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Histone acetyltransferase activity of p300 enhances the activation of IL-12 p40 promoter.

Abstract：

:Interleukin-12 (IL-12) is a heterodimeric cytokine produced by macrophages in response to intracellular pathogens and provides an obligatory signal for the differentiation of T-helper-1 cells. p300 is an important histone acetyltransferase (HAT) and has been implicated in the regulation of gene expression. Whether p300 plays a role in the IL-12 expression has not been investigated before. In this study, we analyzed the roles of p300 in the regulation of human IL-12 p40. By using RT-PCR and a series of co-transfection studies, we found that p300 had a stimulating effect on the expression of endogenous IL-12 p40 mRNA and on the activity of IL-12 p40 promoter. We also showed that the HAT activity of p300 was essential to its function in regulating IL-12 promoter, since the mutant p300 with the HAT domain deleted did not have such a stimulation effect. In addition, the adenovirus E1A protein suppressed the p300 function, whereas the mutant E1A lacking the p300 interaction domain did not. Furthermore, p300 was able to reinforce the c-Rel-mediated activation of IL-12 p40. Results presented in this paper implicate that p300 is involved in the transcriptional regulation of IL-12 p40, and IL-12 p40 is one of the target genes of p300.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Sun H,Lu J,Wei L,Wang X,Xu X,Dong M,Huang B

doi

10.1016/j.molimm.2004.05.013

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

1241-6

issue

12

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(04)00256-1

journal_volume

41

pub_type

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