Myxomatous degeneration of the mitral valve complicated by nonbacterial thrombotic endocarditis with systemic embolization.

abstract：:Upon hospital admission a patient was found to have severe anemia and a strongly positive direct antiglobulin test (DAT). The patient was taking probenecid periodically for gout. An antibody was detected in the patient's serum that only reacted with red blood cells (RBCs) when probenecid was added. Eluates from the pa...

journal_title：American journal of clinical pathology

authors： Sosler SD,Behzad O,Garratty G,Lee CL,Postoway N,Khomo O

更新日期：1985-09-01 00:00:00

abstract：:Four commercially available herpes simplex virus 1 (HSV-1) indirect fluorescent antibody (IFA) kits were compared with the use of sera selected because they were negative for HSV antibody by complement fixation (CF less than 1:8) and by ELISA (less than 1:100). However, 14 of 24 (58.3%) of these HSV-1 antibody-negativ...

journal_title：American journal of clinical pathology

authors： Rand KH,Houck HJ,Dickinson M

更新日期：1986-12-01 00:00:00

abstract：:Patients using anticoagulation point-of-care (POC) monitors are advised to periodically test these systems against laboratory methods to monitor performance. The international normalized ratio (INR), however, can vary between test systems owing to different instrument-reagent combinations. In a randomized study evalua...

journal_title：American journal of clinical pathology

authors： Sunderji R,Gin K,Shalansky K,Carter C,Chambers K,Davies C,Schwartz L,Fung A

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVES:Sclerosing pneumocytomas are rare pulmonary neoplasms that are typically benign. However, rare patients experience progressive disease, and therapy targeting specific genetic underpinnings could be an attractive therapeutic option. Recent studies have found recurrent AKT 1 mutations in sclerosing pneumocytom...

journal_title：American journal of clinical pathology

authors： Boland JM,Lee HE,Barr Fritcher EG,Voss JS,Jessen E,Davila JI,Kipp BR,Graham RP,Maleszewski JJ,Yi ES

更新日期：2020-11-04 00:00:00

abstract：Objectives:To analyze interobserver reproducibility and compare practice patterns between academic and community settings of Lower Anogenital Squamous Terminology (LAST). Methods:In total, 132 anal biopsy slides were revised as well as p16 immunostains. Results:LAST was used in 49% of cases (academic center, 68%; sat...

journal_title：American journal of clinical pathology

authors： Roma AA,Liu X,Patil DT,Xie H,Allende D

更新日期：2017-07-01 00:00:00

abstract：:Primary gastric non-Hodgkin lymphoma of mucosa-associated lymphoid tissue (MALT-NHL) is strongly related to Helicobacter pylori (H pylori) infection. CagA positive H pylori strains appear to be more aggressive, as reflected by a greater degree of gastric inflammation and higher levels of Il-8 production. Using a polym...

journal_title：American journal of clinical pathology

authors： de Jong D,van der Hulst RW,Pals G,van Dijk WC,van der Ende A,Tytgat GN,Taal BG,Boot H

更新日期：1996-11-01 00:00:00

abstract：:Infusible platelet membranes (IPMs) prepared from fresh or outdated human platelets have been shown to correct prolonged bleeding times in thrombocytopenic rabbits. In previous trials, IPMs did not seem to be immunogenic and lacked dose-limiting toxicity. The present study was undertaken to explore whether the platele...

journal_title：American journal of clinical pathology

authors： Graham SS,Gonchoroff NJ,Miller JL

更新日期：2001-01-01 00:00:00

abstract：:Annual ampicillin susceptibility rates for Haemophilus influenzae isolates at the St. Paul-Ramsey Medical Center gradually decreased from 100% in 1974 to 83.3% in 1980 and then remained stable at 88.90%. Penicillin susceptibility rates were similar to those for ampicillin. Ampicillin rates were source dependent: eye 9...

journal_title：American journal of clinical pathology

authors： Woolfrey BF,Lally RT,Ireland GK,Quall CO,Ederer MN

更新日期：1984-09-01 00:00:00

abstract：:Estrogen receptor (ER) status of breast carcinomas determines prognosis and treatment. Biochemical ER assays are expensive and time-consuming and require fresh tumor. Immunohistochemical ER was assessed in 68 breast carcinomas, by an automated method using routinely processed formalin-fixed paraffin-embedded tissues, ...

journal_title：American journal of clinical pathology

authors： Cohen C,Unger ER,Sgoutas D,Bradley N,Chenggis M

更新日期：1989-11-01 00:00:00

abstract：:Immunophenotypic analysis is useful in distinguishing reactive from neoplastic lymphoproliferations, particularly when tissue is limited or histologic findings are equivocal. Surface membrane immunoglobulin (SmIg) light chain restriction in B cells is especially helpful in documenting clonality, and the loss of SmIg b...

journal_title：American journal of clinical pathology

authors： Zhao XF,Cherian S,Sargent R,Seethala R,Bonner H,Greenberg B,Bagg A

更新日期：2005-07-01 00:00:00

abstract：:We evaluated a more efficient method of processing liquid-based cervical cytology specimens for human papillomavirus (HPV) DNA testing by Hybrid Capture II (HCII). Aliquots were made from 701 specimens in the following sequence: 4.0, 2.0, 1.0, 0.5, and 1.5 mL. The 4.0-mL aliquot was processed by the standard method (S...

journal_title：American journal of clinical pathology

authors： Castle PE,Garcia-Meijide M,Holladay EB,Chuke R,Payne J,Long A,Siefers H,Demuth F,Lorincz AT

更新日期：2005-02-01 00:00:00

abstract：:Characteristically, mantle cell lymphoma (MCL) expresses surface immunoglobulin (sIg), CD19, CD20, and CD5 and lacks CD10 and CD23. Rare CD5-MCL variants have been described. This report describes a case of leukemic MCL with morphologically and immunophenotypically distinct classic MCL and blastoid-variant MCL (BV-MCL...

journal_title：American journal of clinical pathology

authors： Morice WG,Hodnefield JM,Kurtin PJ,Hanson CA

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVES:BRAF V600E mutation is characteristic of hairy cell leukemia (HCL). A V600E mutation-specific antibody, VE1, has been recently developed. We studied the diagnostic utility of this antibody in HCL and compared it with other B-cell neoplasms. METHODS:VE1 activity was assessed using immunohistochemistry in 90 ...

journal_title：American journal of clinical pathology

authors： Uppal G,Ly V,Wang ZX,Bajaj R,Solomides CC,Banks PM,Medeiros LJ,Peiper SC,Gong JZ

更新日期：2015-01-01 00:00:00

abstract：:Acute toxic hepatic necrosis is common and may be fatal. Predicting clinical outcome may be aided by following serum markers that could indicate recovery or may signify massive (substantial) destruction of functional liver mass. Previously, in a published case of chloroform poisoning, we serially assayed serum biomark...

journal_title：American journal of clinical pathology

authors： Horn KD,Wax P,Schneider SM,Martin TG,Nine JS,Moraca MA,Virji MA,Aronica PA,Rao KN

更新日期：1999-09-01 00:00:00

abstract：:Anaerobiospirillum succiniciproducens is a little-known spiral bacterium. Presented here are two septicemia cases similar in that both occurred in rural northern Virginia, both patients presented with dental infection, and in both cases the organism was first suspected to be Campylobacter. The morphology, motility, bi...

journal_title：American journal of clinical pathology

authors： Park CH,Hixon DL,Endlich JF,O'Connell P,Bradd FT,Mount PM

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:Universal screening of upper tract urothelial carcinoma (UTUC) for Lynch syndrome by mismatch repair (MMR) protein immunohistochemistry (IHC) has been recommended by some investigators. Herein, we assess this recommendation retrospectively by simulating its performance on a retrospective, unselected cohort o...

journal_title：American journal of clinical pathology

authors： Gayhart MG,Johnson N,Paul A,Quillin JM,Hampton LJ,Idowu MO,Smith SC

更新日期：2020-11-04 00:00:00

abstract：:Our purpose was to evaluate the clinical, histologic, and histochemical staining characteristics of intestinal metaplasia (IM) at an endoscopically normal-appearing esophagogastric junction (IM-EGJ) compared with IM in a columnar-lined esophagus (IM-CLE). A prospective study included 253 patients referred for elective...

journal_title：American journal of clinical pathology

authors： van Sandick JW,van Lanschot JB,van Felius L,Haringsma J,Tytgat GN,Dekker W,Drillenburg P,Offerhaus GJ,ten Kate FJ

更新日期：2002-01-01 00:00:00

abstract：:Bleeding problems are symptomatic of platelet delta-storage pool diseases (SPDs) such as Hermansky-Pudlak syndrome. Although at present no cure is available for delta-SPD, early diagnosis is of great importance for prophylactic and supportive treatment. This study tested the usefulness of a flow cytometric assay for p...

journal_title：American journal of clinical pathology

authors： Maurer-Spurej E,Pittendreigh C,Wu JK

更新日期：2007-04-01 00:00:00

abstract：:A teenage male, with Goodpasture's syndrome and serum antiglomerular basement membrane (anti-GBM) antibodies, had a focal proliferative glomerulonephritis with crescents. Immunofluorescence microscopy of his glomeruli using anti-IgG antibodies demonstrated both intense linear GBM staining, and granular subepithelial s...

journal_title：American journal of clinical pathology

authors： Jennette JC,Lamanna RW,Burnette JP,Wilkman AS,Iskander SS

更新日期：1982-09-01 00:00:00

abstract：:Specific esterase activity, a property generally ascribed to cells of granulocytic origin, was found in abnormal erythroid precursors obtained from the bone marrows of six patients with untreated erythroleukemia. These erythroblasts also showed nonspecific esterase activity. Neither specific nor nonspecific esterase a...

journal_title：American journal of clinical pathology

authors： Kass L

更新日期：1977-04-01 00:00:00

abstract：:The pattern of spurious red blood cell parameters caused by serum cold agglutinins has been well characterized for the Coulter counters but not the Ortho ELT-8. The pattern consists of a spurious increase in mean corpuscular volume (MCV), a discrepancy between the hemoglobin and the hematocrit, the latter falsely redu...

journal_title：American journal of clinical pathology

authors： Solanki DL,Blackburn BC

更新日期：1985-02-01 00:00:00

abstract：:Following normalization of blood glucose levels, a marked change in the MCV and in the calculated hematocrit was observed in five patients with transient severe hyperglycemia. The addition of varied concentrations of glucose to blood samples from healthy volunteers and from patients with microcytic, macrocytic, and no...

journal_title：American journal of clinical pathology

authors： Holt JT,DeWandler MJ,Arvan DA

更新日期：1982-05-01 00:00:00

abstract：:Blast-like cells in the cerebrospinal fluid (CSF) of neonates have been identified and previously suggested to be of germinal matrix origin. Twelve additional CSF specimens with blast-like cells collected at the University of Texas Medical Branch, Galveston, between 1985-1992 were analyzed. The cytological features of...

journal_title：American journal of clinical pathology

authors： Jaffey PB,Varma SK,DeMay RM,McLucas EJ,Campbell GA

更新日期：1996-05-01 00:00:00

abstract：:Platelet function testing is important for the diagnostic evaluation of common and rare bleeding disorders. Our study goals were to promote best practices and reduce unnecessary testing variances by developing North American guidelines on platelet function testing. Guidelines were developed by consensus for expert rec...

journal_title：American journal of clinical pathology

authors： Hayward CP,Moffat KA,Raby A,Israels S,Plumhoff E,Flynn G,Zehnder JL

更新日期：2010-12-01 00:00:00

abstract：:Hemizygous TP53 gene deletion is the most important adverse risk factor in chronic lymphocytic leukemia (CLL), but its relationship with p53 protein expression is unclear. We investigated 110 CLL cases and correlated nuclear p53 protein immunoreactivity with TP53 gene deletion status and other CLL-associated genetic r...

journal_title：American journal of clinical pathology

authors： Chang H,Jiang AM,Qi CX

更新日期：2010-01-01 00:00:00

abstract：:A 26-year-old woman who had undergone orthotopic heart transplantation because of dilative cardiomyopathy received a triple-drug immunosuppressive regimen (cyclosporine A, azathioprine, and prednisolone). During her relatively frequent episodes of acute rejection, she was treated with methylprednisolone and repeated a...

journal_title：American journal of clinical pathology

authors： Kemnitz J,Cremer J,Gebel M,Uysal A,Haverich A,Georgii A

更新日期：1990-07-01 00:00:00

abstract：:Several adulterants are used to mask tests for abused drugs in urine. Adulterants such as "Klear" and "Whizzies" contain potassium nitrite, and "Urine Luck" contains pyridinium chlorochromate (PCC). The presence of these adulterants cannot be detected by routine specimen integrity checks (pH, specific gravity, and tem...

journal_title：American journal of clinical pathology

authors： Dasgupta A,Wahed A,Wells A

更新日期：2002-02-01 00:00:00

abstract：:Accurate diagnosis of oral hairy leukoplakia (OHL) is important because it may be an early indicator of undiagnosed HIV infection; moreover, it may be a prognostic indicator. Our purpose was to investigate the histopathologic features of subclinical OHL and to evaluate and support the rationale of detecting subclinica...

journal_title：American journal of clinical pathology

authors： Dias EP,Rocha ML,Silva JúniorA,Spyrides KS,Ferreira SM,Polignano GA,Feijó EC,Da Fonseca EC

更新日期：2000-09-01 00:00:00

abstract：:The standard method for detecting antinuclear antibodies (ANAs) is by immunofluorescence assay (IFA), a method that is labor intensive and subjective. In an attempt to overcome these limitations, several commercial enzyme immunoassays (EIAs) have been developed. We report the results of our evaluation of the ANA Micro...

journal_title：American journal of clinical pathology

authors： Reisner BS,DiBlasi J,Goel N

更新日期：1999-04-01 00:00:00

abstract：:High-volume (200 ml) platelet concentrates prepared by discontinuous-flow centrifugation, with counts as high as ca. 2.0 x 10(12)/l, were stored in either 600 ml-capacity polyvinylchloride bags or 800-ml capacity polyethylene bags. Both polyvinylchloride and polyethylene bags appeared adequate for 24-hour storage of p...

journal_title：American journal of clinical pathology

authors： Rosenstein R,Lawe JE,North JG

更新日期：1980-03-01 00:00:00