Abstract:
:Factor I (C3b/C4b inactivator) is a regulatory protein of the classical and alternative complement pathways. In this paper, we report the sequence of Xenopus factor I cDNA and the deduced protein structure. The basic structure of human preprofactor I, NH2-heavy chain-cleavage peptide-light chain-COOH, is conserved in the frog. However, the frog heavy chain contains a highly charged segment of 29 amino acids, encoded by a poly dA-rich mRNA insert, which is not found in human factor I. The modular structure of the frog heavy chain was analyzed, and found to differ vis-à-vis previously published analyses of human factor I. We also evaluate the timing of factor I transcription during frog embryogenesis.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Kunnath-Muglia LM,Chang GH,Sim RB,Day AJ,Ezekowitz RAdoi
10.1016/0161-5890(93)90040-isubject
Has Abstractpub_date
1993-10-01 00:00:00pages
1249-56issue
14eissn
0161-5890issn
1872-9142journal_volume
30pub_type
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journal_title:Molecular immunology
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journal_title:Molecular immunology
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journal_title:Molecular immunology
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Molecular immunology
pub_type: 杂志文章
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(86)90039-8
更新日期:1986-02-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章,评审
doi:10.1016/j.molimm.2012.11.008
更新日期:2013-06-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(93)90125-u
更新日期:1993-08-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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更新日期:2020-04-16 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2004.07.011
更新日期:2005-02-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2009.11.020
更新日期:2010-02-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2017.12.020
更新日期:2018-02-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(85)90084-7
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pub_type: 杂志文章
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更新日期:1987-10-01 00:00:00
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journal_title:Molecular immunology
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2013.04.006
更新日期:2013-11-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章,评审
doi:10.1016/j.molimm.2016.12.009
更新日期:2017-04-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(84)90143-3
更新日期:1984-10-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章,评审
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更新日期:2002-02-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(82)90189-4
更新日期:1982-11-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1992-04-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2019.04.013
更新日期:2019-07-01 00:00:00
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journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(84)90040-3
更新日期:1984-05-01 00:00:00