Abstract：
:Amyotrophic lateral sclerosis (ALS) is a devastating, neurodegenerative motor neuron disease. The aetiology of ALS remains an enigma which hinders the design of an effective treatment to prevent, postpone, or reverse the pathophysiological changes occurring during the aggressive progression of this disease. During the last decade, basic research within the innate immune system, and in particular the complement system, has revealed new, important roles of the innate immune system during development, homeostasis, and ageing within as well as outside the central nervous system. Several lines of evidence indicate that aberrant activation of the complement system locally in the central nervous system as well as systemically may be involved in the pathophysiology of ALS. This exciting new knowledge could point towards the innate immune system as a potential target of medical intervention in ALS. Recently, the historic perception of ALS as a central neurodegenerative disease has been challenged due to the significant amount of evidence of a dying-back mechanism causing the selective destruction of the motor neurons, indicating that disease onset occurs outside the borders of the blood-brain-barrier. This review addresses the function of the innate immune system during ALS. We emphasize the role of the complement system and specifically suggest the involvement of ficolin-3 from the lectin pathway in the pathophysiology of ALS.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Kjældgaard AL,Pilely K,Olsen KS,Pedersen SW,Lauritsen AØ,Møller K,Garred Pdoi
10.1016/j.molimm.2018.06.007subject
Has Abstractpub_date
2018-10-01 00:00:00pages
14-25eissn
0161-5890issn
1872-9142pii
S0161-5890(18)30196-2journal_volume
102pub_type
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journal_title：Molecular immunology
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doi：10.1016/0161-5890(93)90451-g
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pub_type： 杂志文章
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更新日期：2016-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2006-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2004-03-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2006.11.011
更新日期：2007-04-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2010.11.009
更新日期：2011-06-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(95)00028-d
更新日期：1995-07-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(86)90068-4
更新日期：1986-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.molimm.2007.04.022
更新日期：2007-07-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
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更新日期：2010-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2000-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2021-02-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1982-03-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2016-07-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2017-05-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2007.08.011
更新日期：2008-03-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1994-05-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2007-05-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2006.07.303
更新日期：2007-03-01 00:00:00
abstract：:Monoclonal antibodies (MAbs) raised against trout immunoglobulin (Ig) recognize two independent Ig populations differing in the molecular weight of L chains. The trout Ig population recognized by MAb 2H9 represented congruent to 20% of the total Ig and contained L chains congruent to 26 kDa, whereas the trout Ig popul...
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pub_type： 杂志文章
doi：10.1016/0161-5890(91)90014-b
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