Abstract：
:CD8+ cytolytic T lymphocytes are essential players of anti-tumor immune responses. On tumors, they recognize peptides of about 8-to-10 amino acids that generally result from the degradation of cellular proteins by the proteasome. Until a decade ago, these peptides were thought to solely correspond to linear fragments of proteins that were liberated after the hydrolysis of the peptide bonds located at their extremities. However, several examples of peptides containing two fragments originally distant in the protein sequence challenged this concept and demonstrated that proteasome could also splice peptides together by creating a new peptide bond between two distant fragments. Unexpectedly, peptide splicing emerges as an essential way to increase the peptide repertoire diversity as these spliced peptides were shown to represent up to 25% of the peptides presented on a cell by MHC class I. Here, we review the different steps that led to the discovery of peptide splicing by the proteasome as well as the lightening offered by the recent progresses of mass spectrometry and bioinformatics in the analysis of the spliced peptide repertoire.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Vigneron N,Stroobant V,Ferrari V,Abi Habib J,Van den Eynde BJdoi
10.1016/j.molimm.2018.03.030subject
Has Abstractpub_date
2019-09-01 00:00:00pages
93-102eissn
0161-5890issn
1872-9142pii
S0161-5890(18)30109-3journal_volume
113pub_type
杂志文章,评审abstract：:Evidence suggests that immune dysregulation is associated with autism spectrum disorder (ASD). T cell immunoglobulin and mucin domain-3 (TIM-3) has a critical role in several inflammatory disorders; however, the role of TIM-3 signaling has not been demonstrated in ASD. In the present study, we assessed the role of TIM...
journal_title：Molecular immunology
pub_type： 临床试验,杂志文章
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abstract：:The mis-regulation of nuclear factor-kappa B (NF-kappaB) signal pathway is involved in a variety of inflammatory diseases that leds to the production of inflammatory mediators. Our studies using human U937 promonocytes cells suggested that magnolol, a low molecular weight lignan isolated from the medicinal plant Magno...
journal_title：Molecular immunology
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-11-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1997-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0161-5890(83)90091-3
更新日期：1983-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.molimm.2012.02.111
更新日期：2012-05-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1016/0161-5890(92)90001-e
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pub_type： 杂志文章
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更新日期：1999-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0161-5890(83)90083-4
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pub_type： 杂志文章
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journal_title：Molecular immunology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2015-02-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2006-05-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2015-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：1984-10-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/s0161-5890(99)00094-2
更新日期：1999-10-01 00:00:00
