD

    更新日期：2017-06-01 00:00:00

  • Food antigens and Transglutaminase 2 in IgA nephropathy: Molecular links between gut and kidney.

    abstract：:The transglutaminase 2 (TG2) is one of the enigmatic enzymes with important functional diversity. It plays an important role in several pathologies such as celiac disease (CD). In patients with active CD, the abnormal retrotranscytosis of IgA/gliadin complexes is mediated by Transferrin Receptor 1 (TfR1). This triad a...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2020.02.019

    authors： Abbad L,Monteiro RC,Berthelot L

    更新日期：2020-05-01 00:00:00

  • Quasi-elastic light scattering of antigen-antibody complexes.

    abstract：:Many biological properties of immune complexes (IC) depend upon their size. Quasi-elastic light scattering (QLS) was used to measure a mean equivalent hydrodynamic radius (Rh) and variance of the distribution of model IC composed of bovine serum albumin (BSA) as antigen (Ag) and combinations of two or three well-chara...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(88)90086-7

    authors： Yarmush DM,Murphy RM,Colton CK,Fisch M,Yarmush ML

    更新日期：1988-01-01 00:00:00

  • Molecular comparison of mouse Thy-1 and its human homologue.

    abstract：:Physicochemical techniques were used to verify previous immunochemical studies showing homology of the human Thy-1 (formerly p25) antigen and the murine Thy-1 or theta antigen. Peptide maps and amino acid compositions showed close similarity between these two proteins; however, they were not identical. These data conf...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(82)90216-4

    authors： Bonewald L,Wang AC,Terry E,Zwerner R,Balch CM,Ades EW

    更新日期：1982-03-01 00:00:00

  • The size, shape and stability of complement component C9.

    abstract：:Electron microscopy of specimens of C9 tilted through 90 degrees visualized this protein to be a globular ellipsoid with dimensions of 77 x 70 x 52 A. To check the congruence of this observation with physical properties of the molecule, hydrodynamic parameters for C9 were determined. From this work a frictional ratio ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(93)90156-6

    authors： DiScipio RG

    更新日期：1993-08-01 00:00:00

  • Transcriptome analysis of Traf6 function in the innate immune response of zebrafish embryos.

    abstract：:TRAF6 is a key player at the cross-roads of development and immunity. The analysis of its in vivo molecular function is a great challenge since severe developmental defects and early lethality caused by Traf6 deficiency in knock-out mice interfere with analyses of the immune response. In this study we have used a new ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2010.08.011

    authors： Stockhammer OW,Rauwerda H,Wittink FR,Breit TM,Meijer AH,Spaink HP

    更新日期：2010-11-01 00:00:00

  • Stenotrophomonas-maltophilia inhibits host cellular immunity by activating PD-1/PD-L1 signaling pathway to induce T-cell exhaustion.

    abstract：BACKGROUND:Smalotrophomonas maltophilia(S. maltophilia) is common in nosocomial infections. However, few studies have revealed the effect of S. maltophilia on cellular immunity in the host's immune system up to now. In clinical work, we accidentally discovered that S. maltophilia directly stimulated T cells to secrete ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2020.12.019

    authors： Wang M,Yin S,Qin Q,Peng Y,Hu Z,Zhu X,Liu L,Li X

    更新日期：2021-02-01 00:00:00

  • MiR-143-3p controls TGF-β1-induced cell proliferation and extracellular matrix production in airway smooth muscle via negative regulation of the nuclear factor of activated T cells 1.

    abstract：:MicroRNAs (miRNAs) are small noncoding RNAs that function in diverse biological processes. However, little is known about the precise role of microRNAs in the functioning of airway smooth muscle cells (ASMCs). Here, we investigated the potential role and mechanisms of the miR-143 -3p on proliferation and the extracell...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2016.09.004

    authors： Cheng W,Yan K,Xie LY,Chen F,Yu HC,Huang YX,Dang CX

    更新日期：2016-10-01 00:00:00

  • Quantitation of the immunogenic potential of protein antigens.

    abstract：:A procedure to quantitate the immunogenic potential of protein antigens is presented. It is hypothesized that the intrinsic immunogenicity of an accessible region on the protein arises from the overall structural effect of the presence of the particular assemblage of amino acid residues in the given region. Structural...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(85)90043-4

    authors： Padlan EA

    更新日期：1985-11-01 00:00:00

  • The expanding role of innate lymphoid cells and their T-cell counterparts in gastrointestinal cancers.

    abstract：:Innate lymphoid cells (ILCs) contribute to the regulation of gastrointestinal (GI) homeostasis. Over the past 15 years, there has been a large effort to dissect the mechanisms required for GI homeostasis, with a major focus on different immune cell populations and the cytokines that they produce. In contrast to T-help...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2017.11.013

    authors： Fung KY,Nguyen PM,Putoczki T

    更新日期：2019-06-01 00:00:00

  • Endothelial P2Y2 receptor regulates LPS-induced neutrophil transendothelial migration in vitro.

    abstract：:Previous studies showed that P2 receptors are involved in neutrophil migration via stimulation of chemokine release and by facilitating chemoattractant gradient sensing. Here, we have investigated whether these receptors are involved in LPS-induced neutrophil transendothelial migration (TEM) using a Boyden chamber whe...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2009.11.020

    authors： Kukulski F,Ben Yebdri F,Bahrami F,Fausther M,Tremblay A,Sévigny J

    更新日期：2010-02-01 00:00:00

  • The heterogeneity of bovine IgG2--VIII. The complete cDNA sequence of bovine IgG2a (A2) and an IgG1.

    abstract：:The complete cDNA sequences of two bovine IgGs were obtained by RT-PCR cloning. The first-strand cDNA was prepared from an animal homozygous (A2/A2) for IgG2a; the resulting sequences of the two bovine IgGs reported here were identified as IgG2a(A2) and IgG1. These sequences, and their deduced amino acid sequences, ar...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(95)00107-7

    authors： Kacskovics I,Butler JE

    更新日期：1996-02-01 00:00:00

  • Kinetics of the precipitation of cryoimmunoglobulins.

    abstract：:The kinetics of the cryoprecipitation of two monoclonal IgG and two monoclonal IgM cryoimmunoglobulins, two IgM/IgG mixed cryoglobulins and a series of cold soluble monoclonal IgG and IgM immunoglobulins in the presence of polyethylene glycol have been compared by time dependent turbidity measurements. The effects of ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(87)90001-0

    authors： Lawson EQ,Brandau DT,Trautman PA,Aziz SE,Middaugh CR

    更新日期：1987-09-01 00:00:00

  • The effect of fragment B of staphylococcal protein A on the binding of rabbit IgG to human granulocytes and monocytes.

    abstract：:The effect of fragment B of staphylococcal protein A on the binding of rabbit IgG to human granulocytes has been examined. When rabbit IgG sensitized sheep erythrocytes (EA) were preincubated with increasing amounts of fragment B, a dose dependent inhibition of rosette formation between the human granulocytes and the ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(82)90206-1

    authors： Barnett Foster DE,Sjoquist J,Painter RH

    更新日期：1982-03-01 00:00:00

  • MD-2 regulates LPS-induced NLRP3 inflammasome activation and IL-1beta secretion by a MyD88/NF-κB-dependent pathway in alveolar macrophages cell line.

    abstract：:Myeloid differentiation protein 2 (MD-2) is required in the recognition of lipopolysaccharide (LPS) by toll-like receptor 4 (TLR4), and participates in LPS-induced alveolar macrophage (AM) inflammation during acute lung injury (ALI). Activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflamm...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2017.06.035

    authors： Luo M,Hu L,Li D,Wang Y,He Y,Zhu L,Ren W

    更新日期：2017-10-01 00:00:00

  • Identification of an Sp factor-dependent promoter in GCET, a gene expressed at high levels in germinal center B cells.

    abstract：:Antigen-stimulated B lymphocytes undergo genetic and phenotypic changes in germinal centers (GCs), including affinity maturation of immunoglobulin (Ig) genes and Ig heavy chain isotype switching. Expression of the Germinal Center Expressed Transcript (GCET) gene is up-regulated in murine GC B cells. The human homolog ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2004.06.031

    authors： Steinke JW,Hodsdon W,Parenti S,Ostraat R,Lutz R,Borish L,Hagman J

    更新日期：2004-11-01 00:00:00

  • Novel atypical nucleotide insertions specifically at VH-DH junction generate exceptionally long CDR3H in cattle antibodies.

    abstract：:Some IgM cattle antibodies are amongst the largest known to exist in jawed vertebrates where CDR3H size may extend up to 61 amino acids. To understand the origin of such an exceptionally long CDR3H, bovine D(H) gene locus was completely characterized from Holstein cattle that revealed the presence of a total of eight ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2010.02.014

    authors： Koti M,Kataeva G,Kaushik AK

    更新日期：2010-07-01 00:00:00

  • Crystal structure of Drosophila PGRP-SD suggests binding to DAP-type but not lysine-type peptidoglycan.

    abstract：:In Drosophila the synthesis of antimicrobial peptides in response to microbial infections is under the control of the Toll and immune deficiency (Imd) signaling pathways. The Toll signaling pathway responds mainly to Gram-positive bacterial and fungal infection while the Imd pathway mediates the response to Gram-negat...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2008.01.015

    authors： Leone P,Bischoff V,Kellenberger C,Hetru C,Royet J,Roussel A

    更新日期：2008-05-01 00:00:00