Impaired anti-leukemic immune response in PKCtheta-deficient mice.

abstract：:Host-derived macrophage migration inhibitory factor (MIF) has been implicated in the pathogenesis of malaria infection, especially in malarial anemia. Although two Plasmodium parasite-derived MIF orthologs, Plasmodium falciparum MIF and P. berghei MIF were identified recently, the crystal structure and the precise rol...

journal_title：Molecular immunology

authors： Shao D,Zhong X,Zhou YF,Han Z,Lin Y,Wang Z,Bu L,Zhang L,Su XD,Wang H

更新日期：2010-01-01 00:00:00

abstract：:Two recombinant mouse mammary tumor virus (MMTV) subunit vaccines have been constructed, in which linear sequences of the envelope gp 52 glycoprotein (EP3) or the superantigen (SAg) have been fused to single or multiple repeats of a T-cell epitope (P30) from tetanus toxin. Histidine tags or glutathione-S-transferase (...

journal_title：Molecular immunology

authors： Astori M,Kraehenbuhl JP

更新日期：1996-09-01 00:00:00

abstract：:PKZ, protein kinase containing Z-DNA binding domains, is a novel member of eIF2α kinase in fish. PKZ can be up-regulated in response to Poly I:C or heat stress, and it has a typical eIF2α kinase activity. However, the relationship between fish PKZ and apoptosis remains unclear. In the present study, effects of PKZ on ...

journal_title：Molecular immunology

authors： Wu C,Hu Y,Fan L,Wang H,Sun Z,Deng S,Liu Y,Hu C

更新日期：2016-01-01 00:00:00

abstract：:Hepcidins are antimicrobial peptides that play important roles in resisting pathogenic infection. Through hybridization of a phage library, the cDNA sequences of three hepcidin-like antimicrobial peptides (named TH1-5, TH2-2, and TH2-3) in tilapia, Oreochromis mossambicus, were determined. The complete hepcidin cDNA s...

journal_title：Molecular immunology

authors： Huang PH,Chen JY,Kuo CM

更新日期：2007-03-01 00:00:00

abstract：:Calcium signals are crucial for diverse cellular functions including adhesion, differentiation, proliferation, effector functions and gene expression. After engagement of the B cell receptor, the intracellular calcium ion (Ca(2+)) concentration is increased promoting the activation of various signaling cascades. While...

journal_title：Molecular immunology

authors： Baba Y,Matsumoto M,Kurosaki T

更新日期：2014-12-01 00:00:00

abstract：:The site of the murine IgG1 molecule that regulates catabolism has recently been shown to encompass amino acids that are located at the CH2-CH3 domain interface. The CH2 and CH3 domains are connected to each other by a relatively flexible "mini-hinge" region, and flexibility in this region could clearly affect the ori...

journal_title：Molecular immunology

authors： Kim JK,Tsen MF,Ghetie V,Ward ES

更新日期：1995-05-01 00:00:00

abstract：:A number of studies have showed that High mobility group box-1 (HMGB1), which played key role in inflammation activation by triggering the toll like receptor 4 (TLR4) signaling axis in hepatic fibrogenesis, may share similar inflammation stimulating mechanism with LPS. Herein, we introduced a recently established anti...

journal_title：Molecular immunology

authors： Zhang H,Liu Z,Liu S

更新日期：2016-01-01 00:00:00

abstract：:Porcine deltacoronavirus (PDCoV) is an emerging swine coronavirus causing diarrhea and intestinal damage in nursing piglets. Previous work showed that PDCoV infection inhibits type I interferon (IFN) production. To further identify and characterize the PDCoV-encoded IFN antagonists will broaden our understanding of it...

journal_title：Molecular immunology

authors： Liu X,Fang P,Fang L,Hong Y,Zhu X,Wang D,Peng G,Xiao S

更新日期：2019-10-01 00:00:00

abstract：:Monoclonal antibodies (MAbs) raised against trout immunoglobulin (Ig) recognize two independent Ig populations differing in the molecular weight of L chains. The trout Ig population recognized by MAb 2H9 represented congruent to 20% of the total Ig and contained L chains congruent to 26 kDa, whereas the trout Ig popul...

journal_title：Molecular immunology

authors： Sánchez C,Domínguez J

更新日期：1991-11-01 00:00:00

abstract：:Type III interferons (IFN-λs) comprise a group of newly identified antiviral cytokines that are functionally similar to type I IFNs and elicit first-line antiviral responses. Recently, type III IFNs were identified in several species; however, little information is available about type III IFNs in ducks. We compared t...

journal_title：Molecular immunology

authors： Zhang Z,Zou T,Hu X,Jin H

更新日期：2015-12-01 00:00:00

abstract：:C-reactive protein (CRP) is a pattern recognition molecule that binds several microbial and host ligands. Ligand-bound CRP activates the complement system via the classical pathway. Previously, we identified human complement factor H-related protein 4 (CFHR4), a member of the factor H protein family, as a CRP binding ...

journal_title：Molecular immunology

authors： Hebecker M,Okemefuna AI,Perkins SJ,Mihlan M,Huber-Lang M,Józsi M

更新日期：2010-03-01 00:00:00

abstract：:Despite the fact that was one of the first systems to be discovered and investigated in the innate immunity, Complement is continuing to receive growing attention by the scientific community. Complement is involved in several diseases such as diabetes, atherosclerosis or Systemic Lupus Erythematous. Successful therape...

journal_title：Molecular immunology

authors： Castellano G

更新日期：2015-11-01 00:00:00

abstract：:Selection of specific antibodies from large repertoires is of importance in generating antibodies to specific structural determinants and in studying structure-function relationships. Alkaline phosphatase (AP) has several isozymes with various degrees of homology and a range of common synthetic substrates. We have pre...

journal_title：Molecular immunology

authors： Jain V,Saini D,Goswami P,Sinha S

更新日期：2007-01-01 00:00:00

abstract：:In Drosophila the synthesis of antimicrobial peptides in response to microbial infections is under the control of the Toll and immune deficiency (Imd) signaling pathways. The Toll signaling pathway responds mainly to Gram-positive bacterial and fungal infection while the Imd pathway mediates the response to Gram-negat...

journal_title：Molecular immunology

authors： Leone P,Bischoff V,Kellenberger C,Hetru C,Royet J,Roussel A

更新日期：2008-05-01 00:00:00

abstract：:Pathogenic fungi represent a major threat particularly to immunocompromised hosts, leading to severe, and often lethal, systemic opportunistic infections. Although the impaired immune status of the host is clearly the most important factor leading to disease, virulence factors of the fungus also play a role. Factor H ...

journal_title：Molecular immunology

authors： Vogl G,Lesiak I,Jensen DB,Perkhofer S,Eck R,Speth C,Lass-Flörl C,Zipfel PF,Blom AM,Dierich MP,Würzner R

更新日期：2008-03-01 00:00:00

abstract：:The paradigm that B cells mainly play a central role in adaptive immunity may have to be reevaluated because B-1 lineage cells have been found to exhibit innate-like functions, such as phagocytic and bactericidal activities. Therefore, the evolutionary connection of B-1 lineage cells between innate and adaptive immuni...

journal_title：Molecular immunology

authors： Zhu LY,Shao T,Nie L,Zhu LY,Xiang LX,Shao JZ

更新日期：2016-01-01 00:00:00

abstract：:The MHC class II transactivator (CIITA) acts in the cell nucleus as the master regulator of MHC class II (MHC II) gene expression. It is important to study CIITA regulation in multiple myeloma since MHC expression is central to ability of myeloma cells to present antigen and to the ability of the immune system to reco...

journal_title：Molecular immunology

authors： Zhao M,Flynt FL,Hong M,Chen H,Gilbert CA,Briley NT,Bolick SC,Wright KL,Piskurich JF

更新日期：2007-04-01 00:00:00

abstract：:A Brucella abortus protein with a molecular weight of 50 kDa has been shown to bind bovine immunoglobulin G from healthy, brucellosis-free animals. The Brucella immunoglobulin G binding molecule appears to be a protein, since it is susceptible to proteolysis. The protein is presumed to be located on the cell surface, ...

journal_title：Molecular immunology

authors： Bricker BJ,Tabatabai LB,Mayfield JE

更新日期：1991-01-01 00:00:00

abstract：:Interferon (IFN)-γ is highly upregulated during heart inflammation and enhances the production of pro-inflammatory cytokines. Absent in Melanoma 2 (AIM2) is an IFN-inducible protein implicated as a component of the inflammasome. Here we seek to determine the role of AIM2 during inflammation in cardiac cells. We found ...

journal_title：Molecular immunology

authors： Furrer A,Hottiger MO,Valaperti A

更新日期：2016-06-01 00:00:00

abstract：:We recently identified IgE-binding epitopes of bovine serum albumin (BSA), the major beef allergen, and found that the major epitope structure contains an EXXV motif. Here we report hypoallergenic analogue peptides of BSA that preserve T cell reactivity to retain the capacity to induce immunotolerance. Substitution of...

journal_title：Molecular immunology

authors： Tanabe S,Shibata R,Nishimura T

更新日期：2004-07-01 00:00:00

abstract：:Gene regulatory network (GRN) subcircuits have been described for cell fate progressions in animal development. The hallmark of these subcircuits is the integration of promoters, and positive- and negative-acting promoter binding proteins, such that an alteration in function of any one member of the defined subcircuit...

journal_title：Molecular immunology

authors： Xu L,Niesen MI,Blanck G

更新日期：2009-02-01 00:00:00

abstract：:The diagnosis and therapy of allergic disorders are usually performed with crude extracts which are a heterogeneous mixture of proteins with different allergenic potency. The knowledge of the allergenic composition is a key step for diagnostic and therapeutic options. Parietaria judaica pollen represents one of the ma...

journal_title：Molecular immunology

authors： Bonura A,Gulino L,Trapani A,Di Felice G,Tinghino R,Amoroso S,Geraci D,Valenta R,Westritschnig K,Scala E,Mari A,Colombo P

更新日期：2008-05-01 00:00:00

abstract：:Ovalbumin (OVA) is a major allergen (Gal d II) of hen egg white and is often the cause of hypersensitivity reactions to food. Further knowledge of the antigenic and allergenic epitopes of allergens will provide better treatment of this disease. To analyse these epitopes we produced a panel of monoclonal antibodies (mA...

journal_title：Molecular immunology

authors： Kahlert H,Petersen A,Becker WM,Schlaak M

更新日期：1992-10-01 00:00:00

abstract：:The murine pre-B cell line R2-bfl, which can be induced to differentiate in vitro, was used to study germline transcription of variable regions of the light chain loci. RNA from these cells was subjected to a 3'-RACE and germline transcripts from 17 individual Vkappa gene segments belonging to 12 Vkappa families were ...

journal_title：Molecular immunology

authors： Düber S,Engel H,Rolink A,Kretschmer K,Weiss S

更新日期：2003-12-01 00:00:00

abstract：:The ability of bovine IgG preparations to bind to the various distinct human leukocyte Fc gamma receptors was studied. In experiments using intact cells and isolated Fc gamma receptors, it was demonstrated that bovine IgG can bind to Fc gamma receptors of four human cell types but not to Fc gamma receptors of human ne...

journal_title：Molecular immunology

authors： Kulczycki A Jr

更新日期：1987-03-01 00:00:00

abstract：:Jackfruit lectin, jacalin, prepared from two batches of jackfruit seeds showed a different specificity in precipitating reaction in Agarose gel with various purified immunoglobulins and secretory components. Jacalin-P, extracted from jackfruit seeds from the Philippines, reacts only with serum IgA and secretory IgA of...

journal_title：Molecular immunology

authors： Kondoh H,Kobayashi K,Hagiwara K

更新日期：1987-11-01 00:00:00

abstract：:Mangiferin is the major bioactive ingredient in the leaves of Mangifera indica L., Aqueous extract of such leaves have been traditionally used as an indigenous remedy for respiratory diseases including cough and asthma in Traditional Chinese Medicine. Mangiferin was shown to exert its anti-asthmatic effect by modulati...

journal_title：Molecular immunology

authors： Yun C,Chang M,Hou G,Lan T,Yuan H,Su Z,Zhu D,Liang W,Li Q,Zhu H,Zhang J,Lu Y,Deng J,Guo H

更新日期：2019-10-01 00:00:00

abstract：:An antigen-coated plate radioimmunoassay was used to detect antibodies against homologous glutaraldehyde-modified albumin (in monomeric or polymeric form) in normal mouse sera. Mouse antibodies reacted also with heterologous glutaraldehyde-treated albumin; for instance human albumin. Immunoelectrophoresis of purified ...

journal_title：Molecular immunology

authors： Onică D,Mărgineanu I,Medeşan C,Călugăru A,Manciulea M

更新日期：1982-08-01 00:00:00

abstract：:Quiescent T lymphocytes reorganize the actin cytoskeleton subsequent to interaction with antigen presenting cells bearing the appropriate peptide antigen. Although both biochemical and genetic evidence indicate that T cell receptor-dependent cytoskeletal reorganization is critical to T cell activation, the mechanisms ...

journal_title：Molecular immunology

authors： Lu Q,Liu X,Trama J,Roti MA,Go WY,Ho SN

更新日期：2004-06-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a pleiotropic cytokine that regulates hematopoiesis, inflammation, immune responses and bone homeostasis in mammals. Fish IL-6 has been cloned in recent years but to date no functional studies have been reported. Thus, in this paper we present for the first time in fish the functional character...

journal_title：Molecular immunology

authors： Costa MM,Maehr T,Diaz-Rosales P,Secombes CJ,Wang T

更新日期：2011-09-01 00:00:00