Atypical aHUS: State of the art.

abstract：:A study aiming at cloning and characterizing natural antibodies to human immunodeficiency virus type 1 (HIV-1) targets is described. In particular, we report the molecular cloning of a Fab molecule binding the HIV-1/Tat protein from a seronegative patient. The Fab was characterized for its binding specificity and inve...

journal_title：Molecular immunology

authors： Mancini N,Perotti M,Carletti S,Canducci F,Sampaolo M,Clementi M,Burioni R

更新日期：2006-03-01 00:00:00

abstract：:Nine monoclonal antibodies (MAbs) directed against crystallized human adenovirus type 1 (Ad h 1) hexon were tested with purified homologous and heterologous hexon preparations by gel diffusion. Six MAbs formed a single line with the homologous hexon in a 2-well pattern, and 3 MAbs formed lines only in biclonal combina...

journal_title：Molecular immunology

authors： Adám E,Nász I,Lengyel A,Erdei J,Fachet J

更新日期：1985-08-01 00:00:00

abstract：:It is widely believed that migrating immune cells utilise the intercellular junctions as routes of passage, and in doing so cause the transient disruption of junctional structures. Thus there is much interest in the molecules that have been identified at cell-cell contact points and their potential involvement in the ...

journal_title：Molecular immunology

authors： Williams LA,Martin-Padura I,Dejana E,Hogg N,Simmons DL

更新日期：1999-12-01 00:00:00

abstract：:Candida albicans the most frequently isolated clinical fungal pathogen can cause local as well as systemic and life-threatening infections particularly in immune-compromised individuals. A better and more detailed understanding how C. albicans evades human immune attack is therefore needed for identifying fungal immun...

journal_title：Molecular immunology

authors： Luo S,Dasari P,Reiher N,Hartmann A,Jacksch S,Wende E,Barz D,Niemiec MJ,Jacobsen I,Beyersdorf N,Hünig T,Klos A,Skerka C,Zipfel PF

更新日期：2018-01-01 00:00:00

abstract：:Topoisomerase cDNA and various fragments thereof generated by the DNA polymerase chain reaction were cloned into plasmid expression vectors (pET series) and the expressed polypeptides were probed with scleroderma sera from seven different patients immunoreactive with topoisomerase I. All sera reacted selectively with ...

journal_title：Molecular immunology

authors： Piccinini G,Cardellini E,Reimer G,Arnett FC,Durban E

更新日期：1991-04-01 00:00:00

abstract：:Although granulocyte colony-stimulating factor(G-CSF) has pathogenic roles in several immune inflammatory diseases, its role in periodontitis has not been investigated. Here we detected local expression of G-CSF using public datasets in the Gene Expression Omnibus (GEO) database, and immune cell infiltration into ging...

journal_title：Molecular immunology

authors： Zhang Z,Yuan W,Deng J,Wang D,Zhang T,Peng L,Tian H,Wang Z,Ma J

更新日期：2020-01-01 00:00:00

abstract：:REV1 plays a key role in vertebrate translesion synthesis. Although its deoxycytidyl transferase activity is dispensable for tolerance of DNA damage caused by a number of mutagens, its extreme C terminus, which interacts with other translesion polymerases and PCNA, is essential. By examining immunoglobulin diversifica...

journal_title：Molecular immunology

authors： Ross AL,Sale JE

更新日期：2006-04-01 00:00:00

abstract：:Pulmonary exposure to innocuous aeroallergens is a common event leading to inhalation tolerance. Distinct subsets of pulmonary dendritic cells (DC) and regulatory T cells (T(Reg)) play critical roles in mediating and maintaining such tolerance. In asthmatics, the same aeroallergens drive a maladaptive, Th2-biased immu...

journal_title：Molecular immunology

authors： Köhl J,Wills-Karp M

更新日期：2007-01-01 00:00:00

abstract：:Stimulation of cells of the rat basophilic leukemia line RBL-2H3, which are used as a model in biochemical studies of mast cells, by antigen or by the calcium ionophore ionomycin, are known to cause secretion of mediators of inflammation. These stimuli have now been found to cause a decrease in the cells' cytosolic pH...

journal_title：Molecular immunology

authors： Gertler R,Pecht I

更新日期：1988-11-01 00:00:00

abstract：:T-cell-replacing factor (TRF)/IL-5 is a T-cell-derived glycoprotein which has pleiotropic activity on lymphoid and myeloid cells. IL-5 polypeptide translated into Xenopus oocytes are heterogeneous in molecular size (40,000 to 60,000 under nonreducing conditions) and yields a monomeric form (Mr of 25,000 to 30,000) und...

journal_title：Molecular immunology

authors： Takahashi T,Yamaguchi N,Mita S,Yamaguchi Y,Suda T,Tominaga A,Kikuchi Y,Miura Y,Takatsu K

更新日期：1990-09-01 00:00:00

abstract：:Symmetry in antibody plus complement mediated killing between a T15 idiotype-bearing monoclonal antibody (HPC-M2) and an anti-T15 monoclonal antibody (B36-82) is demonstrated. The HPC-M2 antibody is also shown to be multispecific in its effector function, since it lyses both phosphorylcholine coated erythrocytes, and ...

journal_title：Molecular immunology

authors： Cooper-Willis A,Hoffmann GW

更新日期：1983-08-01 00:00:00

abstract：:Natural killer cells fail to lyse target cells expressing sufficient levels of self MHC class I molecules, providing one mechanism to secure self tolerance. Inhibition of lysis is mediated by inhibitory receptors expressed by NK cells, such as the murine Ly49 receptors, human KIR receptors and CD94/NKG2A, expressed by...

journal_title：Molecular immunology

authors： Salmon-Divon M,Höglund P,Johansson MH,Johansson S,Mehr R

更新日期：2005-02-01 00:00:00

abstract：:Dendritic cells (DCs) are recruited to inflammatory sites where they phagocytose and process antigens for subsequent presentation to the T lymphocytes in the lymphoid tissue. Several leukocyte chemoattractants and their specific receptors have been shown to induce the migration of DC. The complement protein C1q has mu...

journal_title：Molecular immunology

authors： Vegh Z,Kew RR,Gruber BL,Ghebrehiwet B

更新日期：2006-03-01 00:00:00

abstract：:The globular C1q heterotrimer is a subunit of the C1 complement factor. Binding of the C1q subunit to the constant (Fc) part of antibody molecules is a first step and key event of complement activation. Although three-dimensional structures of C1q and antibody Fc subunits have been determined experimentally no atomic ...

journal_title：Molecular immunology

authors： Schneider S,Zacharias M

更新日期：2012-05-01 00:00:00

abstract：:Porphyromonas gingivalis causes periodontal diseases and its lipopolysaccharide (LPS) is considered as a major virulence factor responsible for pathogenesis. Since initial recognition of P. gingivalis LPS (Pg.LPS) in the oral cavity might be crucial for the host response, we identified Pg.LPS-binding proteins (Pg.LPS-...

journal_title：Molecular immunology

authors： Choi S,Baik JE,Jeon JH,Cho K,Seo DG,Kum KY,Yun CH,Han SH

更新日期：2011-09-01 00:00:00

abstract：:T-lymphocyte proliferative responses were determined with peripheral blood lymphocytes (PBL), peritoneal exudate lymphocytes (PEL) and lymph node lymphocytes (LNL) of guinea pigs immunized with horse cytochrome c (HCytc). The proliferative response of PBL activated by peptide 81-104 from animals immunized with HCytc w...

journal_title：Molecular immunology

authors： Wang KM,Reichlin M

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND:The complement system is well known for its role in innate immunity via the classical, the alternative and the lectin pathways, although recent investigations suggest expanding roles in adipose tissue. Properdin stabilizes C3 convertase following alternative complement activation. Properdin is also present i...

journal_title：Molecular immunology

authors： Gauvreau D,Roy C,Tom FQ,Lu H,Miegueu P,Richard D,Song WC,Stover C,Cianflone K

更新日期：2012-05-01 00:00:00

abstract：:Macrophages play an important role both in innate and adaptive immune responses. Treatment with interferon (IFN) γ together with lipopolysaccharide (LPS) activates pro-inflammatory macrophages which secrete various pro-inflammatory cytokines including IL-12. IL-12 promotes a Th1 type immune response by directly contro...

journal_title：Molecular immunology

authors： Boonyatecha N,Sangphech N,Wongchana W,Kueanjinda P,Palaga T

更新日期：2012-07-01 00:00:00

abstract：:Cell-cell signaling represents an essential hallmark of multicellular organisms, which necessarily require a means of communicating between different cell populations, particularly immune cells. Cytokine receptor signaling through the Janus kinase/Signal Transducer and Activator of Transcription/Suppressor of Cytokine...

journal_title：Molecular immunology

authors： Liongue C,Taznin T,Ward AC

更新日期：2016-03-01 00:00:00

abstract：:In two recent articles published in Molecular Immunology, Steere and colleagues continue their search for an autoimmune mechanism of arthritis in patients who have failed short-course antibiotic therapy for Borrelia burgdorferi, the spirochetal agent of Lyme disease. As in previous attempts, the authors fail to elucid...

journal_title：Molecular immunology

authors： Stricker RB,Johnson L

更新日期：2008-06-01 00:00:00

abstract：:Peptide binding to major histocompatibility complex (MHC) class II molecules is optimal at mildly acidic pH. X-ray crystal structures solved for the murine class II molecule I-E(k) revealed an interesting localization of negatively charged residues within the P6 pocket, which may have implications in the pH dependency...

journal_title：Molecular immunology

authors： Dao CT,Weber DA,Jensen PE

更新日期：2002-06-01 00:00:00

abstract：:The binding of a T cell-presented peptide to MHC class II alpha,beta chains occurs as a concurrent process with the release of the associated invariant chain (Ii) by cathepsin B. Ii was digested by cathepsin B from solubilized, MHC class II alpha,beta,Ii complexes in the presence of N-hydroxysuccinimidyl-4-azidobenzoa...

journal_title：Molecular immunology

authors： Daibata M,Xu M,Humphreys RE,Reyes VE

更新日期：1994-03-01 00:00:00

abstract：:We have recently developed an in vitro culture model enabling the large-scale expansion of switched-memory B lymphocytes, producing a polyclonal human IgG repertoire. Given the importance of glycosylation for the functions of immunoglobulins, we analyzed the N-glycosylation profiles of the immunoglobulin G (IgG) in th...

journal_title：Molecular immunology

authors： Ritamo I,Cloutier M,Valmu L,Néron S,Räbinä J

更新日期：2014-02-01 00:00:00

abstract：:Antibodies that recognize Xenopus class II molecules have been developed. Mouse monoclonal antibodies were prepared by immunizing BALB/c mice with frog MHC antigens that had been partially purified with alloantisera, and by immunizing mouse spleen cells in vitro with activated Xenopus T lymphocytes. In addition, five ...

journal_title：Molecular immunology

authors： Flajnik MF,Ferrone S,Cohen N,Du Pasquier L

更新日期：1990-05-01 00:00:00

abstract：:A sheep cDNA library was screened with a human C mu probe, and the complete nucleotide sequence of a 1923 nt cDNA was determined. It contains sequences corresponding to all the exons (VH, DH, JH, CH1, CH2, CH3 and CH4) characteristic of the immunoglobulin mu heavy chain regions. The deduced amino acid sequence shows a...

journal_title：Molecular immunology

authors： Patri S,Nau F

更新日期：1992-07-01 00:00:00

abstract：UNLABELLED:C5L2, a G-protein-coupled receptor (GPCR), has been identified as an ASP (C3adesArg) and C5a receptor. Controversy exists regarding both ligand binding and functionality. ASP activation of C5L2 is proposed to regulate fat storage. C5L2 is also proposed as a decoy receptor for C5a, an inflammatory mediator, b...

journal_title：Molecular immunology

authors： Cui W,Simaan M,Laporte S,Lodge R,Cianflone K

更新日期：2009-09-01 00:00:00

abstract：:This report demonstrates that a marker of human embryonic endoderm and embryonal carcinoma cells recognized by a hybridoma antibody FC 10.2, involves Type 1 blood group chains with the sequence Gal beta 1 leads to 3G1cNAc beta 1 leads to 3Gal beta 1 leads to 4G1c. This conclusion has been reached from antigenic analys...

journal_title：Molecular immunology

authors： Gooi HC,Williams LK,Uemura K,Hounsell EF,McIlhinney RA,Feizi T

更新日期：1983-06-01 00:00:00

abstract：:V(D)J recombination is a mechanism peculiar to the somatic rearrangement of antigen receptor genes. It requires both expression of the RAG-1 and RAG-2 recombinases and accessibility of the substrate to its recombinase and post-cleavage/DNA repair stage. TCR revision is a genetic correction mechanism that changes T cel...

journal_title：Molecular immunology

authors： Lantelme E,Orlando L,Porcedda P,Turinetto V,De Marchi M,Amoroso A,Mantovani S,Giachino C

更新日期：2008-01-01 00:00:00

abstract：:Infection of ruminants and humans with Fasciola gigantica is attracting increasing attention due to its economic impact and public health significance. However, little is known of innate immune responses during F. gigantica infection. Here, we investigated the expression profiles of genes involved in Toll-like recepto...

journal_title：Molecular immunology

authors： Zhang FK,Hou JL,Guo AJ,Tian AL,Sheng ZA,Zheng WB,Huang WY,Elsheikha HM,Zhu XQ

更新日期：2018-02-01 00:00:00

abstract：:In extension of the hypothesis that an amphipathic alpha helix of Ii (Phe146-Val164) bound to the foreign antigen-presenting site (desetope) of class II MHC molecules through hydrophobic amino acid residues (Phe146, Leu150, Leu153, Met157, Ile160, Val164) which were present in an axial strip along one side of the Ii h...

journal_title：Molecular immunology

authors： Stille CJ,Thomas LJ,Reyes VE,Humphreys RE

更新日期：1987-10-01 00:00:00