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Evolutionary implication of B-1 lineage cells from innate to adaptive immunity.

Abstract：

:The paradigm that B cells mainly play a central role in adaptive immunity may have to be reevaluated because B-1 lineage cells have been found to exhibit innate-like functions, such as phagocytic and bactericidal activities. Therefore, the evolutionary connection of B-1 lineage cells between innate and adaptive immunities have received much attention. In this review, we summarized various innate-like characteristics of B-1 lineage cells, such as natural antibody production, antigen-presenting function in primary adaptive immunity, and T cell-independent immune responses. These characteristics seem highly conserved between fish B cells and mammalian B-1 cells during vertebrate evolution. We proposed an evolutionary outline of B cells by comparing biological features, including morphology, phenotype, ontogeny, and functional activity between B-1 lineage cells and macrophages or B-2 cells. The B-1 lineage may be a transitional cell type between phagocytic cells (e.g., macrophages) and B-2 cells that functionally connects innate and adaptive immunities. Our discussion would contribute to the understanding on the origination of B cells specialized in adaptive immunity from innate immunity. The results might provide further insight into the evolution of the immune system as a whole.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Zhu LY,Shao T,Nie L,Zhu LY,Xiang LX,Shao JZ

doi

10.1016/j.molimm.2015.10.014

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

123-30

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(15)30103-6

journal_volume

69

pub_type

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