当前位置： SCI文献检索 > MOLECULAR IMMUNOLOGY期刊下所有文献 > Role of complement in diabetes.

Role of complement in diabetes.

Abstract：

:Accumulating evidence suggests a role for the complement system in the pathogenesis of diabetes and the vascular complications that characterise this condition. Complement proteins contribute to the development of type 1 diabetes (T1D) by enhancing the underlying organ-specific autoimmune processes. Complement upregulation and activation is also an important feature of insulin resistance and the development of type 2 diabetes (T2D). Moreover, animal and human studies indicate that complement proteins are involved in the pathogenic mechanisms leading to diabetic microvascular and macrovascular complications. The adverse vascular effects of complement appear to be related to enhancement of the inflammatory process and the predisposition to a thrombotic environment, eventually leading to vascular occlusion. Complement proteins have been considered as therapeutic targets to prevent or treat vascular disease but studies have been mainly conducted in animal models, while human work has been both limited and inconclusive so far. Further studies are needed to understand the potential role of complement proteins as therapeutic targets for reversal of the pathological processes leading to T1D and T2D and for the prevention/treatment of diabetic vascular complications.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Ajjan RA,Schroeder V

doi

10.1016/j.molimm.2019.07.031

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

270-277

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(19)30344-X

journal_volume

114

pub_type

杂志文章,评审

相关文献

MOLECULAR IMMUNOLOGY文献大全
  • Engineered protein containing crotoxin epitopes induces neutralizing antibodies in immunized rabbits.

    abstract：:Crotoxin (Ctx) is the main lethal component of Crotalus durissus terrificus venom. It is a neurotoxin, composed of two subunits associated by noncovalent interactions, the non-toxic acid subunit (CA), named Crotapotin, and the basic subunit (CB), with phospholipase A2 (PLA2) activity. Employing the SPOT synthesis tech...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2020.01.012

    authors： Molina Molina DA,Guerra-Duarte C,Costal-Oliveira F,Almeida Rocha E,Rego Rodrigues C,Machado-de-Ávila RA,Soccol VT,Chávez-Olórtegui C

    更新日期：2020-03-01 00:00:00

  • Isolation and characterization of chicken and turkey beta 2-microglobulin.

    abstract：:Chicken and turkey beta 2-m were isolated from citrated plasma in sequential use of three chromatographic steps: affinity chromatography, gel filtration chromatography and anion-exchange chromatography. The purified protein was identified as beta 2-m by reaction with a beta 2-m specific monoclonal antibody and by the ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(86)90015-5

    authors： Skjødt K,Welinder KG,Crone M,Verland S,Salomonsen J,Simonsen M

    更新日期：1986-12-01 00:00:00

  • Solid-phase antigen binding by purified immunoproteins from antigen-specific monoclonal T cell hybridomas.

    abstract：:We have developed two distinct solid-phase immunoassays for the detection of antigen binding activity by products of antigen binding T cell hybridomas in the absence of MHC. Two suppressor T cell hybridomas studied (34s-18 and 34s-704) are specific for keyhole limpet hemocyanin, a protein antigen, and the other suppre...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(89)90043-6

    authors： Bristow CL,Marchalonis JJ

    更新日期：1989-07-01 00:00:00

  • Elicitation of distinct populations of monoclonal antibodies specific for the variable domains of monoclonal anti-fluorescein antibody 4-4-20.

    abstract：:Armenian hamsters were immunized with non-liganded, partially liganded or affinity-labeled anti-fluorescein Mab 4-4-20. Seventeen hybridoma producing monoclonal anti-4-4-20 antibodies were characterized from chemically-mediated fusions of immune hamster lymphocytes with murine Sp2/O-Ag14 myeloma cells. Distinct popula...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(93)90125-u

    authors： Weidner KM,Denzin LK,Kim ML,Mallender WD,Miklasz SD,Voss EW Jr

    更新日期：1993-08-01 00:00:00

  • Cloning, expression and characterization of mugwort pollen allergen Art v 2, a pathogenesis-related protein from family group 1.

    abstract：:Mugwort (Artemisia vulgaris) belongs to the Compositae family, and is one of the main causes of allergy in late summer and autumn. The aim of the study was to characterize the allergen Art v 2 from mugwort pollen. Skin prick tests, performed in 19 patients allergic to mugwort and 10 control patients, showed an Art v 2...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2007.04.022

    authors： Arilla MC,Ibarrola I,Puente Y,Daza JC,Martínez A,Asturias JA

    更新日期：2007-07-01 00:00:00

  • Fine specificity of a monoclonal anti-testicular cell antibody for glycolipids with terminal N-acetyl-D-glucosamine structure.

    abstract：:The specificity of a mouse anti-testicular cell monoclonal antibody, J1, was investigated. Previous studies suggested that N-acetyl-D-glucosamine (GlcNAc) was a constituent of the determinant recognized by J1. When the antibody was tested against a variety of purified glycolipids containing this saccharide in terminal...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(84)90142-1

    authors： Symington FW,Fenderson BA,Hakomori S

    更新日期：1984-10-01 00:00:00

  • Serum complement C1q level is associated with acute coronary syndrome.

    abstract：BACKGROUND AND OBJECTIVES:The complement system plays an important role in the development of acute coronary syndrome (ACS). Complement C1q is an important initial component of the classical complement pathway and closely related to many chronic inflammatory diseases, including atherosclerosis (AS). We aimed to determi...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2020.02.012

    authors： Ni XN,Yan SB,Zhang K,Sai WW,Zhang QY,Ti Y,Wang ZH,Zhang W,Zheng CY,Zhong M

    更新日期：2020-04-01 00:00:00

  • Cloning and molecular characterization of a human recombinant IgG Fab binding to the Tat protein of human immunodeficiency virus type 1 (HIV-1) derived from the repertoire of a seronegative patient.

    abstract：:A study aiming at cloning and characterizing natural antibodies to human immunodeficiency virus type 1 (HIV-1) targets is described. In particular, we report the molecular cloning of a Fab molecule binding the HIV-1/Tat protein from a seronegative patient. The Fab was characterized for its binding specificity and inve...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2005.08.003

    authors： Mancini N,Perotti M,Carletti S,Canducci F,Sampaolo M,Clementi M,Burioni R

    更新日期：2006-03-01 00:00:00

  • Targeted inhibition of GATA-6 attenuates airway inflammation and remodeling by regulating caveolin-1 through TLR2/MyD88/NF-κB in murine model of asthma.

    abstract：:The purpose of this study was to evaluate the effects of GATA-6 on airway inflammation and remodeling and the underlying mechanisms in a murine model of chronic asthma. Female BALB/c mice were randomly divided into four groups: phosphate-buffered saline control (PBS), ovalbumin (OVA)-induced asthma group (OVA), OVA+ s...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2016.05.017

    authors： Fang P,Shi HY,Wu XM,Zhang YH,Zhong YJ,Deng WJ,Zhang YP,Xie M

    更新日期：2016-07-01 00:00:00

  • Complement escape of human pathogenic bacteria by acquisition of complement regulators.

    abstract：:Pathogenic micro-organisms employ a broad range of strategies to survive in and to persistently infect the human host. Far from being completely understood by which highly sophisticated means invading pathogens overcome the host's destructive immune defence, there is a growing body of evidence on particular mechanisms...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2005.06.016

    authors： Kraiczy P,Würzner R

    更新日期：2006-01-01 00:00:00

  • Immunochemical data suggesting a pattern for the evolution of human placental alkaline phosphatase.

    abstract：:Hyperimmune absorbed rabbit antisera which were reactive with epitopes specific for individual variants of human placental alkaline phosphatase were tested for their reactivity with primate placental alkaline phosphatases. Using the three epitope-specific reactivities defined previously, we found that: epitope I is pr...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(84)90074-9

    authors： Doellgast GJ,Wei SC

    更新日期：1984-03-01 00:00:00

  • The immune response to Epstein-Barr nuclear antigen: conformational and structural features of antibody binding to synthetic peptides.

    abstract：:Naturally developing human antibodies to the Epstein-Barr nuclear antigen recognize synthetic peptides containing sequences from the unusual glycine-alanine region of this protein. We tested antibody binding to a series of peptides of from five to 20 amino acids in length. Peptides as small as seven amino acids could ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(84)90114-7

    authors： Rhodes G,Houghten R,Taulane JP,Carson D,Vaughan J

    更新日期：1984-11-01 00:00:00

  • Isolation and sequence of a cDNA coding for the immunoglobulin mu chain of the sheep.

    abstract：:A sheep cDNA library was screened with a human C mu probe, and the complete nucleotide sequence of a 1923 nt cDNA was determined. It contains sequences corresponding to all the exons (VH, DH, JH, CH1, CH2, CH3 and CH4) characteristic of the immunoglobulin mu heavy chain regions. The deduced amino acid sequence shows a...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(92)90120-m

    authors： Patri S,Nau F

    更新日期：1992-07-01 00:00:00

  • Non-traditional roles of complement in type 2 diabetes: Metabolism, insulin secretion and homeostasis.

    abstract：:Type 2 Diabetes (T2D) is a disease of increasing importance and represents a growing burden on global healthcare and human health. In T2D, loss of effectiveness of insulin signaling in peripheral tissues cannot be compensated for by adequate insulin secretion, leading to hyperglycemia and resultant complications. In r...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2016.12.009

    authors： King BC,Blom AM

    更新日期：2017-04-01 00:00:00

  • Inactivation of the KSRP gene modifies collagen antibody induced arthritis.

    abstract：:The KH type splicing regulatory protein (KSRP) is a nucleic acid binding protein, which negatively regulates the stability and/or translatability of many mRNA species encoding immune-relevant proteins. As KSRP is expressed in immune cells including T and B cells, neutrophils, macrophages and dendritic cells, we wanted...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2017.05.003

    authors： Käfer R,Schrick K,Schmidtke L,Montermann E,Hobernik D,Bros M,Chen CY,Kleinert H,Pautz A

    更新日期：2017-07-01 00:00:00

  • Clinical relevance and prognostic significance of PD-1/PD-Ls in non-metastatic bladder cancer: A role for PD-L2.

    abstract：BACKGROUND:Bladder cancer (BC) can be successfully treated by manipulating immune responses with intravesical Bacillus Calmette-Guerin instillation or targeting the PD-1/PD-L signaling pathway. In the present study we investigated the prognostic significance of the immune checkpoint inhibitor PD-1 and its ligands PD-L1...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2020.05.010

    authors： Ariafar A,Ghaedi M,Rezaeifard S,Shahriari S,Zeighami S,Ghaderi A,Faghih Z

    更新日期：2020-08-01 00:00:00

  • Variable region cDNA sequences of three mouse monoclonal anti-idiotypic antibodies specific for anti-alpha(1----6)dextrans with groove- or cavity-type combining sites.

    abstract：:The variables regions of three syngeneic anti-idiotypic antibodies (Ab2s) were cloned and sequenced. They are encoded by different VL genes, two are from different members of V kappa-Ox1 superfamily. The H chains are encoded by VH genes belonging to three different VH families, J558, Q52 and 7183. Together with a prev...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(92)90045-y

    authors： Chen J,Borden P,Liao J,Kabat EA

    更新日期：1992-09-01 00:00:00

  • Specificity and degeneracy: T cell recognition in CNS autoimmunity.

    abstract：:T cells play a crucial role in the pathogenesis of most autoimmune disorders. However, target antigens and pathomechanisms leading to human autoimmune diseases are still largely unknown. Cross-recognition of T cells between self and foreign antigens has been considered as a driving force in generating autoimmunity. He...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.molimm.2003.11.012

    authors： Zhou D,Hemmer B

    更新日期：2004-02-01 00:00:00

  • The potential role of VPREB1 gene copy number variation in susceptibility to rheumatoid arthritis.

    abstract：:Although the etiology of rheumatoid arthritis (RA) remains unknown, it has been widely suggested that RA has a genetic background. In humans, a copy number loss of 22q11.2, a region harboring the VPREB1 gene, has been suggested to be associated with several immunologic disorders, but there has been no study on the cop...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2010.11.009

    authors： Yim SH,Chung YJ,Jin EH,Shim SC,Kim JY,Kim YS,Hu HJ,Shin SH,Pae HO,Zouali M,Chung HT

    更新日期：2011-06-01 00:00:00

  • Identification of the binding site of two monoclonal antibodies to human protamine.

    abstract：:We have previously developed a number of monoclonal antibodies (Mabs) that bind to protamine. One of these antibodies, Hup1N, binds to human protamine 1 but not to protamine 2. In contrast, Mab HupA binds both protamine 1 and protamine 2. The epitopes for these two Mabs were observed to overlap, and were localized to ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(93)90436-f

    authors： Stanker LH,Wyrobek A,McKeown C,Balhorn R

    更新日期：1993-12-01 00:00:00

  • Effects of eosinophils on mast cells: a new pathway for the perpetuation of allergic inflammation.

    abstract：:Mast cells have a clear-cut pathologic role in allergy, participating in a number of chronic inflammatory conditions, in helmintic parasitosis, and in some solid tumor reactions, but also in physiological situations, such as wound healing and innate immunity. Mast cells release a large number of proinflammatory, immun...

    journal_title：Molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0161-5890(02)00090-1

    authors： Piliponsky AM,Gleich GJ,Bar I,Levi-Schaffer F

    更新日期：2002-09-01 00:00:00

  • Chemokine-mediated inflammation: Identification of a possible regulatory role for CCR2.

    abstract：:The chemokine receptor CCR2 binds four pro-inflammatory monocyte chemoattractant proteins, designated MCP1/CCL2, MCP2/CCL8, MCP3/CCL7 and MCP4/CCL13. This study demonstrates the important biology of this receptor during the response to the chemokine milieu. Competitive chemotaxis and calcium flux assays were performed...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2006.09.033

    authors： O'Boyle G,Brain JG,Kirby JA,Ali S

    更新日期：2007-03-01 00:00:00

  • Unique biochemical properties of a mutant MHC class I molecule, H-2Ksm1.

    abstract：:This study describes serological and biochemical properties of a novel MHC class I molecule. The mutant H-2Ksm1 molecule was discovered in a mouse because of loss of reactivity of its peripheral blood lymphocytes to monoclonal antibodies. This mutation in the H-2Ks molecule is the first in vivo mutation described that...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(92)90223-k

    authors： Hasenkrug KJ,Kesari KV,Nathenson SG

    更新日期：1992-12-01 00:00:00

  • Definition of the peptide binding motif within DRB1*1401 restricted epitopes by peptide competition and structural modeling.

    abstract：:This study identified the peptide-binding motif of HLA-DRA/DRB1*1401 (DR1401). First, peptides containing DR1401 restricted epitopes were identified using tetramer-guided epitope mapping. Among these, an influenza B peptide was selected for the motif study. After confirming the binding register for this peptide using ...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2007.12.013

    authors： James EA,Moustakas AK,Berger D,Huston L,Papadopoulos GK,Kwok WW

    更新日期：2008-05-01 00:00:00

  • In silico prediction of FVIII epitopes recognised by natural autoantibodies in polyvalent immunoglobulin concentrates.

    abstract：:Inhibitory antibodies directed against blood coagulation factor VIII (FVIII) impair FVIII replacement therapy, constituting a serious complication in haemophilic and autoimmune patients. Identifying B-cell FVIII epitopes and mapping them on the molecule remain important challenges. Using a combination of different alg...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2006.09.034

    authors： Di Giambattista M,Branckaert T,Hougardy V,Kemball-Cook G,Laub R

    更新日期：2007-03-01 00:00:00

  • The tick-over theory revisited: formation and regulation of the soluble alternative complement C3 convertase (C3(H2O)Bb).

    abstract：:The molecular interactions between the components of the C3 convertase of the alternative pathway (AP) of complement and its regulators, in both surface-bound and fluid-phase form, are still incompletely understood. The fact that the AP convertase is labile makes studies difficult to perform. According to the so calle...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2007.11.003

    authors： Bexborn F,Andersson PO,Chen H,Nilsson B,Ekdahl KN

    更新日期：2008-04-01 00:00:00

  • A monoclonal antibody (RH1-38) which inhibits multiple systems of cell-mediated cytotoxicity--I. Identification of a novel epitope on a killer cell surface bimolecular complex important in the cytotoxic response.

    abstract：:This paper presents the initial characterization of a mouse monoclonal antibody (RH1-38) which blocks, in the absence of complement, three different systems of cell-mediated cytotoxicity. This monoclonal antibody markedly inhibits cytotoxicity mediated by human natural killer cells, a monocyte-like cell [phorbol myris...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(85)90140-3

    authors： Hall RE

    更新日期：1985-07-01 00:00:00

  • Polymorphism in a kappa I primary (AL) amyloid protein (BAN).

    abstract：:In an attempt to understand the relationship of amino acid sequence to the formation of primary or multiple myeloma-related amyloid (AL amyloid), we have determined the complete amino acid sequence of amyloid protein BAN. This protein belongs to the kappa I immunoglobulin light chain subgroup and has a polypeptide cha...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/0161-5890(86)90173-2

    authors： Dwulet FE,O'Connor TP,Benson MD

    更新日期：1986-01-01 00:00:00

  • MLKL deficiency inhibits DSS-induced colitis independent of intestinal microbiota.

    abstract：:The maintenance of intestinal tissue homeostasis is vital for the resistance against inflammatory bowel diseases (IBDs). Necroptosis is identified as an alternative mode of regulated cell death, which plays a pivotal role in tissue homeostasis. Thus, the roles of RIP3-mediated necroptosis in intestinal inflammation ha...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2019.01.018

    authors： Zhang J,Qin D,Yang YJ,Hu GQ,Qin XX,Du CT,Chen W

    更新日期：2019-03-01 00:00:00

  • Involvement of multiple transcription factors in regulation of IL-β-induced MCP-1 expression in alveolar type II epithelial cells.

    abstract：:During acute lung injury, a large number of monocytes are recruited into the pulmonary tissue, which is mainly mediated by local production of monocyte chemotactic protein 1 (MCP-1). As an essential component of the lung tissues, alveolar type II epithelial cells are one of the major sources of MCP-1. Therefore, uncov...

    journal_title：Molecular immunology

    pub_type： 杂志文章

    doi：10.1016/j.molimm.2019.04.013

    authors： Yan C,Li B,Liu X,Deng C,Cai R,Shen Y,Tang H

    更新日期：2019-07-01 00:00:00