Abstract:
:Membrane immunoglobulins are integral proteins on B cell surfaces that bind foreign antigens and are critically involved in the regulation of the immune response. Based upon the model of serum IgG, it has been assumed that membrane immunoglobulins are essentially four chain disulfide-linked structures of the form H2L2, where H represents an immunoglobulin heavy chain, and L a light chain. We show here that membrane immunoglobulins of the mu and delta isotypes are present on spleen cell surfaces in a much more diverse group of disulfide linked structures. In some cases mIg is linked into structures as large as H5L5, while in other instances mu or delta chains appear to be linked by disulfide interactions to non-immunoglobulin molecules. These various structural complexes may represent distinct functional entities, as the association of mIg with the cytoskeleton after mIg cross-linking appears to depend upon its structural subgroup.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Alhasan S,Santini R,Li Q,Rosenspire Adoi
10.1016/0161-5890(93)90451-gsubject
Has Abstractpub_date
1993-12-01 00:00:00pages
1593-9issue
17eissn
0161-5890issn
1872-9142journal_volume
30pub_type
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