Hereditary C1 inhibitor deficiency is associated with high spontaneous amidase activity.

abstract：:The Class II Transactivator (CIITA) is the master regulator of Major Histocompatibility Class II (MHC II) genes. Transcription of CIITA through the IFN-γ inducible CIITA promoter IV (CIITA pIV) during activation is characterized by a decrease in trimethylation of histone H3 lysine 27 (H3K27me3), catalyzed by the histo...

journal_title：Molecular immunology

authors： Boyd NH,Morgan JE,Greer SF

更新日期：2015-10-01 00:00:00

abstract：:MHC class I molecules present short peptides, usually 8-10 amino acids in length, to CD8(+) T cells. These peptides are typically generated from full-length endogenously synthesized proteins degraded by the antigen processing machinery of the target cell. However, exogenous proteins, whether originating from intracell...

journal_title：Molecular immunology

authors： Wolf BJ,Princiotta MF

更新日期：2011-01-01 00:00:00

abstract：:In humans, the CD4 molecule is expressed on a subset of T-cells and at various levels on myeloid and lymphoid cells. The mechanisms regulating human CD4 gene expression are yet poorly understood. We speculated that the CD4 silencer, which operates in CD8+ T-cells to repress CD4 expression, could be responsible for CD4...

journal_title：Molecular immunology

authors： Mouly E,Dorival C,Pflumio F,Baillou C,Coulombel L,Levy Y,Lemoine FM,Klatzmann D,Marodon G

更新日期：2007-01-01 00:00:00

abstract：:Anti-DNP activity was found in normal human immunoglobulins with average affinities (10(4)-10(6) l/mole) and frequencies (15-2%) that correlate well with those expected from multispecific binding sites. ...

journal_title：Molecular immunology

authors： Ortega E,Kostovetzky M,Larralde C

更新日期：1984-10-01 00:00:00

abstract：:Class switch DNA recombination (CSR) substitutes an immunoglobulin (Ig) constant heavy chain (C(H)) region with a different C(H) region, thereby endowing an antibody with different biological effector functions. CSR requires activation-induced cytidine deaminase (AID) and occurrence of double-strand DNA breaks (DSBs) ...

journal_title：Molecular immunology

authors： Zan H,Casali P

更新日期：2008-11-01 00:00:00

abstract：:One of the major obstacles in the successful clinical application of monoclonal antibodies has been the development of host immune responses to murine Ig constant and variable regions. While the CDR grafting of MAbs may alleviate many of these problems, the potential remains that one or more murine CDRs on the human I...

journal_title：Molecular immunology

authors： Iwahashi M,Milenic DE,Padlan EA,Bei R,Schlom J,Kashmiri SV

更新日期：1999-10-01 00:00:00

abstract：:The translation of mRNA within total RNA of German (Blattella germanica) cockroaches was performed using a rabbit reticulocyte lysate system. Analysis of the translation products by SDS-PAGE and combined autoradiography revealed several synthesized proteins with apparent molecular weights ranging from 20 kD to 110 kD....

journal_title：Molecular immunology

authors： Helm R,Cockrell G,Sharkey P,Brenner R,Burks AW

更新日期：1993-12-01 00:00:00

abstract：:Mice deficient for SPI-group ETS transcription factors PU.1 or SPI-B fail to generate lymphocytes or do not mount normal antibody mediated immune responses, respectively. PU.1 expression is restricted to B-, T-lymphocytes and macrophages, while SPI-B is expressed in B- and T-lymphocytes. SPI-C is an ETS transcription ...

journal_title：Molecular immunology

authors： Carlsson R,Persson C,Leanderson T

更新日期：2003-06-01 00:00:00

abstract：:The functional importance of various cell membrane bound molecules was studied and compared in the NK cytotoxicity and CTL activity. LFA-1 and CD2 participate in both killing functions, while CD3 and CD8/CD4 as well as MHC class I molecules are involved only in CTL activity. Nevertheless CD2- and beta 2-microglobulin ...

journal_title：Molecular immunology

authors： Petrányi GG,Pócsik E,Kotlán B,Görög G,Benczur M

更新日期：1986-11-01 00:00:00

abstract：:Cathepsin L protease belongs to the papain-like cysteine proteases family, plays indispensable roles in animals' pathological and physiological processes. However, little is known about Cathepsin L in silkworm, Bombyx mori. Herein, a novel Cathepsin L-like (Cat L-like) was cloned and identified from silkworm by the ra...

journal_title：Molecular immunology

authors： Pan G,Zhang K,Li C,Hu X,Kausar S,Gu H,Yang L,Cui H

更新日期：2020-12-26 00:00:00

abstract：:The complement system is a vital component of the immune-priveliged human eye that is always active at a low-grade level, preventing harmful intraocular injuries caused by accumulation of turnover products and controlling pathogens to preserve eye homeostasis and vision. The complement system is a double-edged sword t...

journal_title：Molecular immunology

authors： Mohlin C,Sandholm K,Ekdahl KN,Nilsson B

更新日期：2017-09-01 00:00:00

abstract：:The molecular interactions between the components of the C3 convertase of the alternative pathway (AP) of complement and its regulators, in both surface-bound and fluid-phase form, are still incompletely understood. The fact that the AP convertase is labile makes studies difficult to perform. According to the so calle...

journal_title：Molecular immunology

authors： Bexborn F,Andersson PO,Chen H,Nilsson B,Ekdahl KN

更新日期：2008-04-01 00:00:00

abstract：:Topoisomerase cDNA and various fragments thereof generated by the DNA polymerase chain reaction were cloned into plasmid expression vectors (pET series) and the expressed polypeptides were probed with scleroderma sera from seven different patients immunoreactive with topoisomerase I. All sera reacted selectively with ...

journal_title：Molecular immunology

authors： Piccinini G,Cardellini E,Reimer G,Arnett FC,Durban E

更新日期：1991-04-01 00:00:00

abstract：:A phosphorylcholine (PC)-binding IgG (Mab2) antibody produced by a hybridoma derived from a BALB/c mouse which had been immunized against Trichinella spiralis was found to bind to the immunizing antigen (TSC) but not to other PC-associated antigens such as pneumococcal antigen (PNC) and PC-conjugated ovalbumin (PC-OVA...

journal_title：Molecular immunology

authors： Lim PL,Leung DT,Chui YL,Ma CH

更新日期：1994-10-01 00:00:00

abstract：:Scygonadin is a novel antimicrobial peptide, which was originally isolated from the seminal plasma of the mud crab, Scylla serrata. Based on the partial 20-residue NH(2)-terminal sequence of the peptide, H-Gly-Gln-Ala-Leu-Asn-Lys-Leu-Met-Pro-Lys-Ile-Val-Ser-Ala-Ile-Ile-Tyr-Met-Val-Gly-OH, scygonadin was cloned from th...

journal_title：Molecular immunology

authors： Wang KJ,Huang WS,Yang M,Chen HY,Bo J,Li SJ,Wang GZ

更新日期：2007-03-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) in patients and certain mouse models exhibits a strong sex bias. Additionally, in most patients, increased serum levels of type I interferon (IFN-α) are associated with severity of the disease. Because increased levels of B cell activating factor (BAFF) in SLE patients and mouse mode...

journal_title：Molecular immunology

authors： Panchanathan R,Choubey D

更新日期：2013-01-01 00:00:00

abstract：:The purpose of this study was to evaluate the effects of GATA-6 on airway inflammation and remodeling and the underlying mechanisms in a murine model of chronic asthma. Female BALB/c mice were randomly divided into four groups: phosphate-buffered saline control (PBS), ovalbumin (OVA)-induced asthma group (OVA), OVA+ s...

journal_title：Molecular immunology

authors： Fang P,Shi HY,Wu XM,Zhang YH,Zhong YJ,Deng WJ,Zhang YP,Xie M

更新日期：2016-07-01 00:00:00

abstract：:Calcium signals are crucial for diverse cellular functions including adhesion, differentiation, proliferation, effector functions and gene expression. After engagement of the B cell receptor, the intracellular calcium ion (Ca(2+)) concentration is increased promoting the activation of various signaling cascades. While...

journal_title：Molecular immunology

authors： Baba Y,Matsumoto M,Kurosaki T

更新日期：2014-12-01 00:00:00

abstract：:Suppressor of cytokine signaling 3 (SOCS3) is a negative regulator of TBK1 and interferon pathway and the expression of SOCS3 is closely correlated with symptoms of influenza patients. However, whether deletion of Socs3 in the lung epithelial cells would affect influenza lung replication and inflammation in vivo is un...

journal_title：Molecular immunology

authors： Li L,Wu H,Li Q,Chen J,Xu K,Xu J,Su X

更新日期：2020-09-01 00:00:00

abstract：:We designed the peptide (C3) mimetic carboxyl-terminus (Cterminus) of capsid protein of porcine circovirus type 2b (PCV2b-1A/1B) inducing humoral immunity and generating hybridomas. The positive reactivity of the mAbs to PCV2 capsid protein was demonstrated by Western blot assay. Those mAbs also showed positive signal...

journal_title：Molecular immunology

authors： Hung LC,Cheng IC

更新日期：2017-05-01 00:00:00

abstract：:The binding specificity of rat alveolar macrophages (AM phi) for sheep erythrocytes (E) coated with gangliosides GM1, GM2, GM3, GD1a, GD1b or GT1b was analyzed in a rosette assay by studying the inhibitory effect of gangliosides, various carbohydrates, IgG, C3b-like C3, and fibronectin in this assay. The uptake of gan...

journal_title：Molecular immunology

authors： Förster O,Boltz-Nitulescu G,Holzinger C,Wiltschke C,Riedl M,Ortel B,Fellinger A,Bernheimer H

更新日期：1986-11-01 00:00:00

abstract：:The lymphocyte antigen CD6 has been extensively studied in humans, but has not been reported in mouse. Here we describe the isolation and characterization of a cDNA clone encoding the murine homologue of the human lymphocyte antigen CD6. Comparison of the predicted amino acid sequence of human and murine CD6 shows tha...

journal_title：Molecular immunology

authors： Whitney G,Bowen M,Neubauer M,Aruffo A

更新日期：1995-01-01 00:00:00

abstract：:Although the beneficial effects of probiotics on wide variety of diseases have been shown, little is known about how probiotics modulate the immune system. In this study we elucidated the underlying mechanisms how Lactobacillus casei (L. casei) protects against rheumatoid arthritis (RA) progression by investigating th...

journal_title：Molecular immunology

authors： So JS,Kwon HK,Lee CG,Yi HJ,Park JA,Lim SY,Hwang KC,Jeon YH,Im SH

更新日期：2008-05-01 00:00:00

abstract：:Prolactin has several immune functions in fish however, the effects on innate and specific components of rainbow trout immunity are currently unknown. Therefore in this study, prolactin peptide (pPRL) injection in rainbow trout generated anti-PRL antibodies that were confirmed through Western blot assays of fish brain...

journal_title：Molecular immunology

authors： Villalba M,Gómez G,Torres L,Maldonado N,Espiñeira C,Payne G,Vargas-Chacoff L,Figueroa J,Yáñez A,Olavarría VH

更新日期：2020-11-01 00:00:00

abstract：:The immune system protects from infections primarily by detecting and eliminating invading pathogens. This is predominantly mediated by innate immune cells like neutrophils, monocytes and dendritic cells (DCs) expressing specific receptors recognizing pathogen-associated molecular patterns. DC activation by pathogens ...

journal_title：Molecular immunology

authors： Bieber K,Autenrieth SE

更新日期：2020-05-01 00:00:00

abstract：:We report the construction, expression and purification of a bispecific single-chain Fv antibody fragment produced in Escherichia coli. The protein possesses a dual specificity: the single-chain FvB1 portion is directed to the Idiotype of BCL1 lymphoma cells, the single-chain Fv2C11 moiety binds to the CD3 marker on T...

journal_title：Molecular immunology

authors： De Jonge J,Brissinck J,Heirman C,Demanet C,Leo O,Moser M,Thielemans K

更新日期：1995-12-01 00:00:00

abstract：:As an initial step towards the molecular analysis of the murine V kappa locus, a cosmid library from BALB/cJ mouse liver DNA was screened with probes representing 10 V kappa families. Of eight cosmids that were isolated from the initial screen, five contained a single restriction fragment that hybridized to the probes...

journal_title：Molecular immunology

authors： Lawler AM,Umar A,Gearhart PJ

更新日期：1992-03-01 00:00:00

abstract：:Human IgE against helminths is a normal component of the whole protective response elicitesd during infection, when specific IgE to a great number of antigens is produced; however, few of those IgE binding components are actually allergens. In general, considering the strong Th2/IgE responses during helminth infection...

journal_title：Molecular immunology

authors： Caraballo L,Coronado S

更新日期：2018-08-01 00:00:00

abstract：:The human C epsilon gene produces a number of alternatively spliced heavy chain transcripts of which some encode functional IgE isoforms. We now show that differentially processed epsilon mRNA variants also exist in the mouse and are generated by differential polyadenylation and alternative splicing of primary epsilon...

journal_title：Molecular immunology

authors： Anand S,Batista FD,Tkach T,Efremov DG,Burrone OR

更新日期：1997-02-01 00:00:00

abstract：:T regulatory (Treg)/T-helper (Th) 17 imbalance has been shown to integrate with epigenetics to result in the development of autoimmune diseases. We aim to investigate the influence of disease staging on Treg/Th17 cells and whether the aberrant DNA methylation is implicated in the development of rheumatoid arthritis (R...

journal_title：Molecular immunology

authors： Huang Y,Wang H,Ba X,Chen Z,Wang Y,Qin K,Huang Y,Shen P,Tu S

更新日期：2020-11-01 00:00:00