Development of North American consensus guidelines for medical laboratories that perform and interpret platelet function testing using light transmission aggregometry.

Abstract:

:Platelet function testing is important for the diagnostic evaluation of common and rare bleeding disorders. Our study goals were to promote best practices and reduce unnecessary testing variances by developing North American guidelines on platelet function testing. Guidelines were developed by consensus for expert recommendations (minimum level for approval, 70%) that included recommendations on the evaluation and interpretation of light transmission platelet aggregometry (LTA). To assess consensus, medical opinions on recommendations were gathered from diagnostic laboratories that perform LTA, in collaboration with the Quality Management Program-Laboratory Services (QMP-LS) in Ontario, Canada (10 laboratories), and the North American Specialized Coagulation Laboratory Association (NASCOLA; 47 laboratories, 5 overlapping the QMP-LS group). Adequate consensus was achieved for all and 89% of recommendations for the QMP-LS and NASCOLA groups, respectively. The recommendations adopted provide North American laboratories with additional guidance on platelet function testing, including how to interpret LTA abnormalities.

journal_name

Am J Clin Pathol

authors

Hayward CP,Moffat KA,Raby A,Israels S,Plumhoff E,Flynn G,Zehnder JL

doi

10.1309/AJCP9V3RRVNZMKDS

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

955-63

issue

6

eissn

0002-9173

issn

1943-7722

pii

134/6/955

journal_volume

134

pub_type

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