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Molecular cloning and characterization of a porcine UL16 binding protein (ULBP)-like cDNA.

Abstract：

:UL16 binding proteins (ULBPs) are ligands for the NK cell activating receptor NKG2D. A cDNA encoding a porcine ULBP-like protein (PULBP) was cloned and the predicted amino acid sequence exhibited 35-52% identity to human ULBPs. Southern blot analysis suggested that there is only one ULBP-like gene in the pig genome. Transcripts of PULBP and another potential NKG2D ligand, MIC2, were detected by RT-PCR in a wide range of tissues. Recombinant PULBP-Fc and human ULBP2-Fc fusion proteins were made and used to examine PULBP binding to porcine PBMCs and a human NK cell line (NKL cells). PULBP-Fc bound to a subpopulation of porcine PBMCs but not NKL cells. Conversely, human ULBP2-Fc did not bind to porcine PBMCs but did stably interact with NKL cells.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

García-Borges CN,Phanavanh B,Saraswati S,Dennis RA,Crew MD

doi

10.1016/j.molimm.2004.09.020

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

665-71

issue

6

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(04)00354-2

journal_volume

42

pub_type

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