Intestinal metaplasia of the esophagus or esophagogastric junction: evidence of distinct clinical, pathologic, and histochemical staining features.

Abstract:

:Our purpose was to evaluate the clinical, histologic, and histochemical staining characteristics of intestinal metaplasia (IM) at an endoscopically normal-appearing esophagogastric junction (IM-EGJ) compared with IM in a columnar-lined esophagus (IM-CLE). A prospective study included 253 patients referred for elective upper gastrointestinal endoscopy. Biopsy specimens were obtained from 2 cm above and immediately distal to the squamocolumnar junction, the gastric corpus, and the antrum. Any red mucosa above the EGJ was sampled. IM-CLE (prevalence, 5.5%) typically occurred in white male smokers with a long history of reflux symptoms. IM-EGJ (prevalence, 9.1%) was associated with corpus and antrum gastritis and with IM at these sites. IM-CLE usually (13/14 [93%]) was the incomplete type IM, whereas only 12 (52%) of 23 patients in the IM-EGJ group had incomplete IM. IM-EGJ and IM-CLE should be considered as separate entities. Further research is needed to evaluate whether neoplastic progression of IM-EGJ is related to its mucin profile.

journal_name

Am J Clin Pathol

authors

van Sandick JW,van Lanschot JB,van Felius L,Haringsma J,Tytgat GN,Dekker W,Drillenburg P,Offerhaus GJ,ten Kate FJ

doi

10.1309/N15U-FN5R-3M5D-PE0U

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

117-25

issue

1

eissn

0002-9173

issn

1943-7722

journal_volume

117

pub_type

杂志文章
  • BRAF mutation status in gastrointestinal stromal tumors.

    abstract::Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors characterized by mutations of KIT or PDGFRA. The objectives of this study were to evaluate BRAF mutations in GISTs and then to correlate BRAF mutational status in the tumor with clinical parameters, with B-raf expression, and with activation of some cellul...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPPCKGA2QGBJ1R

    authors: Hostein I,Faur N,Primois C,Boury F,Denard J,Emile JF,Bringuier PP,Scoazec JY,Coindre JM

    更新日期:2010-01-01 00:00:00

  • Non-Hodgkin's lymphomas of the sinonasal region: histologic subtypes and their clinicopathologic features.

    abstract::The authors describe 11 patients with non-Hodgkin's lymphoma arising in the nasal cavity or paranasal sinuses. Seven were men and four were women. The median age of the women was 76 years; the median age of the men was 45 years. The most common presenting symptoms were nasal obstruction and unilateral facial swelling....

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/81.6.721

    authors: Frierson HF Jr,Mills SE,Innes DJ Jr

    更新日期:1984-06-01 00:00:00

  • Sysmex SE-9000 hematology analyzer: performance evaluation on leukocyte differential counts using an NCCLS H20-A protocol. National Committee for Clinical Laboratory Standards.

    abstract::We evaluated the performance (ie, imprecision, inaccuracy, and analytic sensitivity) of the Sysmex SE-9000 commercial hematology analyzer (TOA Medical Electronics, Kobe, Japan) on differential leukocyte counts according to the National Committee for Clinical Laboratory Standards H20-A protocol. The results obtained we...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/108.6.674

    authors: Buttarello M,Bulian P,Temporin V,Rizzotti P

    更新日期:1997-12-01 00:00:00

  • Essential thrombocythemia with acquired von Willebrand's disease.

    abstract::Two patients with essential thrombocythemia showed a marked decrease in ristocetin-induced platelet aggregation in addition to other aggregation defects during routine aggregation studies for prolonged bleeding times. Further investigation revealed type I von Willebrand's disease (vWD) in one patient and a variant of ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/88.1.102

    authors: Raman BK,Sawdyk M,Saeed SM

    更新日期:1987-07-01 00:00:00

  • Immunophenotypic analysis of anaplastic large cell lymphoma by flow cytometry.

    abstract::We studied the antigen expression profiles of 19 anaplastic large cell lymphoma (ALCL) cases by multiparameter flow cytometry. The neoplastic cells expressed CD45, HLA-DR, and CD30 in all cases. At least 1 T cell-associated antigen was expressed in each case (CD2, 12/17 [71%]; CD4, 12/19 [63%]; CD3, 6/19 [32%]; CD7, 6...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/HEFL-7KC4-35KF-WEX8

    authors: Juco J,Holden JT,Mann KP,Kelley LG,Li S

    更新日期:2003-02-01 00:00:00

  • Immunohistochemistry of Warthin's tumor.

    abstract::This study describes results of fresh-frozen immunohistochemistry applied to two typical Warthin's tumors. Polyclonal follicular center cell staining and an apparent reduction in the number of T-lymphocytes were found. These observations tend to support the concept that the lymphoid infiltrate in Warthin's tumor repre...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/74.6.795

    authors: Tubbs RR,Sheibani K,Weiss RA,Lee V,Sebek BA,Valenzuela R

    更新日期:1980-12-01 00:00:00

  • Epstein-Barr virus infection associated with bone marrow fibrin-ring granuloma.

    abstract::We previously reported 24 cases of marrow fibrin-ring granuloma (FRG) encountered in 1 institution and concluded that, contrary to previous studies showing marrow FRG as a diagnostic marker for Q fever, Epstein-Barr virus (EBV) was the most common proven cause of such FRG. The present study characterized patients with...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPB7SX7QXASPSK

    authors: Chung HJ,Chi HS,Jang S,Park CJ

    更新日期:2010-02-01 00:00:00

  • Frozen-Section Checklist Implementation Improves Quality and Patient Safety.

    abstract:OBJECTIVES:An intraoperative consultation (IOC) checklist was developed and implemented aimed at standardizing slide labeling and monitoring metrics central to quality and safety in surgical pathology. DESIGN:Data were collected for all IOC cases over a 9-month period. Slide labeling defect rates and IOC turnaround ti...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqz009

    authors: Chen Y,Anderson KR,Xu J,Goldsmith JD,Heher YK

    更新日期:2019-05-03 00:00:00

  • Oral lichen planus and chronic hepatitis C: a controversial association.

    abstract::Our aim was to study the possible association between oral lichen planus and chronic hepatitis C in patients from the state of Minas Gerais, Brazil. Two groups of patients were studied: group 1, 50 patients with oral lichen planus evaluated for the presence of chronic hepatitis C; and group 2, 215 patients with chroni...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/HDWCT36P0GMGP40V

    authors: de Mattos Camargo Grossmann S,de Aguiar MC,Teixeira R,do Carmo MA

    更新日期:2007-05-01 00:00:00

  • Evaluation of three commercial enzyme immunoassays for toxoplasma and cytomegalovirus antibodies.

    abstract::Three commercially available enzyme immunoassays (EIAs) were evaluated for specificity and sensitivity compared to immunofluorescent assays (IFAs) for detection of IgG and IgM antibodies to Toxoplasma gondii (Toxo) and Cytomegalovirus (CMV). A panel of 78 sera were tested, including specimens known to contain Toxo IgG...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.3.428

    authors: Van Enk RA,James KK,Thompson KD

    更新日期:1991-03-01 00:00:00

  • Value of p63 and cytokeratin 5/6 as immunohistochemical markers for the differential diagnosis of poorly differentiated and undifferentiated carcinomas.

    abstract::To facilitate the differential diagnosis of poorly differentiated metastatic carcinomas of unknown primary site, we evaluated p63 and cytokeratin (CK) 5/6 as immunohistochemical markers for squamous cell carcinomas. The study cases were as follows: squamous cell carcinoma of the lungs, head/neck, esophagus, cervix ute...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/21TW-2NDG-JRK4-PFJX

    authors: Kaufmann O,Fietze E,Mengs J,Dietel M

    更新日期:2001-12-01 00:00:00

  • The diagnostic role of claudins in serous effusions.

    abstract::We analyzed the diagnostic role of claudins in effusion cytology in 325 effusions, including 218 ovarian, 49 breast, 15 cervical or endometrial, 10 gastrointestinal, and 8 lung adenocarcinomas and 25 malignant mesotheliomas (MMs). Specimens were analyzed for claudin-1 and claudin-3 expression using immunohistochemical...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/V025QRN3R9CJGNPX

    authors: Kleinberg L,Holth A,Fridman E,Schwartz I,Shih IeM,Davidson B

    更新日期:2007-06-01 00:00:00

  • Relationship of pathologic factors to efficacy of sorafenib treatment in patients with metastatic clear cell renal cell carcinoma.

    abstract:OBJECTIVES:To evaluate the predictive value of growth patterns in patients undergoing sorafenib treatment for metastatic clear cell renal cell carcinomas (CCRCCs). METHODS:Forty-eight patients were analyzed, each of whom underwent nephrectomy and received sorafenib treatment for metastatic CCRCC. Progression-free surv...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPM8RJ2ECAWOGQ

    authors: Araki H,Tsuzuki T,Kimura T,Tanaka K,Yamada S,Sassa N,Yoshino Y,Hattori R,Gotoh M

    更新日期:2015-04-01 00:00:00

  • Comparison of the clinic microscopy laboratory with the cytopathology laboratory in the detection of malignant cells in body fluids.

    abstract::The clinical microscopy (fluids) laboratory evaluates almost every body fluid that is obtained in the hospital. Because the fluids laboratory functions at all hours, it is often the first laboratory to receive a body fluid. In addition to its primary purpose of quantitating categories of cells, the medical technologis...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/102.4.439

    authors: Ben-Ezra J,Stastny JF,Harris AC,Bork L,Frable WJ

    更新日期:1994-10-01 00:00:00

  • A new solid phase passive hemagglutination test for IgM antibody to hepatitis B core antigen.

    abstract::There is a need for a simple, sensitive, specific, and inexpensive test for immunoglobulin M antibody to hepatitis B core antigen (anti-HBc IgM). A solid phase passive hemagglutination test (SP-PHA) was developed for this purpose and compared with the enzyme-linked immunosorbent assay (ELISA) test. Hepatitis B core an...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/87.2.267

    authors: Petchclai B,Khupulsup K,Kurathong S

    更新日期:1987-02-01 00:00:00

  • Does the size matter?: Prostate weight does not predict PSA recurrence after radical prostatectomy.

    abstract::Previous studies suggest that low prostate weight is a significant negative prognostic factor for prostate cancer. In the current study, the data for 431 men who underwent radical retropubic prostatectomy between 1990 and 1998 were analyzed for association between prostate weight and various clinical and pathologic pa...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPPHGXDI94SGAC

    authors: Davidson DD,Koch MO,Lin H,Jones TD,Biermann K,Cheng L

    更新日期:2010-04-01 00:00:00

  • Gonadoblastoma with tubal pregnancy.

    abstract::A case of unilateral gonadoblastoma in association with a ruptured ectopic tubal pregnancy is presented. The patient had normal menstrual history prior to a missed period followed by abdominal pain and the passage of clots. The surgical specimens, in addition to the ruptured tubal pregnancy, showed nodular foci of typ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/65.1.121

    authors: Pratt-Thomas HR,Cooper JM

    更新日期:1976-01-01 00:00:00

  • A double-blind comparative immunotypic study between two institutions phenotyping non-Hodgkin's lymphomas.

    abstract::To establish the feasibility of immunotyping specimens transported over great distance, the University of Arizona and the Cleveland Clinic exchanged 39 lymphoma cases (26 B-cell, 13 T-cell cases) via air express for phenotyping. They were exchanged with the use of glass slides with adherent snap-frozen sections. The m...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/87.4.478

    authors: Grogan TM,Tubbs RR

    更新日期:1987-04-01 00:00:00

  • JAK2 mutations across a spectrum of venous thrombosis cases.

    abstract::The JAK2(V617F)mutation is recurrent in polycythemia vera and essential thrombocythemia, which are myeloproliferative neoplasms frequently associated with arterial and venous thromboembolism. It has also been reported as a marker for occult myeloproliferative disorder (MPD) in patients with splanchnic venous thrombosi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP7VO4HAIZYATP

    authors: Shetty S,Kulkarni B,Pai N,Mukundan P,Kasatkar P,Ghosh K

    更新日期:2010-07-01 00:00:00

  • False negative results resulting from antigen excess by immunophenotyping a leukemia patient with a whole blood method.

    abstract::A patient with prolymphocytic leukemia was immunophenotyped by whole blood and Ficoll-Hypaque methods. Discordance was noted between the two methods, especially for the HLE1, B1, I2, and T1B monoclonal markers. The disparity in results reflected the use of 15 X 10(6) cells versus 1 X 10(6) cells per reaction tube. Thi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/91.2.227

    authors: Warzynski MJ,Podgurski AE,Boldt DM,Hetzel PC

    更新日期:1989-02-01 00:00:00

  • Development of North American consensus guidelines for medical laboratories that perform and interpret platelet function testing using light transmission aggregometry.

    abstract::Platelet function testing is important for the diagnostic evaluation of common and rare bleeding disorders. Our study goals were to promote best practices and reduce unnecessary testing variances by developing North American guidelines on platelet function testing. Guidelines were developed by consensus for expert rec...

    journal_title:American journal of clinical pathology

    pub_type: 共识发展会议,杂志文章,实务指引

    doi:10.1309/AJCP9V3RRVNZMKDS

    authors: Hayward CP,Moffat KA,Raby A,Israels S,Plumhoff E,Flynn G,Zehnder JL

    更新日期:2010-12-01 00:00:00

  • Primary CD20+CD10+CD8+ T-cell lymphoma of the skin with IgH and TCR beta gene rearrangement.

    abstract::Most cutaneous T-cell lymphomas are derived from mature postthymic T cells of the CD4 subtype. When other less common profiles are encountered, a diagnostic challenge is posed. Accurate categorization is critical because of the specificity of therapeutic regimens, including biologics. A 65-year-old woman was seen in 2...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/HPYG-FLNX-KFBH-DQEV

    authors: Magro CM,Seilstad KH,Porcu P,Morrison CD

    更新日期:2006-07-01 00:00:00

  • Fetal-maternal hemorrhage detection in Ontario.

    abstract::The results from fetal-maternal hemorrhage (FMH) detection and quantitation external quality assessment surveys conducted in Ontario indicate that the rosette test had a sensitivity and specificity for an FMH of more than 10 mL of 1.0 and 0.75, respectively, compared with 0.96 and 0.92, respectively, for acid elution....

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/3U97-V732-7JBD-PAYN

    authors: Lafferty JD,Raby A,Crawford L,Linkins LA,Richardson H,Crowther M

    更新日期:2003-01-01 00:00:00

  • Chemokines and their receptors: roles in specific clinical conditions and measurement in the clinical laboratory.

    abstract::Considerable progress has been achieved in our knowledge of the function of the chemokine system and in understanding its role in the pathophysiology of human diseases. This complex system, presently including approximately 50 cytokines and 20 receptors, coordinates leukocyte recruitment in a variety of human diseases...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/M6U4B8L6TNAK4G9L

    authors: Locati M,Bonecchi R,Corsi MM

    更新日期:2005-06-01 00:00:00

  • Signet ring cell lymphoma. A report of a case and review of the literature.

    abstract::A case of signet ring cell lymphoma, a rare variant of follicular center cell lymphoma, is presented with a review of 20 other such lymphomas previously reported in the English literature. The histologic, immunocytologic, and electron microscopic features are described with speculation as to the possible relationship ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/81.3.358

    authors: Silberman S,Fresco R,Steinecker PH

    更新日期:1984-03-01 00:00:00

  • Detection of enteroviral infection in paraffin-embedded tissue by the RNA polymerase chain reaction technique.

    abstract::A method using the RNA polymerase chain reaction technique to diagnose infection retrospectively using single-stranded RNA enteroviruses in paraffin-embedded tissue blocks is reported. This method takes advantage of extreme sequence conservation in the 5' untranslated region of the enteroviral genome and uses two roun...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/96.5.568

    authors: Redline RW,Genest DR,Tycko B

    更新日期:1991-11-01 00:00:00

  • Strategies for the analysis of oncogene overexpression. Studies of the neu oncogene in breast carcinoma.

    abstract::The development of a consistent strategy for the analysis of oncogene expression at the cellular level is essential for understanding the roles of these genes in the development and progression of human neoplasia. Detection of the neu oncogene products in breast carcinoma was selected as a model for analysis of oncoge...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/94.2.125

    authors: Naber SP,Tsutsumi Y,Yin S,Zolnay SA,Mobtaker H,Marks PJ,McKenzie SJ,DeLellis RA,Wolfe HJ

    更新日期:1990-08-01 00:00:00

  • Review of negative Papanicolaou tests. Is the retrospective 5-year review necessary?

    abstract::New federal regulations require review of all available negative gynecologic smears within the previous 5 years for each patient with a current high grade squamous intraepithelial lesion (HGSIL) or above. Two university hospitals retrospectively reviewed all patients who had HGSIL or above and who had prior negative s...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/101.1.19

    authors: Allen KA,Zaleski S,Cohen MB

    更新日期:1994-01-01 00:00:00

  • Workload recording by microcomputer.

    abstract::Workload recording as designed by the College of American Pathologists has proven to be an invaluable aid in the assessment of overall laboratory operation. The administrative information derived from the compilation of these workload statistics is utilized to provide effective and these workload statistics is utilize...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/74.4.469

    authors: Norbut AM,Foulis PR,Mendelow H

    更新日期:1980-10-01 00:00:00

  • Clinically relevant differences in prothrombin time and INR values related to blood sample collection in plastic vs glass tubes.

    abstract::We compared prothrombin times (PTs) and international normalized ratios (INRs) for blood samples drawn into plastic vs glass collection tubes. We collected 60 venous blood samples into 4.5-mL glass and 2 plastic tubes (2.7 and 3.5 mL). An additional 153 samples, including 63 from warfarin-anticoagulated patients, were...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Fiebig EW,Etzell JE,Ng VL

    更新日期:2005-12-01 00:00:00